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Q8BQS5 (ADR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adiponectin receptor protein 2
Gene names
Name:Adipor2
Synonyms:D6Ucla1e
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin. Ref.3

Subunit structure

May form homomultimer and heteromultimers By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity. Note: Localized to the cell membrane and intracellular organelles By similarity.

Tissue specificity

Highly expressed in liver. Expressed at intermediate level in heart, kidney, lung and skeletal muscle. Weakly expressed in brain, spleen and testis. Ref.3

Sequence similarities

Belongs to the ADIPOR family.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Molecular functionReceptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadiponectin-activated signaling pathway

Inferred from direct assay Ref.3. Source: MGI

fatty acid oxidation

Inferred from sequence or structural similarity Ref.3. Source: UniProtKB

female pregnancy

Inferred from electronic annotation. Source: Ensembl

heart development

Inferred from electronic annotation. Source: Ensembl

hormone-mediated signaling pathway

Inferred from sequence or structural similarity Ref.3. Source: UniProtKB

negative regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of glucose import

Inferred from electronic annotation. Source: Ensembl

response to nutrient

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from direct assay Ref.3. Source: MGI

   Molecular_functionadiponectin binding

Inferred from physical interaction Ref.3. Source: MGI

hormone binding

Inferred from sequence or structural similarity Ref.3. Source: UniProtKB

identical protein binding

Inferred from direct assay Ref.3. Source: MGI

protein heterodimerization activity

Inferred from physical interaction Ref.3. Source: MGI

receptor activity

Inferred from direct assay Ref.3. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BQS5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BQS5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     281-283: VFV → ECM
     284-386: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 386386Adiponectin receptor protein 2
PRO_0000218830

Regions

Topological domain1 – 147147Cytoplasmic Potential
Transmembrane148 – 16821Helical; Name=1; Potential
Topological domain169 – 18113Extracellular Potential
Transmembrane182 – 20221Helical; Name=2; Potential
Topological domain203 – 22018Cytoplasmic Potential
Transmembrane221 – 24121Helical; Name=3; Potential
Topological domain242 – 2454Extracellular Potential
Transmembrane246 – 26621Helical; Name=4; Potential
Topological domain267 – 27812Cytoplasmic Potential
Transmembrane279 – 29921Helical; Name=5; Potential
Topological domain300 – 3078Extracellular Potential
Transmembrane308 – 32821Helical; Name=6; Potential
Topological domain329 – 34214Cytoplasmic Potential
Transmembrane343 – 36321Helical; Name=7; Potential
Topological domain364 – 38623Extracellular Potential

Natural variations

Alternative sequence281 – 2833VFV → ECM in isoform 2.
VSP_008887
Alternative sequence284 – 386103Missing in isoform 2.
VSP_008888

Experimental info

Sequence conflict921E → G in BAC32799. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 14, 2003. Version 2.
Checksum: 7760178D3A52E9CA

FASTA38643,981
        10         20         30         40         50         60 
MNEPAKHRLG CTRTPEPDIR LRKGHQLDDT RGSNNDNYQG DLEPSLETPV CSSYYENSPE 

        70         80         90        100        110        120 
EPECHDDNSQ EDEGFMGMSP LLQAHHAMER MEEFVCKVWE GRWRVIPHDV LPDWLKDNDF 

       130        140        150        160        170        180 
LLHGHRPPMP SFRACFKSIF RIHTETGNIW THLLGCVFFL CLGIFYMFRP NISFVAPLQE 

       190        200        210        220        230        240 
KVVFGLFFLG AILCLSFSWL FHTVYCHSEG VSRLFSKLDY SGIALLIMGS FVPWLYYSFY 

       250        260        270        280        290        300 
CNPQPCFIYL IVICVLGIAA IIVSQWDMFA TPQYRGVRAG VFVGLGLSGI IPTLHYVISE 

       310        320        330        340        350        360 
GFLKAATIGQ IGWLMLMASL YITGAALYAA RIPERFFPGK CDIWFHSHQL FHIFVVAGAF 

       370        380 
VHFHGVSNLQ EFRFMIGGGC TEEDAL 

« Hide

Isoform 2 [UniParc].

Checksum: BBDF76E059857B06
Show »

FASTA28332,688

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Adipose tissue and Spinal cord.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N.
Tissue: Liver and Mammary gland.
[3]"Cloning of adiponectin receptors that mediate antidiabetic metabolic effects."
Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., Sugiyama T., Miyagishi M., Hara K., Tsunoda M., Murakami K., Ohteki T., Uchida S., Takekawa S., Waki H., Tsuno N.H., Shibata Y., Terauchi Y. expand/collapse author list , Froguel P., Tobe K., Koyasu S., Taira K., Kitamura T., Shimizu T., Nagai R., Kadowaki T.
Nature 423:762-769(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK039667 mRNA. Translation: BAC30412.1.
AK046591 mRNA. Translation: BAC32799.1.
BC024094 mRNA. Translation: AAH24094.2.
BC064109 mRNA. Translation: AAH64109.1.
RefSeqNP_932102.2. NM_197985.3.
XP_006506601.1. XM_006506538.1.
UniGeneMm.291826.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY650.

Proteomic databases

PRIDEQ8BQS5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032272; ENSMUSP00000032272; ENSMUSG00000030168. [Q8BQS5-1]
ENSMUST00000169744; ENSMUSP00000126138; ENSMUSG00000030168. [Q8BQS5-1]
GeneID68465.
KEGGmmu:68465.
UCSCuc009dmd.1. mouse. [Q8BQS5-1]
uc009dmf.1. mouse. [Q8BQS5-2]

Organism-specific databases

CTD79602.
MGIMGI:93830. Adipor2.

Phylogenomic databases

eggNOGCOG1272.
GeneTreeENSGT00530000062926.
HOGENOMHOG000197115.
HOVERGENHBG013916.
InParanoidQ8BQS5.
KOK07297.
OMAYMFRPNM.
OrthoDBEOG7BS49P.
PhylomeDBQ8BQS5.
TreeFamTF313640.

Gene expression databases

ArrayExpressQ8BQS5.
BgeeQ8BQS5.
CleanExMM_ADIPOR2.
GenevestigatorQ8BQS5.

Family and domain databases

InterProIPR004254. HlyIII-related.
[Graphical view]
PANTHERPTHR20855. PTHR20855. 1 hit.
PfamPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSADIPOR2. mouse.
NextBio327220.
PROQ8BQS5.
SOURCESearch...

Entry information

Entry nameADR2_MOUSE
AccessionPrimary (citable) accession number: Q8BQS5
Secondary accession number(s): Q8CA45, Q8CID6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 14, 2003
Last modified: April 16, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot