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Protein

Succinate dehydrogenase assembly factor 3, mitochondrial

Gene

Sdhaf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit Sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.By similarity

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase assembly factor 3, mitochondrialBy similarity
Short name:
SDH assembly factor 3By similarity
Short name:
SDHAF3By similarity
Gene namesi
Name:Sdhaf3By similarity
Synonyms:Acn9By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1913288. Sdhaf3.

Subcellular locationi

  • Mitochondrion matrix By similarity

GO - Cellular componenti

  • mitochondrial intermembrane space Source: HGNC
  • mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionSequence analysisAdd
BLAST
Chaini31 – 12595Succinate dehydrogenase assembly factor 3, mitochondrialPRO_0000042654Add
BLAST

Proteomic databases

MaxQBiQ8BQU3.
PaxDbiQ8BQU3.
PRIDEiQ8BQU3.

Expressioni

Gene expression databases

BgeeiQ8BQU3.
CleanExiMM_ACN9.
ExpressionAtlasiQ8BQU3. baseline and differential.
GenevisibleiQ8BQU3. MM.

Interactioni

Subunit structurei

Interacts with Sdhb within an Sdha-Sdhb subcomplex.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040935.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I LYR family. SDHAF3 subfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4100. Eukaryota.
ENOG4111Y90. LUCA.
GeneTreeiENSGT00390000010029.
HOGENOMiHOG000039506.
HOVERGENiHBG080818.
InParanoidiQ8BQU3.
OMAiEFRRHKS.
OrthoDBiEOG72NRS8.
PhylomeDBiQ8BQU3.
TreeFamiTF105635.

Family and domain databases

InterProiIPR008381. ACN9.
[Graphical view]
PANTHERiPTHR13137. PTHR13137. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BQU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGKHVSRVR ALYRRILLLH RALPPDLKAL GDQYVKDEFR RHKTVGPGEA
60 70 80 90 100
QRFLKEWETY AAVLWQQAED SRQSSTGKAC FGTSLPEEKL NDFRDEQIGQ
110 120
LQELMQEATK PNRQFSITES TKPQL
Length:125
Mass (Da):14,468
Last modified:March 1, 2003 - v1
Checksum:i46787E6C1C74E3ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028031 mRNA. Translation: BAC25710.1.
AK046436 mRNA. Translation: BAC32728.1.
CCDSiCCDS39423.1.
RefSeqiNP_001071181.1. NM_001077713.1.
UniGeneiMm.389086.
Mm.490412.

Genome annotation databases

EnsembliENSMUST00000040826; ENSMUSP00000040935; ENSMUSG00000042505.
GeneIDi71238.
KEGGimmu:71238.
UCSCiuc009axa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028031 mRNA. Translation: BAC25710.1.
AK046436 mRNA. Translation: BAC32728.1.
CCDSiCCDS39423.1.
RefSeqiNP_001071181.1. NM_001077713.1.
UniGeneiMm.389086.
Mm.490412.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040935.

Proteomic databases

MaxQBiQ8BQU3.
PaxDbiQ8BQU3.
PRIDEiQ8BQU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040826; ENSMUSP00000040935; ENSMUSG00000042505.
GeneIDi71238.
KEGGimmu:71238.
UCSCiuc009axa.1. mouse.

Organism-specific databases

CTDi57001.
MGIiMGI:1913288. Sdhaf3.

Phylogenomic databases

eggNOGiKOG4100. Eukaryota.
ENOG4111Y90. LUCA.
GeneTreeiENSGT00390000010029.
HOGENOMiHOG000039506.
HOVERGENiHBG080818.
InParanoidiQ8BQU3.
OMAiEFRRHKS.
OrthoDBiEOG72NRS8.
PhylomeDBiQ8BQU3.
TreeFamiTF105635.

Miscellaneous databases

PROiQ8BQU3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BQU3.
CleanExiMM_ACN9.
ExpressionAtlasiQ8BQU3. baseline and differential.
GenevisibleiQ8BQU3. MM.

Family and domain databases

InterProiIPR008381. ACN9.
[Graphical view]
PANTHERiPTHR13137. PTHR13137. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina.

Entry informationi

Entry nameiSDHF3_MOUSE
AccessioniPrimary (citable) accession number: Q8BQU3
Secondary accession number(s): Q8BT21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.