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Q8BRB7

- KAT6B_MOUSE

UniProt

Q8BRB7 - KAT6B_MOUSE

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Protein

Histone acetyltransferase KAT6B

Gene
Kat6b, Myst4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity By similarity. Involved in cerebral cortex development.1 Publication

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei633 – 6331 By similarity
Active sitei675 – 6751Nucleophile By similarity
Binding sitei713 – 7131Acetyl-CoA By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri214 – 27360PHD-type 1Add
BLAST
Zinc fingeri270 – 32152PHD-type 2Add
BLAST
Zinc fingeri567 – 58923C2HC-typeAdd
BLAST

GO - Molecular functioni

  1. acetyltransferase activity Source: UniProtKB
  2. DNA binding Source: InterPro
  3. histone acetyltransferase activity Source: UniProtKB
  4. transcription factor binding Source: UniProtKB
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. histone acetylation Source: UniProtKB
  2. histone H3 acetylation Source: UniProtKB
  3. negative regulation of transcription, DNA-templated Source: UniProtKB
  4. nucleosome assembly Source: InterPro
  5. positive regulation of transcription, DNA-templated Source: UniProtKB
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_226917. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase KAT6B (EC:2.3.1.48)
Alternative name(s):
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4
Short name:
MYST-4
Protein querkopf
Gene namesi
Name:Kat6b
Synonyms:Myst4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1858746. Kat6b.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. MOZ/MORF histone acetyltransferase complex Source: UniProtKB
  2. nucleosome Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice have a low body weight, craniofacial abnormalities, and defects in cortex development. Mice carrying a gene trap insertion in the gene, produces approximately 5% of the normal amount of mRNA. The hypomorphic mutant displays a number of defects that mirror SBBYSS syndrome, although the phenotype is milder. Mice are of normal size at birth but fail to thrive and have brain developmental defects as well as craniofacial defects. Observed abnormalities include short and narrow palpebral fissures, low set ears, and malocclusion. Similar to individuals with SBBYSS, mice carrying the gene trap insertion have long, slender feet and disproportionally long first digits.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18721872Histone acetyltransferase KAT6BPRO_0000051577Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei633 – 6331N6-acetyllysine; by autocatalysis By similarity
Modified residuei856 – 8561N6-acetyllysine1 Publication
Modified residuei860 – 8601N6-acetyllysine1 Publication
Modified residuei862 – 8621N6-acetyllysine By similarity

Post-translational modificationi

Autoacetylated By similarity.
Autoacetylation at Lys-633 is required for proper function By similarity.

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ8BRB7.

PTM databases

PhosphoSiteiQ8BRB7.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Developmental stagei

Strongly expressed in the ventricular zone of the developing cerebral cortex.1 Publication

Gene expression databases

ArrayExpressiQ8BRB7.
BgeeiQ8BRB7.
GenevestigatoriQ8BRB7.

Interactioni

Subunit structurei

Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3 By similarity. Interacts with RUNX1 and RUNX2 By similarity.

Protein-protein interaction databases

BioGridi207589. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8BRB7.
SMRiQ8BRB7. Positions 212-321, 536-808.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 17774H15Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni362 – 535174Negatively regulates HAT activity By similarityAdd
BLAST
Regioni536 – 826291Catalytic By similarityAdd
BLAST
Regioni570 – 826257Interaction with BRPF1 By similarityAdd
BLAST
Regioni674 – 6785Acetyl-CoA binding By similarity
Regioni683 – 6897Acetyl-CoA binding By similarity
Regioni1359 – 1872514Interaction with RUNX1 and RUNX2 By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi888 – 8969Poly-Glu
Compositional biasi899 – 90810Poly-Glu
Compositional biasi1008 – 10136Poly-Glu
Compositional biasi1154 – 117522Poly-GluAdd
BLAST
Compositional biasi1209 – 12179Poly-Glu
Compositional biasi1393 – 1562170Ser-richAdd
BLAST
Compositional biasi1760 – 1860101Met-richAdd
BLAST

Domaini

The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression By similarity.

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5027.
GeneTreeiENSGT00550000074503.
HOGENOMiHOG000234365.
HOVERGENiHBG052563.
InParanoidiQ8BRB7.
KOiK11306.
OMAiLRWTPIL.
OrthoDBiEOG7WHH8N.
TreeFamiTF106483.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.40.10. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR005818. Histone_H1/H5_H15.
IPR002717. MOZ_SAS.
IPR011991. WHTH_DNA-bd_dom.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
PF01853. MOZ_SAS. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00526. H15. 1 hit.
SM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51504. H15. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BRB7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVKLANPLYT EWILEAVQKI KKQKQRPSEE RICHAVSTSH GLDKKTVSEQ     50
LELSVQDGSV LKVTNKGLAS YKDPDNPGRF SSVKPGTFPK PTKGSKGPPC 100
NDLRNVDWNK LLKRAIEGLE EPNGSSLKNI EKYLRSQSDL TGTTNHPAFQ 150
QRLRLGAKRA VNNGRLLKEG PQYRVNSGSS DGKGAPQYPS AFPSSLPPVS 200
LLPHEKDQPR ADPIPICSFC LGTKESNREK KPEELLSCAD CGSSGHPSCL 250
KFCPELTANV KALRWQCIEC KTCSACRVQG KNADNMLFCD SCDRGFHMEC 300
CDPPLSRMPK GMWICQVCRP KKKGRKLLHE KAAQIKRRYA KPIGRPKNKL 350
KQRLLSVTSD EGSMSAFTGR GSPGRGQKTK VSTTPSSGHA ASGKHSSSRL 400
AVTDPTRPGA TTKTTTSSTY ISASTLKVNK KTKGLIDGLT KFFTPSPDGR 450
RSRGEIIDFS KHYRPRKKVS QKQSCTSHVL ATDTDIKISI KQESADVSLV 500
GNKELVTEED LDVFKQAQEL SWEKIECESG VEDCGRYPSV IEFGKYEIQT 550
WYSSPYPQEY ARLPKLYLCE FCLKYMKSKN ILLRHSKKCG WFHPPANEIY 600
RRKDLSVFEV DGNMSKIYCQ NLCLLAKLFL DHKTLYYDVE PFLFYVLTKN 650
DEKGCHLVGY FSKEKLCQQK YNVSCIMIMP QHQRQGFGRF LIDFSYLLSR 700
REGQAGSPEK PLSDLGRLSY LAYWKSVILE YLYRHHERHI SIKAISRATG 750
MCPHDIATTL QHLHMIDRRD GRFVIIRREK LILGHMEKLK NCSRPNELDP 800
ESLRWTPMLI SNAVVSEEER EAEKEAERLM EQASCWEKEE QEILSSRVSS 850
RQSSAKVQSK NKYLHSPERR PVAGERGQLL ELSKESSEEE EEEEEEDDEE 900
EEEEEEEESI QTSPPRLTKP QSVSIKRKRP FVVKKKRGRK RRRINSSVTT 950
ETISETTEVL NEPFDNSDEE RPMPQLEPTC EIPVEEGGRK PVLRKAFPHQ 1000
PGKKRQTEEE EGEDNHFFKT AALCRKDVDD DAEHLKEGSK DNPEPLKCRQ 1050
VWPKGAKRGL SKWKQSKERK TGFKLNLYTP PETPMEPEDQ VTIEEQKELS 1100
EDKGSPVGME REVTETVDAL LPQEGSRREE TGIPVSPHKS PGGKVDEEDL 1150
IRGEEEGEEE GEEEGEREEQ EEEEEVTTEK DLDGAKSKEN PEPEISMEKE 1200
DPVHLGDHEE DEDEEEEPSH NEDHDADDED DGHMEAANME RGDLPRETFK 1250
DALEGQEAFL DLSIQPSHSN PEVLMNCGVD LTMSCNSEPK ELAGDTGTAP 1300
ESDAEPPEEQ TQKQDQKNSD GVDAELEEGG PAAVEIDSET AQAVQSLTQE 1350
NREHDDTFPD CAETQEACRS LQNYTHTDQS PQIATTLDEC QQSDHSSPVS 1400
SVHSHPGQSV RSVNSPSVPA LENSYAQISP DQTAITVPPL QNMETSPMMD 1450
VPSVSDHSQQ VVDSGFSDLG SIESTTENYE NPSSYDSTMG GSICGNGSSQ 1500
NSCSYSSLTS SNLTQNSCAV TQQMSNISGS CSMLQQTSIS SPPTCSVKSP 1550
QGCVVERPPS SSQQLAQCSM AANFTPPMQL ADIPETSNAN IGLYERMGQS 1600
DFGAGHYPQP SATFSLAKLQ QLTNTLIDHS LPYSHSAAVT SYANSASLST 1650
PLSNTGLVQL SQSPHSVPGG PQAQATMTPP PNLTPPPMNL PPPLLQRNMA 1700
ASNIGISHSQ RLQTQIASKG HVSMRTKAAS LSPAAATHQS QIYGRSQTVA 1750
MQGPARTLTM QRGMNMSVNL MPAPAYNVNS VNMNMNTLNA MNGYSMSQPM 1800
MNSGYHSNHG YMNQTPQYPM QMQMGMMGSQ PYAQQPMQTP PHANMMYTAP 1850
GHHGYMNTGM SKQSLNGSYM RR 1872
Length:1,872
Mass (Da):208,526
Last modified:July 27, 2011 - v3
Checksum:i2807D9D473EE22C7
GO
Isoform 2 (identifier: Q8BRB7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     374-482: Missing.

Show »
Length:1,763
Mass (Da):196,867
Checksum:i667EEDB2F43FF958
GO

Sequence cautioni

The sequence BAC33305.1 differs from that shown. Reason: Probable intron retention.
The sequence BAC34930.1 differs from that shown. Reason: Probable intron retention.
The sequence BAC38771.1 differs from that shown. Reason: Probable intron retention.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei374 – 482109Missing in isoform 2. VSP_014592Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1033 – 10331E → Q in AAF26744. 1 Publication
Sequence conflicti1418 – 14181V → I in AAF26744. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF222800 mRNA. Translation: AAF26744.1.
AK045188 mRNA. Translation: BAC32253.2.
AK048336 mRNA. Translation: BAC33305.1. Sequence problems.
AK052307 mRNA. Translation: BAC34930.1. Sequence problems.
AK083123 mRNA. Translation: BAC38771.1. Sequence problems.
AC115122 Genomic DNA. No translation available.
AC148978 Genomic DNA. No translation available.
AY294423 Genomic DNA. Translation: AAQ01512.1.
CCDSiCCDS59615.1. [Q8BRB7-2]
RefSeqiNP_059507.2. NM_017479.3. [Q8BRB7-2]
XP_006519331.1. XM_006519268.1. [Q8BRB7-1]
XP_006519333.1. XM_006519270.1. [Q8BRB7-2]
UniGeneiMm.248967.

Genome annotation databases

EnsembliENSMUST00000069648; ENSMUSP00000066693; ENSMUSG00000021767. [Q8BRB7-1]
ENSMUST00000182405; ENSMUSP00000138377; ENSMUSG00000021767. [Q8BRB7-2]
ENSMUST00000182855; ENSMUSP00000138511; ENSMUSG00000021767. [Q8BRB7-2]
ENSMUST00000182964; ENSMUSP00000138421; ENSMUSG00000021767. [Q8BRB7-1]
GeneIDi54169.
KEGGimmu:54169.
UCSCiuc007slg.2. mouse. [Q8BRB7-2]
uc007slk.1. mouse. [Q8BRB7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF222800 mRNA. Translation: AAF26744.1 .
AK045188 mRNA. Translation: BAC32253.2 .
AK048336 mRNA. Translation: BAC33305.1 . Sequence problems.
AK052307 mRNA. Translation: BAC34930.1 . Sequence problems.
AK083123 mRNA. Translation: BAC38771.1 . Sequence problems.
AC115122 Genomic DNA. No translation available.
AC148978 Genomic DNA. No translation available.
AY294423 Genomic DNA. Translation: AAQ01512.1 .
CCDSi CCDS59615.1. [Q8BRB7-2 ]
RefSeqi NP_059507.2. NM_017479.3. [Q8BRB7-2 ]
XP_006519331.1. XM_006519268.1. [Q8BRB7-1 ]
XP_006519333.1. XM_006519270.1. [Q8BRB7-2 ]
UniGenei Mm.248967.

3D structure databases

ProteinModelPortali Q8BRB7.
SMRi Q8BRB7. Positions 212-321, 536-808.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207589. 1 interaction.

PTM databases

PhosphoSitei Q8BRB7.

Proteomic databases

PRIDEi Q8BRB7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000069648 ; ENSMUSP00000066693 ; ENSMUSG00000021767 . [Q8BRB7-1 ]
ENSMUST00000182405 ; ENSMUSP00000138377 ; ENSMUSG00000021767 . [Q8BRB7-2 ]
ENSMUST00000182855 ; ENSMUSP00000138511 ; ENSMUSG00000021767 . [Q8BRB7-2 ]
ENSMUST00000182964 ; ENSMUSP00000138421 ; ENSMUSG00000021767 . [Q8BRB7-1 ]
GeneIDi 54169.
KEGGi mmu:54169.
UCSCi uc007slg.2. mouse. [Q8BRB7-2 ]
uc007slk.1. mouse. [Q8BRB7-1 ]

Organism-specific databases

CTDi 23522.
MGIi MGI:1858746. Kat6b.

Phylogenomic databases

eggNOGi COG5027.
GeneTreei ENSGT00550000074503.
HOGENOMi HOG000234365.
HOVERGENi HBG052563.
InParanoidi Q8BRB7.
KOi K11306.
OMAi LRWTPIL.
OrthoDBi EOG7WHH8N.
TreeFami TF106483.

Enzyme and pathway databases

Reactomei REACT_226917. HATs acetylate histones.

Miscellaneous databases

NextBioi 311014.
PROi Q8BRB7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BRB7.
Bgeei Q8BRB7.
Genevestigatori Q8BRB7.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.30.40.10. 1 hit.
3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR005818. Histone_H1/H5_H15.
IPR002717. MOZ_SAS.
IPR011991. WHTH_DNA-bd_dom.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00538. Linker_histone. 1 hit.
PF01853. MOZ_SAS. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view ]
SMARTi SM00526. H15. 1 hit.
SM00249. PHD. 2 hits.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEi PS51504. H15. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development."
    Thomas T., Voss A.K., Chowdhury K., Gruss P.
    Development 127:2537-2548(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, ENZYME ACTIVITY, FUNCTION, DISRUPTION PHENOTYPE.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-933 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryo, Head, Heart and Hippocampus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "Genomic sequence analysis in the mouse T-complex region."
    Brathwaite M.E., Waeltz P., Qian Y., Dudekula D., Schlessinger D., Nagaraja R.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 696-1872.
    Strain: C57BL/6J.
  5. "Whole-exome-sequencing identifies mutations in histone acetyltransferase gene KAT6B in individuals with the Say-Barber-Biesecker variant of Ohdo syndrome."
    Clayton-Smith J., O'Sullivan J., Daly S., Bhaskar S., Day R., Anderson B., Voss A.K., Thomas T., Biesecker L.G., Smith P., Fryer A., Chandler K.E., Kerr B., Tassabehji M., Lynch S.A., Krajewska-Walasek M., McKee S., Smith J.
    , Sweeney E., Mansour S., Mohammed S., Donnai D., Black G.
    Am. J. Hum. Genet. 89:675-681(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-856 AND LYS-860, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiKAT6B_MOUSE
AccessioniPrimary (citable) accession number: Q8BRB7
Secondary accession number(s): E9QK86
, Q7TNW5, Q8BG35, Q8C441, Q9JKX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi