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Q8BRH4

- KMT2C_MOUSE

UniProt

Q8BRH4 - KMT2C_MOUSE

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Protein
Histone-lysine N-methyltransferase 2C
Gene
Kmt2c, Mll3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei4817 – 48171S-adenosyl-L-methionine By similarity
Metal bindingi4843 – 48431Zinc By similarity
Metal bindingi4891 – 48911Zinc By similarity
Metal bindingi4893 – 48931Zinc By similarity
Metal bindingi4898 – 48981Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi34 – 4613A.T hook
Add
BLAST
Zinc fingeri340 – 39051PHD-type 1
Add
BLAST
Zinc fingeri343 – 38846RING-type
Add
BLAST
Zinc fingeri387 – 43751PHD-type 2
Add
BLAST
Zinc fingeri435 – 48854DHHC-type
Add
BLAST
Zinc fingeri463 – 51957PHD-type 3
Add
BLAST
Zinc fingeri950 – 100354PHD-type 4
Add
BLAST
Zinc fingeri1000 – 105051PHD-type 5
Add
BLAST
Zinc fingeri1077 – 113256PHD-type 6
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. histone methyltransferase activity (H3-K4 specific) Source: MGI
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. histone methylation Source: UniProtKB
  2. intracellular signal transduction Source: InterPro
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase 2C (EC:2.1.1.43)
Short name:
Lysine N-methyltransferase 2C
Alternative name(s):
Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog
Gene namesi
Name:Kmt2c
Synonyms:Mll3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2444959. Kmt2c.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. histone methyltransferase complex Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 49034903Histone-lysine N-methyltransferase 2C
PRO_0000124880Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461Phosphoserine By similarity
Modified residuei89 – 891Phosphoserine By similarity
Modified residuei751 – 7511N6-acetyllysine By similarity
Modified residuei1294 – 12941Phosphoserine By similarity
Modified residuei1497 – 14971N6-acetyllysine By similarity
Modified residuei1761 – 17611N6-acetyllysine1 Publication
Modified residuei2005 – 20051N6-acetyllysine1 Publication
Modified residuei2796 – 27961N6-acetyllysine1 Publication
Modified residuei2803 – 28031N6-acetyllysine By similarity
Modified residuei2826 – 28261N6-acetyllysine By similarity
Modified residuei2862 – 28621N6-acetyllysine1 Publication
Modified residuei3709 – 37091N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8BRH4.
PRIDEiQ8BRH4.

PTM databases

PhosphoSiteiQ8BRH4.

Expressioni

Tissue specificityi

In adult, detected in testis, kidney, spleen and lung, weakly expressed in brain and absent in heart and liver. First detected throughout the embryo at 8 dpc when expression is strong in forebrain neuroepithelium and absent in heart. Expressed in the eye lens between 10 and 14.5 dpc. By 13 dpc, expressed strongly in spinal cord, hand/foot plates and gonads.1 Publication

Gene expression databases

ArrayExpressiQ8BRH4.
BgeeiQ8BRH4.
CleanExiMM_MLL3.
GenevestigatoriQ8BRH4.

Interactioni

Subunit structurei

Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin By similarity. Interacts with histone H3 By similarity.

Protein-protein interaction databases

IntActiQ8BRH4. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8BRH4.
SMRiQ8BRH4. Positions 245-330, 341-438, 465-517, 953-1050, 1079-1132, 1613-1702, 4391-4499, 4753-4903.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4537 – 459761FYR N-terminal
Add
BLAST
Domaini4598 – 468386FYR C-terminal
Add
BLAST
Domaini4763 – 4879117SET
Add
BLAST
Domaini4887 – 490317Post-SET
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4840 – 48412S-adenosyl-L-methionine binding By similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1330 – 135223 Reviewed prediction
Add
BLAST
Coiled coili1743 – 179048 Reviewed prediction
Add
BLAST
Coiled coili3047 – 307428 Reviewed prediction
Add
BLAST
Coiled coili3166 – 319328 Reviewed prediction
Add
BLAST
Coiled coili3224 – 327047 Reviewed prediction
Add
BLAST
Coiled coili3387 – 343246 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi384 – 487104Cys-rich
Add
BLAST
Compositional biasi970 – 1099130Cys-rich
Add
BLAST
Compositional biasi1519 – 156850Pro-rich
Add
BLAST
Compositional biasi1708 – 178780Gln-rich
Add
BLAST
Compositional biasi1831 – 2622792Pro-rich
Add
BLAST
Compositional biasi2682 – 278099Asp-rich
Add
BLAST
Compositional biasi3022 – 3504483Gln-rich
Add
BLAST

Domaini

The SET domain interacts with histone H3 but not H2A, H2B and H4, and may have a H3 lysine specific methylation activity By similarity.

Sequence similaritiesi

Contains 1 post-SET domain.
Contains 1 SET domain.

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000113602.
HOVERGENiHBG045586.
InParanoidiQ8BRH4.
PhylomeDBiQ8BRH4.

Family and domain databases

Gene3Di3.30.40.10. 6 hits.
InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR009071. HMG_box_dom.
IPR000637. HMGI/Y_DNA-bd_CS.
IPR003616. Post-SET_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001214. SET_dom.
IPR001594. Znf_DHHC_palmitoyltrfase.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00628. PHD. 2 hits.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00384. AT_hook. 2 hits.
SM00109. C1. 2 hits.
SM00542. FYRC. 1 hit.
SM00541. FYRN. 1 hit.
SM00398. HMG. 1 hit.
SM00249. PHD. 8 hits.
SM00508. PostSET. 1 hit.
SM00184. RING. 4 hits.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
SSF57903. SSF57903. 6 hits.
PROSITEiPS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS00354. HMGI_Y. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS50216. ZF_DHHC. 1 hit.
PS01359. ZF_PHD_1. 5 hits.
PS50016. ZF_PHD_2. 6 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BRH4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSEEDRSAE QQQPPPAPPE EPGAPAPSPA AADKRPRGRP RKDGASPFQR     50
ARKKPRSRGK STVEDEDSMD GLETTETENI VETEIKEQSV EEDAETEVDS 100
SKQPVSALQR SVSEESANSL VSVGVEAKIS EQLCAFCYCG EKSSLGQGDL 150
KQFRVTPGLT LPWKDQPSNK DIDDNSSGTC EKIQNYAPRK QRGQRKERPP 200
QQSAVSCVSV STQTACEDQA GKLWDELSLV GLPDAIDVQA LFDSTGTCWA 250
HHRCVEWSLG ICQMEEPLLV NVDKAVVSGS TERCAFCKHL GATIKCCEEK 300
CTQMYHYPCA AGAGTFQDFS HFFLLCPEHI DQAPERSKED ANCAVCDSPG 350
DLLDQFFCTT CGQHYHGMCL DIAVTPLKRA GWQCPECKVC QNCKQSGEDS 400
KMLVCDTCDK GYHTFCLQPV MKSVPTNGWK CKNCRICIEC GTRSSTQWHH 450
NCLICDTCYQ QQDNLCPFCG KCYHPELQKD MLHCNMCKRW VHLECDKPTD 500
QELDSQLKED YICMYCKHLG AEIDPLHPGN EVEMPELPTD YASGMEIEGT 550
EDEVVFLEQT VNKDVSDHQC RPGIVPDVQV YTEEPQKSNP LESPDTVGLI 600
TSESSDNKMN PDLANEIAHE VDTEKTEMLS KGRHVCEEDQ NEDRMEVTEN 650
IEVLPHQTIV PQEDLLLSED SEVASKELSP PKSAPETAAP EALLSPHSER 700
SLSCKEPLLT ERVQEEMEQK ENSEFSTGCV DFEMTLAVDS CDKDSSCQGD 750
KYVELPAEEE STFSSATDLN KADVSSSSTL CSDLPSCDML HGYPPAFNSA 800
AGSIMPTTYI SVTPKIGMGK PAITKRKFSP GRPRSKQGAW SNHNTVSPPS 850
WAPDTSEGRE IFKPRQLSGS AIWSIKVGRG SGFPGKRRPR GAGLSGRGGR 900
GRSKLKSGIG AVVLPGVSAA DISSNKDEEE NSMHNTVVLF SSSDKFTLQQ 950
DMCVVCGSFG QGAEGRLLAC SQCGQCYHPY CVSIKITKVV LSKGWRCLEC 1000
TVCEACGKAT DPGRLLLCDD CDISYHTYCL DPPLQTVPKG GWKCKWCVWC 1050
RHCGATSAGL RCEWQNNYTQ CAPCASLSSC PVCCRNYREE DLILQCRQCD 1100
RWMHAVCQNL NTEEEVENVA DIGFDCSMCR PYMPVSNVPS SDCCDSSLVA 1150
QIVTKVKELD PPKTYTQDGV CLTESGMSQL QSLTVTAPRR KRTKPKLKLK 1200
IINQNSVAVL QTPPDIQSEH SRDGEMDDSR EGELMDCDGK SESSPEREAG 1250
DDETKGIEGT DAIKKRKRKP YRPGIGGFMV RQRSRTGQGK AKRSVVRKDS 1300
SGSISEQLPS RDDGWREQLP DTLVDEPVSV AENTDKIKKR YRKRKNKLEE 1350
TFPAYLQEAF FGKDLLDTSR QNKLSVDNLS EDAAQLSFKT GFLDPSSDPL 1400
LSSSSTSAKP GTQGTADDPL ADISEVLNTD DDILGIISDD LAKSVDHSDI 1450
GPTTADASSL PQPGVSQSSR PLTEEQLDGI LSPELDKMVT DGAILGKLYK 1500
IPELGGKDVE DLFTAVLSPA TTQPAPLPQP PPPPQLLPMH NQDVFSRMPL 1550
MNGLIGPSPH LPHNSLPPGS GLGTFPAIAQ SPYTDVRDKS PAFNAIASDP 1600
NSSWAPTTPS MEGENDTLSN AQRSTLKWEK EEALGEMATV APVLYTNINF 1650
PNLKEEFPDW TTRVKQIAKL WRKASSQERA PYVQKARDNR AALRINKVQM 1700
SNDSMKRQQQ QDSIDPSSRI DSDLFKDPLK QRESEHEQEW KFRQQMRQKS 1750
KQQAKIEATQ KLEQVKNEQQ QQQQQQQQQQ QQQLASQHLL VAPGSDTPSS 1800
GAQSPLTPQA GNGNVSPAQT FHKDLFSKHL PGTPASTPSD GVFVKPQPPP 1850
PPSTPSRIPV QESLSQSQNS QPPSPQMFSP GSSHSRPPSP VDPYAKMVGT 1900
PRPPPGGHSF PRRNSVTPVE NCVPLSSVPR PIHMNETSAT RPSPARDLCA 1950
SSMTNSDPYA KPPDTPRPMM TDQFSKPFSL PRSPVISEQS TKGPLTTGTS 2000
DHFTKPSPRT DAFQRQRLPD PYAGPSLTPA PLGNGPFKTP LHPPPSQDPY 2050
GSVSQTSRRL SVDPYERPAL TPRPVDNFSH SQSNDPYSHP PLTPHPAMTE 2100
SFTHASRAFP QPGTISRSAS QDPYSQPPGT PRPLIDSYSQ TSGTARSNPD 2150
PYSQPPGTPR PNTIDPYSQQ PPTPRPSPQT DMFVSSVANQ RHTDPYTHHL 2200
GPPRPGISVP YSQPPAVPRP RTSEGFTRPS SARPALMPNQ DPFLQAAQNR 2250
VPGLPGPLIR PPDTCSQTPR PPGPGRIDTF THASSSAVRD PYDQPPVTPR 2300
PHSESFGTSQ VVHDLVDRPV PGSEGNFSTS SNLPVSSQGQ QFSSVSQLPG 2350
PVPTSGGTDT QNTVNMSQAD TEKLRQRQKL REIILQQQQQ KKIASRQEKG 2400
PQDTAVVPHP VPLPHWQPES INQAFTRPPP PYPGSTRSPV IPPLGPRYAV 2450
FPKDQRGPYP PEVAGMGMRP HGFRFGFPGA GHGPMPSQDR FHVPQQIQGS 2500
GIPPHIRRPM SMEMPRPSNN PPLNNPVGLP QHFPPQGLPV QQHNILGQAF 2550
IELRHRAPDG RSRLPFAASP SSVIESPSHP RHGNFLPRPD FPGPRHTDPI 2600
RQPSQCLSNQ LPVHPNLEQV PPSQQEQGHP AHQSSIVMRP LNHPLSGEFS 2650
EAPLSTSTPA ETSPDNLEIA GQSSAGLEEK LDSDDPSVKE LDVKDLEGVE 2700
VKDLDDEDLE NLNLDTEDGK GDDLDTLDNL ETNDPNLDDL LRSGEFDIIA 2750
YTDPELDLGD KKSMFNEELD LNVPIDDKLD NQCASVEPKT RDQGDKTMVL 2800
EDKDLPQRKS SVSSEIKTEA LSPYSKEEIQ SEIKNHDDSR GDADTACSQA 2850
ASAQTNHSDR GKTALLTTDQ DMLEKRCNQE NAGPVVSAIQ GSTPLPARDV 2900
MNSCDITGST PVLSSLLSNE KCDDSDIRPS GSSPPSLPIS PSTHGSSLPP 2950
TLIVPPSPLL DNTVNSNVTV VPRINHAFSQ GVPVNPGFIQ GQSSVNHNLG 3000
TGKPTNQTVP LTNQSSTMSG PQQLMIPQTL AQQNRERPLL LEEQPLLLQD 3050
LLDQERQEQQ QQRQMQAMIR QRSEPFFPNI DFDAITDPIM KAKMVALKGI 3100
NKVMAQNSLG MPPMVMSRFP FMGPSVAGTQ NNDGQTLVPQ AVAQDGSITH 3150
QISRPNPPNF GPGFVNDSQR KQYEEWLQET QQLLQMQQKY LEEQIGAHRK 3200
SKKALSAKQR TAKKAGREFP EEDAEQLKHV TEQQSMVQKQ LEQIRKQQKE 3250
HAELIEDYRI KQQQQQQQCA LAPPILMPGV QPQPPLVPGA TSLTMSQPNF 3300
PMVPQQLQHQ QHTAVISGHT SPARMPSLPG WQSNSASAHL PLNPPRIQPP 3350
IAQLSLKTCT PAPGTVSSAN PQNGPPPRVE FDDNNPFSES FQERERKERL 3400
REQQERQRVQ LMQEVDRQRA LQQRMEMEQH CLMGAELANR TPVSQMPFYG 3450
SDRPCDFLQP PRPLQQSPQH QQQIGPVLQQ QNVQQGSVNS PPNQTFMQTN 3500
EQRQVGPPSF VPDSPSASGG SPNFHSVKPG HGNLPGSSFQ QSPLRPPFTP 3550
ILPGTSPVAN SNVPCGQDPA VTQGQNYSGS SQSLIQLYSD IIPEEKGKKK 3600
RTRKKKKDDD AESGKAPSTP HSDCAAPLTP GLSETTSTPA VSSPSELPQQ 3650
RQQEPVEPVP VPTPNVSAGQ PCIESENKLP NSEFIKETSN QQTHVNAEAD 3700
KPSVETPNKT EEIKLEKAET QPSQEDTKVE EKTGNKIKDI VAGPVSSIQC 3750
PSHPVGTPTT KGDTGNELLK HLLKNKKASS LLTQKPEGTL SSDESSTKDG 3800
KLIEKQSPAE GLQTLGAQMQ GGFGGGNSQL PKTDGASENK KQRSKRTQRT 3850
GEKAAPRSKK RKKDEEEKQA MYSSSDSFTH LKQQNNLSNP PTPPASLPPT 3900
PPPMACQKMA NGFATTEELA GKAGVLVSHE VARALGPKPF QLPFRPQDDL 3950
LARAIAQGPK TVDVPASLPT PPHNNHEELR IQDHYGDRDT PDSFVPSSSP 4000
ESVVGVEVNK YPDLSLVKEE PPEPVPSPII PILPSISGKN SESRRNDIKT 4050
EPGTLFFTSP FGSSPNGPRS GLISVAITLH PTAAENISSV VAAFSDLLHV 4100
RIPNSYEVSN APDVPPMGLV SSHRVNPSLE YRQHLLLRGP PPGSANPPRL 4150
ATSYRLKQPN VPFPPTSNGL SGYKDSSHGP AEGASLRPQW CCHCKVVILG 4200
SGVRKSCKDL TFVNKGSREN TKRMEKDIVF CSNNCFILYS SAAQAKNSDN 4250
KESLPSLPQS PMKEPSKAFH QYSNNISTLD VHCLPQFQEK VSPPASPPIS 4300
FPPAFEAAKV ESKPDELKVT VKLKPRLRTV PVGLEDCRPL NKKWRGMKWK 4350
KWSIHIVIPK GTFKPPCEDE IDEFLKKLGT CLKPDPVPKD CRKCCFCHEE 4400
GDGLTDGPAR LLNLDLDLWV HLNCALWSTE VYETQAGALI NVELALRRGL 4450
QMKCVFCHKT GATSGCHRFR CTNIYHFTCA TKAQCMFFKD KTMLCPMHKP 4500
KGIHEQQLSY FAVFRRVYVQ RDEVRQIASI VQRGERDHTF RVGSLIFHTI 4550
GQLLPQQMQA FHSPKALFPV GYEASRLYWS TRYANRRCRY LCSIEEKDGR 4600
PVFVIRIVEQ GHEDLVLSDS SPKDVWDKIL EPVACVRKKS EMLQLFPAYL 4650
KGEDLFGLTV SAVARIAESL PGVEACENYT FRYGRNPLME LPLAVNPTGC 4700
ARSEPKMSAH VKRFVLRPHT LNSTSTSKSF QSTVTGELNA PYSKQFVHSK 4750
SSQYRRMKTE WKSNVYLARS RIQGLGLYAA RDIEKHTMVI EYIGTIIRNE 4800
VANRKEKLYE SQNRGVYMFR MDNDHVIDAT LTGGPARYIN HSCAPNCVAE 4850
VVTFERGHKI IISSNRRIQK GEELCYDYKF DFEDDQHKIP CHCGAVNCRK 4900
WMN 4903
Length:4,903
Mass (Da):540,187
Last modified:October 10, 2003 - v2
Checksum:i0B896490B081BA6C
GO
Isoform 2 (identifier: Q8BRH4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     839-878: Missing.
     1414-1448: Missing.
     1791-3080: Missing.
     3814-3884: Missing.
     4714-4717: Missing.

Show »
Length:3,463
Mass (Da):383,966
Checksum:iD14871D89FC23DAB
GO

Sequence cautioni

The sequence AAN11291.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei839 – 87840Missing in isoform 2.
VSP_020568Add
BLAST
Alternative sequencei1414 – 144835Missing in isoform 2.
VSP_020569Add
BLAST
Alternative sequencei1791 – 30801290Missing in isoform 2.
VSP_020570Add
BLAST
Alternative sequencei3814 – 388471Missing in isoform 2.
VSP_020571Add
BLAST
Alternative sequencei4714 – 47174Missing in isoform 2.
VSP_020572

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 369SPAAADKRP → RSFVCGCGA in AAN11291. 1 Publication
Sequence conflicti276 – 2761V → A in AAN11291. 1 Publication
Sequence conflicti433 – 4408NCRICIEC → VSDFLICF in BAC32109. 1 Publication
Sequence conflicti533 – 5331E → G in AAN11291. 1 Publication
Sequence conflicti577 – 5771D → DA in AAN11291. 1 Publication
Sequence conflicti675 – 6751S → C in BAC35712. 1 Publication
Sequence conflicti720 – 7201K → E in AAN11291. 1 Publication
Sequence conflicti763 – 7631F → L in AAN11291. 1 Publication
Sequence conflicti791 – 7911H → Y in AAN11291. 1 Publication
Sequence conflicti1324 – 13252VD → LH in AAN11291. 1 Publication
Sequence conflicti1737 – 17371E → V in AAN11291. 1 Publication
Sequence conflicti1776 – 17761Q → R in AAN11291. 1 Publication
Sequence conflicti3236 – 32361M → MM in AAN11291. 1 Publication
Sequence conflicti3423 – 34242QR → P in AAN11291. 1 Publication
Sequence conflicti3657 – 36571E → G in AAN11291. 1 Publication
Sequence conflicti3668 – 36681A → V in AAN11291. 1 Publication
Sequence conflicti4283 – 42831C → Y in AAN11291. 1 Publication
Sequence conflicti4306 – 43061E → D in AAN11291. 1 Publication
Sequence conflicti4520 – 45201Q → R in AAN11291. 1 Publication
Sequence conflicti4531 – 45311V → G in AAN11291. 1 Publication
Sequence conflicti4649 – 46491Y → H in AAN11291. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY138582 mRNA. Translation: AAN11291.1. Different initiation.
AC116469 Genomic DNA. No translation available.
AC127319 Genomic DNA. No translation available.
AC134910 Genomic DNA. No translation available.
AK044828 mRNA. Translation: BAC32109.1.
AK054270 mRNA. Translation: BAC35712.2.
AK077567 mRNA. Translation: BAC36867.1.
AY036886 mRNA. Translation: AAK70213.1.
AY036887 mRNA. Translation: AAK70214.1.
UniGeneiMm.332268.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY138582 mRNA. Translation: AAN11291.1 . Different initiation.
AC116469 Genomic DNA. No translation available.
AC127319 Genomic DNA. No translation available.
AC134910 Genomic DNA. No translation available.
AK044828 mRNA. Translation: BAC32109.1 .
AK054270 mRNA. Translation: BAC35712.2 .
AK077567 mRNA. Translation: BAC36867.1 .
AY036886 mRNA. Translation: AAK70213.1 .
AY036887 mRNA. Translation: AAK70214.1 .
UniGenei Mm.332268.

3D structure databases

ProteinModelPortali Q8BRH4.
SMRi Q8BRH4. Positions 245-330, 341-438, 465-517, 953-1050, 1079-1132, 1613-1702, 4391-4499, 4753-4903.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8BRH4. 3 interactions.

PTM databases

PhosphoSitei Q8BRH4.

Proteomic databases

PaxDbi Q8BRH4.
PRIDEi Q8BRH4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:2444959. Kmt2c.

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000113602.
HOVERGENi HBG045586.
InParanoidi Q8BRH4.
PhylomeDBi Q8BRH4.

Miscellaneous databases

ChiTaRSi MLL3. mouse.
PROi Q8BRH4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BRH4.
Bgeei Q8BRH4.
CleanExi MM_MLL3.
Genevestigatori Q8BRH4.

Family and domain databases

Gene3Di 3.30.40.10. 6 hits.
InterProi IPR017956. AT_hook_DNA-bd_motif.
IPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR009071. HMG_box_dom.
IPR000637. HMGI/Y_DNA-bd_CS.
IPR003616. Post-SET_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001214. SET_dom.
IPR001594. Znf_DHHC_palmitoyltrfase.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00628. PHD. 2 hits.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00384. AT_hook. 2 hits.
SM00109. C1. 2 hits.
SM00542. FYRC. 1 hit.
SM00541. FYRN. 1 hit.
SM00398. HMG. 1 hit.
SM00249. PHD. 8 hits.
SM00508. PostSET. 1 hit.
SM00184. RING. 4 hits.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
SSF57903. SSF57903. 6 hits.
PROSITEi PS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS00354. HMGI_Y. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS50216. ZF_DHHC. 1 hit.
PS01359. ZF_PHD_1. 5 hits.
PS50016. ZF_PHD_2. 6 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and expression analysis during embryo development of the mouse ortholog of MLL3."
    Brun M.-E., Gasca S., Girard C., Bouton K., De Massy B., De Sario A.
    Gene 371:25-33(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-814 AND 4803-4903.
    Strain: C57BL/6J.
    Tissue: Embryo.
  4. "Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects."
    Tan Y.C., Chow V.T.
    Cancer Detect. Prev. 25:454-469(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 957-1376 AND 4214-4894.
    Tissue: Myeloma.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1761; LYS-2005; LYS-2796 AND LYS-2862, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiKMT2C_MOUSE
AccessioniPrimary (citable) accession number: Q8BRH4
Secondary accession number(s): Q5YLV9
, Q8BK12, Q8C6M3, Q923H5, Q923H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: June 11, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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