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Protein

Echinoderm microtubule-associated protein-like 5

Gene

Eml5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Echinoderm microtubule-associated protein-like 5
Short name:
EMAP-5
Gene namesi
Name:Eml5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2442513. Eml5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19771977Echinoderm microtubule-associated protein-like 5PRO_0000284396Add
BLAST

Proteomic databases

EPDiQ8BQM8.
MaxQBiQ8BQM8.
PaxDbiQ8BQM8.
PRIDEiQ8BQM8.

PTM databases

iPTMnetiQ8BQM8.
PhosphoSiteiQ8BQM8.

Expressioni

Gene expression databases

BgeeiQ8BQM8.
CleanExiMM_EML5.
GenevisibleiQ8BQM8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065643.

Structurei

3D structure databases

ProteinModelPortaliQ8BQM8.
SMRiQ8BQM8. Positions 7-594, 658-1266, 1471-1970.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati59 – 10042WD 1Add
BLAST
Repeati104 – 14542WD 2Add
BLAST
Repeati148 – 18740WD 3Add
BLAST
Repeati195 – 23339WD 4Add
BLAST
Repeati235 – 27339WD 5Add
BLAST
Repeati280 – 32142WD 6Add
BLAST
Repeati323 – 36240WD 7Add
BLAST
Repeati406 – 44540WD 8Add
BLAST
Repeati449 – 48840WD 9Add
BLAST
Repeati561 – 60141WD 10Add
BLAST
Repeati725 – 76642WD 11Add
BLAST
Repeati770 – 81142WD 12Add
BLAST
Repeati814 – 85340WD 13Add
BLAST
Repeati861 – 90040WD 14Add
BLAST
Repeati901 – 94040WD 15Add
BLAST
Repeati996 – 103540WD 16Add
BLAST
Repeati1038 – 107740WD 17Add
BLAST
Repeati1080 – 112041WD 18Add
BLAST
Repeati1236 – 127641WD 19Add
BLAST
Repeati1420 – 147152WD 20Add
BLAST
Repeati1475 – 151642WD 21Add
BLAST
Repeati1519 – 155840WD 22Add
BLAST
Repeati1568 – 160639WD 23Add
BLAST
Repeati1608 – 165447WD 24Add
BLAST
Repeati1699 – 173941WD 25Add
BLAST
Repeati1741 – 178242WD 26Add
BLAST
Repeati1783 – 182240WD 27Add
BLAST
Repeati1895 – 193440WD 28Add
BLAST
Repeati1940 – 197738WD 29Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat EMAP family.Curated
Contains 29 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2106. Eukaryota.
ENOG410XNTQ. LUCA.
GeneTreeiENSGT00550000074369.
HOGENOMiHOG000031037.
HOVERGENiHBG107846.
InParanoidiQ8BQM8.
KOiK18597.
OMAiPEKLQTN.
OrthoDBiEOG7GN2KS.
PhylomeDBiQ8BQM8.
TreeFamiTF317832.

Family and domain databases

Gene3Di2.130.10.10. 9 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR005108. HELP.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 2 hits.
PF03451. HELP. 3 hits.
PF00400. WD40. 8 hits.
[Graphical view]
SMARTiSM00320. WD40. 29 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 10 hits.
SSF50998. SSF50998. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BQM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARSAPSCH LRLEWVYGYR GHQCRNNLYY TAAKEIVYFV AGVGVVYSPR
60 70 80 90 100
EHRQKFFRGH SDDIISLALH PERVLVATGQ VGKEPYICVW DSYTVQTVSV
110 120 130 140 150
LKDVHTHGIA CLAFDLDGQR LVSVGLDSKN AVCVWDWKRG RMLSMAPGHT
160 170 180 190 200
DRIFDISWDL YQPNKLVSCG VKHIKFWSLC GNALTPKRGV FGKTGDLQTI
210 220 230 240 250
LCLACARDEL TYSGALNGDI YVWKGINLIR TIQGAHTAGI FSMNSCEEGF
260 270 280 290 300
ATGGRDGCIR LWDLTFKPIT VIDLRETEQG YKGLSVRSVC WRGDHILVGT
310 320 330 340 350
QDSEIFEIVV HERNKPFLIM QGHCEGELWA LAVHPTKPLA VTGSDDRSVR
360 370 380 390 400
IWSLVDHALI ARCNMEEPIR CAAVNVDGIH LALGMKDGSF TVLRVRDMTE
410 420 430 440 450
VVHIKDRKEA IHELKYSPDG AYLAVGCNDS SVDIYGVAQR YKKVGECVGS
460 470 480 490 500
LSFITHLDWS SDSRYLQTND GSGKRLLYKM PGGKEVTSKE EIKGMHWASW
510 520 530 540 550
TCVAGLEVNG IWPKYSDIND INSVDGNYVG QVLVTADDYG VVKLFRYPCL
560 570 580 590 600
RKGAKFRKYI GHSAHVTNVR WSHDYQWVIS IGGADHSVFQ WKFIPERKLK
610 620 630 640 650
DALHIAPQES LAESNSDESD SDLSDVPELD SEIEQETQLT YHRQVYKEDL
660 670 680 690 700
PQLKEQCKEK QKSATSKRRE RTPGTSIRLH FIHGYRGYDC RSNLFYTQIG
710 720 730 740 750
EIVYHVAAVG VIYNRQQNTQ RFYLGHDDDI LCLAIHPLKD YVATGQVGRD
760 770 780 790 800
PSIHVWDTET IKPLSILKGY HQYGICAVDF SADGKRLASV GIDDSHTIVL
810 820 830 840 850
WDWKKGEKLS VTRGSKDKIF VVKMNPYVPD KLITAGIKHM KFWRRAGGGL
860 870 880 890 900
IGKKGYVGTL GKNDTMMCAV YGWTEEMAFS GTSTGDVCIW RDVFLVKTVK
910 920 930 940 950
AHDGPVFSMH ALEKGFVTGG KDGMVALWDD SFERCLKTYA IKRADLAPGS
960 970 980 990 1000
KGLLLEDNPS IRAISLGHGH ILVGTKNGEI LEVDKSGPIT LLVQGHMEGE
1010 1020 1030 1040 1050
VWGLATHPYL PICATVSDDK TLRIWDLSPS HCMLAVRKLK KGGRCCCFSP
1060 1070 1080 1090 1100
DGKALAVGLN DGSFLMANAD TLEDLVSFHH RKDIISDIRF SPGSGKYLAV
1110 1120 1130 1140 1150
ASHDSFVDIY NVTSSKRVGV CKGATSYITH IDWDSRGKLL QVNTGAKEQL
1160 1170 1180 1190 1200
FFEAPRGKRQ TIPSVEVEKI SWATWTSVLG LCCEGIWPVI GEVTEVTASC
1210 1220 1230 1240 1250
LTSDKMVLAT GDDLGFVKLF RYPAKGKFGK FKKYVAHSTH VTNVRWTYDD
1260 1270 1280 1290 1300
SMLVTLGGAD MSLMVWTNEV ESHREKKYCD SEESDIDSEE DGGYDSDVTR
1310 1320 1330 1340 1350
ENEISYTIRA LSTNIRPMFG VKPHLQQKEP SVDERQGVVR GSRPPVSRAP
1360 1370 1380 1390 1400
PQPEKLQSNN VGKKKRPIED LVLELAFGYR GRDCRNNVHY LNDGDDIIYH
1410 1420 1430 1440 1450
TASIGILHNV ATGTQSFYQE HNDDILCLTV NQHPKFINIV ATGQVGDSAD
1460 1470 1480 1490 1500
MSATAPSVHI WDAVNKQTLS ILRCSHSKGV CSVSFSATGK LLLSVGLDPE
1510 1520 1530 1540 1550
HTVTIWRWQE GAKIASRGGH NQRIFVAEFR PDSDTQFVSV GIKHVKFWTL
1560 1570 1580 1590 1600
AGRALLSKKG LLSSLEDARM QTMLAVAFGA NNLTFTGTIS GDVCVWKDHI
1610 1620 1630 1640 1650
LCRVVARAHN GPVFAMYTTL RDGLIVTGGK ERPSKEGGAV KLWDQELRRC
1660 1670 1680 1690 1700
RAFRLETGQV TDCVRSVCRG KGKILVGTRN SEIIEVGEKN AACNILVNGH
1710 1720 1730 1740 1750
VDGPIWGLAT HPSRDFFLSA AEDGTVRLWD IADKKMLNKV NLGHAARTVC
1760 1770 1780 1790 1800
YSPEGDMVAI GMKNGEFIIL LVSSLKIWGK KRDRRCAIHD IRFSPDSRYL
1810 1820 1830 1840 1850
AVGSSENSVD FYDLTLGPTL NRISYCKDIP SFVIQMDFSA DSRHLQVSSG
1860 1870 1880 1890 1900
CYKRHVYEVP SGKHLVDHAA IDRITWATWT SILGDEVMGI WSRHAEKADV
1910 1920 1930 1940 1950
TCACVSHSGI SLVTGDDFGM VKLYDFPCPE KFAKHKRFLG HSPHVTNIRF
1960 1970
TSGDRHVVSA GGDDCSLFVW KCVHMPH
Length:1,977
Mass (Da):220,106
Last modified:April 17, 2007 - v2
Checksum:i92111219F74E8427
GO

Sequence cautioni

The sequence BAC31743.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC33148.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1648 – 167629RRCRA…GKILV → GDAGPSGLRQDKSQIVFGLC AEAKARYYL in BAC31743 (PubMed:16141072).CuratedAdd
BLAST
Sequence conflicti1668 – 16714CRGK → FVFQ in AAH27154 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159193 Genomic DNA. No translation available.
AK044024 mRNA. Translation: BAC31743.1. Different initiation.
AK047762 mRNA. Translation: BAC33148.1. Different initiation.
BC027154 mRNA. Translation: AAH27154.1.
CCDSiCCDS36519.1.
RefSeqiNP_001074660.1. NM_001081191.1.
UniGeneiMm.390484.
Mm.446675.
Mm.447154.
Mm.463212.

Genome annotation databases

EnsembliENSMUST00000065716; ENSMUSP00000065643; ENSMUSG00000051166.
GeneIDi319670.
KEGGimmu:319670.
UCSCiuc007orn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159193 Genomic DNA. No translation available.
AK044024 mRNA. Translation: BAC31743.1. Different initiation.
AK047762 mRNA. Translation: BAC33148.1. Different initiation.
BC027154 mRNA. Translation: AAH27154.1.
CCDSiCCDS36519.1.
RefSeqiNP_001074660.1. NM_001081191.1.
UniGeneiMm.390484.
Mm.446675.
Mm.447154.
Mm.463212.

3D structure databases

ProteinModelPortaliQ8BQM8.
SMRiQ8BQM8. Positions 7-594, 658-1266, 1471-1970.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065643.

PTM databases

iPTMnetiQ8BQM8.
PhosphoSiteiQ8BQM8.

Proteomic databases

EPDiQ8BQM8.
MaxQBiQ8BQM8.
PaxDbiQ8BQM8.
PRIDEiQ8BQM8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065716; ENSMUSP00000065643; ENSMUSG00000051166.
GeneIDi319670.
KEGGimmu:319670.
UCSCiuc007orn.1. mouse.

Organism-specific databases

CTDi161436.
MGIiMGI:2442513. Eml5.

Phylogenomic databases

eggNOGiKOG2106. Eukaryota.
ENOG410XNTQ. LUCA.
GeneTreeiENSGT00550000074369.
HOGENOMiHOG000031037.
HOVERGENiHBG107846.
InParanoidiQ8BQM8.
KOiK18597.
OMAiPEKLQTN.
OrthoDBiEOG7GN2KS.
PhylomeDBiQ8BQM8.
TreeFamiTF317832.

Miscellaneous databases

PROiQ8BQM8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BQM8.
CleanExiMM_EML5.
GenevisibleiQ8BQM8. MM.

Family and domain databases

Gene3Di2.130.10.10. 9 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR005108. HELP.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 2 hits.
PF03451. HELP. 3 hits.
PF00400. WD40. 8 hits.
[Graphical view]
SMARTiSM00320. WD40. 29 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 10 hits.
SSF50998. SSF50998. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-488 AND 1648-1977.
    Strain: C57BL/6J.
    Tissue: Brain cortex and Corpus striatum.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1668-1977.
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiEMAL5_MOUSE
AccessioniPrimary (citable) accession number: Q8BQM8
Secondary accession number(s): Q8BRL0, Q8R2W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: June 8, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.