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Protein

Adiponectin receptor protein 2

Gene

Adipor2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:17327425, PubMed:17068142, PubMed:17268472, PubMed:24742672). Required for normal body fat and glucose homeostasis (PubMed:17327425, PubMed:17068142, PubMed:17268472, PubMed:24742672). ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake (PubMed:12802337, PubMed:17268472, PubMed:24742672). Has intermediate affinity for globular and full-length adiponectin (PubMed:12802337). Required for normal revascularization after chronic ischemia caused by severing of blood vessels (PubMed:24742672).5 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi202 – 2021ZincBy similarity
Metal bindingi348 – 3481ZincBy similarity
Metal bindingi352 – 3521ZincBy similarity

GO - Molecular functioni

  • adipokinetic hormone receptor activity Source: UniProtKB
  • adiponectin binding Source: MGI
  • identical protein binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: MGI
  • receptor activity Source: MGI

GO - Biological processi

  • adiponectin-activated signaling pathway Source: UniProtKB
  • fatty acid oxidation Source: UniProtKB
  • female pregnancy Source: Ensembl
  • glucose homeostasis Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: GOC
  • heart development Source: Ensembl
  • hormone-mediated signaling pathway Source: UniProtKB
  • negative regulation of cell growth Source: Ensembl
  • positive regulation of glucose import Source: Ensembl
  • response to nutrient Source: Ensembl
  • vascular wound healing Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Adiponectin receptor protein 2
Gene namesi
Name:Adipor2
Synonyms:D6Ucla1e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:93830. Adipor2.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

  • Note: Localized to the cell membrane and intracellular organelles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 147147CytoplasmicBy similarityAdd
BLAST
Transmembranei148 – 16821Helical; Name=1By similarityAdd
BLAST
Topological domaini169 – 18113ExtracellularBy similarityAdd
BLAST
Transmembranei182 – 20221Helical; Name=2By similarityAdd
BLAST
Topological domaini203 – 21311CytoplasmicBy similarityAdd
BLAST
Transmembranei214 – 23421Helical; Name=3By similarityAdd
BLAST
Topological domaini235 – 24511ExtracellularBy similarityAdd
BLAST
Transmembranei246 – 26621Helical; Name=4By similarityAdd
BLAST
Topological domaini267 – 2737CytoplasmicBy similarity
Transmembranei274 – 29421Helical; Name=5By similarityAdd
BLAST
Topological domaini295 – 30915ExtracellularBy similarityAdd
BLAST
Transmembranei310 – 33021Helical; Name=6By similarityAdd
BLAST
Topological domaini331 – 34818CytoplasmicBy similarityAdd
BLAST
Transmembranei349 – 36921Helical; Name=7By similarityAdd
BLAST
Topological domaini370 – 38617ExtracellularBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant mice are viable and fertile, and display increased glucose tolerance (PubMed:17327425, PubMed:17068142, PubMed:17268472, PubMed:24742672). On a high fat diet, they have lower fasting insulin levels than wild-type (PubMed:17327425, PubMed:24742672). Mutant mice have lower plasma cholesterol levels on a high fat diet, and possibly also on normal chow (PubMed:17327425, PubMed:17068142). The precise phenotype may depend on the experimental details and on genotype. Male and female mutant mice are somewhat leaner than wild-type on standard chow and do not display increased weight gain on a high fat diet (PubMed:17327425, PubMed:24742672). Mutant mice have normal body weight on standard chow, but decreased weight gain on a high-fat diet (PubMed:17068142). Female mutant mice display lower total body fat than wild-type on a high fat diet (PubMed:17327425). Both male and femal mice have reduced levels of white and brown adipose tissue relative to wild-type (PubMed:17327425). Mutant male mice display decreased testis weight, atrophy of the seminiferous tubules and aspermia (PubMed:17327425). Both male and female mice diplay incrased brain weight relative to wild-type (PubMed:17327425). Mutant mice have increased locomotor activity and increased energy expenditure on a high fat diet (PubMed:17327425). Mutant mice display impaired revascularization, limb retraction, atrophy and necrosis in response to limb ischemia caused by severing the femoral artery (PubMed:24742672). Hepatocytes from mice lacking both Adipor1 and Adipor2 show loss of adiponectin binding and lack of adiponectin-mediated activation of AMPK and Ppara (PubMed:17268472). Mice lacking both Adipor1 and Adipor2 display elevated glucose and insulin levels in blood plasma, indicative of glucose intolerance and insulin resistance (PubMed:17268472).4 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386Adiponectin receptor protein 2PRO_0000218830Add
BLAST

Proteomic databases

PRIDEiQ8BQS5.

Expressioni

Tissue specificityi

Detected in liver and quadriceps muscle (at protein level) (PubMed:17327425). Highly expressed in liver (PubMed:12802337). Highly expressed in white adipose tissue, and at intermediate levels in brown adipose tissue (PubMed:24742672). Expressed at intermediate level in heart, kidney, lung and skeletal muscle. Weakly expressed in brain, spleen and testis.3 Publications

Gene expression databases

BgeeiQ8BQS5.
CleanExiMM_ADIPOR2.
ExpressionAtlasiQ8BQS5. baseline and differential.
GenevisibleiQ8BQS5. MM.

Interactioni

Subunit structurei

May form homooligomers and heterooligomers with ADIPOR1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032272.

Family & Domainsi

Domaini

The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.By similarity

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00530000062926.
HOGENOMiHOG000197115.
HOVERGENiHBG013916.
InParanoidiQ8BQS5.
KOiK07297.
OMAiISEEHEC.
OrthoDBiEOG7BS49P.
PhylomeDBiQ8BQS5.
TreeFamiTF313640.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BQS5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNEPAKHRLG CTRTPEPDIR LRKGHQLDDT RGSNNDNYQG DLEPSLETPV
60 70 80 90 100
CSSYYENSPE EPECHDDNSQ EDEGFMGMSP LLQAHHAMER MEEFVCKVWE
110 120 130 140 150
GRWRVIPHDV LPDWLKDNDF LLHGHRPPMP SFRACFKSIF RIHTETGNIW
160 170 180 190 200
THLLGCVFFL CLGIFYMFRP NISFVAPLQE KVVFGLFFLG AILCLSFSWL
210 220 230 240 250
FHTVYCHSEG VSRLFSKLDY SGIALLIMGS FVPWLYYSFY CNPQPCFIYL
260 270 280 290 300
IVICVLGIAA IIVSQWDMFA TPQYRGVRAG VFVGLGLSGI IPTLHYVISE
310 320 330 340 350
GFLKAATIGQ IGWLMLMASL YITGAALYAA RIPERFFPGK CDIWFHSHQL
360 370 380
FHIFVVAGAF VHFHGVSNLQ EFRFMIGGGC TEEDAL
Length:386
Mass (Da):43,981
Last modified:November 14, 2003 - v2
Checksum:i7760178D3A52E9CA
GO
Isoform 2 (identifier: Q8BQS5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-283: VFV → ECM
     284-386: Missing.

Show »
Length:283
Mass (Da):32,688
Checksum:iBBDF76E059857B06
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921E → G in BAC32799 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei281 – 2833VFV → ECM in isoform 2. 1 PublicationVSP_008887
Alternative sequencei284 – 386103Missing in isoform 2. 1 PublicationVSP_008888Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039667 mRNA. Translation: BAC30412.1.
AK046591 mRNA. Translation: BAC32799.1.
BC024094 mRNA. Translation: AAH24094.2.
BC064109 mRNA. Translation: AAH64109.1.
CCDSiCCDS20473.1. [Q8BQS5-1]
RefSeqiNP_932102.2. NM_197985.3. [Q8BQS5-1]
XP_006506601.1. XM_006506538.2. [Q8BQS5-1]
XP_011239750.1. XM_011241448.1. [Q8BQS5-1]
UniGeneiMm.291826.

Genome annotation databases

EnsembliENSMUST00000032272; ENSMUSP00000032272; ENSMUSG00000030168. [Q8BQS5-1]
ENSMUST00000169744; ENSMUSP00000126138; ENSMUSG00000030168. [Q8BQS5-1]
GeneIDi68465.
KEGGimmu:68465.
UCSCiuc009dmd.1. mouse. [Q8BQS5-1]
uc009dmf.1. mouse. [Q8BQS5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039667 mRNA. Translation: BAC30412.1.
AK046591 mRNA. Translation: BAC32799.1.
BC024094 mRNA. Translation: AAH24094.2.
BC064109 mRNA. Translation: AAH64109.1.
CCDSiCCDS20473.1. [Q8BQS5-1]
RefSeqiNP_932102.2. NM_197985.3. [Q8BQS5-1]
XP_006506601.1. XM_006506538.2. [Q8BQS5-1]
XP_011239750.1. XM_011241448.1. [Q8BQS5-1]
UniGeneiMm.291826.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032272.

Chemistry

GuidetoPHARMACOLOGYi650.

Proteomic databases

PRIDEiQ8BQS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032272; ENSMUSP00000032272; ENSMUSG00000030168. [Q8BQS5-1]
ENSMUST00000169744; ENSMUSP00000126138; ENSMUSG00000030168. [Q8BQS5-1]
GeneIDi68465.
KEGGimmu:68465.
UCSCiuc009dmd.1. mouse. [Q8BQS5-1]
uc009dmf.1. mouse. [Q8BQS5-2]

Organism-specific databases

CTDi79602.
MGIiMGI:93830. Adipor2.

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00530000062926.
HOGENOMiHOG000197115.
HOVERGENiHBG013916.
InParanoidiQ8BQS5.
KOiK07297.
OMAiISEEHEC.
OrthoDBiEOG7BS49P.
PhylomeDBiQ8BQS5.
TreeFamiTF313640.

Miscellaneous databases

ChiTaRSiAdipor2. mouse.
NextBioi327220.
PROiQ8BQS5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BQS5.
CleanExiMM_ADIPOR2.
ExpressionAtlasiQ8BQS5. baseline and differential.
GenevisibleiQ8BQS5. MM.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Adipose tissue and Spinal cord.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Liver and Mammary gland.
  3. Cited for: FUNCTION, TISSUE SPECIFICITY.
  4. Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.
  5. "Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes."
    Liu Y., Michael M.D., Kash S., Bensch W.R., Monia B.P., Murray S.F., Otto K.A., Syed S.K., Bhanot S., Sloop K.W., Sullivan J.M., Reifel-Miller A.
    Endocrinology 148:683-692(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.
  6. Cited for: DISRUPTION PHENOTYPE, FUNCTION.
  7. "Divergent roles for adiponectin receptor 1 (AdipoR1) and AdipoR2 in mediating revascularization and metabolic dysfunction in vivo."
    Parker-Duffen J.L., Nakamura K., Silver M., Zuriaga M.A., MacLauchlan S., Aprahamian T.R., Walsh K.
    J. Biol. Chem. 289:16200-16213(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiADR2_MOUSE
AccessioniPrimary (citable) accession number: Q8BQS5
Secondary accession number(s): Q8CA45, Q8CID6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 14, 2003
Last modified: July 22, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.