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Q8BQZ8

- KCNS3_MOUSE

UniProt

Q8BQZ8 - KCNS3_MOUSE

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Protein
Potassium voltage-gated channel subfamily S member 3
Gene
Kcns3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity and reduces the ion flow By similarity.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 3
Alternative name(s):
Voltage-gated potassium channel subunit Kv9.3
Gene namesi
Name:Kcns3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1098804. Kcns3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 185185Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei186 – 20621Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Topological domaini207 – 21812Extracellular Reviewed prediction
Add
BLAST
Transmembranei219 – 23921Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Topological domaini240 – 25314Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei254 – 27421Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Topological domaini275 – 28713Extracellular Reviewed prediction
Add
BLAST
Transmembranei288 – 30821Helical; Name=Segment S4; Reviewed prediction
Add
BLAST
Topological domaini309 – 32315Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei324 – 34421Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Topological domaini345 – 35713Extracellular Reviewed prediction
Add
BLAST
Intramembranei358 – 37821Pore-forming; Name=Segment H5; Reviewed prediction
Add
BLAST
Topological domaini379 – 3857Extracellular Reviewed prediction
Transmembranei386 – 40621Helical; Name=Segment S6; Reviewed prediction
Add
BLAST
Topological domaini407 – 49185Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Potassium voltage-gated channel subfamily S member 3
PRO_0000320143Add
BLAST

Proteomic databases

PRIDEiQ8BQZ8.

Expressioni

Gene expression databases

ArrayExpressiQ8BQZ8.
BgeeiQ8BQZ8.
GenevestigatoriQ8BQZ8.

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8BQZ8.
SMRiQ8BQZ8. Positions 14-416.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi370 – 3756Selectivity filter By similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00740000115408.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ8BQZ8.
KOiK04933.
OMAiWDQKSND.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ8BQZ8.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BQZ8-1 [UniParc]FASTAAdd to Basket

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MVFGEFFHRP GQDEELVNLN VGGFKQSVDQ STLLRFPHTR LGKLLTCHSE    50
EAILELCDDY SVADKEYYFD RNPFLFRYVL NFYYTGKLHV MEELCVFSFC 100
QEIEYWGINE LFIDSCCSSR YQERKEESHD KDWDQKSNDV STDSSFEESS 150
LFEKELEKFD ELRFGQLRKK IWIRMENPAY CLSAKLIAIS SLSVVLASIV 200
AMCVHSMSEF QNEDGEVDDP VLEGVEIACI AWFTGELAIR LVAAPSQKKF 250
WKNPLNIIDF VSIIPFYATL AVDTKEEESE DIENMGKVVQ ILRLMRIFRI 300
LKLARHSVGL RSLGATLRHS YHEVGLLLLF LSVGISIFSV LIYSVEKDEH 350
KSSLTSIPIC WWWATISMTT VGYGDTHPVT LAGKIIASTC IICGILVVAL 400
PITIIFNKFS KYYQKQKDME VDQCSEDPPE KCHELPYFNI RDVYAQQVHA 450
FITSLSSIGI VVSDPDSTDA SSVEDNEDAY NTASLENCTG K 491
Length:491
Mass (Da):55,993
Last modified:March 1, 2003 - v1
Checksum:iB36B818126D439C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK046054 mRNA. Translation: BAC32583.1.
AK162957 mRNA. Translation: BAE37134.1.
BC132164 mRNA. Translation: AAI32165.1.
BC132464 mRNA. Translation: AAI32465.1.
CCDSiCCDS25813.1.
RefSeqiNP_001162036.1. NM_001168564.1.
NP_775593.1. NM_173417.3.
XP_006515143.1. XM_006515080.1.
UniGeneiMm.113278.

Genome annotation databases

EnsembliENSMUST00000055673; ENSMUSP00000060706; ENSMUSG00000043673.
ENSMUST00000164495; ENSMUSP00000129412; ENSMUSG00000043673.
GeneIDi238076.
KEGGimmu:238076.
UCSCiuc007nas.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK046054 mRNA. Translation: BAC32583.1 .
AK162957 mRNA. Translation: BAE37134.1 .
BC132164 mRNA. Translation: AAI32165.1 .
BC132464 mRNA. Translation: AAI32465.1 .
CCDSi CCDS25813.1.
RefSeqi NP_001162036.1. NM_001168564.1.
NP_775593.1. NM_173417.3.
XP_006515143.1. XM_006515080.1.
UniGenei Mm.113278.

3D structure databases

ProteinModelPortali Q8BQZ8.
SMRi Q8BQZ8. Positions 14-416.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8BQZ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055673 ; ENSMUSP00000060706 ; ENSMUSG00000043673 .
ENSMUST00000164495 ; ENSMUSP00000129412 ; ENSMUSG00000043673 .
GeneIDi 238076.
KEGGi mmu:238076.
UCSCi uc007nas.1. mouse.

Organism-specific databases

CTDi 3790.
MGIi MGI:1098804. Kcns3.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00740000115408.
HOGENOMi HOG000231016.
HOVERGENi HBG052230.
InParanoidi Q8BQZ8.
KOi K04933.
OMAi WDQKSND.
OrthoDBi EOG7CRTPP.
PhylomeDBi Q8BQZ8.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 383663.
PROi Q8BQZ8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BQZ8.
Bgeei Q8BQZ8.
Genevestigatori Q8BQZ8.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina and Spinal cord.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKCNS3_MOUSE
AccessioniPrimary (citable) accession number: Q8BQZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi