Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8BQZ8

- KCNS3_MOUSE

UniProt

Q8BQZ8 - KCNS3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Potassium voltage-gated channel subfamily S member 3

Gene

Kcns3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity).By similarity

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 3
Alternative name(s):
Voltage-gated potassium channel subunit Kv9.3
Gene namesi
Name:Kcns3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1098804. Kcns3.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Potassium voltage-gated channel subfamily S member 3PRO_0000320143Add
BLAST

Proteomic databases

PRIDEiQ8BQZ8.

Expressioni

Gene expression databases

BgeeiQ8BQZ8.
ExpressionAtlasiQ8BQZ8. baseline and differential.
GenevestigatoriQ8BQZ8.

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8BQZ8.
SMRiQ8BQZ8. Positions 14-416.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 185185CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini207 – 21812ExtracellularSequence AnalysisAdd
BLAST
Topological domaini240 – 25314CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini275 – 28713ExtracellularSequence AnalysisAdd
BLAST
Topological domaini309 – 32315CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini345 – 35713ExtracellularSequence AnalysisAdd
BLAST
Topological domaini379 – 3857ExtracellularSequence Analysis
Topological domaini407 – 49185CytoplasmicSequence AnalysisAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei358 – 37821Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei186 – 20621Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei219 – 23921Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei254 – 27421Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei288 – 30821Helical; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei324 – 34421Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei386 – 40621Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi370 – 3756Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ8BQZ8.
KOiK04933.
OMAiWDQKSND.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ8BQZ8.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BQZ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVFGEFFHRP GQDEELVNLN VGGFKQSVDQ STLLRFPHTR LGKLLTCHSE
60 70 80 90 100
EAILELCDDY SVADKEYYFD RNPFLFRYVL NFYYTGKLHV MEELCVFSFC
110 120 130 140 150
QEIEYWGINE LFIDSCCSSR YQERKEESHD KDWDQKSNDV STDSSFEESS
160 170 180 190 200
LFEKELEKFD ELRFGQLRKK IWIRMENPAY CLSAKLIAIS SLSVVLASIV
210 220 230 240 250
AMCVHSMSEF QNEDGEVDDP VLEGVEIACI AWFTGELAIR LVAAPSQKKF
260 270 280 290 300
WKNPLNIIDF VSIIPFYATL AVDTKEEESE DIENMGKVVQ ILRLMRIFRI
310 320 330 340 350
LKLARHSVGL RSLGATLRHS YHEVGLLLLF LSVGISIFSV LIYSVEKDEH
360 370 380 390 400
KSSLTSIPIC WWWATISMTT VGYGDTHPVT LAGKIIASTC IICGILVVAL
410 420 430 440 450
PITIIFNKFS KYYQKQKDME VDQCSEDPPE KCHELPYFNI RDVYAQQVHA
460 470 480 490
FITSLSSIGI VVSDPDSTDA SSVEDNEDAY NTASLENCTG K
Length:491
Mass (Da):55,993
Last modified:March 1, 2003 - v1
Checksum:iB36B818126D439C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK046054 mRNA. Translation: BAC32583.1.
AK162957 mRNA. Translation: BAE37134.1.
BC132164 mRNA. Translation: AAI32165.1.
BC132464 mRNA. Translation: AAI32465.1.
CCDSiCCDS25813.1.
RefSeqiNP_001162036.1. NM_001168564.1.
NP_775593.1. NM_173417.3.
XP_006515143.1. XM_006515080.1.
UniGeneiMm.113278.

Genome annotation databases

EnsembliENSMUST00000055673; ENSMUSP00000060706; ENSMUSG00000043673.
ENSMUST00000164495; ENSMUSP00000129412; ENSMUSG00000043673.
GeneIDi238076.
KEGGimmu:238076.
UCSCiuc007nas.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK046054 mRNA. Translation: BAC32583.1 .
AK162957 mRNA. Translation: BAE37134.1 .
BC132164 mRNA. Translation: AAI32165.1 .
BC132464 mRNA. Translation: AAI32465.1 .
CCDSi CCDS25813.1.
RefSeqi NP_001162036.1. NM_001168564.1.
NP_775593.1. NM_173417.3.
XP_006515143.1. XM_006515080.1.
UniGenei Mm.113278.

3D structure databases

ProteinModelPortali Q8BQZ8.
SMRi Q8BQZ8. Positions 14-416.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8BQZ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055673 ; ENSMUSP00000060706 ; ENSMUSG00000043673 .
ENSMUST00000164495 ; ENSMUSP00000129412 ; ENSMUSG00000043673 .
GeneIDi 238076.
KEGGi mmu:238076.
UCSCi uc007nas.1. mouse.

Organism-specific databases

CTDi 3790.
MGIi MGI:1098804. Kcns3.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118981.
HOGENOMi HOG000231016.
HOVERGENi HBG052230.
InParanoidi Q8BQZ8.
KOi K04933.
OMAi WDQKSND.
OrthoDBi EOG7CRTPP.
PhylomeDBi Q8BQZ8.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 383663.
PROi Q8BQZ8.
SOURCEi Search...

Gene expression databases

Bgeei Q8BQZ8.
ExpressionAtlasi Q8BQZ8. baseline and differential.
Genevestigatori Q8BQZ8.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina and Spinal cord.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKCNS3_MOUSE
AccessioniPrimary (citable) accession number: Q8BQZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3