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Q8BQN6 (OZF_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein OZF
Alternative name(s):
Only zinc finger protein
Zinc finger protein 146
Gene names
Name:Znf146
Synonyms:Ozf, Zfp146
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed in heart, brain, liver, lung, skeletal muscle and kidney, and at much lower level in spleen and testicle. Expressed in lactating mammary gland. Ref.1 Ref.4

Disruption phenotype

Mice lacking Zfp146 in mammary gland display impaired mammary gland development. They cannot sustain full growth of their pups. This phenotype is associated with an impaired mammary gland development noticeable only after mid-gestation. Ref.4

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 10 C2H2-type zinc fingers.

Sequence caution

The sequence BAC33129.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Zinc finger protein OZF
PRO_0000047277

Regions

Zinc finger16 – 3823C2H2-type 1
Zinc finger44 – 6623C2H2-type 2
Zinc finger72 – 9423C2H2-type 3
Zinc finger100 – 12223C2H2-type 4
Zinc finger128 – 15023C2H2-type 5
Zinc finger156 – 17823C2H2-type 6
Zinc finger184 – 20623C2H2-type 7
Zinc finger212 – 23423C2H2-type 8
Zinc finger240 – 26223C2H2-type 9
Zinc finger268 – 29023C2H2-type 10
Region212 – 29281Interaction with TERF2IP By similarity

Amino acid modifications

Cross-link157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Cross-link169Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8BQN6 [UniParc].

Last modified November 8, 2005. Version 2.
Checksum: A0F985ABBEE7CADD

FASTA29233,093
        10         20         30         40         50         60 
MSQLSQQRIL SGGSPFACKV CGKLFSHKSN LTEHEHFHSR EKPFECNECG KAFSQKQYVI 

        70         80         90        100        110        120 
KHQSTHSGEK LFECSDCGKA FSQKENLLTH QKIHTGEKPF ECKDCGKAFI QKSNLIRHQR 

       130        140        150        160        170        180 
THTGEKPFIC KECGKTFSGK SNLTEHEKIH IGEKPFKCNE CGTAFGQKKY LIKHQNIHTG 

       190        200        210        220        230        240 
EKPYECNECG KAFSQRTSLI VHVRIHSGDK PYECNVCGKA FSQSSSLTVH VRSHTGEKPY 

       250        260        270        280        290 
GCNECGKAFS QFSTLALHLR IHTGKKPYQC SECGKAFSQK SHHIRHQKIH TH 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, characterization, and chromosome assignment of Zfp146 the mouse ortholog of human ZNF146, a gene amplified and overexpressed in pancreatic cancer, and Zfp260 a closely related gene."
Blottiere L., Apiou F., Ferbus D., Guenzi C., Dutrillaux B., Prosperi M.-T., Goubin G.
Cytogenet. Cell Genet. 85:297-300(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Corpus striatum.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Targeted expression of the only zinc finger gene in transgenic mice is associated with impaired mammary development."
Besnar N., Persuy M.-A., Stinnakre M.-G., Lepourry L., Da Silva J.C., Goubin G., Vilotte J.-L.
Transgenic Res. 11:505-513(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ224763 mRNA. Translation: CAB38320.1.
AK047696 mRNA. Translation: BAC33129.1. Different initiation.
BC127038 mRNA. Translation: AAI27039.1.
BC127039 mRNA. Translation: AAI27040.1.
CCDSCCDS21079.1.
RefSeqNP_036110.1. NM_011980.3.
XP_006540071.1. XM_006540008.1.
XP_006540072.1. XM_006540009.1.
XP_006540073.1. XM_006540010.1.
XP_006540074.1. XM_006540011.1.
XP_006540075.1. XM_006540012.1.
XP_006544231.1. XM_006544168.1.
UniGeneMm.446516.
Mm.456449.

3D structure databases

ProteinModelPortalQ8BQN6.
SMRQ8BQN6. Positions 15-291.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BQN6.

Proteomic databases

PaxDbQ8BQN6.
PRIDEQ8BQN6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000062181; ENSMUSP00000058588; ENSMUSG00000037029.
GeneID102643033.
26465.
KEGGmmu:102643033.
mmu:26465.
UCSCuc009gdn.1. mouse.

Organism-specific databases

CTD26465.
MGIMGI:1347092. Zfp146.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00750000117724.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidA0JNX3.
OMANHLVSHI.
OrthoDBEOG7KSX7Q.
PhylomeDBQ8BQN6.
TreeFamTF337055.

Gene expression databases

BgeeQ8BQN6.
CleanExMM_ZFP146.
GenevestigatorQ8BQN6.

Family and domain databases

Gene3D3.30.160.60. 10 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio304587.
PROQ8BQN6.
SOURCESearch...

Entry information

Entry nameOZF_MOUSE
AccessionPrimary (citable) accession number: Q8BQN6
Secondary accession number(s): A0JNX3, Q9Z0Q5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot