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Protein

Transmembrane and TPR repeat-containing protein 3

Gene

Tmtc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response.By similarity

Caution

GO - Biological processi

  • bud outgrowth involved in lung branching Source: MGI
  • cell differentiation Source: MGI
  • lung alveolus development Source: MGI
  • lung development Source: MGI
  • muscle fiber development Source: MGI
  • positive regulation of proteasomal protein catabolic process Source: UniProtKB
  • post-embryonic development Source: MGI
  • regulation of gene expression Source: MGI
  • response to endoplasmic reticulum stress Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and TPR repeat-containing protein 3
Gene namesi
Name:Tmtc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3036255 Tmtc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei141 – 163HelicalSequence analysisAdd BLAST23
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002802941 – 920Transmembrane and TPR repeat-containing protein 3Add BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi499N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei508PhosphotyrosineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8BRH0
PeptideAtlasiQ8BRH0
PRIDEiQ8BRH0

PTM databases

iPTMnetiQ8BRH0
PhosphoSitePlusiQ8BRH0

Interactioni

Protein-protein interaction databases

IntActiQ8BRH0 1 interactor.
MINTiQ8BRH0
STRINGi10090.ENSMUSP00000061470

Structurei

3D structure databases

ProteinModelPortaliQ8BRH0
SMRiQ8BRH0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati417 – 450TPR 1Add BLAST34
Repeati451 – 484TPR 2Add BLAST34
Repeati486 – 518TPR 3Add BLAST33
Repeati533 – 567TPR 4Add BLAST35
Repeati568 – 601TPR 5Add BLAST34
Repeati602 – 635TPR 6Add BLAST34
Repeati673 – 706TPR 7Add BLAST34
Repeati708 – 740TPR 8Add BLAST33
Repeati741 – 775TPR 9Add BLAST35
Repeati777 – 809TPR 10Add BLAST33

Sequence similaritiesi

Belongs to the TMTC family.Curated

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
HOGENOMiHOG000007190
HOVERGENiHBG094080
InParanoidiQ8BRH0
PhylomeDBiQ8BRH0

Family and domain databases

Gene3Di1.25.40.103 hits
InterProiView protein in InterPro
IPR013618 DUF1736
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF08409 DUF1736, 1 hit
PF00515 TPR_1, 1 hit
PF13174 TPR_6, 1 hit
PF13181 TPR_8, 6 hits
SMARTiView protein in SMART
SM00028 TPR, 9 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 9 hits
PS50293 TPR_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BRH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLEGKMADIN FKEVTLIVSV VAACYWNSLF CGFVFDDVSA ILDNKDLHPS
60 70 80 90 100
TPLKTLFQND FWGTPMSEER SHKSYRPLTV LTFRLNYLLS ELKPMSYHLL
110 120 130 140 150
NTVFHAVVSV IFLKVCRLFL DKRSSMIAAL LFAVHPIHTE AVTGVVGRAE
160 170 180 190 200
LLSSVFFLAA FLSYTKSKGP DNSIVWTPIV LTVFLVAVAT LCKEQGITVV
210 220 230 240 250
GICCVYEVFV AQGYTLPMLC TVAGQFLRGK GSIPLSMLQT LVKLIVLMLS
260 270 280 290 300
TLLLVVVRVQ VIQSQLPVFT RFDNPAAVSP TPTRQLTFNY LLPVNAWLLL
310 320 330 340 350
NPSELCCDWT MGTIPLIESF LDVRNLATFA FFCFLGALGI FSLRYPGDSS
360 370 380 390 400
KTVLMALCLM ALPFIPASNL FFPVGFVVAE RVLYVPSMGF CILVAHGWQK
410 420 430 440 450
ISNKSVLKKL SWVCLSMVIL THALKTLHRN WDWESEYTLF MSALKVNKNN
460 470 480 490 500
AKLWNNVGHA LENEKNFEKA LKYFLQATHV QPDDIGAHMN VGRTYKNLNR
510 520 530 540 550
SREAEASYML AKSLMPQIIP GKKYAARIAP NHLNVYINLA NLIRANESRL
560 570 580 590 600
EEADQLYRQA ISMRPDFKQA YISRGELLLK MNKPLKAKEA YLKALELDRN
610 620 630 640 650
NADLWYNLAI VYIELKEPNE ALKNFNRALE LNPKHKLALF NSAILMQESG
660 670 680 690 700
EVKLRPEARK RLLNYVNEEP QDANGYFNLG MLAMDDKKDS EAESWMKKAI
710 720 730 740 750
KLQPDFRSAL FNLALLYSQT AKELKALPIL EELLKYYPDH TKGLILKGDI
760 770 780 790 800
LMNQKKDIPG AKKCFEKILE MDPSNVQGKH NLCVVYFEEK ELLKAERCLV
810 820 830 840 850
ETLALAPHEE YIQRHLSIVR DRISSSGIVE QPLAPADKTP GTEEREEIPS
860 870 880 890 900
EDVKEISSES RPPQILKTNN NRNSKSNKQS TENADQDAPH KTTKDIKEIE
910 920
KKRVAALKRL EEIERILNGE
Length:920
Mass (Da):104,198
Last modified:March 20, 2007 - v2
Checksum:iEAEE8BD242C5EC3C
GO
Isoform 2 (identifier: Q8BRH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     651-658: EVKLRPEA → KFPENVSI
     659-920: Missing.

Note: No experimental confirmation available.
Show »
Length:658
Mass (Da):74,210
Checksum:iCD7D19ABB2708017
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti501S → T in BAE38405 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023620651 – 658EVKLRPEA → KFPENVSI in isoform 2. 1 Publication8
Alternative sequenceiVSP_023621659 – 920Missing in isoform 2. 1 PublicationAdd BLAST262

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044857 mRNA Translation: BAC32122.1
AK165838 mRNA Translation: BAE38405.1
AC153501 Genomic DNA No translation available.
CCDSiCCDS24150.1 [Q8BRH0-2]
CCDS48684.1 [Q8BRH0-1]
RefSeqiNP_001028504.1, NM_001033332.2
NP_001103483.1, NM_001110013.1
UniGeneiMm.296805

Genome annotation databases

GeneIDi237500
KEGGimmu:237500

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTMTC3_MOUSE
AccessioniPrimary (citable) accession number: Q8BRH0
Secondary accession number(s): Q3TMN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: February 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome