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Q8BQZ8 (KCNS3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily S member 3
Alternative name(s):
Voltage-gated potassium channel subunit Kv9.3
Gene names
Name:Kcns3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potassium channel subunit. Modulates channel activity and reduces the ion flow By similarity.

Subunit structure

Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.

Sequence similarities

Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Potassium voltage-gated channel subfamily S member 3
PRO_0000320143

Regions

Topological domain1 – 185185Cytoplasmic Potential
Transmembrane186 – 20621Helical; Name=Segment S1; Potential
Topological domain207 – 21812Extracellular Potential
Transmembrane219 – 23921Helical; Name=Segment S2; Potential
Topological domain240 – 25314Cytoplasmic Potential
Transmembrane254 – 27421Helical; Name=Segment S3; Potential
Topological domain275 – 28713Extracellular Potential
Transmembrane288 – 30821Helical; Name=Segment S4; Potential
Topological domain309 – 32315Cytoplasmic Potential
Transmembrane324 – 34421Helical; Name=Segment S5; Potential
Topological domain345 – 35713Extracellular Potential
Intramembrane358 – 37821Pore-forming; Name=Segment H5; Potential
Topological domain379 – 3857Extracellular Potential
Transmembrane386 – 40621Helical; Name=Segment S6; Potential
Topological domain407 – 49185Cytoplasmic Potential
Motif370 – 3756Selectivity filter By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8BQZ8 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: B36B818126D439C5

FASTA49155,993
        10         20         30         40         50         60 
MVFGEFFHRP GQDEELVNLN VGGFKQSVDQ STLLRFPHTR LGKLLTCHSE EAILELCDDY 

        70         80         90        100        110        120 
SVADKEYYFD RNPFLFRYVL NFYYTGKLHV MEELCVFSFC QEIEYWGINE LFIDSCCSSR 

       130        140        150        160        170        180 
YQERKEESHD KDWDQKSNDV STDSSFEESS LFEKELEKFD ELRFGQLRKK IWIRMENPAY 

       190        200        210        220        230        240 
CLSAKLIAIS SLSVVLASIV AMCVHSMSEF QNEDGEVDDP VLEGVEIACI AWFTGELAIR 

       250        260        270        280        290        300 
LVAAPSQKKF WKNPLNIIDF VSIIPFYATL AVDTKEEESE DIENMGKVVQ ILRLMRIFRI 

       310        320        330        340        350        360 
LKLARHSVGL RSLGATLRHS YHEVGLLLLF LSVGISIFSV LIYSVEKDEH KSSLTSIPIC 

       370        380        390        400        410        420 
WWWATISMTT VGYGDTHPVT LAGKIIASTC IICGILVVAL PITIIFNKFS KYYQKQKDME 

       430        440        450        460        470        480 
VDQCSEDPPE KCHELPYFNI RDVYAQQVHA FITSLSSIGI VVSDPDSTDA SSVEDNEDAY 

       490 
NTASLENCTG K 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Corpora quadrigemina and Spinal cord.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK046054 mRNA. Translation: BAC32583.1.
AK162957 mRNA. Translation: BAE37134.1.
BC132164 mRNA. Translation: AAI32165.1.
BC132464 mRNA. Translation: AAI32465.1.
RefSeqNP_001162036.1. NM_001168564.1.
NP_775593.1. NM_173417.3.
XP_006515143.1. XM_006515080.1.
UniGeneMm.113278.

3D structure databases

ProteinModelPortalQ8BQZ8.
SMRQ8BQZ8. Positions 14-416.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ8BQZ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000055673; ENSMUSP00000060706; ENSMUSG00000043673.
ENSMUST00000164495; ENSMUSP00000129412; ENSMUSG00000043673.
GeneID238076.
KEGGmmu:238076.
UCSCuc007nas.1. mouse.

Organism-specific databases

CTD3790.
MGIMGI:1098804. Kcns3.

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00740000115408.
HOGENOMHOG000231016.
HOVERGENHBG052230.
InParanoidQ8BQZ8.
KOK04933.
OMAWDQKSND.
OrthoDBEOG7CRTPP.
PhylomeDBQ8BQZ8.
TreeFamTF313103.

Gene expression databases

ArrayExpressQ8BQZ8.
BgeeQ8BQZ8.
GenevestigatorQ8BQZ8.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

NextBio383663.
PROQ8BQZ8.
SOURCESearch...

Entry information

Entry nameKCNS3_MOUSE
AccessionPrimary (citable) accession number: Q8BQZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot