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Protein

Echinoderm microtubule-associated protein-like 5

Gene

Eml5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Echinoderm microtubule-associated protein-like 5
Short name:
EMAP-5
Gene namesi
Name:Eml5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2442513. Eml5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002843961 – 1977Echinoderm microtubule-associated protein-like 5Add BLAST1977

Proteomic databases

MaxQBiQ8BQM8.
PaxDbiQ8BQM8.
PRIDEiQ8BQM8.

PTM databases

iPTMnetiQ8BQM8.
PhosphoSitePlusiQ8BQM8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000051166.
CleanExiMM_EML5.
GenevisibleiQ8BQM8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065643.

Structurei

3D structure databases

ProteinModelPortaliQ8BQM8.
SMRiQ8BQM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati59 – 100WD 1Add BLAST42
Repeati104 – 145WD 2Add BLAST42
Repeati148 – 187WD 3Add BLAST40
Repeati195 – 233WD 4Add BLAST39
Repeati235 – 273WD 5Add BLAST39
Repeati280 – 321WD 6Add BLAST42
Repeati323 – 362WD 7Add BLAST40
Repeati406 – 445WD 8Add BLAST40
Repeati449 – 488WD 9Add BLAST40
Repeati561 – 601WD 10Add BLAST41
Repeati725 – 766WD 11Add BLAST42
Repeati770 – 811WD 12Add BLAST42
Repeati814 – 853WD 13Add BLAST40
Repeati861 – 900WD 14Add BLAST40
Repeati901 – 940WD 15Add BLAST40
Repeati996 – 1035WD 16Add BLAST40
Repeati1038 – 1077WD 17Add BLAST40
Repeati1080 – 1120WD 18Add BLAST41
Repeati1236 – 1276WD 19Add BLAST41
Repeati1420 – 1471WD 20Add BLAST52
Repeati1475 – 1516WD 21Add BLAST42
Repeati1519 – 1558WD 22Add BLAST40
Repeati1568 – 1606WD 23Add BLAST39
Repeati1608 – 1654WD 24Add BLAST47
Repeati1699 – 1739WD 25Add BLAST41
Repeati1741 – 1782WD 26Add BLAST42
Repeati1783 – 1822WD 27Add BLAST40
Repeati1895 – 1934WD 28Add BLAST40
Repeati1940 – 1977WD 29Add BLAST38

Sequence similaritiesi

Belongs to the WD repeat EMAP family.Curated
Contains 29 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2106. Eukaryota.
ENOG410XNTQ. LUCA.
GeneTreeiENSGT00550000074369.
HOGENOMiHOG000031037.
HOVERGENiHBG107846.
InParanoidiQ8BQM8.
KOiK18597.
OMAiPEKLQTN.
OrthoDBiEOG091G00FB.
PhylomeDBiQ8BQM8.
TreeFamiTF317832.

Family and domain databases

Gene3Di2.130.10.10. 9 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR005108. HELP.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 2 hits.
PF03451. HELP. 3 hits.
PF00400. WD40. 8 hits.
[Graphical view]
SMARTiSM00320. WD40. 29 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 10 hits.
SSF50998. SSF50998. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BQM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARSAPSCH LRLEWVYGYR GHQCRNNLYY TAAKEIVYFV AGVGVVYSPR
60 70 80 90 100
EHRQKFFRGH SDDIISLALH PERVLVATGQ VGKEPYICVW DSYTVQTVSV
110 120 130 140 150
LKDVHTHGIA CLAFDLDGQR LVSVGLDSKN AVCVWDWKRG RMLSMAPGHT
160 170 180 190 200
DRIFDISWDL YQPNKLVSCG VKHIKFWSLC GNALTPKRGV FGKTGDLQTI
210 220 230 240 250
LCLACARDEL TYSGALNGDI YVWKGINLIR TIQGAHTAGI FSMNSCEEGF
260 270 280 290 300
ATGGRDGCIR LWDLTFKPIT VIDLRETEQG YKGLSVRSVC WRGDHILVGT
310 320 330 340 350
QDSEIFEIVV HERNKPFLIM QGHCEGELWA LAVHPTKPLA VTGSDDRSVR
360 370 380 390 400
IWSLVDHALI ARCNMEEPIR CAAVNVDGIH LALGMKDGSF TVLRVRDMTE
410 420 430 440 450
VVHIKDRKEA IHELKYSPDG AYLAVGCNDS SVDIYGVAQR YKKVGECVGS
460 470 480 490 500
LSFITHLDWS SDSRYLQTND GSGKRLLYKM PGGKEVTSKE EIKGMHWASW
510 520 530 540 550
TCVAGLEVNG IWPKYSDIND INSVDGNYVG QVLVTADDYG VVKLFRYPCL
560 570 580 590 600
RKGAKFRKYI GHSAHVTNVR WSHDYQWVIS IGGADHSVFQ WKFIPERKLK
610 620 630 640 650
DALHIAPQES LAESNSDESD SDLSDVPELD SEIEQETQLT YHRQVYKEDL
660 670 680 690 700
PQLKEQCKEK QKSATSKRRE RTPGTSIRLH FIHGYRGYDC RSNLFYTQIG
710 720 730 740 750
EIVYHVAAVG VIYNRQQNTQ RFYLGHDDDI LCLAIHPLKD YVATGQVGRD
760 770 780 790 800
PSIHVWDTET IKPLSILKGY HQYGICAVDF SADGKRLASV GIDDSHTIVL
810 820 830 840 850
WDWKKGEKLS VTRGSKDKIF VVKMNPYVPD KLITAGIKHM KFWRRAGGGL
860 870 880 890 900
IGKKGYVGTL GKNDTMMCAV YGWTEEMAFS GTSTGDVCIW RDVFLVKTVK
910 920 930 940 950
AHDGPVFSMH ALEKGFVTGG KDGMVALWDD SFERCLKTYA IKRADLAPGS
960 970 980 990 1000
KGLLLEDNPS IRAISLGHGH ILVGTKNGEI LEVDKSGPIT LLVQGHMEGE
1010 1020 1030 1040 1050
VWGLATHPYL PICATVSDDK TLRIWDLSPS HCMLAVRKLK KGGRCCCFSP
1060 1070 1080 1090 1100
DGKALAVGLN DGSFLMANAD TLEDLVSFHH RKDIISDIRF SPGSGKYLAV
1110 1120 1130 1140 1150
ASHDSFVDIY NVTSSKRVGV CKGATSYITH IDWDSRGKLL QVNTGAKEQL
1160 1170 1180 1190 1200
FFEAPRGKRQ TIPSVEVEKI SWATWTSVLG LCCEGIWPVI GEVTEVTASC
1210 1220 1230 1240 1250
LTSDKMVLAT GDDLGFVKLF RYPAKGKFGK FKKYVAHSTH VTNVRWTYDD
1260 1270 1280 1290 1300
SMLVTLGGAD MSLMVWTNEV ESHREKKYCD SEESDIDSEE DGGYDSDVTR
1310 1320 1330 1340 1350
ENEISYTIRA LSTNIRPMFG VKPHLQQKEP SVDERQGVVR GSRPPVSRAP
1360 1370 1380 1390 1400
PQPEKLQSNN VGKKKRPIED LVLELAFGYR GRDCRNNVHY LNDGDDIIYH
1410 1420 1430 1440 1450
TASIGILHNV ATGTQSFYQE HNDDILCLTV NQHPKFINIV ATGQVGDSAD
1460 1470 1480 1490 1500
MSATAPSVHI WDAVNKQTLS ILRCSHSKGV CSVSFSATGK LLLSVGLDPE
1510 1520 1530 1540 1550
HTVTIWRWQE GAKIASRGGH NQRIFVAEFR PDSDTQFVSV GIKHVKFWTL
1560 1570 1580 1590 1600
AGRALLSKKG LLSSLEDARM QTMLAVAFGA NNLTFTGTIS GDVCVWKDHI
1610 1620 1630 1640 1650
LCRVVARAHN GPVFAMYTTL RDGLIVTGGK ERPSKEGGAV KLWDQELRRC
1660 1670 1680 1690 1700
RAFRLETGQV TDCVRSVCRG KGKILVGTRN SEIIEVGEKN AACNILVNGH
1710 1720 1730 1740 1750
VDGPIWGLAT HPSRDFFLSA AEDGTVRLWD IADKKMLNKV NLGHAARTVC
1760 1770 1780 1790 1800
YSPEGDMVAI GMKNGEFIIL LVSSLKIWGK KRDRRCAIHD IRFSPDSRYL
1810 1820 1830 1840 1850
AVGSSENSVD FYDLTLGPTL NRISYCKDIP SFVIQMDFSA DSRHLQVSSG
1860 1870 1880 1890 1900
CYKRHVYEVP SGKHLVDHAA IDRITWATWT SILGDEVMGI WSRHAEKADV
1910 1920 1930 1940 1950
TCACVSHSGI SLVTGDDFGM VKLYDFPCPE KFAKHKRFLG HSPHVTNIRF
1960 1970
TSGDRHVVSA GGDDCSLFVW KCVHMPH
Length:1,977
Mass (Da):220,106
Last modified:April 17, 2007 - v2
Checksum:i92111219F74E8427
GO

Sequence cautioni

The sequence BAC31743 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC33148 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1648 – 1676RRCRA…GKILV → GDAGPSGLRQDKSQIVFGLC AEAKARYYL in BAC31743 (PubMed:16141072).CuratedAdd BLAST29
Sequence conflicti1668 – 1671CRGK → FVFQ in AAH27154 (PubMed:15489334).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159193 Genomic DNA. No translation available.
AK044024 mRNA. Translation: BAC31743.1. Different initiation.
AK047762 mRNA. Translation: BAC33148.1. Different initiation.
BC027154 mRNA. Translation: AAH27154.1.
CCDSiCCDS36519.1.
RefSeqiNP_001074660.1. NM_001081191.1.
UniGeneiMm.390484.
Mm.446675.
Mm.447154.
Mm.463212.

Genome annotation databases

EnsembliENSMUST00000065716; ENSMUSP00000065643; ENSMUSG00000051166.
GeneIDi319670.
KEGGimmu:319670.
UCSCiuc007orn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159193 Genomic DNA. No translation available.
AK044024 mRNA. Translation: BAC31743.1. Different initiation.
AK047762 mRNA. Translation: BAC33148.1. Different initiation.
BC027154 mRNA. Translation: AAH27154.1.
CCDSiCCDS36519.1.
RefSeqiNP_001074660.1. NM_001081191.1.
UniGeneiMm.390484.
Mm.446675.
Mm.447154.
Mm.463212.

3D structure databases

ProteinModelPortaliQ8BQM8.
SMRiQ8BQM8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065643.

PTM databases

iPTMnetiQ8BQM8.
PhosphoSitePlusiQ8BQM8.

Proteomic databases

MaxQBiQ8BQM8.
PaxDbiQ8BQM8.
PRIDEiQ8BQM8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065716; ENSMUSP00000065643; ENSMUSG00000051166.
GeneIDi319670.
KEGGimmu:319670.
UCSCiuc007orn.1. mouse.

Organism-specific databases

CTDi161436.
MGIiMGI:2442513. Eml5.

Phylogenomic databases

eggNOGiKOG2106. Eukaryota.
ENOG410XNTQ. LUCA.
GeneTreeiENSGT00550000074369.
HOGENOMiHOG000031037.
HOVERGENiHBG107846.
InParanoidiQ8BQM8.
KOiK18597.
OMAiPEKLQTN.
OrthoDBiEOG091G00FB.
PhylomeDBiQ8BQM8.
TreeFamiTF317832.

Miscellaneous databases

PROiQ8BQM8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051166.
CleanExiMM_EML5.
GenevisibleiQ8BQM8. MM.

Family and domain databases

Gene3Di2.130.10.10. 9 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR005108. HELP.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 2 hits.
PF03451. HELP. 3 hits.
PF00400. WD40. 8 hits.
[Graphical view]
SMARTiSM00320. WD40. 29 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 10 hits.
SSF50998. SSF50998. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEMAL5_MOUSE
AccessioniPrimary (citable) accession number: Q8BQM8
Secondary accession number(s): Q8BRL0, Q8R2W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.