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Protein

Regulator of G-protein signaling 7-binding protein

Gene

Rgs7bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation.4 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 7-binding protein
Alternative name(s):
R7 family-binding protein
Gene namesi
Name:Rgs7bp
Synonyms:D13Bwg1146e, R7bp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:106334. Rgs7bp.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi242 – 247Missing : Abolishes nuclear localization and palmitoylation. 1 Publication6
Mutagenesisi243R → E: Abolishes nuclear localization; when associated with E-246. 1 Publication1
Mutagenesisi246R → E: Abolishes nuclear localization; when associated with E-243. 1 Publication1
Mutagenesisi252 – 253CC → AA: Abolishes palmitoylation. 1 Publication2
Mutagenesisi252C → S: Strongly reduces palmitoylation and its ability to regulate GPCR signaling. Abolishes palmitoylation ant its ability to regulate GPCR signaling; when associated with S-253. 1 Publication1
Mutagenesisi253C → S: Strongly reduces palmitoylation and its ability to regulate GPCR signaling. Abolishes palmitoylation ant its ability to regulate GPCR signaling; when associated with S-252. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002875961 – 257Regulator of G-protein signaling 7-binding proteinAdd BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi252S-palmitoyl cysteine2 Publications1
Lipidationi253S-palmitoyl cysteine2 Publications1

Post-translational modificationi

Palmitoylation regulates the cell membrane and nuclear shuttling and the regulation of GPCR signaling. Upon depalmitoylation, it is targeted into the nucleus.2 Publications

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ8BQP9.
PeptideAtlasiQ8BQP9.
PRIDEiQ8BQP9.

PTM databases

iPTMnetiQ8BQP9.
PhosphoSitePlusiQ8BQP9.
SwissPalmiQ8BQP9.

Expressioni

Tissue specificityi

Specifically expressed in the central nervous system including the retina but not in other non-neuronal tissues (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000021719.
GenevisibleiQ8BQP9. MM.

Interactioni

Subunit structurei

Interacts with 'R7' family proteins RGS6, RGS7, RGS9 and RGS11. Component of some R7-Gbeta5 complex composed of some R7 protein (RGS6, RGS7, RGS9 or RGS11), Gbeta5 (GNB5) and RGS7BP.2 Publications

Protein-protein interaction databases

BioGridi206866. 5 interactors.
STRINGi10090.ENSMUSP00000066614.

Structurei

3D structure databases

ProteinModelPortaliQ8BQP9.
SMRiQ8BQP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi242 – 247Nuclear localization signal2 Publications6

Domaini

The nuclear localization signal is both required for nuclear localization and palmitoylation.1 Publication

Sequence similaritiesi

Belongs to the RGS7BP/RGS9BP family.Curated

Phylogenomic databases

eggNOGiENOG410IH1X. Eukaryota.
ENOG410YXJD. LUCA.
GeneTreeiENSGT00390000006968.
HOGENOMiHOG000154060.
HOVERGENiHBG104928.
InParanoidiQ8BQP9.
OMAiGSLQLHR.
OrthoDBiEOG091G0GG3.
PhylomeDBiQ8BQP9.
TreeFamiTF330985.

Family and domain databases

InterProiIPR026512. RGS7BP/RGS9BP.
[Graphical view]
PANTHERiPTHR21029. PTHR21029. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BQP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAPNGRKK RPSRSTRSSI FQISKPPLQS GDWERRGSGS ESAHKTQRAL
60 70 80 90 100
DDCKMLVQEF NTQVALYREL VISIGDVSVS CPSLRAEMHK TRTKGCEMAR
110 120 130 140 150
QAHQKLAAIS GPEDGEIHPE ICRLYIQLQC CLEMYTTEML KSICLLGSLQ
160 170 180 190 200
FHRKGKEASG GAKNLDSKIE ENAETPALED SLSSPLESQQ QCWQVATDIE
210 220 230 240 250
NTERDMREMK NLLSKLRETM PLPLKNQDDS SLLNLTPYPM VRRRKRRFFG

LCCLVSS
Length:257
Mass (Da):29,023
Last modified:March 1, 2003 - v1
Checksum:i1825969A5E64D544
GO

Sequence cautioni

The sequence BAC29358 differs from that shown. Reason: Frameshift at positions 36 and 217.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15S → A in BAB32250 (PubMed:16141072).Curated1
Sequence conflicti47Q → R in BAB32250 (PubMed:16141072).Curated1
Sequence conflicti73S → F in BAB32250 (PubMed:16141072).Curated1
Sequence conflicti138E → Q in BAE23346 (PubMed:16141072).Curated1
Sequence conflicti146L → V in BAB32250 (PubMed:16141072).Curated1
Sequence conflicti188S → G in AAI18958 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ104214 mRNA. Translation: AAZ09201.1.
AK020910 mRNA. Translation: BAB32250.1.
AK036240 mRNA. Translation: BAC29358.1. Frameshift.
AK046733 mRNA. Translation: BAC32849.1.
AK137417 mRNA. Translation: BAE23346.1.
BC118957 mRNA. Translation: AAI18958.1.
CCDSiCCDS36774.1.
RefSeqiNP_084155.2. NM_029879.2.
UniGeneiMm.100348.

Genome annotation databases

EnsembliENSMUST00000063551; ENSMUSP00000066614; ENSMUSG00000021719.
GeneIDi52882.
KEGGimmu:52882.
UCSCiuc007rtp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ104214 mRNA. Translation: AAZ09201.1.
AK020910 mRNA. Translation: BAB32250.1.
AK036240 mRNA. Translation: BAC29358.1. Frameshift.
AK046733 mRNA. Translation: BAC32849.1.
AK137417 mRNA. Translation: BAE23346.1.
BC118957 mRNA. Translation: AAI18958.1.
CCDSiCCDS36774.1.
RefSeqiNP_084155.2. NM_029879.2.
UniGeneiMm.100348.

3D structure databases

ProteinModelPortaliQ8BQP9.
SMRiQ8BQP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206866. 5 interactors.
STRINGi10090.ENSMUSP00000066614.

PTM databases

iPTMnetiQ8BQP9.
PhosphoSitePlusiQ8BQP9.
SwissPalmiQ8BQP9.

Proteomic databases

PaxDbiQ8BQP9.
PeptideAtlasiQ8BQP9.
PRIDEiQ8BQP9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063551; ENSMUSP00000066614; ENSMUSG00000021719.
GeneIDi52882.
KEGGimmu:52882.
UCSCiuc007rtp.1. mouse.

Organism-specific databases

CTDi401190.
MGIiMGI:106334. Rgs7bp.

Phylogenomic databases

eggNOGiENOG410IH1X. Eukaryota.
ENOG410YXJD. LUCA.
GeneTreeiENSGT00390000006968.
HOGENOMiHOG000154060.
HOVERGENiHBG104928.
InParanoidiQ8BQP9.
OMAiGSLQLHR.
OrthoDBiEOG091G0GG3.
PhylomeDBiQ8BQP9.
TreeFamiTF330985.

Miscellaneous databases

ChiTaRSiRgs7bp. mouse.
PROiQ8BQP9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021719.
GenevisibleiQ8BQP9. MM.

Family and domain databases

InterProiIPR026512. RGS7BP/RGS9BP.
[Graphical view]
PANTHERiPTHR21029. PTHR21029. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiR7BP_MOUSE
AccessioniPrimary (citable) accession number: Q8BQP9
Secondary accession number(s): Q0VF69
, Q3UVC4, Q8CBD6, Q9CTP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.