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Unreviewed, UniProtKB/TrEMBL Q8BRD8 (Q8BRD8_MOUSE)

Last modified January 19, 2010. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    Putative uncharacterized protein EMBL BAC32198.1
Gene names
Name: Apc MGI 88039
OrganismMus musculus (Mouse) EMBL BAC32198.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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Ontologies

Gene Ontology (GO)
   Biological processT cell differentiation in the thymus

Inferred from mutant phenotype. Source: MGI

Wnt receptor signaling pathway through beta-catenin

Inferred from mutant phenotype. Source: MGI

anterior/posterior pattern formation

Inferred from mutant phenotype. Source: MGI

axis specification

Inferred from mutant phenotype. Source: MGI

axonogenesis

Inferred from mutant phenotype. Source: MGI

cell cycle arrest

Inferred from electronic annotation. Source: Compara

cell migration

Inferred from mutant phenotype. Source: MGI

chromosome organization

Inferred from genetic interaction. Source: MGI

cytokinesis after mitosis

Inferred from mutant phenotype. Source: MGI

dorsal/ventral pattern formation

Inferred from mutant phenotype. Source: MGI

establishment or maintenance of cell polarity

Inferred from electronic annotation. Source: Compara

hair follicle development

Inferred from mutant phenotype. Source: MGI

kidney development

Inferred from mutant phenotype. Source: MGI

mitotic cell cycle spindle assembly checkpoint

Inferred from electronic annotation. Source: Compara

mitotic metaphase/anaphase transition

Inferred from genetic interaction. Source: MGI

muscle homeostasis

Inferred from genetic interaction. Source: MGI

negative regulation of MAPKKK cascade

Inferred from genetic interaction. Source: MGI

negative regulation of Wnt receptor signaling pathway

Inferred from genetic interaction. Source: MGI

negative regulation of apoptosis

Inferred from mutant phenotype. Source: MGI

negative regulation of cyclin-dependent protein kinase activity

Inferred from electronic annotation. Source: Compara

negative regulation of epithelial cell proliferation involved in prostate gland development

Inferred from mutant phenotype. Source: MGI

negative regulation of microtubule depolymerization

Inferred from mutant phenotype. Source: MGI

negative regulation of odontogenesis

Inferred from mutant phenotype. Source: MGI

positive regulation of apoptosis

Inferred from mutant phenotype. Source: MGI

positive regulation of cell adhesion

Inferred from mutant phenotype. Source: MGI

positive regulation of cell division

Inferred from mutant phenotype. Source: MGI

positive regulation of cell migration

Inferred from mutant phenotype. Source: MGI

positive regulation of epithelial cell differentiation

Inferred from genetic interaction. Source: MGI

positive regulation of microtubule polymerization

Inferred from mutant phenotype. Source: MGI

positive regulation of protein catabolic process

Inferred from mutant phenotype. Source: MGI

positive regulation of pseudopodium assembly

Inferred from electronic annotation. Source: Compara

protein complex assembly

Inferred from electronic annotation. Source: Compara

proximal/distal pattern formation

Inferred from mutant phenotype. Source: MGI

regulation of attachment of spindle microtubules to kinetochore

Inferred from mutant phenotype. Source: MGI

regulation of nitrogen compound metabolic process

Inferred from mutant phenotype. Source: MGI

regulation of osteoblast differentiation

Inferred from mutant phenotype. Source: MGI

regulation of osteoclast differentiation

Inferred from mutant phenotype. Source: MGI

response to DNA damage stimulus

Inferred from electronic annotation. Source: Compara

response to drug

Inferred from electronic annotation. Source: Compara

retina development in camera-type eye

Inferred from mutant phenotype. Source: MGI

skin development

Inferred from mutant phenotype. Source: MGI

somatic stem cell maintenance

Inferred from genetic interaction. Source: MGI

thymus development

Inferred from mutant phenotype. Source: MGI

   Cellular componentAxin-APC-beta-catenin-GSK3B complex

Inferred from electronic annotation. Source: Compara

axon part

Inferred from direct assay. Source: MGI

beta-catenin destruction complex

Inferred from electronic annotation. Source: Compara

cell projection membrane

Inferred from direct assay. Source: MGI

centrosome

Inferred from electronic annotation. Source: Compara

cytoplasmic microtubule

Inferred from direct assay. Source: MGI

growth cone

Inferred from direct assay. Source: MGI

kinetochore

Inferred from electronic annotation. Source: Compara

lateral plasma membrane

Inferred from electronic annotation. Source: Compara

nucleus

Inferred from direct assay. Source: MGI

   Molecular functionbeta-catenin binding

Inferred from direct assay. Source: MGI

microtubule binding

Inferred from electronic annotation. Source: Compara

protein kinase binding

Inferred from electronic annotation. Source: Compara

protein kinase regulator activity

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

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Sequences

Sequence LengthMass (Da)Tools
Q8BRD8-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: F7C9949868B01993

FASTA48955,218
        10         20         30         40         50         60 
MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ LQGSIEDETM 

        70         80         90        100        110        120 
TSGQIDLLER LKEFNLDSNF PGVKLRSKMS LRSYGSREGS VSSRSGECSP VPMGSFPRRT 

       130        140        150        160        170        180 
FVNGSRESTG YLEELEKERS LLLADLDKEE KEKDWYYAQL QNLTKRIDSL PLTENFSLQT 

       190        200        210        220        230        240 
DMTRRQLEYE ARQIRAAMEE QLGTCQDMEK RAQRRIARIQ QIEKDILRVR QLLQSQAAEA 

       250        260        270        280        290        300 
ERSSQSRHDA ASHEAGRQHE GHGVAESNTA ASSSGQSPAT RVDHETASVL SSSGTHSAPR 

       310        320        330        340        350        360 
RLTSHLGTKV EMVYSLLSML GTHDKDDMSR TLLAMSSSQD SCISMRQSGC LPLLIQLLHG 

       370        380        390        400        410        420 
NDKDSVLLGN SRGSKEARAR ASAALHNIIH SQPDDKRGRR EIRVLHLLEQ IRAYCETCWE 

       430        440        450        460        470        480 
WQEAHEQGMD QDKNPMPAPV EHQICPAVCV LMKLSFDEEH RHAMNELGKI KAFLTPQIHA 


AECLKHKRN

« Hide

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References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J EMBL BAC32198.1.
Tissue: Parthenogenote EMBL BAC32198.1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK045053 mRNA. Translation: BAC32198.1.
IPIIPI00896736.
UniGeneMm.384171

3D structure databases

HSSPHSSP built from PDB template 1DEB based on UniProtKB P25054.
SMRQ8BRD8. Positions 2-55, 128-237.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8BRD8.

Genome annotation databases

EnsemblENSMUST00000079362; ENSMUSP00000078337; ENSMUSG00000005871; Mus musculus. [Genome view]
UCSCuc008ekd.1. mouse.

Organism-specific databases

MGIMGI:88039. Apc.

Phylogenomic databases

HOVERGENQ8BRD8.
InParanoidQ8BRD8.

Gene expression databases

ArrayExpressQ8BRD8.
BgeeQ8BRD8.
GenevestigatorQ8BRD8.

Family and domain databases

InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
Gene3DG3DSA:1.25.10.10. ARM-like. 1 hit.
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameQ8BRD8_MOUSE
AccessionPrimary (citable) accession number: Q8BRD8
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: January 19, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information