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Q8BRB7

- KAT6B_MOUSE

UniProt

Q8BRB7 - KAT6B_MOUSE

Protein

Histone acetyltransferase KAT6B

Gene

Kat6b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity By similarity. Involved in cerebral cortex development.By similarity1 Publication

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei633 – 6331By similarity
    Active sitei675 – 6751NucleophileBy similarity
    Binding sitei713 – 7131Acetyl-CoABy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri214 – 27360PHD-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri270 – 32152PHD-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri567 – 58923C2HC-typeAdd
    BLAST

    GO - Molecular functioni

    1. acetyltransferase activity Source: UniProtKB
    2. DNA binding Source: InterPro
    3. histone acetyltransferase activity Source: UniProtKB
    4. transcription factor binding Source: UniProtKB
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histone acetylation Source: UniProtKB
    2. histone H3 acetylation Source: UniProtKB
    3. negative regulation of transcription, DNA-templated Source: UniProtKB
    4. nucleosome assembly Source: InterPro
    5. positive regulation of transcription, DNA-templated Source: UniProtKB
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Acyltransferase, Chromatin regulator, Repressor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_226917. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase KAT6B (EC:2.3.1.48)
    Alternative name(s):
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4
    Short name:
    MYST-4
    Protein querkopf
    Gene namesi
    Name:Kat6b
    Synonyms:Myst4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1858746. Kat6b.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. MOZ/MORF histone acetyltransferase complex Source: UniProtKB
    2. nucleosome Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice have a low body weight, craniofacial abnormalities, and defects in cortex development. Mice carrying a gene trap insertion in the gene, produces approximately 5% of the normal amount of mRNA. The hypomorphic mutant displays a number of defects that mirror SBBYSS syndrome, although the phenotype is milder. Mice are of normal size at birth but fail to thrive and have brain developmental defects as well as craniofacial defects. Observed abnormalities include short and narrow palpebral fissures, low set ears, and malocclusion. Similar to individuals with SBBYSS, mice carrying the gene trap insertion have long, slender feet and disproportionally long first digits.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18721872Histone acetyltransferase KAT6BPRO_0000051577Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei633 – 6331N6-acetyllysine; by autocatalysisBy similarity
    Modified residuei856 – 8561N6-acetyllysine1 Publication
    Modified residuei860 – 8601N6-acetyllysine1 Publication
    Modified residuei862 – 8621N6-acetyllysineBy similarity

    Post-translational modificationi

    Autoacetylated.By similarity
    Autoacetylation at Lys-633 is required for proper function.By similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ8BRB7.

    PTM databases

    PhosphoSiteiQ8BRB7.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Developmental stagei

    Strongly expressed in the ventricular zone of the developing cerebral cortex.1 Publication

    Gene expression databases

    ArrayExpressiQ8BRB7.
    BgeeiQ8BRB7.
    GenevestigatoriQ8BRB7.

    Interactioni

    Subunit structurei

    Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with RUNX1 and RUNX2.By similarity

    Protein-protein interaction databases

    BioGridi207589. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BRB7.
    SMRiQ8BRB7. Positions 212-321, 536-808.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini104 – 17774H15PROSITE-ProRule annotationAdd
    BLAST
    Domaini533 – 807275MYST-type HATAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni362 – 535174Negatively regulates HAT activityBy similarityAdd
    BLAST
    Regioni536 – 826291CatalyticBy similarityAdd
    BLAST
    Regioni570 – 826257Interaction with BRPF1By similarityAdd
    BLAST
    Regioni674 – 6785Acetyl-CoA bindingBy similarity
    Regioni683 – 6897Acetyl-CoA bindingBy similarity
    Regioni1359 – 1872514Interaction with RUNX1 and RUNX2By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi888 – 8969Poly-Glu
    Compositional biasi899 – 90810Poly-Glu
    Compositional biasi1008 – 10136Poly-Glu
    Compositional biasi1154 – 117522Poly-GluAdd
    BLAST
    Compositional biasi1209 – 12179Poly-Glu
    Compositional biasi1393 – 1562170Ser-richAdd
    BLAST
    Compositional biasi1760 – 1860101Met-richAdd
    BLAST

    Domaini

    The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.By similarity

    Sequence similaritiesi

    Belongs to the MYST (SAS/MOZ) family.Curated
    Contains 1 C2HC-type zinc finger.Curated
    Contains 1 H15 (linker histone H1/H5 globular) domain.PROSITE-ProRule annotation
    Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri214 – 27360PHD-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri270 – 32152PHD-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri567 – 58923C2HC-typeAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5027.
    GeneTreeiENSGT00550000074503.
    HOGENOMiHOG000234365.
    HOVERGENiHBG052563.
    InParanoidiQ8BRB7.
    KOiK11306.
    OMAiLRWTPIL.
    OrthoDBiEOG7WHH8N.
    TreeFamiTF106483.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.30.40.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR005818. Histone_H1/H5_H15.
    IPR002717. MOZ_SAS.
    IPR011991. WHTH_DNA-bd_dom.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00538. Linker_histone. 1 hit.
    PF01853. MOZ_SAS. 1 hit.
    PF00628. PHD. 1 hit.
    [Graphical view]
    SMARTiSM00526. H15. 1 hit.
    SM00249. PHD. 2 hits.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS51504. H15. 1 hit.
    PS51726. MYST_HAT. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BRB7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVKLANPLYT EWILEAVQKI KKQKQRPSEE RICHAVSTSH GLDKKTVSEQ     50
    LELSVQDGSV LKVTNKGLAS YKDPDNPGRF SSVKPGTFPK PTKGSKGPPC 100
    NDLRNVDWNK LLKRAIEGLE EPNGSSLKNI EKYLRSQSDL TGTTNHPAFQ 150
    QRLRLGAKRA VNNGRLLKEG PQYRVNSGSS DGKGAPQYPS AFPSSLPPVS 200
    LLPHEKDQPR ADPIPICSFC LGTKESNREK KPEELLSCAD CGSSGHPSCL 250
    KFCPELTANV KALRWQCIEC KTCSACRVQG KNADNMLFCD SCDRGFHMEC 300
    CDPPLSRMPK GMWICQVCRP KKKGRKLLHE KAAQIKRRYA KPIGRPKNKL 350
    KQRLLSVTSD EGSMSAFTGR GSPGRGQKTK VSTTPSSGHA ASGKHSSSRL 400
    AVTDPTRPGA TTKTTTSSTY ISASTLKVNK KTKGLIDGLT KFFTPSPDGR 450
    RSRGEIIDFS KHYRPRKKVS QKQSCTSHVL ATDTDIKISI KQESADVSLV 500
    GNKELVTEED LDVFKQAQEL SWEKIECESG VEDCGRYPSV IEFGKYEIQT 550
    WYSSPYPQEY ARLPKLYLCE FCLKYMKSKN ILLRHSKKCG WFHPPANEIY 600
    RRKDLSVFEV DGNMSKIYCQ NLCLLAKLFL DHKTLYYDVE PFLFYVLTKN 650
    DEKGCHLVGY FSKEKLCQQK YNVSCIMIMP QHQRQGFGRF LIDFSYLLSR 700
    REGQAGSPEK PLSDLGRLSY LAYWKSVILE YLYRHHERHI SIKAISRATG 750
    MCPHDIATTL QHLHMIDRRD GRFVIIRREK LILGHMEKLK NCSRPNELDP 800
    ESLRWTPMLI SNAVVSEEER EAEKEAERLM EQASCWEKEE QEILSSRVSS 850
    RQSSAKVQSK NKYLHSPERR PVAGERGQLL ELSKESSEEE EEEEEEDDEE 900
    EEEEEEEESI QTSPPRLTKP QSVSIKRKRP FVVKKKRGRK RRRINSSVTT 950
    ETISETTEVL NEPFDNSDEE RPMPQLEPTC EIPVEEGGRK PVLRKAFPHQ 1000
    PGKKRQTEEE EGEDNHFFKT AALCRKDVDD DAEHLKEGSK DNPEPLKCRQ 1050
    VWPKGAKRGL SKWKQSKERK TGFKLNLYTP PETPMEPEDQ VTIEEQKELS 1100
    EDKGSPVGME REVTETVDAL LPQEGSRREE TGIPVSPHKS PGGKVDEEDL 1150
    IRGEEEGEEE GEEEGEREEQ EEEEEVTTEK DLDGAKSKEN PEPEISMEKE 1200
    DPVHLGDHEE DEDEEEEPSH NEDHDADDED DGHMEAANME RGDLPRETFK 1250
    DALEGQEAFL DLSIQPSHSN PEVLMNCGVD LTMSCNSEPK ELAGDTGTAP 1300
    ESDAEPPEEQ TQKQDQKNSD GVDAELEEGG PAAVEIDSET AQAVQSLTQE 1350
    NREHDDTFPD CAETQEACRS LQNYTHTDQS PQIATTLDEC QQSDHSSPVS 1400
    SVHSHPGQSV RSVNSPSVPA LENSYAQISP DQTAITVPPL QNMETSPMMD 1450
    VPSVSDHSQQ VVDSGFSDLG SIESTTENYE NPSSYDSTMG GSICGNGSSQ 1500
    NSCSYSSLTS SNLTQNSCAV TQQMSNISGS CSMLQQTSIS SPPTCSVKSP 1550
    QGCVVERPPS SSQQLAQCSM AANFTPPMQL ADIPETSNAN IGLYERMGQS 1600
    DFGAGHYPQP SATFSLAKLQ QLTNTLIDHS LPYSHSAAVT SYANSASLST 1650
    PLSNTGLVQL SQSPHSVPGG PQAQATMTPP PNLTPPPMNL PPPLLQRNMA 1700
    ASNIGISHSQ RLQTQIASKG HVSMRTKAAS LSPAAATHQS QIYGRSQTVA 1750
    MQGPARTLTM QRGMNMSVNL MPAPAYNVNS VNMNMNTLNA MNGYSMSQPM 1800
    MNSGYHSNHG YMNQTPQYPM QMQMGMMGSQ PYAQQPMQTP PHANMMYTAP 1850
    GHHGYMNTGM SKQSLNGSYM RR 1872
    Length:1,872
    Mass (Da):208,526
    Last modified:July 27, 2011 - v3
    Checksum:i2807D9D473EE22C7
    GO
    Isoform 2 (identifier: Q8BRB7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         374-482: Missing.

    Show »
    Length:1,763
    Mass (Da):196,867
    Checksum:i667EEDB2F43FF958
    GO

    Sequence cautioni

    The sequence BAC33305.1 differs from that shown. Reason: Probable intron retention.
    The sequence BAC34930.1 differs from that shown. Reason: Probable intron retention.
    The sequence BAC38771.1 differs from that shown. Reason: Probable intron retention.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1033 – 10331E → Q in AAF26744. (PubMed:10821753)Curated
    Sequence conflicti1418 – 14181V → I in AAF26744. (PubMed:10821753)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei374 – 482109Missing in isoform 2. 1 PublicationVSP_014592Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF222800 mRNA. Translation: AAF26744.1.
    AK045188 mRNA. Translation: BAC32253.2.
    AK048336 mRNA. Translation: BAC33305.1. Sequence problems.
    AK052307 mRNA. Translation: BAC34930.1. Sequence problems.
    AK083123 mRNA. Translation: BAC38771.1. Sequence problems.
    AC115122 Genomic DNA. No translation available.
    AC148978 Genomic DNA. No translation available.
    AY294423 Genomic DNA. Translation: AAQ01512.1.
    CCDSiCCDS59615.1. [Q8BRB7-2]
    RefSeqiNP_059507.2. NM_017479.3. [Q8BRB7-2]
    XP_006519331.1. XM_006519268.1. [Q8BRB7-1]
    XP_006519333.1. XM_006519270.1. [Q8BRB7-2]
    UniGeneiMm.248967.

    Genome annotation databases

    EnsembliENSMUST00000069648; ENSMUSP00000066693; ENSMUSG00000021767. [Q8BRB7-1]
    ENSMUST00000182405; ENSMUSP00000138377; ENSMUSG00000021767. [Q8BRB7-2]
    ENSMUST00000182855; ENSMUSP00000138511; ENSMUSG00000021767. [Q8BRB7-2]
    ENSMUST00000182964; ENSMUSP00000138421; ENSMUSG00000021767. [Q8BRB7-1]
    GeneIDi54169.
    KEGGimmu:54169.
    UCSCiuc007slg.2. mouse. [Q8BRB7-2]
    uc007slk.1. mouse. [Q8BRB7-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF222800 mRNA. Translation: AAF26744.1 .
    AK045188 mRNA. Translation: BAC32253.2 .
    AK048336 mRNA. Translation: BAC33305.1 . Sequence problems.
    AK052307 mRNA. Translation: BAC34930.1 . Sequence problems.
    AK083123 mRNA. Translation: BAC38771.1 . Sequence problems.
    AC115122 Genomic DNA. No translation available.
    AC148978 Genomic DNA. No translation available.
    AY294423 Genomic DNA. Translation: AAQ01512.1 .
    CCDSi CCDS59615.1. [Q8BRB7-2 ]
    RefSeqi NP_059507.2. NM_017479.3. [Q8BRB7-2 ]
    XP_006519331.1. XM_006519268.1. [Q8BRB7-1 ]
    XP_006519333.1. XM_006519270.1. [Q8BRB7-2 ]
    UniGenei Mm.248967.

    3D structure databases

    ProteinModelPortali Q8BRB7.
    SMRi Q8BRB7. Positions 212-321, 536-808.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207589. 1 interaction.

    PTM databases

    PhosphoSitei Q8BRB7.

    Proteomic databases

    PRIDEi Q8BRB7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000069648 ; ENSMUSP00000066693 ; ENSMUSG00000021767 . [Q8BRB7-1 ]
    ENSMUST00000182405 ; ENSMUSP00000138377 ; ENSMUSG00000021767 . [Q8BRB7-2 ]
    ENSMUST00000182855 ; ENSMUSP00000138511 ; ENSMUSG00000021767 . [Q8BRB7-2 ]
    ENSMUST00000182964 ; ENSMUSP00000138421 ; ENSMUSG00000021767 . [Q8BRB7-1 ]
    GeneIDi 54169.
    KEGGi mmu:54169.
    UCSCi uc007slg.2. mouse. [Q8BRB7-2 ]
    uc007slk.1. mouse. [Q8BRB7-1 ]

    Organism-specific databases

    CTDi 23522.
    MGIi MGI:1858746. Kat6b.

    Phylogenomic databases

    eggNOGi COG5027.
    GeneTreei ENSGT00550000074503.
    HOGENOMi HOG000234365.
    HOVERGENi HBG052563.
    InParanoidi Q8BRB7.
    KOi K11306.
    OMAi LRWTPIL.
    OrthoDBi EOG7WHH8N.
    TreeFami TF106483.

    Enzyme and pathway databases

    Reactomei REACT_226917. HATs acetylate histones.

    Miscellaneous databases

    NextBioi 311014.
    PROi Q8BRB7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BRB7.
    Bgeei Q8BRB7.
    Genevestigatori Q8BRB7.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.30.40.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR005818. Histone_H1/H5_H15.
    IPR002717. MOZ_SAS.
    IPR011991. WHTH_DNA-bd_dom.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00538. Linker_histone. 1 hit.
    PF01853. MOZ_SAS. 1 hit.
    PF00628. PHD. 1 hit.
    [Graphical view ]
    SMARTi SM00526. H15. 1 hit.
    SM00249. PHD. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS51504. H15. 1 hit.
    PS51726. MYST_HAT. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development."
      Thomas T., Voss A.K., Chowdhury K., Gruss P.
      Development 127:2537-2548(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, ENZYME ACTIVITY, FUNCTION, DISRUPTION PHENOTYPE.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-933 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Embryo, Head, Heart and Hippocampus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "Genomic sequence analysis in the mouse T-complex region."
      Brathwaite M.E., Waeltz P., Qian Y., Dudekula D., Schlessinger D., Nagaraja R.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 696-1872.
      Strain: C57BL/6J.
    5. "Whole-exome-sequencing identifies mutations in histone acetyltransferase gene KAT6B in individuals with the Say-Barber-Biesecker variant of Ohdo syndrome."
      Clayton-Smith J., O'Sullivan J., Daly S., Bhaskar S., Day R., Anderson B., Voss A.K., Thomas T., Biesecker L.G., Smith P., Fryer A., Chandler K.E., Kerr B., Tassabehji M., Lynch S.A., Krajewska-Walasek M., McKee S., Smith J.
      , Sweeney E., Mansour S., Mohammed S., Donnai D., Black G.
      Am. J. Hum. Genet. 89:675-681(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-856 AND LYS-860, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiKAT6B_MOUSE
    AccessioniPrimary (citable) accession number: Q8BRB7
    Secondary accession number(s): E9QK86
    , Q7TNW5, Q8BG35, Q8C441, Q9JKX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 107 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3