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Q8BRH4 (KMT2C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase 2C

Short name=Lysine N-methyltransferase 2C
EC=2.1.1.43
Alternative name(s):
Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog
Gene names
Name:Kmt2c
Synonyms:Mll3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length4903 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subunit structure

Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin By similarity. Interacts with histone H3 By similarity.

Subcellular location

Nucleus Probable.

Tissue specificity

In adult, detected in testis, kidney, spleen and lung, weakly expressed in brain and absent in heart and liver. First detected throughout the embryo at 8 dpc when expression is strong in forebrain neuroepithelium and absent in heart. Expressed in the eye lens between 10 and 14.5 dpc. By 13 dpc, expressed strongly in spinal cord, hand/foot plates and gonads. Ref.1

Domain

The SET domain interacts with histone H3 but not H2A, H2B and H4, and may have a H3 lysine specific methylation activity By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.

Contains 1 A.T hook DNA-binding domain.

Contains 1 DHHC-type zinc finger.

Contains 1 FYR C-terminal domain.

Contains 1 FYR N-terminal domain.

Contains 6 PHD-type zinc fingers.

Contains 1 post-SET domain.

Contains 1 RING-type zinc finger.

Contains 1 SET domain.

Sequence caution

The sequence AAN11291.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BRH4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BRH4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     839-878: Missing.
     1414-1448: Missing.
     1791-3080: Missing.
     3814-3884: Missing.
     4714-4717: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 49034903Histone-lysine N-methyltransferase 2C
PRO_0000124880

Regions

Domain4537 – 459761FYR N-terminal
Domain4598 – 468386FYR C-terminal
Domain4763 – 4879117SET
Domain4887 – 490317Post-SET
DNA binding34 – 4613A.T hook
Zinc finger340 – 39051PHD-type 1
Zinc finger343 – 38846RING-type
Zinc finger387 – 43751PHD-type 2
Zinc finger435 – 48854DHHC-type
Zinc finger463 – 51957PHD-type 3
Zinc finger950 – 100354PHD-type 4
Zinc finger1000 – 105051PHD-type 5
Zinc finger1077 – 113256PHD-type 6
Region4840 – 48412S-adenosyl-L-methionine binding By similarity
Coiled coil1330 – 135223 Potential
Coiled coil1743 – 179048 Potential
Coiled coil3047 – 307428 Potential
Coiled coil3166 – 319328 Potential
Coiled coil3224 – 327047 Potential
Coiled coil3387 – 343246 Potential
Compositional bias384 – 487104Cys-rich
Compositional bias970 – 1099130Cys-rich
Compositional bias1519 – 156850Pro-rich
Compositional bias1708 – 178780Gln-rich
Compositional bias1831 – 2622792Pro-rich
Compositional bias2682 – 278099Asp-rich
Compositional bias3022 – 3504483Gln-rich

Sites

Metal binding48431Zinc By similarity
Metal binding48911Zinc By similarity
Metal binding48931Zinc By similarity
Metal binding48981Zinc By similarity
Binding site48171S-adenosyl-L-methionine By similarity

Amino acid modifications

Modified residue461Phosphoserine By similarity
Modified residue891Phosphoserine By similarity
Modified residue7511N6-acetyllysine By similarity
Modified residue12941Phosphoserine By similarity
Modified residue14971N6-acetyllysine By similarity
Modified residue17611N6-acetyllysine Ref.5
Modified residue20051N6-acetyllysine Ref.5
Modified residue27961N6-acetyllysine Ref.5
Modified residue28031N6-acetyllysine By similarity
Modified residue28261N6-acetyllysine By similarity
Modified residue28621N6-acetyllysine Ref.5
Modified residue37091N6-acetyllysine By similarity

Natural variations

Alternative sequence839 – 87840Missing in isoform 2.
VSP_020568
Alternative sequence1414 – 144835Missing in isoform 2.
VSP_020569
Alternative sequence1791 – 30801290Missing in isoform 2.
VSP_020570
Alternative sequence3814 – 388471Missing in isoform 2.
VSP_020571
Alternative sequence4714 – 47174Missing in isoform 2.
VSP_020572

Experimental info

Sequence conflict28 – 369SPAAADKRP → RSFVCGCGA in AAN11291. Ref.1
Sequence conflict2761V → A in AAN11291. Ref.1
Sequence conflict433 – 4408NCRICIEC → VSDFLICF in BAC32109. Ref.3
Sequence conflict5331E → G in AAN11291. Ref.1
Sequence conflict5771D → DA in AAN11291. Ref.1
Sequence conflict6751S → C in BAC35712. Ref.3
Sequence conflict7201K → E in AAN11291. Ref.1
Sequence conflict7631F → L in AAN11291. Ref.1
Sequence conflict7911H → Y in AAN11291. Ref.1
Sequence conflict1324 – 13252VD → LH in AAN11291. Ref.1
Sequence conflict17371E → V in AAN11291. Ref.1
Sequence conflict17761Q → R in AAN11291. Ref.1
Sequence conflict32361M → MM in AAN11291. Ref.1
Sequence conflict3423 – 34242QR → P in AAN11291. Ref.1
Sequence conflict36571E → G in AAN11291. Ref.1
Sequence conflict36681A → V in AAN11291. Ref.1
Sequence conflict42831C → Y in AAN11291. Ref.1
Sequence conflict43061E → D in AAN11291. Ref.1
Sequence conflict45201Q → R in AAN11291. Ref.1
Sequence conflict45311V → G in AAN11291. Ref.1
Sequence conflict46491Y → H in AAN11291. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 10, 2003. Version 2.
Checksum: 0B896490B081BA6C

FASTA4,903540,187
        10         20         30         40         50         60 
MSSEEDRSAE QQQPPPAPPE EPGAPAPSPA AADKRPRGRP RKDGASPFQR ARKKPRSRGK 

        70         80         90        100        110        120 
STVEDEDSMD GLETTETENI VETEIKEQSV EEDAETEVDS SKQPVSALQR SVSEESANSL 

       130        140        150        160        170        180 
VSVGVEAKIS EQLCAFCYCG EKSSLGQGDL KQFRVTPGLT LPWKDQPSNK DIDDNSSGTC 

       190        200        210        220        230        240 
EKIQNYAPRK QRGQRKERPP QQSAVSCVSV STQTACEDQA GKLWDELSLV GLPDAIDVQA 

       250        260        270        280        290        300 
LFDSTGTCWA HHRCVEWSLG ICQMEEPLLV NVDKAVVSGS TERCAFCKHL GATIKCCEEK 

       310        320        330        340        350        360 
CTQMYHYPCA AGAGTFQDFS HFFLLCPEHI DQAPERSKED ANCAVCDSPG DLLDQFFCTT 

       370        380        390        400        410        420 
CGQHYHGMCL DIAVTPLKRA GWQCPECKVC QNCKQSGEDS KMLVCDTCDK GYHTFCLQPV 

       430        440        450        460        470        480 
MKSVPTNGWK CKNCRICIEC GTRSSTQWHH NCLICDTCYQ QQDNLCPFCG KCYHPELQKD 

       490        500        510        520        530        540 
MLHCNMCKRW VHLECDKPTD QELDSQLKED YICMYCKHLG AEIDPLHPGN EVEMPELPTD 

       550        560        570        580        590        600 
YASGMEIEGT EDEVVFLEQT VNKDVSDHQC RPGIVPDVQV YTEEPQKSNP LESPDTVGLI 

       610        620        630        640        650        660 
TSESSDNKMN PDLANEIAHE VDTEKTEMLS KGRHVCEEDQ NEDRMEVTEN IEVLPHQTIV 

       670        680        690        700        710        720 
PQEDLLLSED SEVASKELSP PKSAPETAAP EALLSPHSER SLSCKEPLLT ERVQEEMEQK 

       730        740        750        760        770        780 
ENSEFSTGCV DFEMTLAVDS CDKDSSCQGD KYVELPAEEE STFSSATDLN KADVSSSSTL 

       790        800        810        820        830        840 
CSDLPSCDML HGYPPAFNSA AGSIMPTTYI SVTPKIGMGK PAITKRKFSP GRPRSKQGAW 

       850        860        870        880        890        900 
SNHNTVSPPS WAPDTSEGRE IFKPRQLSGS AIWSIKVGRG SGFPGKRRPR GAGLSGRGGR 

       910        920        930        940        950        960 
GRSKLKSGIG AVVLPGVSAA DISSNKDEEE NSMHNTVVLF SSSDKFTLQQ DMCVVCGSFG 

       970        980        990       1000       1010       1020 
QGAEGRLLAC SQCGQCYHPY CVSIKITKVV LSKGWRCLEC TVCEACGKAT DPGRLLLCDD 

      1030       1040       1050       1060       1070       1080 
CDISYHTYCL DPPLQTVPKG GWKCKWCVWC RHCGATSAGL RCEWQNNYTQ CAPCASLSSC 

      1090       1100       1110       1120       1130       1140 
PVCCRNYREE DLILQCRQCD RWMHAVCQNL NTEEEVENVA DIGFDCSMCR PYMPVSNVPS 

      1150       1160       1170       1180       1190       1200 
SDCCDSSLVA QIVTKVKELD PPKTYTQDGV CLTESGMSQL QSLTVTAPRR KRTKPKLKLK 

      1210       1220       1230       1240       1250       1260 
IINQNSVAVL QTPPDIQSEH SRDGEMDDSR EGELMDCDGK SESSPEREAG DDETKGIEGT 

      1270       1280       1290       1300       1310       1320 
DAIKKRKRKP YRPGIGGFMV RQRSRTGQGK AKRSVVRKDS SGSISEQLPS RDDGWREQLP 

      1330       1340       1350       1360       1370       1380 
DTLVDEPVSV AENTDKIKKR YRKRKNKLEE TFPAYLQEAF FGKDLLDTSR QNKLSVDNLS 

      1390       1400       1410       1420       1430       1440 
EDAAQLSFKT GFLDPSSDPL LSSSSTSAKP GTQGTADDPL ADISEVLNTD DDILGIISDD 

      1450       1460       1470       1480       1490       1500 
LAKSVDHSDI GPTTADASSL PQPGVSQSSR PLTEEQLDGI LSPELDKMVT DGAILGKLYK 

      1510       1520       1530       1540       1550       1560 
IPELGGKDVE DLFTAVLSPA TTQPAPLPQP PPPPQLLPMH NQDVFSRMPL MNGLIGPSPH 

      1570       1580       1590       1600       1610       1620 
LPHNSLPPGS GLGTFPAIAQ SPYTDVRDKS PAFNAIASDP NSSWAPTTPS MEGENDTLSN 

      1630       1640       1650       1660       1670       1680 
AQRSTLKWEK EEALGEMATV APVLYTNINF PNLKEEFPDW TTRVKQIAKL WRKASSQERA 

      1690       1700       1710       1720       1730       1740 
PYVQKARDNR AALRINKVQM SNDSMKRQQQ QDSIDPSSRI DSDLFKDPLK QRESEHEQEW 

      1750       1760       1770       1780       1790       1800 
KFRQQMRQKS KQQAKIEATQ KLEQVKNEQQ QQQQQQQQQQ QQQLASQHLL VAPGSDTPSS 

      1810       1820       1830       1840       1850       1860 
GAQSPLTPQA GNGNVSPAQT FHKDLFSKHL PGTPASTPSD GVFVKPQPPP PPSTPSRIPV 

      1870       1880       1890       1900       1910       1920 
QESLSQSQNS QPPSPQMFSP GSSHSRPPSP VDPYAKMVGT PRPPPGGHSF PRRNSVTPVE 

      1930       1940       1950       1960       1970       1980 
NCVPLSSVPR PIHMNETSAT RPSPARDLCA SSMTNSDPYA KPPDTPRPMM TDQFSKPFSL 

      1990       2000       2010       2020       2030       2040 
PRSPVISEQS TKGPLTTGTS DHFTKPSPRT DAFQRQRLPD PYAGPSLTPA PLGNGPFKTP 

      2050       2060       2070       2080       2090       2100 
LHPPPSQDPY GSVSQTSRRL SVDPYERPAL TPRPVDNFSH SQSNDPYSHP PLTPHPAMTE 

      2110       2120       2130       2140       2150       2160 
SFTHASRAFP QPGTISRSAS QDPYSQPPGT PRPLIDSYSQ TSGTARSNPD PYSQPPGTPR 

      2170       2180       2190       2200       2210       2220 
PNTIDPYSQQ PPTPRPSPQT DMFVSSVANQ RHTDPYTHHL GPPRPGISVP YSQPPAVPRP 

      2230       2240       2250       2260       2270       2280 
RTSEGFTRPS SARPALMPNQ DPFLQAAQNR VPGLPGPLIR PPDTCSQTPR PPGPGRIDTF 

      2290       2300       2310       2320       2330       2340 
THASSSAVRD PYDQPPVTPR PHSESFGTSQ VVHDLVDRPV PGSEGNFSTS SNLPVSSQGQ 

      2350       2360       2370       2380       2390       2400 
QFSSVSQLPG PVPTSGGTDT QNTVNMSQAD TEKLRQRQKL REIILQQQQQ KKIASRQEKG 

      2410       2420       2430       2440       2450       2460 
PQDTAVVPHP VPLPHWQPES INQAFTRPPP PYPGSTRSPV IPPLGPRYAV FPKDQRGPYP 

      2470       2480       2490       2500       2510       2520 
PEVAGMGMRP HGFRFGFPGA GHGPMPSQDR FHVPQQIQGS GIPPHIRRPM SMEMPRPSNN 

      2530       2540       2550       2560       2570       2580 
PPLNNPVGLP QHFPPQGLPV QQHNILGQAF IELRHRAPDG RSRLPFAASP SSVIESPSHP 

      2590       2600       2610       2620       2630       2640 
RHGNFLPRPD FPGPRHTDPI RQPSQCLSNQ LPVHPNLEQV PPSQQEQGHP AHQSSIVMRP 

      2650       2660       2670       2680       2690       2700 
LNHPLSGEFS EAPLSTSTPA ETSPDNLEIA GQSSAGLEEK LDSDDPSVKE LDVKDLEGVE 

      2710       2720       2730       2740       2750       2760 
VKDLDDEDLE NLNLDTEDGK GDDLDTLDNL ETNDPNLDDL LRSGEFDIIA YTDPELDLGD 

      2770       2780       2790       2800       2810       2820 
KKSMFNEELD LNVPIDDKLD NQCASVEPKT RDQGDKTMVL EDKDLPQRKS SVSSEIKTEA 

      2830       2840       2850       2860       2870       2880 
LSPYSKEEIQ SEIKNHDDSR GDADTACSQA ASAQTNHSDR GKTALLTTDQ DMLEKRCNQE 

      2890       2900       2910       2920       2930       2940 
NAGPVVSAIQ GSTPLPARDV MNSCDITGST PVLSSLLSNE KCDDSDIRPS GSSPPSLPIS 

      2950       2960       2970       2980       2990       3000 
PSTHGSSLPP TLIVPPSPLL DNTVNSNVTV VPRINHAFSQ GVPVNPGFIQ GQSSVNHNLG 

      3010       3020       3030       3040       3050       3060 
TGKPTNQTVP LTNQSSTMSG PQQLMIPQTL AQQNRERPLL LEEQPLLLQD LLDQERQEQQ 

      3070       3080       3090       3100       3110       3120 
QQRQMQAMIR QRSEPFFPNI DFDAITDPIM KAKMVALKGI NKVMAQNSLG MPPMVMSRFP 

      3130       3140       3150       3160       3170       3180 
FMGPSVAGTQ NNDGQTLVPQ AVAQDGSITH QISRPNPPNF GPGFVNDSQR KQYEEWLQET 

      3190       3200       3210       3220       3230       3240 
QQLLQMQQKY LEEQIGAHRK SKKALSAKQR TAKKAGREFP EEDAEQLKHV TEQQSMVQKQ 

      3250       3260       3270       3280       3290       3300 
LEQIRKQQKE HAELIEDYRI KQQQQQQQCA LAPPILMPGV QPQPPLVPGA TSLTMSQPNF 

      3310       3320       3330       3340       3350       3360 
PMVPQQLQHQ QHTAVISGHT SPARMPSLPG WQSNSASAHL PLNPPRIQPP IAQLSLKTCT 

      3370       3380       3390       3400       3410       3420 
PAPGTVSSAN PQNGPPPRVE FDDNNPFSES FQERERKERL REQQERQRVQ LMQEVDRQRA 

      3430       3440       3450       3460       3470       3480 
LQQRMEMEQH CLMGAELANR TPVSQMPFYG SDRPCDFLQP PRPLQQSPQH QQQIGPVLQQ 

      3490       3500       3510       3520       3530       3540 
QNVQQGSVNS PPNQTFMQTN EQRQVGPPSF VPDSPSASGG SPNFHSVKPG HGNLPGSSFQ 

      3550       3560       3570       3580       3590       3600 
QSPLRPPFTP ILPGTSPVAN SNVPCGQDPA VTQGQNYSGS SQSLIQLYSD IIPEEKGKKK 

      3610       3620       3630       3640       3650       3660 
RTRKKKKDDD AESGKAPSTP HSDCAAPLTP GLSETTSTPA VSSPSELPQQ RQQEPVEPVP 

      3670       3680       3690       3700       3710       3720 
VPTPNVSAGQ PCIESENKLP NSEFIKETSN QQTHVNAEAD KPSVETPNKT EEIKLEKAET 

      3730       3740       3750       3760       3770       3780 
QPSQEDTKVE EKTGNKIKDI VAGPVSSIQC PSHPVGTPTT KGDTGNELLK HLLKNKKASS 

      3790       3800       3810       3820       3830       3840 
LLTQKPEGTL SSDESSTKDG KLIEKQSPAE GLQTLGAQMQ GGFGGGNSQL PKTDGASENK 

      3850       3860       3870       3880       3890       3900 
KQRSKRTQRT GEKAAPRSKK RKKDEEEKQA MYSSSDSFTH LKQQNNLSNP PTPPASLPPT 

      3910       3920       3930       3940       3950       3960 
PPPMACQKMA NGFATTEELA GKAGVLVSHE VARALGPKPF QLPFRPQDDL LARAIAQGPK 

      3970       3980       3990       4000       4010       4020 
TVDVPASLPT PPHNNHEELR IQDHYGDRDT PDSFVPSSSP ESVVGVEVNK YPDLSLVKEE 

      4030       4040       4050       4060       4070       4080 
PPEPVPSPII PILPSISGKN SESRRNDIKT EPGTLFFTSP FGSSPNGPRS GLISVAITLH 

      4090       4100       4110       4120       4130       4140 
PTAAENISSV VAAFSDLLHV RIPNSYEVSN APDVPPMGLV SSHRVNPSLE YRQHLLLRGP 

      4150       4160       4170       4180       4190       4200 
PPGSANPPRL ATSYRLKQPN VPFPPTSNGL SGYKDSSHGP AEGASLRPQW CCHCKVVILG 

      4210       4220       4230       4240       4250       4260 
SGVRKSCKDL TFVNKGSREN TKRMEKDIVF CSNNCFILYS SAAQAKNSDN KESLPSLPQS 

      4270       4280       4290       4300       4310       4320 
PMKEPSKAFH QYSNNISTLD VHCLPQFQEK VSPPASPPIS FPPAFEAAKV ESKPDELKVT 

      4330       4340       4350       4360       4370       4380 
VKLKPRLRTV PVGLEDCRPL NKKWRGMKWK KWSIHIVIPK GTFKPPCEDE IDEFLKKLGT 

      4390       4400       4410       4420       4430       4440 
CLKPDPVPKD CRKCCFCHEE GDGLTDGPAR LLNLDLDLWV HLNCALWSTE VYETQAGALI 

      4450       4460       4470       4480       4490       4500 
NVELALRRGL QMKCVFCHKT GATSGCHRFR CTNIYHFTCA TKAQCMFFKD KTMLCPMHKP 

      4510       4520       4530       4540       4550       4560 
KGIHEQQLSY FAVFRRVYVQ RDEVRQIASI VQRGERDHTF RVGSLIFHTI GQLLPQQMQA 

      4570       4580       4590       4600       4610       4620 
FHSPKALFPV GYEASRLYWS TRYANRRCRY LCSIEEKDGR PVFVIRIVEQ GHEDLVLSDS 

      4630       4640       4650       4660       4670       4680 
SPKDVWDKIL EPVACVRKKS EMLQLFPAYL KGEDLFGLTV SAVARIAESL PGVEACENYT 

      4690       4700       4710       4720       4730       4740 
FRYGRNPLME LPLAVNPTGC ARSEPKMSAH VKRFVLRPHT LNSTSTSKSF QSTVTGELNA 

      4750       4760       4770       4780       4790       4800 
PYSKQFVHSK SSQYRRMKTE WKSNVYLARS RIQGLGLYAA RDIEKHTMVI EYIGTIIRNE 

      4810       4820       4830       4840       4850       4860 
VANRKEKLYE SQNRGVYMFR MDNDHVIDAT LTGGPARYIN HSCAPNCVAE VVTFERGHKI 

      4870       4880       4890       4900 
IISSNRRIQK GEELCYDYKF DFEDDQHKIP CHCGAVNCRK WMN 

« Hide

Isoform 2 [UniParc].

Checksum: D14871D89FC23DAB
Show »

FASTA3,463383,966

References

« Hide 'large scale' references
[1]"Characterization and expression analysis during embryo development of the mouse ortholog of MLL3."
Brun M.-E., Gasca S., Girard C., Bouton K., De Massy B., De Sario A.
Gene 371:25-33(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
Strain: BALB/c.
Tissue: Testis.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-814 AND 4803-4903.
Strain: C57BL/6J.
Tissue: Embryo.
[4]"Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects."
Tan Y.C., Chow V.T.
Cancer Detect. Prev. 25:454-469(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 957-1376 AND 4214-4894.
Tissue: Myeloma.
[5]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1761; LYS-2005; LYS-2796 AND LYS-2862, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY138582 mRNA. Translation: AAN11291.1. Different initiation.
AC116469 Genomic DNA. No translation available.
AC127319 Genomic DNA. No translation available.
AC134910 Genomic DNA. No translation available.
AK044828 mRNA. Translation: BAC32109.1.
AK054270 mRNA. Translation: BAC35712.2.
AK077567 mRNA. Translation: BAC36867.1.
AY036886 mRNA. Translation: AAK70213.1.
AY036887 mRNA. Translation: AAK70214.1.
UniGeneMm.332268.

3D structure databases

ProteinModelPortalQ8BRH4.
SMRQ8BRH4. Positions 245-330, 341-438, 465-517, 953-1050, 1079-1132, 1613-1702, 4391-4499, 4753-4903.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8BRH4. 3 interactions.

PTM databases

PhosphoSiteQ8BRH4.

Proteomic databases

PaxDbQ8BRH4.
PRIDEQ8BRH4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:2444959. Kmt2c.

Phylogenomic databases

eggNOGCOG2940.
HOGENOMHOG000113602.
HOVERGENHBG045586.
InParanoidQ8BRH4.
PhylomeDBQ8BRH4.

Gene expression databases

ArrayExpressQ8BRH4.
BgeeQ8BRH4.
CleanExMM_MLL3.
GenevestigatorQ8BRH4.

Family and domain databases

Gene3D3.30.40.10. 6 hits.
InterProIPR017956. AT_hook_DNA-bd_motif.
IPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR009071. HMG_box_dom.
IPR000637. HMGI/Y_DNA-bd_CS.
IPR003616. Post-SET_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001214. SET_dom.
IPR001594. Znf_DHHC_palmitoyltrfase.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00628. PHD. 2 hits.
PF00856. SET. 1 hit.
[Graphical view]
SMARTSM00384. AT_hook. 2 hits.
SM00109. C1. 2 hits.
SM00542. FYRC. 1 hit.
SM00541. FYRN. 1 hit.
SM00398. HMG. 1 hit.
SM00249. PHD. 8 hits.
SM00508. PostSET. 1 hit.
SM00184. RING. 4 hits.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
SSF57903. SSF57903. 6 hits.
PROSITEPS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS00354. HMGI_Y. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS50216. ZF_DHHC. 1 hit.
PS01359. ZF_PHD_1. 5 hits.
PS50016. ZF_PHD_2. 6 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMLL3. mouse.
PROQ8BRH4.
SOURCESearch...

Entry information

Entry nameKMT2C_MOUSE
AccessionPrimary (citable) accession number: Q8BRH4
Secondary accession number(s): Q5YLV9 expand/collapse secondary AC list , Q8BK12, Q8C6M3, Q923H5, Q923H6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: June 11, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot