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Protein

Zinc finger protein OZF

Gene

Znf146

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 3823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri44 – 6623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri72 – 9423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri100 – 12223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri128 – 15023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri156 – 17823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri184 – 20623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: GO_Central

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein OZF
Alternative name(s):
Only zinc finger protein
Zinc finger protein 146
Gene namesi
Name:Znf146
Synonyms:Ozf, Zfp146
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1347092. Zfp146.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleolus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice lacking Zfp146 in mammary gland display impaired mammary gland development. They cannot sustain full growth of their pups. This phenotype is associated with an impaired mammary gland development noticeable only after mid-gestation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Zinc finger protein OZFPRO_0000047277Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki157 – 157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki169 – 169Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ8BQN6.
PRIDEiQ8BQN6.

PTM databases

PhosphoSiteiQ8BQN6.

Expressioni

Tissue specificityi

Expressed in heart, brain, liver, lung, skeletal muscle and kidney, and at much lower level in spleen and testicle. Expressed in lactating mammary gland.2 Publications

Gene expression databases

BgeeiQ8BQN6.
CleanExiMM_ZFP146.
GenevestigatoriQ8BQN6.

Interactioni

Subunit structurei

Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8BQN6.
SMRiQ8BQN6. Positions 15-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni212 – 29281Interaction with TERF2IPBy similarityAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 3823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri44 – 6623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri72 – 9423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri100 – 12223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri128 – 15023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri156 – 17823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri184 – 20623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00750000117724.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8BQN6.
OMAiNHLVSHI.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8BQN6.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BQN6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQLSQQRIL SGGSPFACKV CGKLFSHKSN LTEHEHFHSR EKPFECNECG
60 70 80 90 100
KAFSQKQYVI KHQSTHSGEK LFECSDCGKA FSQKENLLTH QKIHTGEKPF
110 120 130 140 150
ECKDCGKAFI QKSNLIRHQR THTGEKPFIC KECGKTFSGK SNLTEHEKIH
160 170 180 190 200
IGEKPFKCNE CGTAFGQKKY LIKHQNIHTG EKPYECNECG KAFSQRTSLI
210 220 230 240 250
VHVRIHSGDK PYECNVCGKA FSQSSSLTVH VRSHTGEKPY GCNECGKAFS
260 270 280 290
QFSTLALHLR IHTGKKPYQC SECGKAFSQK SHHIRHQKIH TH
Length:292
Mass (Da):33,093
Last modified:November 8, 2005 - v2
Checksum:iA0F985ABBEE7CADD
GO

Sequence cautioni

The sequence BAC33129.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224763 mRNA. Translation: CAB38320.1.
AK047696 mRNA. Translation: BAC33129.1. Different initiation.
BC127038 mRNA. Translation: AAI27039.1.
BC127039 mRNA. Translation: AAI27040.1.
CCDSiCCDS21079.1.
RefSeqiNP_036110.1. NM_011980.3.
XP_006540071.1. XM_006540008.1.
XP_006540072.1. XM_006540009.1.
XP_006540073.1. XM_006540010.1.
XP_006540074.1. XM_006540011.1.
XP_006540075.1. XM_006540012.1.
XP_006544231.1. XM_006544168.1.
UniGeneiMm.446516.
Mm.456449.

Genome annotation databases

EnsembliENSMUST00000062181; ENSMUSP00000058588; ENSMUSG00000037029.
GeneIDi102643033.
26465.
KEGGimmu:102643033.
mmu:26465.
UCSCiuc009gdn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224763 mRNA. Translation: CAB38320.1.
AK047696 mRNA. Translation: BAC33129.1. Different initiation.
BC127038 mRNA. Translation: AAI27039.1.
BC127039 mRNA. Translation: AAI27040.1.
CCDSiCCDS21079.1.
RefSeqiNP_036110.1. NM_011980.3.
XP_006540071.1. XM_006540008.1.
XP_006540072.1. XM_006540009.1.
XP_006540073.1. XM_006540010.1.
XP_006540074.1. XM_006540011.1.
XP_006540075.1. XM_006540012.1.
XP_006544231.1. XM_006544168.1.
UniGeneiMm.446516.
Mm.456449.

3D structure databases

ProteinModelPortaliQ8BQN6.
SMRiQ8BQN6. Positions 15-291.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8BQN6.

Proteomic databases

PaxDbiQ8BQN6.
PRIDEiQ8BQN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062181; ENSMUSP00000058588; ENSMUSG00000037029.
GeneIDi102643033.
26465.
KEGGimmu:102643033.
mmu:26465.
UCSCiuc009gdn.1. mouse.

Organism-specific databases

CTDi26465.
MGIiMGI:1347092. Zfp146.

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00750000117724.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8BQN6.
OMAiNHLVSHI.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8BQN6.
TreeFamiTF337055.

Miscellaneous databases

NextBioi304587.
PROiQ8BQN6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BQN6.
CleanExiMM_ZFP146.
GenevestigatoriQ8BQN6.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization, and chromosome assignment of Zfp146 the mouse ortholog of human ZNF146, a gene amplified and overexpressed in pancreatic cancer, and Zfp260 a closely related gene."
    Blottiere L., Apiou F., Ferbus D., Guenzi C., Dutrillaux B., Prosperi M.-T., Goubin G.
    Cytogenet. Cell Genet. 85:297-300(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpus striatum.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Targeted expression of the only zinc finger gene in transgenic mice is associated with impaired mammary development."
    Besnar N., Persuy M.-A., Stinnakre M.-G., Lepourry L., Da Silva J.C., Goubin G., Vilotte J.-L.
    Transgenic Res. 11:505-513(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiOZF_MOUSE
AccessioniPrimary (citable) accession number: Q8BQN6
Secondary accession number(s): A0JNX3, Q9Z0Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: February 4, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.