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Q8BQN6

- OZF_MOUSE

UniProt

Q8BQN6 - OZF_MOUSE

Protein

Zinc finger protein OZF

Gene

Znf146

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri16 – 3823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri44 – 6623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri72 – 9423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri100 – 12223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri128 – 15023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri156 – 17823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri184 – 20623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri212 – 23423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri240 – 26223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 29023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein OZF
    Alternative name(s):
    Only zinc finger protein
    Zinc finger protein 146
    Gene namesi
    Name:Znf146
    Synonyms:Ozf, Zfp146
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1347092. Zfp146.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleolus Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice lacking Zfp146 in mammary gland display impaired mammary gland development. They cannot sustain full growth of their pups. This phenotype is associated with an impaired mammary gland development noticeable only after mid-gestation.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Zinc finger protein OZFPRO_0000047277Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki157 – 157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
    Cross-linki169 – 169Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiQ8BQN6.
    PRIDEiQ8BQN6.

    PTM databases

    PhosphoSiteiQ8BQN6.

    Expressioni

    Tissue specificityi

    Expressed in heart, brain, liver, lung, skeletal muscle and kidney, and at much lower level in spleen and testicle. Expressed in lactating mammary gland.2 Publications

    Gene expression databases

    BgeeiQ8BQN6.
    CleanExiMM_ZFP146.
    GenevestigatoriQ8BQN6.

    Interactioni

    Subunit structurei

    Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BQN6.
    SMRiQ8BQN6. Positions 15-291.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni212 – 29281Interaction with TERF2IPBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri16 – 3823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri44 – 6623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri72 – 9423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri100 – 12223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri128 – 15023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri156 – 17823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri184 – 20623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri212 – 23423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri240 – 26223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 29023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117724.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiA0JNX3.
    OMAiNHLVSHI.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ8BQN6.
    TreeFamiTF337055.

    Family and domain databases

    Gene3Di3.30.160.60. 10 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 10 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BQN6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQLSQQRIL SGGSPFACKV CGKLFSHKSN LTEHEHFHSR EKPFECNECG    50
    KAFSQKQYVI KHQSTHSGEK LFECSDCGKA FSQKENLLTH QKIHTGEKPF 100
    ECKDCGKAFI QKSNLIRHQR THTGEKPFIC KECGKTFSGK SNLTEHEKIH 150
    IGEKPFKCNE CGTAFGQKKY LIKHQNIHTG EKPYECNECG KAFSQRTSLI 200
    VHVRIHSGDK PYECNVCGKA FSQSSSLTVH VRSHTGEKPY GCNECGKAFS 250
    QFSTLALHLR IHTGKKPYQC SECGKAFSQK SHHIRHQKIH TH 292
    Length:292
    Mass (Da):33,093
    Last modified:November 8, 2005 - v2
    Checksum:iA0F985ABBEE7CADD
    GO

    Sequence cautioni

    The sequence BAC33129.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ224763 mRNA. Translation: CAB38320.1.
    AK047696 mRNA. Translation: BAC33129.1. Different initiation.
    BC127038 mRNA. Translation: AAI27039.1.
    BC127039 mRNA. Translation: AAI27040.1.
    CCDSiCCDS21079.1.
    RefSeqiNP_036110.1. NM_011980.3.
    XP_006540071.1. XM_006540008.1.
    XP_006540072.1. XM_006540009.1.
    XP_006540073.1. XM_006540010.1.
    XP_006540074.1. XM_006540011.1.
    XP_006540075.1. XM_006540012.1.
    XP_006544231.1. XM_006544168.1.
    UniGeneiMm.446516.
    Mm.456449.

    Genome annotation databases

    EnsembliENSMUST00000062181; ENSMUSP00000058588; ENSMUSG00000037029.
    GeneIDi102643033.
    26465.
    KEGGimmu:102643033.
    mmu:26465.
    UCSCiuc009gdn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ224763 mRNA. Translation: CAB38320.1 .
    AK047696 mRNA. Translation: BAC33129.1 . Different initiation.
    BC127038 mRNA. Translation: AAI27039.1 .
    BC127039 mRNA. Translation: AAI27040.1 .
    CCDSi CCDS21079.1.
    RefSeqi NP_036110.1. NM_011980.3.
    XP_006540071.1. XM_006540008.1.
    XP_006540072.1. XM_006540009.1.
    XP_006540073.1. XM_006540010.1.
    XP_006540074.1. XM_006540011.1.
    XP_006540075.1. XM_006540012.1.
    XP_006544231.1. XM_006544168.1.
    UniGenei Mm.446516.
    Mm.456449.

    3D structure databases

    ProteinModelPortali Q8BQN6.
    SMRi Q8BQN6. Positions 15-291.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BQN6.

    Proteomic databases

    PaxDbi Q8BQN6.
    PRIDEi Q8BQN6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000062181 ; ENSMUSP00000058588 ; ENSMUSG00000037029 .
    GeneIDi 102643033.
    26465.
    KEGGi mmu:102643033.
    mmu:26465.
    UCSCi uc009gdn.1. mouse.

    Organism-specific databases

    CTDi 26465.
    MGIi MGI:1347092. Zfp146.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117724.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi A0JNX3.
    OMAi NHLVSHI.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q8BQN6.
    TreeFami TF337055.

    Miscellaneous databases

    NextBioi 304587.
    PROi Q8BQN6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BQN6.
    CleanExi MM_ZFP146.
    Genevestigatori Q8BQN6.

    Family and domain databases

    Gene3Di 3.30.160.60. 10 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 10 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, characterization, and chromosome assignment of Zfp146 the mouse ortholog of human ZNF146, a gene amplified and overexpressed in pancreatic cancer, and Zfp260 a closely related gene."
      Blottiere L., Apiou F., Ferbus D., Guenzi C., Dutrillaux B., Prosperi M.-T., Goubin G.
      Cytogenet. Cell Genet. 85:297-300(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Corpus striatum.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Targeted expression of the only zinc finger gene in transgenic mice is associated with impaired mammary development."
      Besnar N., Persuy M.-A., Stinnakre M.-G., Lepourry L., Da Silva J.C., Goubin G., Vilotte J.-L.
      Transgenic Res. 11:505-513(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiOZF_MOUSE
    AccessioniPrimary (citable) accession number: Q8BQN6
    Secondary accession number(s): A0JNX3, Q9Z0Q5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3