Q8BQS5 (ADR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adiponectin receptor protein 2

Gene names

Name:	Adipor2
Synonyms:	D6Ucla1e

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin. Ref.3
Subunit structure	May form homomultimer and heteromultimers By similarity.
Subcellular location	Membrane; Multi-pass membrane protein By similarity. Note: Localized to the cell membrane and intracellular organelles By similarity.
Tissue specificity	Highly expressed in liver. Expressed at intermediate level in heart, kidney, lung and skeletal muscle. Weakly expressed in brain, spleen and testis. Ref.3
Sequence similarities	Belongs to the ADIPOR family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fatty acid oxidation Inferred from sequence or structural similarity Ref.3. Source: UniProtKB hormone-mediated signaling pathway Inferred from sequence or structural similarity Ref.3. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	hormone binding Inferred from sequence or structural similarity Ref.3. Source: UniProtKB identical protein binding Inferred from direct assay Ref.3. Source: MGI receptor activity Inferred from direct assay Ref.3. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8BQS5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8BQS5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     281-283: VFV → ECM
     284-386: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 386	386	Adiponectin receptor protein 2		PRO_0000218830
Regions
	Topological domain	1 – 147	147	Cytoplasmic Potential
	Transmembrane	148 – 168	21	Helical; Name=1; Potential
	Topological domain	169 – 181	13	Extracellular Potential
	Transmembrane	182 – 202	21	Helical; Name=2; Potential
	Topological domain	203 – 220	18	Cytoplasmic Potential
	Transmembrane	221 – 241	21	Helical; Name=3; Potential
	Topological domain	242 – 245	4	Extracellular Potential
	Transmembrane	246 – 266	21	Helical; Name=4; Potential
	Topological domain	267 – 278	12	Cytoplasmic Potential
	Transmembrane	279 – 299	21	Helical; Name=5; Potential
	Topological domain	300 – 307	8	Extracellular Potential
	Transmembrane	308 – 328	21	Helical; Name=6; Potential
	Topological domain	329 – 342	14	Cytoplasmic Potential
	Transmembrane	343 – 363	21	Helical; Name=7; Potential
	Topological domain	364 – 386	23	Extracellular Potential
Natural variations
	Alternative sequence	281 – 283	3	VFV → ECM in isoform 2.		VSP_008887
	Alternative sequence	284 – 386	103	Missing in isoform 2.		VSP_008888
Experimental info
	Sequence conflict	92	1	E → G in BAC32799. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 14, 2003. Version 2. Checksum: 7760178D3A52E9CA	FASTA	386	43,981
	10 20 30 40 50 60 MNEPAKHRLG CTRTPEPDIR LRKGHQLDDT RGSNNDNYQG DLEPSLETPV CSSYYENSPE 70 80 90 100 110 120 EPECHDDNSQ EDEGFMGMSP LLQAHHAMER MEEFVCKVWE GRWRVIPHDV LPDWLKDNDF 130 140 150 160 170 180 LLHGHRPPMP SFRACFKSIF RIHTETGNIW THLLGCVFFL CLGIFYMFRP NISFVAPLQE 190 200 210 220 230 240 KVVFGLFFLG AILCLSFSWL FHTVYCHSEG VSRLFSKLDY SGIALLIMGS FVPWLYYSFY 250 260 270 280 290 300 CNPQPCFIYL IVICVLGIAA IIVSQWDMFA TPQYRGVRAG VFVGLGLSGI IPTLHYVISE 310 320 330 340 350 360 GFLKAATIGQ IGWLMLMASL YITGAALYAA RIPERFFPGK CDIWFHSHQL FHIFVVAGAF 370 380 VHFHGVSNLQ EFRFMIGGGC TEEDAL
	Isoform 2 [UniParc]. Checksum: BBDF76E059857B06	FASTA	283	32,688
	10 20 30 40 50 60 MNEPAKHRLG CTRTPEPDIR LRKGHQLDDT RGSNNDNYQG DLEPSLETPV CSSYYENSPE 70 80 90 100 110 120 EPECHDDNSQ EDEGFMGMSP LLQAHHAMER MEEFVCKVWE GRWRVIPHDV LPDWLKDNDF 130 140 150 160 170 180 LLHGHRPPMP SFRACFKSIF RIHTETGNIW THLLGCVFFL CLGIFYMFRP NISFVAPLQE 190 200 210 220 230 240 KVVFGLFFLG AILCLSFSWL FHTVYCHSEG VSRLFSKLDY SGIALLIMGS FVPWLYYSFY 250 260 270 280 CNPQPCFIYL IVICVLGIAA IIVSQWDMFA TPQYRGVRAG ECM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J. Tissue: Adipose tissue and Spinal cord.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: FVB/N. Tissue: Liver and Mammary gland.
[3]	"Cloning of adiponectin receptors that mediate antidiabetic metabolic effects." Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., Sugiyama T., Miyagishi M., Hara K., Tsunoda M., Murakami K., Ohteki T., Uchida S., Takekawa S., Waki H., Tsuno N.H., Shibata Y., Terauchi Y. , Froguel P., Tobe K., Koyasu S., Taira K., Kitamura T., Shimizu T., Nagai R., Kadowaki T. Nature 423:762-769(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK039667 mRNA. Translation: BAC30412.1. AK046591 mRNA. Translation: BAC32799.1. BC024094 mRNA. Translation: AAH24094.2. BC064109 mRNA. Translation: AAH64109.1.
IPI	IPI00132304. IPI00395202.
RefSeq	NP_932102.2. NM_197985.3.
UniGene	Mm.291826.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q8BQS5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000032272; ENSMUSP00000032272; ENSMUSG00000030168. ENSMUST00000169744; ENSMUSP00000126138; ENSMUSG00000030168.
GeneID	68465.
KEGG	mmu:68465.
UCSC	uc009dmd.1. mouse. uc009dmf.1. mouse.
Organism-specific databases
CTD	79602.
MGI	MGI:93830. Adipor2.
Phylogenomic databases
eggNOG	COG1272.
GeneTree	ENSGT00530000062926.
HOGENOM	HOG000197115.
HOVERGEN	HBG013916.
InParanoid	Q8BQS5.
KO	K07297.
OMA	YMFRPNM.
OrthoDB	EOG408N8G.
Gene expression databases
ArrayExpress	Q8BQS5.
Bgee	Q8BQS5.
CleanEx	MM_ADIPOR2.
Genevestigator	Q8BQS5.
GermOnline	ENSMUSG00000030168. Mus musculus.
Family and domain databases
InterPro	IPR004254. HlyIII-related. [Graphical view]
PANTHER	PTHR20855. PTHR20855. 1 hit.
Pfam	PF03006. HlyIII. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ADIPOR2. mouse.
NextBio	327220.
SOURCE	Search...

Entry information

Entry name

ADR2_MOUSE

Accession

Primary (citable) accession number: Q8BQS5
Secondary accession number(s): Q8CA45, Q8CID6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	November 14, 2003
Last modified:	May 29, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program