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Protein

Probable palmitoyltransferase ZDHHC14

Gene

Zdhhc14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei195S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC14 (EC:2.3.1.225)
Alternative name(s):
NEW1 domain-containing protein
Short name:
NEW1CP
Zinc finger DHHC domain-containing protein 14
Short name:
DHHC-14
Gene namesi
Name:Zdhhc14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2653229. Zdhhc14.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128921 – 489Probable palmitoyltransferase ZDHHC14Add BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei456PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ8BQQ1.
PeptideAtlasiQ8BQQ1.
PRIDEiQ8BQQ1.

PTM databases

iPTMnetiQ8BQQ1.
PhosphoSitePlusiQ8BQQ1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034265.
CleanExiMM_ZDHHC14.
GenevisibleiQ8BQQ1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086589.

Structurei

3D structure databases

ProteinModelPortaliQ8BQQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 215DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000242943.
HOVERGENiHBG056239.
InParanoidiQ8BQQ1.
KOiK16675.
OMAiHVGHQFL.
OrthoDBiEOG091G0BOW.
PhylomeDBiQ8BQQ1.
TreeFamiTF312923.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BQQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPGGGGPMK DCEYSQISTH SSSPMESPHK KKKIAARRKW EVFPGRNKFF
60 70 80 90 100
CNGRIMMARQ TGVFYLTLIL ILVTSGLFFA FDCRYLAEKI TPAIPVVGGI
110 120 130 140 150
LFFFVMGTLL RTSFSDPGVL PRATPDEAAD LERQIDIANG TSSGGYRPPP
160 170 180 190 200
RTKEVVINGQ TVKLKYCFTC KIFRPPRASH CSLCDNCVEQ FDHHCPWVGN
210 220 230 240 250
CVGKRNYRFF YMFILSLSFL TVFIFAFVIT HVIHRSQQKG FLDALKDSPA
260 270 280 290 300
SVLEAVICFF SVWSIIGLSG FHTYLISSNQ TTNEDIKGSW SNKRGKENYN
310 320 330 340 350
PYSYGNIFTN CCVALCGPIS PSLIDRRGYV QPDTPQPAAP SNGITMYGAT
360 370 380 390 400
QSQSDMCDQD QCIQSTKFVL QAAATPLLQS EPSLTSEELH MPGKPGLGTP
410 420 430 440 450
CASLTLGQPT PPSSMPNLAT EATLSDIMPL KDEHGGHQFL TPDEAPSPPR
460 470 480
MLGAGSPLAH SRTMHMLGLA SQDSLHEDSV RGLVKLSSV
Length:489
Mass (Da):53,659
Last modified:March 1, 2003 - v1
Checksum:iEFF96E948FA45A03
GO
Isoform 2 (identifier: Q8BQQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.

Show »
Length:384
Mass (Da):41,897
Checksum:iF0A4E27B8C026B31
GO

Sequence cautioni

The sequence BAC38040 differs from that shown. Reason: Frameshift at position 7.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti274Y → C in AAN47141 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0162721 – 105Missing in isoform 2. 1 PublicationAdd BLAST105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542387 mRNA. Translation: AAN47141.1.
AK046719 mRNA. Translation: BAC32845.1.
AK080845 mRNA. Translation: BAC38040.1. Frameshift.
BC059814 mRNA. Translation: AAH59814.1.
CCDSiCCDS37422.1. [Q8BQQ1-1]
RefSeqiNP_666185.3. NM_146073.3. [Q8BQQ1-1]
UniGeneiMm.487663.
Mm.491143.

Genome annotation databases

EnsembliENSMUST00000089185; ENSMUSP00000086589; ENSMUSG00000034265. [Q8BQQ1-1]
GeneIDi224454.
KEGGimmu:224454.
UCSCiuc008aff.1. mouse. [Q8BQQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542387 mRNA. Translation: AAN47141.1.
AK046719 mRNA. Translation: BAC32845.1.
AK080845 mRNA. Translation: BAC38040.1. Frameshift.
BC059814 mRNA. Translation: AAH59814.1.
CCDSiCCDS37422.1. [Q8BQQ1-1]
RefSeqiNP_666185.3. NM_146073.3. [Q8BQQ1-1]
UniGeneiMm.487663.
Mm.491143.

3D structure databases

ProteinModelPortaliQ8BQQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086589.

PTM databases

iPTMnetiQ8BQQ1.
PhosphoSitePlusiQ8BQQ1.

Proteomic databases

PaxDbiQ8BQQ1.
PeptideAtlasiQ8BQQ1.
PRIDEiQ8BQQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089185; ENSMUSP00000086589; ENSMUSG00000034265. [Q8BQQ1-1]
GeneIDi224454.
KEGGimmu:224454.
UCSCiuc008aff.1. mouse. [Q8BQQ1-1]

Organism-specific databases

CTDi79683.
MGIiMGI:2653229. Zdhhc14.

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000242943.
HOVERGENiHBG056239.
InParanoidiQ8BQQ1.
KOiK16675.
OMAiHVGHQFL.
OrthoDBiEOG091G0BOW.
PhylomeDBiQ8BQQ1.
TreeFamiTF312923.

Miscellaneous databases

PROiQ8BQQ1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034265.
CleanExiMM_ZDHHC14.
GenevisibleiQ8BQQ1. MM.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDH14_MOUSE
AccessioniPrimary (citable) accession number: Q8BQQ1
Secondary accession number(s): Q8BNR2, Q8CFN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.