Reviewed, UniProtKB/Swiss-Prot Q8BRH4 (MLL3_MOUSE)

Names and origin

Protein names

Recommended name:
    Histone-lysine N-methyltransferase MLL3
    EC=2.1.1.43
Alternative name(s):
    Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog

Gene names

Name:

Mll3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	4903 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/MLL3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subunit structure	Component of the MLL2/MLL3 complex (also named ASCOM complex), at least composed of MLL2, MLL3, ASH2L, RBBP5, DPY30, NCOA6, WDR5, MEN1, KDM6A and PAXIP1/PTIP. Component of the MLL3/MLL4 complex at least composed of MLL3, MLL4, ASH2L, RBBP5, DPY30, WDR5, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Interacts with histone H3 By similarity.
Subcellular location	Nucleus Probable.
Tissue specificity	In adult, detected in testis, kidney, spleen and lung, weakly expressed in brain and absent in heart and liver. First detected throughout the embryo at 8 dpc when expression is strong in forebrain neuroepithelium and absent in heart. Expressed in the eye lens between 10 and 14.5 dpc. By 13 dpc, expressed strongly in spinal cord, hand/foot plates and gonads. Ref.1
Domain	The SET domain interacts with histone H3 but not H2A, H2B and H4, and may have a H3 lysine specific methylation activity By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. Contains 1 A.T hook DNA-binding domain. Contains 1 DHHC-type zinc finger. Contains 6 PHD-type zinc fingers. Contains 1 post-SET domain. Contains 1 RING-type zinc finger. Contains 1 SET domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat Zinc-finger
Ligand	DNA-binding Metal-binding S-adenosyl-L-methionine Zinc
Molecular function	Activator Chromatin regulator Methyltransferase Transferase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	histone methylation Inferred from direct assay. Source: UniProtKB intracellular signaling cascade Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	histone methyltransferase complex Inferred from direct assay. Source: MGI
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW histone methyltransferase activity (H3-K4 specific) Inferred from direct assay. Source: MGI protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8BRH4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8BRH4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     839-878: Missing.
     1414-1448: Missing.
     1791-3080: Missing.
     3814-3884: Missing.
     4714-4717: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 4903	4903	Histone-lysine N-methyltransferase MLL3		PRO_0000124880
Regions
	Domain	4762 – 4883	122	SET
	Domain	4887 – 4903	17	Post-SET
	DNA binding	34 – 46	13	A.T hook
	Zinc finger	340 – 390	51	PHD-type 1
	Zinc finger	343 – 388	46	RING-type
	Zinc finger	387 – 437	51	PHD-type 2
	Zinc finger	435 – 488	54	DHHC-type
	Zinc finger	463 – 519	57	PHD-type 3
	Zinc finger	950 – 1003	54	PHD-type 4
	Zinc finger	1000 – 1050	51	PHD-type 5
	Zinc finger	1077 – 1132	56	PHD-type 6
	Region	4840 – 4841	2	S-adenosyl-L-methionine binding By similarity
	Coiled coil	1330 – 1352	23	Potential
	Coiled coil	1743 – 1790	48	Potential
	Coiled coil	3047 – 3074	28	Potential
	Coiled coil	3166 – 3193	28	Potential
	Coiled coil	3224 – 3270	47	Potential
	Coiled coil	3387 – 3432	46	Potential
	Compositional bias	384 – 487	104	Cys-rich
	Compositional bias	970 – 1099	130	Cys-rich
	Compositional bias	1519 – 1568	50	Pro-rich
	Compositional bias	1708 – 1787	80	Gln-rich
	Compositional bias	1831 – 2622	792	Pro-rich
	Compositional bias	2682 – 2780	99	Asp-rich
	Compositional bias	3022 – 3504	483	Gln-rich
Sites
	Metal binding	4843	1	Zinc By similarity
	Metal binding	4891	1	Zinc By similarity
	Metal binding	4893	1	Zinc By similarity
	Metal binding	4898	1	Zinc By similarity
	Binding site	4817	1	S-adenosyl-L-methionine By similarity
Amino acid modifications
	Modified residue	751	1	N6-acetyllysine By similarity
	Modified residue	820	1	N6-acetyllysine By similarity
	Modified residue	1497	1	N6-acetyllysine By similarity
	Modified residue	1761	1	N6-acetyllysine By similarity
	Modified residue	2005	1	N6-acetyllysine By similarity
	Modified residue	2796	1	N6-acetyllysine By similarity
	Modified residue	2803	1	N6-acetyllysine By similarity
	Modified residue	2826	1	N6-acetyllysine By similarity
	Modified residue	3709	1	N6-acetyllysine By similarity
	Modified residue	3938	1	N6-acetyllysine By similarity
	Modified residue	4011	1	Phosphotyrosine By similarity
	Modified residue	4015	1	Phosphoserine By similarity
	Modified residue	4027	1	Phosphoserine By similarity
	Modified residue	4043	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	839 – 878	40	Missing in isoform 2.		VSP_020568
	Alternative sequence	1414 – 1448	35	Missing in isoform 2.		VSP_020569
	Alternative sequence	1791 – 3080	1290	Missing in isoform 2.		VSP_020570
	Alternative sequence	3814 – 3884	71	Missing in isoform 2.		VSP_020571
	Alternative sequence	4714 – 4717	4	Missing in isoform 2.		VSP_020572
Experimental info
	Sequence conflict	28 – 36	9	SPAAADKRP → RSFVCGCGA Ref.1
	Sequence conflict	276	1	V → A Ref.1
	Sequence conflict	433 – 440	8	NCRICIEC → VSDFLICF in BAC32109. Ref.3
	Sequence conflict	533	1	E → G Ref.1
	Sequence conflict	577	1	D → DA Ref.1
	Sequence conflict	675	1	S → C in BAC35712. Ref.3
	Sequence conflict	720	1	K → E Ref.1
	Sequence conflict	763	1	F → L Ref.1
	Sequence conflict	791	1	H → Y Ref.1
	Sequence conflict	1324 – 1325	2	VD → LH Ref.1
	Sequence conflict	1737	1	E → V Ref.1
	Sequence conflict	1776	1	Q → R Ref.1
	Sequence conflict	3236	1	M → MM Ref.1
	Sequence conflict	3423 – 3424	2	QR → P Ref.1
	Sequence conflict	3657	1	E → G Ref.1
	Sequence conflict	3668	1	A → V Ref.1
	Sequence conflict	4283	1	C → Y Ref.1
	Sequence conflict	4306	1	E → D Ref.1
	Sequence conflict	4520	1	Q → R Ref.1
	Sequence conflict	4531	1	V → G Ref.1
	Sequence conflict	4649	1	Y → H Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 10, 2003. Version 2. Checksum: 0B896490B081BA6C	FASTA	4,903	540,187
	10 20 30 40 50 60 MSSEEDRSAE QQQPPPAPPE EPGAPAPSPA AADKRPRGRP RKDGASPFQR ARKKPRSRGK 70 80 90 100 110 120 STVEDEDSMD GLETTETENI VETEIKEQSV EEDAETEVDS SKQPVSALQR SVSEESANSL 130 140 150 160 170 180 VSVGVEAKIS EQLCAFCYCG EKSSLGQGDL KQFRVTPGLT LPWKDQPSNK DIDDNSSGTC 190 200 210 220 230 240 EKIQNYAPRK QRGQRKERPP QQSAVSCVSV STQTACEDQA GKLWDELSLV GLPDAIDVQA 250 260 270 280 290 300 LFDSTGTCWA HHRCVEWSLG ICQMEEPLLV NVDKAVVSGS TERCAFCKHL GATIKCCEEK 310 320 330 340 350 360 CTQMYHYPCA AGAGTFQDFS HFFLLCPEHI DQAPERSKED ANCAVCDSPG DLLDQFFCTT 370 380 390 400 410 420 CGQHYHGMCL DIAVTPLKRA GWQCPECKVC QNCKQSGEDS KMLVCDTCDK GYHTFCLQPV 430 440 450 460 470 480 MKSVPTNGWK CKNCRICIEC GTRSSTQWHH NCLICDTCYQ QQDNLCPFCG KCYHPELQKD 490 500 510 520 530 540 MLHCNMCKRW VHLECDKPTD QELDSQLKED YICMYCKHLG AEIDPLHPGN EVEMPELPTD 550 560 570 580 590 600 YASGMEIEGT EDEVVFLEQT VNKDVSDHQC RPGIVPDVQV YTEEPQKSNP LESPDTVGLI 610 620 630 640 650 660 TSESSDNKMN PDLANEIAHE VDTEKTEMLS KGRHVCEEDQ NEDRMEVTEN IEVLPHQTIV 670 680 690 700 710 720 PQEDLLLSED SEVASKELSP PKSAPETAAP EALLSPHSER SLSCKEPLLT ERVQEEMEQK 730 740 750 760 770 780 ENSEFSTGCV DFEMTLAVDS CDKDSSCQGD KYVELPAEEE STFSSATDLN KADVSSSSTL 790 800 810 820 830 840 CSDLPSCDML HGYPPAFNSA AGSIMPTTYI SVTPKIGMGK PAITKRKFSP GRPRSKQGAW 850 860 870 880 890 900 SNHNTVSPPS WAPDTSEGRE IFKPRQLSGS AIWSIKVGRG SGFPGKRRPR GAGLSGRGGR 910 920 930 940 950 960 GRSKLKSGIG AVVLPGVSAA DISSNKDEEE NSMHNTVVLF SSSDKFTLQQ DMCVVCGSFG 970 980 990 1000 1010 1020 QGAEGRLLAC SQCGQCYHPY CVSIKITKVV LSKGWRCLEC TVCEACGKAT DPGRLLLCDD 1030 1040 1050 1060 1070 1080 CDISYHTYCL DPPLQTVPKG GWKCKWCVWC RHCGATSAGL RCEWQNNYTQ CAPCASLSSC 1090 1100 1110 1120 1130 1140 PVCCRNYREE DLILQCRQCD RWMHAVCQNL NTEEEVENVA DIGFDCSMCR PYMPVSNVPS 1150 1160 1170 1180 1190 1200 SDCCDSSLVA QIVTKVKELD PPKTYTQDGV CLTESGMSQL QSLTVTAPRR KRTKPKLKLK 1210 1220 1230 1240 1250 1260 IINQNSVAVL QTPPDIQSEH SRDGEMDDSR EGELMDCDGK SESSPEREAG DDETKGIEGT 1270 1280 1290 1300 1310 1320 DAIKKRKRKP YRPGIGGFMV RQRSRTGQGK AKRSVVRKDS SGSISEQLPS RDDGWREQLP 1330 1340 1350 1360 1370 1380 DTLVDEPVSV AENTDKIKKR YRKRKNKLEE TFPAYLQEAF FGKDLLDTSR QNKLSVDNLS 1390 1400 1410 1420 1430 1440 EDAAQLSFKT GFLDPSSDPL LSSSSTSAKP GTQGTADDPL ADISEVLNTD DDILGIISDD 1450 1460 1470 1480 1490 1500 LAKSVDHSDI GPTTADASSL PQPGVSQSSR PLTEEQLDGI LSPELDKMVT DGAILGKLYK 1510 1520 1530 1540 1550 1560 IPELGGKDVE DLFTAVLSPA TTQPAPLPQP PPPPQLLPMH NQDVFSRMPL MNGLIGPSPH 1570 1580 1590 1600 1610 1620 LPHNSLPPGS GLGTFPAIAQ SPYTDVRDKS PAFNAIASDP NSSWAPTTPS MEGENDTLSN 1630 1640 1650 1660 1670 1680 AQRSTLKWEK EEALGEMATV APVLYTNINF PNLKEEFPDW TTRVKQIAKL WRKASSQERA 1690 1700 1710 1720 1730 1740 PYVQKARDNR AALRINKVQM SNDSMKRQQQ QDSIDPSSRI DSDLFKDPLK QRESEHEQEW 1750 1760 1770 1780 1790 1800 KFRQQMRQKS KQQAKIEATQ KLEQVKNEQQ QQQQQQQQQQ QQQLASQHLL VAPGSDTPSS 1810 1820 1830 1840 1850 1860 GAQSPLTPQA GNGNVSPAQT FHKDLFSKHL PGTPASTPSD GVFVKPQPPP PPSTPSRIPV 1870 1880 1890 1900 1910 1920 QESLSQSQNS QPPSPQMFSP GSSHSRPPSP VDPYAKMVGT PRPPPGGHSF PRRNSVTPVE 1930 1940 1950 1960 1970 1980 NCVPLSSVPR PIHMNETSAT RPSPARDLCA SSMTNSDPYA KPPDTPRPMM TDQFSKPFSL 1990 2000 2010 2020 2030 2040 PRSPVISEQS TKGPLTTGTS DHFTKPSPRT DAFQRQRLPD PYAGPSLTPA PLGNGPFKTP 2050 2060 2070 2080 2090 2100 LHPPPSQDPY GSVSQTSRRL SVDPYERPAL TPRPVDNFSH SQSNDPYSHP PLTPHPAMTE 2110 2120 2130 2140 2150 2160 SFTHASRAFP QPGTISRSAS QDPYSQPPGT PRPLIDSYSQ TSGTARSNPD PYSQPPGTPR 2170 2180 2190 2200 2210 2220 PNTIDPYSQQ PPTPRPSPQT DMFVSSVANQ RHTDPYTHHL GPPRPGISVP YSQPPAVPRP 2230 2240 2250 2260 2270 2280 RTSEGFTRPS SARPALMPNQ DPFLQAAQNR VPGLPGPLIR PPDTCSQTPR PPGPGRIDTF 2290 2300 2310 2320 2330 2340 THASSSAVRD PYDQPPVTPR PHSESFGTSQ VVHDLVDRPV PGSEGNFSTS SNLPVSSQGQ 2350 2360 2370 2380 2390 2400 QFSSVSQLPG PVPTSGGTDT QNTVNMSQAD TEKLRQRQKL REIILQQQQQ KKIASRQEKG 2410 2420 2430 2440 2450 2460 PQDTAVVPHP VPLPHWQPES INQAFTRPPP PYPGSTRSPV IPPLGPRYAV FPKDQRGPYP 2470 2480 2490 2500 2510 2520 PEVAGMGMRP HGFRFGFPGA GHGPMPSQDR FHVPQQIQGS GIPPHIRRPM SMEMPRPSNN 2530 2540 2550 2560 2570 2580 PPLNNPVGLP QHFPPQGLPV QQHNILGQAF IELRHRAPDG RSRLPFAASP SSVIESPSHP 2590 2600 2610 2620 2630 2640 RHGNFLPRPD FPGPRHTDPI RQPSQCLSNQ LPVHPNLEQV PPSQQEQGHP AHQSSIVMRP 2650 2660 2670 2680 2690 2700 LNHPLSGEFS EAPLSTSTPA ETSPDNLEIA GQSSAGLEEK LDSDDPSVKE LDVKDLEGVE 2710 2720 2730 2740 2750 2760 VKDLDDEDLE NLNLDTEDGK GDDLDTLDNL ETNDPNLDDL LRSGEFDIIA YTDPELDLGD 2770 2780 2790 2800 2810 2820 KKSMFNEELD LNVPIDDKLD NQCASVEPKT RDQGDKTMVL EDKDLPQRKS SVSSEIKTEA 2830 2840 2850 2860 2870 2880 LSPYSKEEIQ SEIKNHDDSR GDADTACSQA ASAQTNHSDR GKTALLTTDQ DMLEKRCNQE 2890 2900 2910 2920 2930 2940 NAGPVVSAIQ GSTPLPARDV MNSCDITGST PVLSSLLSNE KCDDSDIRPS GSSPPSLPIS 2950 2960 2970 2980 2990 3000 PSTHGSSLPP TLIVPPSPLL DNTVNSNVTV VPRINHAFSQ GVPVNPGFIQ GQSSVNHNLG 3010 3020 3030 3040 3050 3060 TGKPTNQTVP LTNQSSTMSG PQQLMIPQTL AQQNRERPLL LEEQPLLLQD LLDQERQEQQ 3070 3080 3090 3100 3110 3120 QQRQMQAMIR QRSEPFFPNI DFDAITDPIM KAKMVALKGI NKVMAQNSLG MPPMVMSRFP 3130 3140 3150 3160 3170 3180 FMGPSVAGTQ NNDGQTLVPQ AVAQDGSITH QISRPNPPNF GPGFVNDSQR KQYEEWLQET 3190 3200 3210 3220 3230 3240 QQLLQMQQKY LEEQIGAHRK SKKALSAKQR TAKKAGREFP EEDAEQLKHV TEQQSMVQKQ 3250 3260 3270 3280 3290 3300 LEQIRKQQKE HAELIEDYRI KQQQQQQQCA LAPPILMPGV QPQPPLVPGA TSLTMSQPNF 3310 3320 3330 3340 3350 3360 PMVPQQLQHQ QHTAVISGHT SPARMPSLPG WQSNSASAHL PLNPPRIQPP IAQLSLKTCT 3370 3380 3390 3400 3410 3420 PAPGTVSSAN PQNGPPPRVE FDDNNPFSES FQERERKERL REQQERQRVQ LMQEVDRQRA 3430 3440 3450 3460 3470 3480 LQQRMEMEQH CLMGAELANR TPVSQMPFYG SDRPCDFLQP PRPLQQSPQH QQQIGPVLQQ 3490 3500 3510 3520 3530 3540 QNVQQGSVNS PPNQTFMQTN EQRQVGPPSF VPDSPSASGG SPNFHSVKPG HGNLPGSSFQ 3550 3560 3570 3580 3590 3600 QSPLRPPFTP ILPGTSPVAN SNVPCGQDPA VTQGQNYSGS SQSLIQLYSD IIPEEKGKKK 3610 3620 3630 3640 3650 3660 RTRKKKKDDD AESGKAPSTP HSDCAAPLTP GLSETTSTPA VSSPSELPQQ RQQEPVEPVP 3670 3680 3690 3700 3710 3720 VPTPNVSAGQ PCIESENKLP NSEFIKETSN QQTHVNAEAD KPSVETPNKT EEIKLEKAET 3730 3740 3750 3760 3770 3780 QPSQEDTKVE EKTGNKIKDI VAGPVSSIQC PSHPVGTPTT KGDTGNELLK HLLKNKKASS 3790 3800 3810 3820 3830 3840 LLTQKPEGTL SSDESSTKDG KLIEKQSPAE GLQTLGAQMQ GGFGGGNSQL PKTDGASENK 3850 3860 3870 3880 3890 3900 KQRSKRTQRT GEKAAPRSKK RKKDEEEKQA MYSSSDSFTH LKQQNNLSNP PTPPASLPPT 3910 3920 3930 3940 3950 3960 PPPMACQKMA NGFATTEELA GKAGVLVSHE VARALGPKPF QLPFRPQDDL LARAIAQGPK 3970 3980 3990 4000 4010 4020 TVDVPASLPT PPHNNHEELR IQDHYGDRDT PDSFVPSSSP ESVVGVEVNK YPDLSLVKEE 4030 4040 4050 4060 4070 4080 PPEPVPSPII PILPSISGKN SESRRNDIKT EPGTLFFTSP FGSSPNGPRS GLISVAITLH 4090 4100 4110 4120 4130 4140 PTAAENISSV VAAFSDLLHV RIPNSYEVSN APDVPPMGLV SSHRVNPSLE YRQHLLLRGP 4150 4160 4170 4180 4190 4200 PPGSANPPRL ATSYRLKQPN VPFPPTSNGL SGYKDSSHGP AEGASLRPQW CCHCKVVILG 4210 4220 4230 4240 4250 4260 SGVRKSCKDL TFVNKGSREN TKRMEKDIVF CSNNCFILYS SAAQAKNSDN KESLPSLPQS 4270 4280 4290 4300 4310 4320 PMKEPSKAFH QYSNNISTLD VHCLPQFQEK VSPPASPPIS FPPAFEAAKV ESKPDELKVT 4330 4340 4350 4360 4370 4380 VKLKPRLRTV PVGLEDCRPL NKKWRGMKWK KWSIHIVIPK GTFKPPCEDE IDEFLKKLGT 4390 4400 4410 4420 4430 4440 CLKPDPVPKD CRKCCFCHEE GDGLTDGPAR LLNLDLDLWV HLNCALWSTE VYETQAGALI 4450 4460 4470 4480 4490 4500 NVELALRRGL QMKCVFCHKT GATSGCHRFR CTNIYHFTCA TKAQCMFFKD KTMLCPMHKP 4510 4520 4530 4540 4550 4560 KGIHEQQLSY FAVFRRVYVQ RDEVRQIASI VQRGERDHTF RVGSLIFHTI GQLLPQQMQA 4570 4580 4590 4600 4610 4620 FHSPKALFPV GYEASRLYWS TRYANRRCRY LCSIEEKDGR PVFVIRIVEQ GHEDLVLSDS 4630 4640 4650 4660 4670 4680 SPKDVWDKIL EPVACVRKKS EMLQLFPAYL KGEDLFGLTV SAVARIAESL PGVEACENYT 4690 4700 4710 4720 4730 4740 FRYGRNPLME LPLAVNPTGC ARSEPKMSAH VKRFVLRPHT LNSTSTSKSF QSTVTGELNA 4750 4760 4770 4780 4790 4800 PYSKQFVHSK SSQYRRMKTE WKSNVYLARS RIQGLGLYAA RDIEKHTMVI EYIGTIIRNE 4810 4820 4830 4840 4850 4860 VANRKEKLYE SQNRGVYMFR MDNDHVIDAT LTGGPARYIN HSCAPNCVAE VVTFERGHKI 4870 4880 4890 4900 IISSNRRIQK GEELCYDYKF DFEDDQHKIP CHCGAVNCRK WMN
	Isoform 2. Checksum: D14871D89FC23DAB	FASTA	3,463	383,966
	10 20 30 40 50 60 MSSEEDRSAE QQQPPPAPPE EPGAPAPSPA AADKRPRGRP RKDGASPFQR ARKKPRSRGK 70 80 90 100 110 120 STVEDEDSMD GLETTETENI VETEIKEQSV EEDAETEVDS SKQPVSALQR SVSEESANSL 130 140 150 160 170 180 VSVGVEAKIS EQLCAFCYCG EKSSLGQGDL KQFRVTPGLT LPWKDQPSNK DIDDNSSGTC 190 200 210 220 230 240 EKIQNYAPRK QRGQRKERPP QQSAVSCVSV STQTACEDQA GKLWDELSLV GLPDAIDVQA 250 260 270 280 290 300 LFDSTGTCWA HHRCVEWSLG ICQMEEPLLV NVDKAVVSGS TERCAFCKHL GATIKCCEEK 310 320 330 340 350 360 CTQMYHYPCA AGAGTFQDFS HFFLLCPEHI DQAPERSKED ANCAVCDSPG DLLDQFFCTT 370 380 390 400 410 420 CGQHYHGMCL DIAVTPLKRA GWQCPECKVC QNCKQSGEDS KMLVCDTCDK GYHTFCLQPV 430 440 450 460 470 480 MKSVPTNGWK CKNCRICIEC GTRSSTQWHH NCLICDTCYQ QQDNLCPFCG KCYHPELQKD 490 500 510 520 530 540 MLHCNMCKRW VHLECDKPTD QELDSQLKED YICMYCKHLG AEIDPLHPGN EVEMPELPTD 550 560 570 580 590 600 YASGMEIEGT EDEVVFLEQT VNKDVSDHQC RPGIVPDVQV YTEEPQKSNP LESPDTVGLI 610 620 630 640 650 660 TSESSDNKMN PDLANEIAHE VDTEKTEMLS KGRHVCEEDQ NEDRMEVTEN IEVLPHQTIV 670 680 690 700 710 720 PQEDLLLSED SEVASKELSP PKSAPETAAP EALLSPHSER SLSCKEPLLT ERVQEEMEQK 730 740 750 760 770 780 ENSEFSTGCV DFEMTLAVDS CDKDSSCQGD KYVELPAEEE STFSSATDLN KADVSSSSTL 790 800 810 820 830 840 CSDLPSCDML HGYPPAFNSA AGSIMPTTYI SVTPKIGMGK PAITKRKFSP GRPRSKQGRG 850 860 870 880 890 900 SGFPGKRRPR GAGLSGRGGR GRSKLKSGIG AVVLPGVSAA DISSNKDEEE NSMHNTVVLF 910 920 930 940 950 960 SSSDKFTLQQ DMCVVCGSFG QGAEGRLLAC SQCGQCYHPY CVSIKITKVV LSKGWRCLEC 970 980 990 1000 1010 1020 TVCEACGKAT DPGRLLLCDD CDISYHTYCL DPPLQTVPKG GWKCKWCVWC RHCGATSAGL 1030 1040 1050 1060 1070 1080 RCEWQNNYTQ CAPCASLSSC PVCCRNYREE DLILQCRQCD RWMHAVCQNL NTEEEVENVA 1090 1100 1110 1120 1130 1140 DIGFDCSMCR PYMPVSNVPS SDCCDSSLVA QIVTKVKELD PPKTYTQDGV CLTESGMSQL 1150 1160 1170 1180 1190 1200 QSLTVTAPRR KRTKPKLKLK IINQNSVAVL QTPPDIQSEH SRDGEMDDSR EGELMDCDGK 1210 1220 1230 1240 1250 1260 SESSPEREAG DDETKGIEGT DAIKKRKRKP YRPGIGGFMV RQRSRTGQGK AKRSVVRKDS 1270 1280 1290 1300 1310 1320 SGSISEQLPS RDDGWREQLP DTLVDEPVSV AENTDKIKKR YRKRKNKLEE TFPAYLQEAF 1330 1340 1350 1360 1370 1380 FGKDLLDTSR QNKLSVDNLS EDAAQLSFKT GFLDPSSDPL LSSSSTSAKP GTQDIGPTTA 1390 1400 1410 1420 1430 1440 DASSLPQPGV SQSSRPLTEE QLDGILSPEL DKMVTDGAIL GKLYKIPELG GKDVEDLFTA 1450 1460 1470 1480 1490 1500 VLSPATTQPA PLPQPPPPPQ LLPMHNQDVF SRMPLMNGLI GPSPHLPHNS LPPGSGLGTF 1510 1520 1530 1540 1550 1560 PAIAQSPYTD VRDKSPAFNA IASDPNSSWA PTTPSMEGEN DTLSNAQRST LKWEKEEALG 1570 1580 1590 1600 1610 1620 EMATVAPVLY TNINFPNLKE EFPDWTTRVK QIAKLWRKAS SQERAPYVQK ARDNRAALRI 1630 1640 1650 1660 1670 1680 NKVQMSNDSM KRQQQQDSID PSSRIDSDLF KDPLKQRESE HEQEWKFRQQ MRQKSKQQAK 1690 1700 1710 1720 1730 1740 IEATQKLEQV KNEQQQQQQQ QQQQQQQQLA SQHLLDFDAI TDPIMKAKMV ALKGINKVMA 1750 1760 1770 1780 1790 1800 QNSLGMPPMV MSRFPFMGPS VAGTQNNDGQ TLVPQAVAQD GSITHQISRP NPPNFGPGFV 1810 1820 1830 1840 1850 1860 NDSQRKQYEE WLQETQQLLQ MQQKYLEEQI GAHRKSKKAL SAKQRTAKKA GREFPEEDAE 1870 1880 1890 1900 1910 1920 QLKHVTEQQS MVQKQLEQIR KQQKEHAELI EDYRIKQQQQ QQQCALAPPI LMPGVQPQPP 1930 1940 1950 1960 1970 1980 LVPGATSLTM SQPNFPMVPQ QLQHQQHTAV ISGHTSPARM PSLPGWQSNS ASAHLPLNPP 1990 2000 2010 2020 2030 2040 RIQPPIAQLS LKTCTPAPGT VSSANPQNGP PPRVEFDDNN PFSESFQERE RKERLREQQE 2050 2060 2070 2080 2090 2100 RQRVQLMQEV DRQRALQQRM EMEQHCLMGA ELANRTPVSQ MPFYGSDRPC DFLQPPRPLQ 2110 2120 2130 2140 2150 2160 QSPQHQQQIG PVLQQQNVQQ GSVNSPPNQT FMQTNEQRQV GPPSFVPDSP SASGGSPNFH 2170 2180 2190 2200 2210 2220 SVKPGHGNLP GSSFQQSPLR PPFTPILPGT SPVANSNVPC GQDPAVTQGQ NYSGSSQSLI 2230 2240 2250 2260 2270 2280 QLYSDIIPEE KGKKKRTRKK KKDDDAESGK APSTPHSDCA APLTPGLSET TSTPAVSSPS 2290 2300 2310 2320 2330 2340 ELPQQRQQEP VEPVPVPTPN VSAGQPCIES ENKLPNSEFI KETSNQQTHV NAEADKPSVE 2350 2360 2370 2380 2390 2400 TPNKTEEIKL EKAETQPSQE DTKVEEKTGN KIKDIVAGPV SSIQCPSHPV GTPTTKGDTG 2410 2420 2430 2440 2450 2460 NELLKHLLKN KKASSLLTQK PEGTLSSDES STKDGKLIEK QSPAEGLQNN LSNPPTPPAS 2470 2480 2490 2500 2510 2520 LPPTPPPMAC QKMANGFATT EELAGKAGVL VSHEVARALG PKPFQLPFRP QDDLLARAIA 2530 2540 2550 2560 2570 2580 QGPKTVDVPA SLPTPPHNNH EELRIQDHYG DRDTPDSFVP SSSPESVVGV EVNKYPDLSL 2590 2600 2610 2620 2630 2640 VKEEPPEPVP SPIIPILPSI SGKNSESRRN DIKTEPGTLF FTSPFGSSPN GPRSGLISVA 2650 2660 2670 2680 2690 2700 ITLHPTAAEN ISSVVAAFSD LLHVRIPNSY EVSNAPDVPP MGLVSSHRVN PSLEYRQHLL 2710 2720 2730 2740 2750 2760 LRGPPPGSAN PPRLATSYRL KQPNVPFPPT SNGLSGYKDS SHGPAEGASL RPQWCCHCKV 2770 2780 2790 2800 2810 2820 VILGSGVRKS CKDLTFVNKG SRENTKRMEK DIVFCSNNCF ILYSSAAQAK NSDNKESLPS 2830 2840 2850 2860 2870 2880 LPQSPMKEPS KAFHQYSNNI STLDVHCLPQ FQEKVSPPAS PPISFPPAFE AAKVESKPDE 2890 2900 2910 2920 2930 2940 LKVTVKLKPR LRTVPVGLED CRPLNKKWRG MKWKKWSIHI VIPKGTFKPP CEDEIDEFLK 2950 2960 2970 2980 2990 3000 KLGTCLKPDP VPKDCRKCCF CHEEGDGLTD GPARLLNLDL DLWVHLNCAL WSTEVYETQA 3010 3020 3030 3040 3050 3060 GALINVELAL RRGLQMKCVF CHKTGATSGC HRFRCTNIYH FTCATKAQCM FFKDKTMLCP 3070 3080 3090 3100 3110 3120 MHKPKGIHEQ QLSYFAVFRR VYVQRDEVRQ IASIVQRGER DHTFRVGSLI FHTIGQLLPQ 3130 3140 3150 3160 3170 3180 QMQAFHSPKA LFPVGYEASR LYWSTRYANR RCRYLCSIEE KDGRPVFVIR IVEQGHEDLV 3190 3200 3210 3220 3230 3240 LSDSSPKDVW DKILEPVACV RKKSEMLQLF PAYLKGEDLF GLTVSAVARI AESLPGVEAC 3250 3260 3270 3280 3290 3300 ENYTFRYGRN PLMELPLAVN PTGCARSEPK MSAHVKRPHT LNSTSTSKSF QSTVTGELNA 3310 3320 3330 3340 3350 3360 PYSKQFVHSK SSQYRRMKTE WKSNVYLARS RIQGLGLYAA RDIEKHTMVI EYIGTIIRNE 3370 3380 3390 3400 3410 3420 VANRKEKLYE SQNRGVYMFR MDNDHVIDAT LTGGPARYIN HSCAPNCVAE VVTFERGHKI 3430 3440 3450 3460 IISSNRRIQK GEELCYDYKF DFEDDQHKIP CHCGAVNCRK WMN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization and expression analysis during embryo development of the mouse ortholog of MLL3." Brun M.-E., Gasca S., Girard C., Bouton K., De Massy B., De Sario A. Gene 371:25-33(2006) [PubMed: 16459028] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY. Strain: BALB/c. Tissue: Testis.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-814 AND 4803-4903. Strain: C57BL/6J. Tissue: Embryo.
[4]	"Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects." Tan Y.C., Chow V.T. Cancer Detect. Prev. 25:454-469(2001) [PubMed: 11718452] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 957-1376 AND 4214-4894. Tissue: Myeloma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY138582 mRNA. Translation: AAN11291.1. Different initiation. AC116469 Genomic DNA. No translation available. AC127319 Genomic DNA. No translation available. AC134910 Genomic DNA. No translation available. AK044828 mRNA. Translation: BAC32109.1. AK054270 mRNA. Translation: BAC35712.2. AK077567 mRNA. Translation: BAC36867.1. AY036886 mRNA. Translation: AAK70213.1. AY036887 mRNA. Translation: AAK70214.1.
IPI	IPI00620674. IPI00623069.
UniGene	Mm.332268
3D structure databases
SMR	Q8BRH4. Positions 341-438, 378-515, 950-1056, 1613-1702, 4763-4903.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8BRH4.
PTM databases
PhosphoSite	Q8BRH4.
Proteomic databases
PRIDE	Q8BRH4.
Genome annotation databases
Ensembl	ENSMUST00000045291; ENSMUSP00000043874; ENSMUSG00000038056; Mus musculus. [Genome view] ENSMUST00000088253; ENSMUSP00000085587; ENSMUSG00000038056; Mus musculus. [Genome view]
UCSC	uc008wsv.1. mouse.
Organism-specific databases
MGI	MGI:2444959. Mll3.
Phylogenomic databases
HOGENOM	HBG445720.
HOVERGEN	Q8BRH4.
InParanoid	Q8BRH4.
Enzyme and pathway databases
BRENDA	2.1.1.43. 244.
Gene expression databases
ArrayExpress	Q8BRH4.
Bgee	Q8BRH4.
CleanEx	MM_MLL3.
Genevestigator	Q8BRH4.
GermOnline	ENSMUSG00000038056. Mus musculus.
Family and domain databases
InterPro	IPR017956. AT_hook_DNA-bd_motif. IPR003889. FYrich_C. IPR018516. FYrich_C_sg. IPR003888. FYrich_N. IPR018518. FYrich_N_sg. IPR000910. HMG_HMG1/HMG2. IPR000637. HMGI/Y_DNA-bd_CS. IPR003616. Post-SET_dom. IPR002219. Prot_Kinase_C-like_PE/DAG_bd. IPR001214. SET_dom. IPR001594. Znf_DHHC. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. IPR001841. Znf_RING. [Graphical view]
Pfam	PF05965. FYRC. 1 hit. PF05964. FYRN. 1 hit. PF00628. PHD. 2 hits. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00384. AT_hook. 2 hits. SM00109. C1. 2 hits. SM00542. FYRC. 1 hit. SM00541. FYRN. 1 hit. SM00398. HMG. 1 hit. SM00249. PHD. 8 hits. SM00508. PostSET. 1 hit. SM00184. RING. 4 hits. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS00354. HMGI_Y. 1 hit. PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. PS50216. ZF_DHHC. 1 hit. PS01359. ZF_PHD_1. 5 hits. PS50016. ZF_PHD_2. 6 hits. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

MLL3_MOUSE

Accession

Primary (citable) accession number: Q8BRH4
Secondary accession number(s): Q5YLV9 , Q8BK12, Q8C6M3, Q923H5, Q923H6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 10, 2003
Last modified:	February 9, 2010
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)