Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8BRH4

- KMT2C_MOUSE

UniProt

Q8BRH4 - KMT2C_MOUSE

Protein

Histone-lysine N-methyltransferase 2C

Gene

Kmt2c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (10 Oct 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei4817 – 48171S-adenosyl-L-methioninePROSITE-ProRule annotation
    Metal bindingi4843 – 48431ZincBy similarity
    Metal bindingi4891 – 48911ZincBy similarity
    Metal bindingi4893 – 48931ZincBy similarity
    Metal bindingi4898 – 48981ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi34 – 4613A.T hookAdd
    BLAST
    Zinc fingeri340 – 39051PHD-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri343 – 38846RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri387 – 43751PHD-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri435 – 48854DHHC-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri463 – 51957PHD-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri950 – 100354PHD-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1000 – 105051PHD-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1077 – 113256PHD-type 6PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. histone methyltransferase activity (H3-K4 specific) Source: MGI
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histone methylation Source: UniProtKB
    2. intracellular signal transduction Source: InterPro
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Methyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase 2C (EC:2.1.1.43)
    Short name:
    Lysine N-methyltransferase 2C
    Alternative name(s):
    Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog
    Gene namesi
    Name:Kmt2c
    Synonyms:Mll3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2444959. Kmt2c.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. histone methyltransferase complex Source: MGI
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 49034903Histone-lysine N-methyltransferase 2CPRO_0000124880Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei46 – 461PhosphoserineBy similarity
    Modified residuei89 – 891PhosphoserineBy similarity
    Modified residuei751 – 7511N6-acetyllysineBy similarity
    Modified residuei1294 – 12941PhosphoserineBy similarity
    Modified residuei1497 – 14971N6-acetyllysineBy similarity
    Modified residuei1761 – 17611N6-acetyllysine1 Publication
    Modified residuei2005 – 20051N6-acetyllysine1 Publication
    Modified residuei2796 – 27961N6-acetyllysine1 Publication
    Modified residuei2803 – 28031N6-acetyllysineBy similarity
    Modified residuei2826 – 28261N6-acetyllysineBy similarity
    Modified residuei2862 – 28621N6-acetyllysine1 Publication
    Modified residuei3709 – 37091N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ8BRH4.
    PRIDEiQ8BRH4.

    PTM databases

    PhosphoSiteiQ8BRH4.

    Expressioni

    Tissue specificityi

    In adult, detected in testis, kidney, spleen and lung, weakly expressed in brain and absent in heart and liver. First detected throughout the embryo at 8 dpc when expression is strong in forebrain neuroepithelium and absent in heart. Expressed in the eye lens between 10 and 14.5 dpc. By 13 dpc, expressed strongly in spinal cord, hand/foot plates and gonads.1 Publication

    Gene expression databases

    ArrayExpressiQ8BRH4.
    BgeeiQ8BRH4.
    CleanExiMM_MLL3.
    GenevestigatoriQ8BRH4.

    Interactioni

    Subunit structurei

    Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin. Interacts with histone H3.By similarity

    Protein-protein interaction databases

    IntActiQ8BRH4. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BRH4.
    SMRiQ8BRH4. Positions 245-330, 341-438, 465-517, 953-1050, 1079-1132, 1613-1702, 4391-4499, 4753-4903.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4537 – 459761FYR N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini4598 – 468386FYR C-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini4763 – 4879117SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini4887 – 490317Post-SETPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni4840 – 48412S-adenosyl-L-methionine bindingBy similarity

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1330 – 135223Sequence AnalysisAdd
    BLAST
    Coiled coili1743 – 179048Sequence AnalysisAdd
    BLAST
    Coiled coili3047 – 307428Sequence AnalysisAdd
    BLAST
    Coiled coili3166 – 319328Sequence AnalysisAdd
    BLAST
    Coiled coili3224 – 327047Sequence AnalysisAdd
    BLAST
    Coiled coili3387 – 343246Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi384 – 487104Cys-richAdd
    BLAST
    Compositional biasi970 – 1099130Cys-richAdd
    BLAST
    Compositional biasi1519 – 156850Pro-richAdd
    BLAST
    Compositional biasi1708 – 178780Gln-richAdd
    BLAST
    Compositional biasi1831 – 2622792Pro-richAdd
    BLAST
    Compositional biasi2682 – 278099Asp-richAdd
    BLAST
    Compositional biasi3022 – 3504483Gln-richAdd
    BLAST

    Domaini

    The SET domain interacts with histone H3 but not H2A, H2B and H4, and may have a H3 lysine specific methylation activity.By similarity

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.PROSITE-ProRule annotation
    Contains 1 A.T hook DNA-binding domain.Curated
    Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation
    Contains 1 FYR C-terminal domain.PROSITE-ProRule annotation
    Contains 1 FYR N-terminal domain.PROSITE-ProRule annotation
    Contains 6 PHD-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri340 – 39051PHD-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri343 – 38846RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri387 – 43751PHD-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri435 – 48854DHHC-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri463 – 51957PHD-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri950 – 100354PHD-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1000 – 105051PHD-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1077 – 113256PHD-type 6PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG2940.
    HOGENOMiHOG000113602.
    HOVERGENiHBG045586.
    InParanoidiQ8BRH4.
    PhylomeDBiQ8BRH4.

    Family and domain databases

    Gene3Di3.30.40.10. 6 hits.
    InterProiIPR017956. AT_hook_DNA-bd_motif.
    IPR003889. FYrich_C.
    IPR003888. FYrich_N.
    IPR009071. HMG_box_dom.
    IPR000637. HMGI/Y_DNA-bd_CS.
    IPR003616. Post-SET_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR001214. SET_dom.
    IPR001594. Znf_DHHC_palmitoyltrfase.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF05965. FYRC. 1 hit.
    PF05964. FYRN. 1 hit.
    PF00628. PHD. 2 hits.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00384. AT_hook. 2 hits.
    SM00109. C1. 2 hits.
    SM00542. FYRC. 1 hit.
    SM00541. FYRN. 1 hit.
    SM00398. HMG. 1 hit.
    SM00249. PHD. 8 hits.
    SM00508. PostSET. 1 hit.
    SM00184. RING. 4 hits.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    SSF57903. SSF57903. 6 hits.
    PROSITEiPS51543. FYRC. 1 hit.
    PS51542. FYRN. 1 hit.
    PS00354. HMGI_Y. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50280. SET. 1 hit.
    PS50216. ZF_DHHC. 1 hit.
    PS01359. ZF_PHD_1. 5 hits.
    PS50016. ZF_PHD_2. 6 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BRH4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSEEDRSAE QQQPPPAPPE EPGAPAPSPA AADKRPRGRP RKDGASPFQR     50
    ARKKPRSRGK STVEDEDSMD GLETTETENI VETEIKEQSV EEDAETEVDS 100
    SKQPVSALQR SVSEESANSL VSVGVEAKIS EQLCAFCYCG EKSSLGQGDL 150
    KQFRVTPGLT LPWKDQPSNK DIDDNSSGTC EKIQNYAPRK QRGQRKERPP 200
    QQSAVSCVSV STQTACEDQA GKLWDELSLV GLPDAIDVQA LFDSTGTCWA 250
    HHRCVEWSLG ICQMEEPLLV NVDKAVVSGS TERCAFCKHL GATIKCCEEK 300
    CTQMYHYPCA AGAGTFQDFS HFFLLCPEHI DQAPERSKED ANCAVCDSPG 350
    DLLDQFFCTT CGQHYHGMCL DIAVTPLKRA GWQCPECKVC QNCKQSGEDS 400
    KMLVCDTCDK GYHTFCLQPV MKSVPTNGWK CKNCRICIEC GTRSSTQWHH 450
    NCLICDTCYQ QQDNLCPFCG KCYHPELQKD MLHCNMCKRW VHLECDKPTD 500
    QELDSQLKED YICMYCKHLG AEIDPLHPGN EVEMPELPTD YASGMEIEGT 550
    EDEVVFLEQT VNKDVSDHQC RPGIVPDVQV YTEEPQKSNP LESPDTVGLI 600
    TSESSDNKMN PDLANEIAHE VDTEKTEMLS KGRHVCEEDQ NEDRMEVTEN 650
    IEVLPHQTIV PQEDLLLSED SEVASKELSP PKSAPETAAP EALLSPHSER 700
    SLSCKEPLLT ERVQEEMEQK ENSEFSTGCV DFEMTLAVDS CDKDSSCQGD 750
    KYVELPAEEE STFSSATDLN KADVSSSSTL CSDLPSCDML HGYPPAFNSA 800
    AGSIMPTTYI SVTPKIGMGK PAITKRKFSP GRPRSKQGAW SNHNTVSPPS 850
    WAPDTSEGRE IFKPRQLSGS AIWSIKVGRG SGFPGKRRPR GAGLSGRGGR 900
    GRSKLKSGIG AVVLPGVSAA DISSNKDEEE NSMHNTVVLF SSSDKFTLQQ 950
    DMCVVCGSFG QGAEGRLLAC SQCGQCYHPY CVSIKITKVV LSKGWRCLEC 1000
    TVCEACGKAT DPGRLLLCDD CDISYHTYCL DPPLQTVPKG GWKCKWCVWC 1050
    RHCGATSAGL RCEWQNNYTQ CAPCASLSSC PVCCRNYREE DLILQCRQCD 1100
    RWMHAVCQNL NTEEEVENVA DIGFDCSMCR PYMPVSNVPS SDCCDSSLVA 1150
    QIVTKVKELD PPKTYTQDGV CLTESGMSQL QSLTVTAPRR KRTKPKLKLK 1200
    IINQNSVAVL QTPPDIQSEH SRDGEMDDSR EGELMDCDGK SESSPEREAG 1250
    DDETKGIEGT DAIKKRKRKP YRPGIGGFMV RQRSRTGQGK AKRSVVRKDS 1300
    SGSISEQLPS RDDGWREQLP DTLVDEPVSV AENTDKIKKR YRKRKNKLEE 1350
    TFPAYLQEAF FGKDLLDTSR QNKLSVDNLS EDAAQLSFKT GFLDPSSDPL 1400
    LSSSSTSAKP GTQGTADDPL ADISEVLNTD DDILGIISDD LAKSVDHSDI 1450
    GPTTADASSL PQPGVSQSSR PLTEEQLDGI LSPELDKMVT DGAILGKLYK 1500
    IPELGGKDVE DLFTAVLSPA TTQPAPLPQP PPPPQLLPMH NQDVFSRMPL 1550
    MNGLIGPSPH LPHNSLPPGS GLGTFPAIAQ SPYTDVRDKS PAFNAIASDP 1600
    NSSWAPTTPS MEGENDTLSN AQRSTLKWEK EEALGEMATV APVLYTNINF 1650
    PNLKEEFPDW TTRVKQIAKL WRKASSQERA PYVQKARDNR AALRINKVQM 1700
    SNDSMKRQQQ QDSIDPSSRI DSDLFKDPLK QRESEHEQEW KFRQQMRQKS 1750
    KQQAKIEATQ KLEQVKNEQQ QQQQQQQQQQ QQQLASQHLL VAPGSDTPSS 1800
    GAQSPLTPQA GNGNVSPAQT FHKDLFSKHL PGTPASTPSD GVFVKPQPPP 1850
    PPSTPSRIPV QESLSQSQNS QPPSPQMFSP GSSHSRPPSP VDPYAKMVGT 1900
    PRPPPGGHSF PRRNSVTPVE NCVPLSSVPR PIHMNETSAT RPSPARDLCA 1950
    SSMTNSDPYA KPPDTPRPMM TDQFSKPFSL PRSPVISEQS TKGPLTTGTS 2000
    DHFTKPSPRT DAFQRQRLPD PYAGPSLTPA PLGNGPFKTP LHPPPSQDPY 2050
    GSVSQTSRRL SVDPYERPAL TPRPVDNFSH SQSNDPYSHP PLTPHPAMTE 2100
    SFTHASRAFP QPGTISRSAS QDPYSQPPGT PRPLIDSYSQ TSGTARSNPD 2150
    PYSQPPGTPR PNTIDPYSQQ PPTPRPSPQT DMFVSSVANQ RHTDPYTHHL 2200
    GPPRPGISVP YSQPPAVPRP RTSEGFTRPS SARPALMPNQ DPFLQAAQNR 2250
    VPGLPGPLIR PPDTCSQTPR PPGPGRIDTF THASSSAVRD PYDQPPVTPR 2300
    PHSESFGTSQ VVHDLVDRPV PGSEGNFSTS SNLPVSSQGQ QFSSVSQLPG 2350
    PVPTSGGTDT QNTVNMSQAD TEKLRQRQKL REIILQQQQQ KKIASRQEKG 2400
    PQDTAVVPHP VPLPHWQPES INQAFTRPPP PYPGSTRSPV IPPLGPRYAV 2450
    FPKDQRGPYP PEVAGMGMRP HGFRFGFPGA GHGPMPSQDR FHVPQQIQGS 2500
    GIPPHIRRPM SMEMPRPSNN PPLNNPVGLP QHFPPQGLPV QQHNILGQAF 2550
    IELRHRAPDG RSRLPFAASP SSVIESPSHP RHGNFLPRPD FPGPRHTDPI 2600
    RQPSQCLSNQ LPVHPNLEQV PPSQQEQGHP AHQSSIVMRP LNHPLSGEFS 2650
    EAPLSTSTPA ETSPDNLEIA GQSSAGLEEK LDSDDPSVKE LDVKDLEGVE 2700
    VKDLDDEDLE NLNLDTEDGK GDDLDTLDNL ETNDPNLDDL LRSGEFDIIA 2750
    YTDPELDLGD KKSMFNEELD LNVPIDDKLD NQCASVEPKT RDQGDKTMVL 2800
    EDKDLPQRKS SVSSEIKTEA LSPYSKEEIQ SEIKNHDDSR GDADTACSQA 2850
    ASAQTNHSDR GKTALLTTDQ DMLEKRCNQE NAGPVVSAIQ GSTPLPARDV 2900
    MNSCDITGST PVLSSLLSNE KCDDSDIRPS GSSPPSLPIS PSTHGSSLPP 2950
    TLIVPPSPLL DNTVNSNVTV VPRINHAFSQ GVPVNPGFIQ GQSSVNHNLG 3000
    TGKPTNQTVP LTNQSSTMSG PQQLMIPQTL AQQNRERPLL LEEQPLLLQD 3050
    LLDQERQEQQ QQRQMQAMIR QRSEPFFPNI DFDAITDPIM KAKMVALKGI 3100
    NKVMAQNSLG MPPMVMSRFP FMGPSVAGTQ NNDGQTLVPQ AVAQDGSITH 3150
    QISRPNPPNF GPGFVNDSQR KQYEEWLQET QQLLQMQQKY LEEQIGAHRK 3200
    SKKALSAKQR TAKKAGREFP EEDAEQLKHV TEQQSMVQKQ LEQIRKQQKE 3250
    HAELIEDYRI KQQQQQQQCA LAPPILMPGV QPQPPLVPGA TSLTMSQPNF 3300
    PMVPQQLQHQ QHTAVISGHT SPARMPSLPG WQSNSASAHL PLNPPRIQPP 3350
    IAQLSLKTCT PAPGTVSSAN PQNGPPPRVE FDDNNPFSES FQERERKERL 3400
    REQQERQRVQ LMQEVDRQRA LQQRMEMEQH CLMGAELANR TPVSQMPFYG 3450
    SDRPCDFLQP PRPLQQSPQH QQQIGPVLQQ QNVQQGSVNS PPNQTFMQTN 3500
    EQRQVGPPSF VPDSPSASGG SPNFHSVKPG HGNLPGSSFQ QSPLRPPFTP 3550
    ILPGTSPVAN SNVPCGQDPA VTQGQNYSGS SQSLIQLYSD IIPEEKGKKK 3600
    RTRKKKKDDD AESGKAPSTP HSDCAAPLTP GLSETTSTPA VSSPSELPQQ 3650
    RQQEPVEPVP VPTPNVSAGQ PCIESENKLP NSEFIKETSN QQTHVNAEAD 3700
    KPSVETPNKT EEIKLEKAET QPSQEDTKVE EKTGNKIKDI VAGPVSSIQC 3750
    PSHPVGTPTT KGDTGNELLK HLLKNKKASS LLTQKPEGTL SSDESSTKDG 3800
    KLIEKQSPAE GLQTLGAQMQ GGFGGGNSQL PKTDGASENK KQRSKRTQRT 3850
    GEKAAPRSKK RKKDEEEKQA MYSSSDSFTH LKQQNNLSNP PTPPASLPPT 3900
    PPPMACQKMA NGFATTEELA GKAGVLVSHE VARALGPKPF QLPFRPQDDL 3950
    LARAIAQGPK TVDVPASLPT PPHNNHEELR IQDHYGDRDT PDSFVPSSSP 4000
    ESVVGVEVNK YPDLSLVKEE PPEPVPSPII PILPSISGKN SESRRNDIKT 4050
    EPGTLFFTSP FGSSPNGPRS GLISVAITLH PTAAENISSV VAAFSDLLHV 4100
    RIPNSYEVSN APDVPPMGLV SSHRVNPSLE YRQHLLLRGP PPGSANPPRL 4150
    ATSYRLKQPN VPFPPTSNGL SGYKDSSHGP AEGASLRPQW CCHCKVVILG 4200
    SGVRKSCKDL TFVNKGSREN TKRMEKDIVF CSNNCFILYS SAAQAKNSDN 4250
    KESLPSLPQS PMKEPSKAFH QYSNNISTLD VHCLPQFQEK VSPPASPPIS 4300
    FPPAFEAAKV ESKPDELKVT VKLKPRLRTV PVGLEDCRPL NKKWRGMKWK 4350
    KWSIHIVIPK GTFKPPCEDE IDEFLKKLGT CLKPDPVPKD CRKCCFCHEE 4400
    GDGLTDGPAR LLNLDLDLWV HLNCALWSTE VYETQAGALI NVELALRRGL 4450
    QMKCVFCHKT GATSGCHRFR CTNIYHFTCA TKAQCMFFKD KTMLCPMHKP 4500
    KGIHEQQLSY FAVFRRVYVQ RDEVRQIASI VQRGERDHTF RVGSLIFHTI 4550
    GQLLPQQMQA FHSPKALFPV GYEASRLYWS TRYANRRCRY LCSIEEKDGR 4600
    PVFVIRIVEQ GHEDLVLSDS SPKDVWDKIL EPVACVRKKS EMLQLFPAYL 4650
    KGEDLFGLTV SAVARIAESL PGVEACENYT FRYGRNPLME LPLAVNPTGC 4700
    ARSEPKMSAH VKRFVLRPHT LNSTSTSKSF QSTVTGELNA PYSKQFVHSK 4750
    SSQYRRMKTE WKSNVYLARS RIQGLGLYAA RDIEKHTMVI EYIGTIIRNE 4800
    VANRKEKLYE SQNRGVYMFR MDNDHVIDAT LTGGPARYIN HSCAPNCVAE 4850
    VVTFERGHKI IISSNRRIQK GEELCYDYKF DFEDDQHKIP CHCGAVNCRK 4900
    WMN 4903
    Length:4,903
    Mass (Da):540,187
    Last modified:October 10, 2003 - v2
    Checksum:i0B896490B081BA6C
    GO
    Isoform 2 (identifier: Q8BRH4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         839-878: Missing.
         1414-1448: Missing.
         1791-3080: Missing.
         3814-3884: Missing.
         4714-4717: Missing.

    Show »
    Length:3,463
    Mass (Da):383,966
    Checksum:iD14871D89FC23DAB
    GO

    Sequence cautioni

    The sequence AAN11291.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 369SPAAADKRP → RSFVCGCGA in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti276 – 2761V → A in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti433 – 4408NCRICIEC → VSDFLICF in BAC32109. (PubMed:16141072)Curated
    Sequence conflicti533 – 5331E → G in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti577 – 5771D → DA in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti675 – 6751S → C in BAC35712. (PubMed:16141072)Curated
    Sequence conflicti720 – 7201K → E in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti763 – 7631F → L in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti791 – 7911H → Y in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti1324 – 13252VD → LH in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti1737 – 17371E → V in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti1776 – 17761Q → R in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti3236 – 32361M → MM in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti3423 – 34242QR → P in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti3657 – 36571E → G in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti3668 – 36681A → V in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti4283 – 42831C → Y in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti4306 – 43061E → D in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti4520 – 45201Q → R in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti4531 – 45311V → G in AAN11291. (PubMed:16459028)Curated
    Sequence conflicti4649 – 46491Y → H in AAN11291. (PubMed:16459028)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei839 – 87840Missing in isoform 2. 1 PublicationVSP_020568Add
    BLAST
    Alternative sequencei1414 – 144835Missing in isoform 2. 1 PublicationVSP_020569Add
    BLAST
    Alternative sequencei1791 – 30801290Missing in isoform 2. 1 PublicationVSP_020570Add
    BLAST
    Alternative sequencei3814 – 388471Missing in isoform 2. 1 PublicationVSP_020571Add
    BLAST
    Alternative sequencei4714 – 47174Missing in isoform 2. 1 PublicationVSP_020572

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY138582 mRNA. Translation: AAN11291.1. Different initiation.
    AC116469 Genomic DNA. No translation available.
    AC127319 Genomic DNA. No translation available.
    AC134910 Genomic DNA. No translation available.
    AK044828 mRNA. Translation: BAC32109.1.
    AK054270 mRNA. Translation: BAC35712.2.
    AK077567 mRNA. Translation: BAC36867.1.
    AY036886 mRNA. Translation: AAK70213.1.
    AY036887 mRNA. Translation: AAK70214.1.
    UniGeneiMm.332268.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY138582 mRNA. Translation: AAN11291.1 . Different initiation.
    AC116469 Genomic DNA. No translation available.
    AC127319 Genomic DNA. No translation available.
    AC134910 Genomic DNA. No translation available.
    AK044828 mRNA. Translation: BAC32109.1 .
    AK054270 mRNA. Translation: BAC35712.2 .
    AK077567 mRNA. Translation: BAC36867.1 .
    AY036886 mRNA. Translation: AAK70213.1 .
    AY036887 mRNA. Translation: AAK70214.1 .
    UniGenei Mm.332268.

    3D structure databases

    ProteinModelPortali Q8BRH4.
    SMRi Q8BRH4. Positions 245-330, 341-438, 465-517, 953-1050, 1079-1132, 1613-1702, 4391-4499, 4753-4903.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8BRH4. 3 interactions.

    PTM databases

    PhosphoSitei Q8BRH4.

    Proteomic databases

    PaxDbi Q8BRH4.
    PRIDEi Q8BRH4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:2444959. Kmt2c.

    Phylogenomic databases

    eggNOGi COG2940.
    HOGENOMi HOG000113602.
    HOVERGENi HBG045586.
    InParanoidi Q8BRH4.
    PhylomeDBi Q8BRH4.

    Miscellaneous databases

    ChiTaRSi MLL3. mouse.
    PROi Q8BRH4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BRH4.
    Bgeei Q8BRH4.
    CleanExi MM_MLL3.
    Genevestigatori Q8BRH4.

    Family and domain databases

    Gene3Di 3.30.40.10. 6 hits.
    InterProi IPR017956. AT_hook_DNA-bd_motif.
    IPR003889. FYrich_C.
    IPR003888. FYrich_N.
    IPR009071. HMG_box_dom.
    IPR000637. HMGI/Y_DNA-bd_CS.
    IPR003616. Post-SET_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR001214. SET_dom.
    IPR001594. Znf_DHHC_palmitoyltrfase.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF05965. FYRC. 1 hit.
    PF05964. FYRN. 1 hit.
    PF00628. PHD. 2 hits.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00384. AT_hook. 2 hits.
    SM00109. C1. 2 hits.
    SM00542. FYRC. 1 hit.
    SM00541. FYRN. 1 hit.
    SM00398. HMG. 1 hit.
    SM00249. PHD. 8 hits.
    SM00508. PostSET. 1 hit.
    SM00184. RING. 4 hits.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    SSF57903. SSF57903. 6 hits.
    PROSITEi PS51543. FYRC. 1 hit.
    PS51542. FYRN. 1 hit.
    PS00354. HMGI_Y. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50280. SET. 1 hit.
    PS50216. ZF_DHHC. 1 hit.
    PS01359. ZF_PHD_1. 5 hits.
    PS50016. ZF_PHD_2. 6 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and expression analysis during embryo development of the mouse ortholog of MLL3."
      Brun M.-E., Gasca S., Girard C., Bouton K., De Massy B., De Sario A.
      Gene 371:25-33(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-814 AND 4803-4903.
      Strain: C57BL/6J.
      Tissue: Embryo.
    4. "Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects."
      Tan Y.C., Chow V.T.
      Cancer Detect. Prev. 25:454-469(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 957-1376 AND 4214-4894.
      Tissue: Myeloma.
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1761; LYS-2005; LYS-2796 AND LYS-2862, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiKMT2C_MOUSE
    AccessioniPrimary (citable) accession number: Q8BRH4
    Secondary accession number(s): Q5YLV9
    , Q8BK12, Q8C6M3, Q923H5, Q923H6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 10, 2003
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3