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Protein
Submitted name:

Interleukin-1 receptor-associated kinase 1

Gene

Irak1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin-1 receptor-associated kinase 1Imported
Gene namesi
Name:Irak1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:107420. Irak1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini213 – 522310Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000063073.
HOGENOMiHOG000015226.
HOVERGENiHBG052144.
OrthoDBiEOG7MD4Q1.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BR10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGPGPGEP VVPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV
60 70 80 90 100
RDQTELRLCE RSEQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT
110 120 130 140 150
AWHPPAPVVP PSTAAPRPSS ISAGSEAGDW SPRKLQSSAS TFLSPAFPGS
160 170 180 190 200
QTHSESELLQ VPLPVSLGPP LPSSAPSSTK QSSPESPVSG LQRAHPSPFC
210 220 230 240 250
WPFCEISQGT CNFSEELRIG EGGFGCVYRA VMRNTTYAVK RLKEEADLEW
260 270 280 290 300
TMVKQSFLTE VEQLSRFRHP NIVDFAGYCA ESGLYCLVYG FLPNGSLEDQ
310 320 330 340 350
LHLQTQACSP LSWPQRLDIL LGTARAIQFL HQDSPSLIHG DIKSSNVLLD
360 370 380 390 400
ERLMPKLGDF GLARFSRFAG AKASQSSTVA RTSTVRGTLA YLPEEYIKTG
410 420 430 440 450
RLAVDTDTFS FGVVILETLA GQRAVRTQGA KTKYLKDLIE DEAEEAGVTL
460 470 480 490 500
KSTQPTLWVG VATDAWAAPI AAQIYKKHLD SRPGPCPPQL GLALAQLACC
510 520 530 540 550
CMHRRAKKRP PMTQVYKRLE GLQAGPPWEL EVAGHGSPSP QENSYMSTTG
560 570 580 590 600
SAQSGDEPWQ PLVVTTRAPA QAAQQLQRSP NQPVESDESV PGLSATLHSW
610 620 630 640 650
HLTPGSHPSP ASFREASCTQ GGTTRESSVR SSPGFQPTTM EGSPTGSSSL
660 670 680 690 700
LSSEPPQIII NPARQKMVQK LALYEEGVLD SLQLLSSGFF PGLDLEPEKS
710
QGPEESDEFQ S
Length:711
Mass (Da):77,398
Last modified:March 1, 2003 - v1
Checksum:i29949D41D04CB5BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672002 Genomic DNA. No translation available.
AK045958 mRNA. Translation: BAC32547.1.
AK143694 mRNA. Translation: BAE25502.1.
RefSeqiNP_001171444.1. NM_001177973.1.
NP_001171446.1. NM_001177975.1.
UniGeneiMm.38241.

Genome annotation databases

EnsembliENSMUST00000114354; ENSMUSP00000109994; ENSMUSG00000031392.
GeneIDi16179.
UCSCiuc009tnq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672002 Genomic DNA. No translation available.
AK045958 mRNA. Translation: BAC32547.1.
AK143694 mRNA. Translation: BAE25502.1.
RefSeqiNP_001171444.1. NM_001177973.1.
NP_001171446.1. NM_001177975.1.
UniGeneiMm.38241.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114354; ENSMUSP00000109994; ENSMUSG00000031392.
GeneIDi16179.
UCSCiuc009tnq.2. mouse.

Organism-specific databases

CTDi3654.
MGIiMGI:107420. Irak1.

Phylogenomic databases

GeneTreeiENSGT00530000063073.
HOGENOMiHOG000015226.
HOVERGENiHBG052144.
OrthoDBiEOG7MD4Q1.

Miscellaneous databases

ChiTaRSiIrak1. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Corpora quadrigeminaImported and SpleenImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Corpora quadrigeminaImported and SpleenImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Corpora quadrigeminaImported and SpleenImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Corpora quadrigeminaImported and SpleenImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Corpora quadrigeminaImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Corpora quadrigeminaImported and SpleenImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SpleenImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Corpora quadrigeminaImported and SpleenImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Corpora quadrigeminaImported and SpleenImported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  11. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8BR10_MOUSE
AccessioniPrimary (citable) accession number: Q8BR10
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.