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Protein

Transmembrane protein 209

Gene

Tmem209

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 209
Gene namesi
Name:Tmem209
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1919899. Tmem209.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821HelicalSequence analysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Transmembrane protein 209PRO_0000331633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111PhosphoserineBy similarity
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Modified residuei98 – 981PhosphoserineBy similarity
Modified residuei201 – 2011PhosphoserineBy similarity
Modified residuei248 – 2481PhosphoserineBy similarity
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence analysis
Modified residuei278 – 2781PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BRG8.
PaxDbiQ8BRG8.
PeptideAtlasiQ8BRG8.
PRIDEiQ8BRG8.

PTM databases

iPTMnetiQ8BRG8.
PhosphoSiteiQ8BRG8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029782.
ExpressionAtlasiQ8BRG8. baseline and differential.
GenevisibleiQ8BRG8. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8BRG8. 1 interaction.
STRINGi10090.ENSMUSP00000110813.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi126 – 20176Ser-richAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4670. Eukaryota.
ENOG410XQWI. LUCA.
GeneTreeiENSGT00390000013963.
HOGENOMiHOG000154623.
HOVERGENiHBG056529.
InParanoidiQ8BRG8.
OMAiYYNITYW.
OrthoDBiEOG091G047K.
PhylomeDBiQ8BRG8.
TreeFamiTF320043.

Family and domain databases

InterProiIPR019176. Cytochrome_B561-rel.
[Graphical view]
PfamiPF09786. CytochromB561_N. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BRG8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMQGDVSPNP SLIDRTIKMR KETETRKVVL AWGLLNVSMA GMIYTEMTGK
60 70 80 90 100
LISTYYNVTY WPLWYIELAL ASLFSLNALF DFWRYFKYTV APTSLVVSPG
110 120 130 140 150
QQALLGLKQA VVQTTPPRDL AATQISPSPP SPSIQGQSVL SYSPSRSPST
160 170 180 190 200
SPKFATSCMT GYSPQLQGLS SGGLGSYSPG VTYSPVSGYN KLASFSLSPS
210 220 230 240 250
SPYPTTVGPV ESSGLRARYR SPPTVYNSPT DKEDYMTDLR TLDTFLRSEE
260 270 280 290 300
EKQHRVKLGS PDSTSPSTSP TFWNYSRSVG DYAQTLKKFQ YQLACRSQAP
310 320 330 340 350
CANKDEADLI SKQAAEEVWA RVTMNRQLLD HMDSWTAKFR NWISETILVP
360 370 380 390 400
LVQEIESVST QMRRMGCPEL QIGEASVTSL KQAALVRAPL IPTLNAIVQY
410 420 430 440 450
LDLTPNQEYL FERIKELSQG GCMSSFRWNR GGDFKGRKWD TDLPTDSAII
460 470 480 490 500
MHVFCTYLDS RLPPHPKYPD GKTFTSQHFV QTPNKPDVTN ENVFCIYQSA
510 520 530 540 550
VNPPHYELIY QRHVYNLPKG RNNMFHTLLM FLYIIKTKES GMLGRVNLGL
560
SGVNILWIFG E
Length:561
Mass (Da):62,982
Last modified:March 1, 2003 - v1
Checksum:i0BE88792DD6BAE05
GO
Isoform 2 (identifier: Q8BRG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: Missing.

Show »
Length:560
Mass (Da):62,851
Checksum:i1E51896C09D39E05
GO
Isoform 3 (identifier: Q8BRG8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-448: Missing.
     545-561: RVNLGLSGVNILWIFGE → N

Note: No experimental confirmation available.
Show »
Length:438
Mass (Da):49,202
Checksum:i7DF3FD82D30AED09
GO

Sequence cautioni

The sequence BAC41016 differs from that shown. Reason: Frameshift at position 553. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391M → I in BAC37329 (PubMed:16141072).Curated
Sequence conflicti68 – 681L → V in BAC37329 (PubMed:16141072).Curated
Sequence conflicti407 – 4071Q → R in BAC37329 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11Missing in isoform 2. 1 PublicationVSP_033284
Alternative sequencei342 – 448107Missing in isoform 3. 1 PublicationVSP_033285Add
BLAST
Alternative sequencei545 – 56117RVNLG…WIFGE → N in isoform 3. 1 PublicationVSP_033286Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029366 mRNA. Translation: BAC26420.1.
AK044877 mRNA. Translation: BAC32126.1.
AK078544 mRNA. Translation: BAC37329.1.
AK089962 mRNA. Translation: BAC41016.1. Frameshift.
BC057109 mRNA. Translation: AAH57109.1.
BC052187 mRNA. Translation: AAH52187.1.
CCDSiCCDS19972.1. [Q8BRG8-1]
CCDS80511.1. [Q8BRG8-2]
RefSeqiNP_001298022.1. NM_001311093.1. [Q8BRG8-2]
NP_848740.3. NM_178625.4. [Q8BRG8-1]
UniGeneiMm.45418.

Genome annotation databases

EnsembliENSMUST00000064330; ENSMUSP00000067667; ENSMUSG00000029782. [Q8BRG8-3]
ENSMUST00000115157; ENSMUSP00000110810; ENSMUSG00000029782. [Q8BRG8-2]
ENSMUST00000115160; ENSMUSP00000110813; ENSMUSG00000029782. [Q8BRG8-1]
ENSMUST00000138823; ENSMUSP00000138292; ENSMUSG00000029782. [Q8BRG8-1]
GeneIDi72649.
KEGGimmu:72649.
UCSCiuc009bfi.1. mouse. [Q8BRG8-3]
uc009bfj.1. mouse. [Q8BRG8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029366 mRNA. Translation: BAC26420.1.
AK044877 mRNA. Translation: BAC32126.1.
AK078544 mRNA. Translation: BAC37329.1.
AK089962 mRNA. Translation: BAC41016.1. Frameshift.
BC057109 mRNA. Translation: AAH57109.1.
BC052187 mRNA. Translation: AAH52187.1.
CCDSiCCDS19972.1. [Q8BRG8-1]
CCDS80511.1. [Q8BRG8-2]
RefSeqiNP_001298022.1. NM_001311093.1. [Q8BRG8-2]
NP_848740.3. NM_178625.4. [Q8BRG8-1]
UniGeneiMm.45418.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BRG8. 1 interaction.
STRINGi10090.ENSMUSP00000110813.

PTM databases

iPTMnetiQ8BRG8.
PhosphoSiteiQ8BRG8.

Proteomic databases

MaxQBiQ8BRG8.
PaxDbiQ8BRG8.
PeptideAtlasiQ8BRG8.
PRIDEiQ8BRG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064330; ENSMUSP00000067667; ENSMUSG00000029782. [Q8BRG8-3]
ENSMUST00000115157; ENSMUSP00000110810; ENSMUSG00000029782. [Q8BRG8-2]
ENSMUST00000115160; ENSMUSP00000110813; ENSMUSG00000029782. [Q8BRG8-1]
ENSMUST00000138823; ENSMUSP00000138292; ENSMUSG00000029782. [Q8BRG8-1]
GeneIDi72649.
KEGGimmu:72649.
UCSCiuc009bfi.1. mouse. [Q8BRG8-3]
uc009bfj.1. mouse. [Q8BRG8-1]

Organism-specific databases

CTDi84928.
MGIiMGI:1919899. Tmem209.

Phylogenomic databases

eggNOGiKOG4670. Eukaryota.
ENOG410XQWI. LUCA.
GeneTreeiENSGT00390000013963.
HOGENOMiHOG000154623.
HOVERGENiHBG056529.
InParanoidiQ8BRG8.
OMAiYYNITYW.
OrthoDBiEOG091G047K.
PhylomeDBiQ8BRG8.
TreeFamiTF320043.

Miscellaneous databases

PROiQ8BRG8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029782.
ExpressionAtlasiQ8BRG8. baseline and differential.
GenevisibleiQ8BRG8. MM.

Family and domain databases

InterProiIPR019176. Cytochrome_B561-rel.
[Graphical view]
PfamiPF09786. CytochromB561_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM209_MOUSE
AccessioniPrimary (citable) accession number: Q8BRG8
Secondary accession number(s): Q80WQ3
, Q8BP02, Q8C202, Q8CDY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.