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Protein

Kelch-like protein 24

Gene

Klhl24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 24
Alternative name(s):
Kainate receptor-interacting protein for GluR6
Short name:
KRIP6
Gene namesi
Name:Klhl24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1923035. Klhl24.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002615951 – 600Kelch-like protein 24Add BLAST600

Proteomic databases

MaxQBiQ8BRG6.
PaxDbiQ8BRG6.
PRIDEiQ8BRG6.

PTM databases

PhosphoSitePlusiQ8BRG6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000062901.
CleanExiMM_KLHL24.
GenevisibleiQ8BRG6. MM.

Interactioni

Subunit structurei

Forms homodimers. Interacts with GRIK2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi217740. 1 interactor.
STRINGi10090.ENSMUSP00000023509.

Structurei

3D structure databases

ProteinModelPortaliQ8BRG6.
SMRiQ8BRG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 133BTBPROSITE-ProRule annotationAdd BLAST68
Domaini168 – 270BACKAdd BLAST103
Repeati314 – 363Kelch 1Add BLAST50
Repeati365 – 407Kelch 2Add BLAST43
Repeati408 – 454Kelch 3Add BLAST47
Repeati456 – 502Kelch 4Add BLAST47
Repeati504 – 544Kelch 5Add BLAST41
Repeati546 – 592Kelch 6Add BLAST47

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00850000132244.
HOGENOMiHOG000230817.
HOVERGENiHBG108068.
InParanoidiQ8BRG6.
KOiK10461.
OMAiEAMDCFL.
OrthoDBiEOG091G037V.
PhylomeDBiQ8BRG6.
TreeFamiTF351654.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030596. KLHL24.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF257. PTHR24412:SF257. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 5 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BRG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLILGRRLN REDLGVRDSP ATKRKVFEMD PKSLTGHEYF DFSSGSSHAE
60 70 80 90 100
NILQIFNEFR DSRLFTDVII CVEGKEFPCH RAVLSACSSY FRAMFCNDHR
110 120 130 140 150
ESREMLVEIN GILAEAMECF LQYVYTGKVK ITTENVQYLF ETSSLFQISV
160 170 180 190 200
LRDACAKFLE EQLDPCNCLG IQRFADTHSL KTLFTKCKTF ALQTFEDVSQ
210 220 230 240 250
HEEFLELDKD ELIDYICSDE LVIGKEEMVF EAVMRWVYRA VDLRRPLLHE
260 270 280 290 300
LLTHVRLPLL HPNYFVQTVE VDQLIQNSPE CYQLLHEARR YHILGNEMMS
310 320 330 340 350
PRTRPRRSTG YSEVIVVVGG CERVGGFNLP YTECYDPVTG EWKSLAKLPE
360 370 380 390 400
FTKSEYAVCA LRNDILVSGG RINSRDVWIY NSQLNIWIRV ASLNKGRWRH
410 420 430 440 450
KMAVLLGKVY VVGGYDGQNR LSSVECYDSF SNRWTEVAPL KEAVSSPAVT
460 470 480 490 500
SCIGKLFVIG GGPDDNTCSD KVQSYDPETN SWLLRAAIPI AKRCITAVSL
510 520 530 540 550
NNLIYVAGGL TKAVYCYDPV EDYWMHVQNT FSRQENCGMS VCNGKIYILG
560 570 580 590 600
GRRENGEATD TILCYDPATS IITGVAAMPR PVSYHGCVTI HRYNEKCFKL
Length:600
Mass (Da):68,364
Last modified:November 28, 2006 - v2
Checksum:iE12633EBBCD69086
GO

Sequence cautioni

The sequence AAH21407 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB29759 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE37423 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8R → T in BAB29759 (PubMed:16141072).Curated1
Sequence conflicti242D → N in BAC32131 (PubMed:16141072).Curated1
Sequence conflicti464D → N in BAC32732 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015239 mRNA. Translation: BAB29759.2. Different initiation.
AK044892 mRNA. Translation: BAC32131.1.
AK046446 mRNA. Translation: BAC32732.1.
AK163616 mRNA. Translation: BAE37423.1. Different initiation.
BC021407 mRNA. Translation: AAH21407.2. Different initiation.
CCDSiCCDS28042.1.
RefSeqiNP_083712.4. NM_029436.3.
XP_006522750.1. XM_006522687.3.
UniGeneiMm.392450.
Mm.392914.
Mm.491662.

Genome annotation databases

EnsembliENSMUST00000023509; ENSMUSP00000023509; ENSMUSG00000062901.
GeneIDi75785.
KEGGimmu:75785.
UCSCiuc007yph.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015239 mRNA. Translation: BAB29759.2. Different initiation.
AK044892 mRNA. Translation: BAC32131.1.
AK046446 mRNA. Translation: BAC32732.1.
AK163616 mRNA. Translation: BAE37423.1. Different initiation.
BC021407 mRNA. Translation: AAH21407.2. Different initiation.
CCDSiCCDS28042.1.
RefSeqiNP_083712.4. NM_029436.3.
XP_006522750.1. XM_006522687.3.
UniGeneiMm.392450.
Mm.392914.
Mm.491662.

3D structure databases

ProteinModelPortaliQ8BRG6.
SMRiQ8BRG6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217740. 1 interactor.
STRINGi10090.ENSMUSP00000023509.

PTM databases

PhosphoSitePlusiQ8BRG6.

Proteomic databases

MaxQBiQ8BRG6.
PaxDbiQ8BRG6.
PRIDEiQ8BRG6.

Protocols and materials databases

DNASUi75785.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023509; ENSMUSP00000023509; ENSMUSG00000062901.
GeneIDi75785.
KEGGimmu:75785.
UCSCiuc007yph.1. mouse.

Organism-specific databases

CTDi54800.
MGIiMGI:1923035. Klhl24.

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00850000132244.
HOGENOMiHOG000230817.
HOVERGENiHBG108068.
InParanoidiQ8BRG6.
KOiK10461.
OMAiEAMDCFL.
OrthoDBiEOG091G037V.
PhylomeDBiQ8BRG6.
TreeFamiTF351654.

Miscellaneous databases

ChiTaRSiKlhl24. mouse.
PROiQ8BRG6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062901.
CleanExiMM_KLHL24.
GenevisibleiQ8BRG6. MM.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030596. KLHL24.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF257. PTHR24412:SF257. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 5 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLH24_MOUSE
AccessioniPrimary (citable) accession number: Q8BRG6
Secondary accession number(s): Q3TQG0
, Q78J30, Q8BQU1, Q9D5K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.