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Protein

Transmembrane and TPR repeat-containing protein 3

Gene

Tmtc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • bud outgrowth involved in lung branching Source: MGI
  • cell differentiation Source: MGI
  • lung alveolus development Source: MGI
  • lung development Source: MGI
  • muscle fiber development Source: MGI
  • post-embryonic development Source: MGI
  • regulation of gene expression Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and TPR repeat-containing protein 3
Gene namesi
Name:Tmtc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3036255. Tmtc3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521HelicalSequence analysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence analysisAdd
BLAST
Transmembranei141 – 16323HelicalSequence analysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence analysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence analysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence analysisAdd
BLAST
Transmembranei326 – 34621HelicalSequence analysisAdd
BLAST
Transmembranei359 – 37921HelicalSequence analysisAdd
BLAST
Transmembranei382 – 40221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 920920Transmembrane and TPR repeat-containing protein 3PRO_0000280294Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi499 – 4991N-linked (GlcNAc...)Sequence analysis
Modified residuei508 – 5081PhosphotyrosineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BRH0.
PaxDbiQ8BRH0.
PRIDEiQ8BRH0.

PTM databases

PhosphoSiteiQ8BRH0.

Expressioni

Gene expression databases

BgeeiQ8BRH0.

Interactioni

Protein-protein interaction databases

IntActiQ8BRH0. 1 interaction.
MINTiMINT-4112053.
STRINGi10090.ENSMUSP00000061470.

Structurei

3D structure databases

ProteinModelPortaliQ8BRH0.
SMRiQ8BRH0. Positions 427-808.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati417 – 45034TPR 1Add
BLAST
Repeati451 – 48434TPR 2Add
BLAST
Repeati486 – 51833TPR 3Add
BLAST
Repeati533 – 56735TPR 4Add
BLAST
Repeati568 – 60134TPR 5Add
BLAST
Repeati602 – 63534TPR 6Add
BLAST
Repeati673 – 70634TPR 7Add
BLAST
Repeati708 – 74033TPR 8Add
BLAST
Repeati741 – 77535TPR 9Add
BLAST
Repeati777 – 80933TPR 10Add
BLAST

Sequence similaritiesi

Belongs to the TMTC family.Curated
Contains 10 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
HOGENOMiHOG000007190.
HOVERGENiHBG094080.
InParanoidiQ8BRH0.
PhylomeDBiQ8BRH0.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013618. DUF1736.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF08409. DUF1736. 1 hit.
PF00515. TPR_1. 1 hit.
PF13174. TPR_6. 1 hit.
PF13181. TPR_8. 6 hits.
[Graphical view]
SMARTiSM00028. TPR. 9 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 9 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BRH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLEGKMADIN FKEVTLIVSV VAACYWNSLF CGFVFDDVSA ILDNKDLHPS
60 70 80 90 100
TPLKTLFQND FWGTPMSEER SHKSYRPLTV LTFRLNYLLS ELKPMSYHLL
110 120 130 140 150
NTVFHAVVSV IFLKVCRLFL DKRSSMIAAL LFAVHPIHTE AVTGVVGRAE
160 170 180 190 200
LLSSVFFLAA FLSYTKSKGP DNSIVWTPIV LTVFLVAVAT LCKEQGITVV
210 220 230 240 250
GICCVYEVFV AQGYTLPMLC TVAGQFLRGK GSIPLSMLQT LVKLIVLMLS
260 270 280 290 300
TLLLVVVRVQ VIQSQLPVFT RFDNPAAVSP TPTRQLTFNY LLPVNAWLLL
310 320 330 340 350
NPSELCCDWT MGTIPLIESF LDVRNLATFA FFCFLGALGI FSLRYPGDSS
360 370 380 390 400
KTVLMALCLM ALPFIPASNL FFPVGFVVAE RVLYVPSMGF CILVAHGWQK
410 420 430 440 450
ISNKSVLKKL SWVCLSMVIL THALKTLHRN WDWESEYTLF MSALKVNKNN
460 470 480 490 500
AKLWNNVGHA LENEKNFEKA LKYFLQATHV QPDDIGAHMN VGRTYKNLNR
510 520 530 540 550
SREAEASYML AKSLMPQIIP GKKYAARIAP NHLNVYINLA NLIRANESRL
560 570 580 590 600
EEADQLYRQA ISMRPDFKQA YISRGELLLK MNKPLKAKEA YLKALELDRN
610 620 630 640 650
NADLWYNLAI VYIELKEPNE ALKNFNRALE LNPKHKLALF NSAILMQESG
660 670 680 690 700
EVKLRPEARK RLLNYVNEEP QDANGYFNLG MLAMDDKKDS EAESWMKKAI
710 720 730 740 750
KLQPDFRSAL FNLALLYSQT AKELKALPIL EELLKYYPDH TKGLILKGDI
760 770 780 790 800
LMNQKKDIPG AKKCFEKILE MDPSNVQGKH NLCVVYFEEK ELLKAERCLV
810 820 830 840 850
ETLALAPHEE YIQRHLSIVR DRISSSGIVE QPLAPADKTP GTEEREEIPS
860 870 880 890 900
EDVKEISSES RPPQILKTNN NRNSKSNKQS TENADQDAPH KTTKDIKEIE
910 920
KKRVAALKRL EEIERILNGE
Length:920
Mass (Da):104,198
Last modified:March 20, 2007 - v2
Checksum:iEAEE8BD242C5EC3C
GO
Isoform 2 (identifier: Q8BRH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     651-658: EVKLRPEA → KFPENVSI
     659-920: Missing.

Note: No experimental confirmation available.
Show »
Length:658
Mass (Da):74,210
Checksum:iCD7D19ABB2708017
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti501 – 5011S → T in BAE38405 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei651 – 6588EVKLRPEA → KFPENVSI in isoform 2. 1 PublicationVSP_023620
Alternative sequencei659 – 920262Missing in isoform 2. 1 PublicationVSP_023621Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044857 mRNA. Translation: BAC32122.1.
AK165838 mRNA. Translation: BAE38405.1.
AC153501 Genomic DNA. No translation available.
CCDSiCCDS24150.1. [Q8BRH0-2]
CCDS48684.1. [Q8BRH0-1]
RefSeqiNP_001028504.1. NM_001033332.2.
NP_001103483.1. NM_001110013.1.
UniGeneiMm.296805.

Genome annotation databases

GeneIDi237500.
KEGGimmu:237500.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044857 mRNA. Translation: BAC32122.1.
AK165838 mRNA. Translation: BAE38405.1.
AC153501 Genomic DNA. No translation available.
CCDSiCCDS24150.1. [Q8BRH0-2]
CCDS48684.1. [Q8BRH0-1]
RefSeqiNP_001028504.1. NM_001033332.2.
NP_001103483.1. NM_001110013.1.
UniGeneiMm.296805.

3D structure databases

ProteinModelPortaliQ8BRH0.
SMRiQ8BRH0. Positions 427-808.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BRH0. 1 interaction.
MINTiMINT-4112053.
STRINGi10090.ENSMUSP00000061470.

PTM databases

PhosphoSiteiQ8BRH0.

Proteomic databases

MaxQBiQ8BRH0.
PaxDbiQ8BRH0.
PRIDEiQ8BRH0.

Protocols and materials databases

DNASUi237500.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi237500.
KEGGimmu:237500.

Organism-specific databases

CTDi160418.
MGIiMGI:3036255. Tmtc3.

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
HOGENOMiHOG000007190.
HOVERGENiHBG094080.
InParanoidiQ8BRH0.
PhylomeDBiQ8BRH0.

Miscellaneous databases

NextBioi383386.
PROiQ8BRH0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BRH0.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013618. DUF1736.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF08409. DUF1736. 1 hit.
PF00515. TPR_1. 1 hit.
PF13174. TPR_6. 1 hit.
PF13181. TPR_8. 6 hits.
[Graphical view]
SMARTiSM00028. TPR. 9 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 9 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-753 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Pancreas.

Entry informationi

Entry nameiTMTC3_MOUSE
AccessioniPrimary (citable) accession number: Q8BRH0
Secondary accession number(s): Q3TMN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: May 11, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.