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Protein

Adiponectin receptor protein 2

Gene

Adipor2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.1 Publication

GO - Molecular functioni

  1. adiponectin binding Source: MGI
  2. hormone binding Source: UniProtKB
  3. identical protein binding Source: MGI
  4. protein heterodimerization activity Source: MGI
  5. receptor activity Source: MGI

GO - Biological processi

  1. adiponectin-activated signaling pathway Source: MGI
  2. fatty acid oxidation Source: UniProtKB
  3. female pregnancy Source: Ensembl
  4. heart development Source: Ensembl
  5. hormone-mediated signaling pathway Source: UniProtKB
  6. negative regulation of cell growth Source: Ensembl
  7. positive regulation of glucose import Source: Ensembl
  8. response to nutrient Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Adiponectin receptor protein 2
Gene namesi
Name:Adipor2
Synonyms:D6Ucla1e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:93830. Adipor2.

Subcellular locationi

  1. Membrane By similarity; Multi-pass membrane protein By similarity

  2. Note: Localized to the cell membrane and intracellular organelles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 147147CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei148 – 16821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini169 – 18113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei182 – 20221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini203 – 22018CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei221 – 24121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini242 – 2454ExtracellularSequence Analysis
Transmembranei246 – 26621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini267 – 27812CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei279 – 29921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini300 – 3078ExtracellularSequence Analysis
Transmembranei308 – 32821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini329 – 34214CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei343 – 36321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini364 – 38623ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386Adiponectin receptor protein 2PRO_0000218830Add
BLAST

Proteomic databases

PRIDEiQ8BQS5.

Expressioni

Tissue specificityi

Highly expressed in liver. Expressed at intermediate level in heart, kidney, lung and skeletal muscle. Weakly expressed in brain, spleen and testis.1 Publication

Gene expression databases

BgeeiQ8BQS5.
CleanExiMM_ADIPOR2.
ExpressionAtlasiQ8BQS5. baseline and differential.
GenevestigatoriQ8BQS5.

Interactioni

Subunit structurei

May form homomultimer and heteromultimers.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00530000062926.
HOGENOMiHOG000197115.
HOVERGENiHBG013916.
InParanoidiQ8BQS5.
KOiK07297.
OMAiISEEHEC.
OrthoDBiEOG7BS49P.
PhylomeDBiQ8BQS5.
TreeFamiTF313640.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BQS5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNEPAKHRLG CTRTPEPDIR LRKGHQLDDT RGSNNDNYQG DLEPSLETPV
60 70 80 90 100
CSSYYENSPE EPECHDDNSQ EDEGFMGMSP LLQAHHAMER MEEFVCKVWE
110 120 130 140 150
GRWRVIPHDV LPDWLKDNDF LLHGHRPPMP SFRACFKSIF RIHTETGNIW
160 170 180 190 200
THLLGCVFFL CLGIFYMFRP NISFVAPLQE KVVFGLFFLG AILCLSFSWL
210 220 230 240 250
FHTVYCHSEG VSRLFSKLDY SGIALLIMGS FVPWLYYSFY CNPQPCFIYL
260 270 280 290 300
IVICVLGIAA IIVSQWDMFA TPQYRGVRAG VFVGLGLSGI IPTLHYVISE
310 320 330 340 350
GFLKAATIGQ IGWLMLMASL YITGAALYAA RIPERFFPGK CDIWFHSHQL
360 370 380
FHIFVVAGAF VHFHGVSNLQ EFRFMIGGGC TEEDAL
Length:386
Mass (Da):43,981
Last modified:November 14, 2003 - v2
Checksum:i7760178D3A52E9CA
GO
Isoform 2 (identifier: Q8BQS5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-283: VFV → ECM
     284-386: Missing.

Show »
Length:283
Mass (Da):32,688
Checksum:iBBDF76E059857B06
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921E → G in BAC32799 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei281 – 2833VFV → ECM in isoform 2. 1 PublicationVSP_008887
Alternative sequencei284 – 386103Missing in isoform 2. 1 PublicationVSP_008888Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039667 mRNA. Translation: BAC30412.1.
AK046591 mRNA. Translation: BAC32799.1.
BC024094 mRNA. Translation: AAH24094.2.
BC064109 mRNA. Translation: AAH64109.1.
CCDSiCCDS20473.1. [Q8BQS5-1]
RefSeqiNP_932102.2. NM_197985.3. [Q8BQS5-1]
XP_006506601.1. XM_006506538.2. [Q8BQS5-1]
UniGeneiMm.291826.

Genome annotation databases

EnsembliENSMUST00000032272; ENSMUSP00000032272; ENSMUSG00000030168. [Q8BQS5-1]
ENSMUST00000169744; ENSMUSP00000126138; ENSMUSG00000030168. [Q8BQS5-1]
GeneIDi68465.
KEGGimmu:68465.
UCSCiuc009dmd.1. mouse. [Q8BQS5-1]
uc009dmf.1. mouse. [Q8BQS5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039667 mRNA. Translation: BAC30412.1.
AK046591 mRNA. Translation: BAC32799.1.
BC024094 mRNA. Translation: AAH24094.2.
BC064109 mRNA. Translation: AAH64109.1.
CCDSiCCDS20473.1. [Q8BQS5-1]
RefSeqiNP_932102.2. NM_197985.3. [Q8BQS5-1]
XP_006506601.1. XM_006506538.2. [Q8BQS5-1]
UniGeneiMm.291826.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi650.

Proteomic databases

PRIDEiQ8BQS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032272; ENSMUSP00000032272; ENSMUSG00000030168. [Q8BQS5-1]
ENSMUST00000169744; ENSMUSP00000126138; ENSMUSG00000030168. [Q8BQS5-1]
GeneIDi68465.
KEGGimmu:68465.
UCSCiuc009dmd.1. mouse. [Q8BQS5-1]
uc009dmf.1. mouse. [Q8BQS5-2]

Organism-specific databases

CTDi79602.
MGIiMGI:93830. Adipor2.

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00530000062926.
HOGENOMiHOG000197115.
HOVERGENiHBG013916.
InParanoidiQ8BQS5.
KOiK07297.
OMAiISEEHEC.
OrthoDBiEOG7BS49P.
PhylomeDBiQ8BQS5.
TreeFamiTF313640.

Miscellaneous databases

ChiTaRSiAdipor2. mouse.
NextBioi327220.
PROiQ8BQS5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BQS5.
CleanExiMM_ADIPOR2.
ExpressionAtlasiQ8BQS5. baseline and differential.
GenevestigatoriQ8BQS5.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Adipose tissue and Spinal cord.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Liver and Mammary gland.
  3. Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiADR2_MOUSE
AccessioniPrimary (citable) accession number: Q8BQS5
Secondary accession number(s): Q8CA45, Q8CID6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 14, 2003
Last modified: April 1, 2015
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.