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Protein
Submitted name:

Putative uncharacterized protein

Gene

Rora

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. core promoter sequence-specific DNA binding Source: MGI
  2. direct ligand regulated sequence-specific DNA binding transcription factor activity Source: MGI
  3. DNA binding Source: MGI
  4. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  5. oxysterol binding Source: MGI
  6. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  7. sequence-specific DNA binding Source: MGI
  8. sequence-specific DNA binding transcription factor activity Source: MGI
  9. steroid hormone receptor activity Source: InterPro
  10. transcription coactivator binding Source: MGI
  11. transcription corepressor binding Source: MGI
  12. transcription factor binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: MGI
  2. cellular response to hypoxia Source: MGI
  3. cellular response to interleukin-1 Source: MGI
  4. cellular response to sterol Source: MGI
  5. cellular response to tumor necrosis factor Source: MGI
  6. cerebellar Purkinje cell differentiation Source: MGI
  7. cGMP metabolic process Source: MGI
  8. circadian rhythm Source: Ensembl
  9. intracellular receptor signaling pathway Source: MGI
  10. muscle cell differentiation Source: MGI
  11. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  12. negative regulation of inflammatory response Source: MGI
  13. nitric oxide biosynthetic process Source: MGI
  14. positive regulation of transcription, DNA-templated Source: MGI
  15. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  16. positive regulation vascular endothelial growth factor production Source: MGI
  17. regulation of macrophage activation Source: MGI
  18. regulation of transcription, DNA-templated Source: MGI
  19. triglyceride homeostasis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:RoraImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:104661. Rora.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

BgeeiQ8BRL5.
ExpressionAtlasiQ8BRL5. baseline and differential.
GenevestigatoriQ8BRL5.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ8BRL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG106848.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003079. ROR_rcpt.
IPR001723. Str_hrmn_rcpt.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
[Graphical view]
PRINTSiPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
SMARTiSM00430. HOLI. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q8BRL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TPEGSKADSA VSSFYLDIQP SPDQSGLDIN GIKPEPICDY TPASGFFPYC
60 70 80 90 100
SFTNGETSPT VSMAELEHLA QNISKSHLET CQYLREELQQ ITWQTFLQEE
110 120 130 140 150
IENYQNKQRE VMWQLCAIKI TEAIQYVVEF AKRIDGFMEL CQNDQIVLLK
160 170 180 190 200
AGSLEVVFIR MCRAFDSQNN TVYFDGKYAS PDVFKSLGCE DFISFVFEFG
210 220 230 240 250
KSLCSMHLTE DEIALFSAFV LMSADRSWLQ EKVKIEKLQQ KIQLALQHVL
260 270 280 290 300
QKNHREDGIL TKLICKVSTL RALCGRHTEK LMAFKAIYPD IVRLHFPPLY
310
KELFTSEFEP AMQIDG
Length:316
Mass (Da):36,183
Last modified:February 28, 2003 - v1
Checksum:i1CC922302653CCDD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043990 mRNA. Translation: BAC31728.1.
UniGeneiMm.378450.
Mm.391890.
Mm.427266.
Mm.445802.
Mm.491288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043990 mRNA. Translation: BAC31728.1.
UniGeneiMm.378450.
Mm.391890.
Mm.427266.
Mm.445802.
Mm.491288.

3D structure databases

ProteinModelPortaliQ8BRL5.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ8BRL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:104661. Rora.

Phylogenomic databases

HOVERGENiHBG106848.

Miscellaneous databases

ChiTaRSiRora. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BRL5.
ExpressionAtlasiQ8BRL5. baseline and differential.
GenevestigatoriQ8BRL5.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003079. ROR_rcpt.
IPR001723. Str_hrmn_rcpt.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
[Graphical view]
PRINTSiPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
SMARTiSM00430. HOLI. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CortexImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CortexImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CortexImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2000)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CortexImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CortexImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CortexImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CortexImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CortexImported.

Entry informationi

Entry nameiQ8BRL5_MOUSE
AccessioniPrimary (citable) accession number: Q8BRL5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 28, 2003
Last sequence update: February 28, 2003
Last modified: March 31, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.