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Protein

HEAT repeat-containing protein 3

Gene

Heatr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
HEAT repeat-containing protein 3
Gene namesi
Name:Heatr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2444491. Heatr3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 679679HEAT repeat-containing protein 3PRO_0000050822Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151PhosphoserineCombined sources
Modified residuei144 – 1441PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BQM4.
MaxQBiQ8BQM4.
PaxDbiQ8BQM4.
PRIDEiQ8BQM4.

PTM databases

iPTMnetiQ8BQM4.
PhosphoSiteiQ8BQM4.

Expressioni

Gene expression databases

BgeeiQ8BQM4.
CleanExiMM_HEATR3.
ExpressionAtlasiQ8BQM4. baseline and differential.
GenevisibleiQ8BQM4. MM.

Interactioni

Protein-protein interaction databases

BioGridi231539. 1 interaction.
STRINGi10090.ENSMUSP00000034079.

Structurei

3D structure databases

ProteinModelPortaliQ8BQM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati38 – 6932HEAT 1Add
BLAST
Repeati74 – 11037HEAT 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 276Poly-Ala

Sequence similaritiesi

Contains 2 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGCR. Eukaryota.
ENOG410Y5P1. LUCA.
GeneTreeiENSGT00390000012529.
HOGENOMiHOG000008167.
HOVERGENiHBG047958.
InParanoidiQ8BQM4.
OMAiQTMASKN.
OrthoDBiEOG7S7SD8.
PhylomeDBiQ8BQM4.
TreeFamiTF324159.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Q8BQM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKSRTKRFK RPQFSPIESC QAEAAAASNG TGDEEDDGPA AELLEKLQHP
60 70 80 90 100
SAEVRECACA GLARLVQQRP ALPDLARRDA VRRLGPLLLD SSLAVRETAA
110 120 130 140 150
GALRNLSACG GFDVCDDMVA KDIMTPLVAL LRECLSGLDS NEMSPQEKAD
160 170 180 190 200
KRNPVESIAN EAVNVLWNVC ECSGRAVSIF NKEGCLEIVL QYLRRFPTSI
210 220 230 240 250
DLAVSVAYCL QTVTEDNPEL LKSFDGTALR VLESALLCPV ASMEYILLKT
260 270 280 290 300
LVAGTIWNLK DIIPSKSQAE IINAILGALS EVLGMNTGNM VIQMKEAETQ
310 320 330 340 350
RLKTAAESED ILANANGDDL VEDDEMEEIP HKRKLRRKTF ISDLLPPTDK
360 370 380 390 400
ELREAMALLT AQQTALEVIV NMCCSEDPSD DEWEELSSSD ESEAFMENSF
410 420 430 440 450
SECSGHLMSP LCLSHEIHSA LTNCLIPEKV FEKTSSPNSV AVDICSKNPT
460 470 480 490 500
WKPLIRKMNT IQCRALMCLQ SLVSLLDIDH LGGAPALQTL AQHLSQILFS
510 520 530 540 550
QPDFAKHDDF LEAISSALRA LLQTMASKNI PQCMTPEQLM TLCREGIHSS
560 570 580 590 600
SIGVRVNVVS ILGITGSVLA KDDGTLDTLK TIGCFLLEVA TKDPSLVVTG
610 620 630 640 650
EALDALFDVF ADGEAAEKAS VQIKLLAALK EFQPVFKMKI RKEGRGKYSP
660 670
DQLCVLDNVK MNLRRFIAYQ ETVEKRLTS
Length:679
Mass (Da):74,305
Last modified:March 1, 2003 - v1
Checksum:iEC4C3A5665DD241E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti282 – 2821V → A in BAC35071 (PubMed:16141072).Curated
Sequence conflicti467 – 4671M → I in BAC35071 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047782 mRNA. Translation: BAC33155.1.
AK052635 mRNA. Translation: BAC35071.1.
BC065060 mRNA. Translation: AAH65060.1.
CCDSiCCDS22508.1.
RefSeqiNP_766345.3. NM_172757.3.
UniGeneiMm.36291.

Genome annotation databases

EnsembliENSMUST00000034079; ENSMUSP00000034079; ENSMUSG00000031657.
GeneIDi234549.
KEGGimmu:234549.
UCSCiuc009mrc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047782 mRNA. Translation: BAC33155.1.
AK052635 mRNA. Translation: BAC35071.1.
BC065060 mRNA. Translation: AAH65060.1.
CCDSiCCDS22508.1.
RefSeqiNP_766345.3. NM_172757.3.
UniGeneiMm.36291.

3D structure databases

ProteinModelPortaliQ8BQM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231539. 1 interaction.
STRINGi10090.ENSMUSP00000034079.

PTM databases

iPTMnetiQ8BQM4.
PhosphoSiteiQ8BQM4.

Proteomic databases

EPDiQ8BQM4.
MaxQBiQ8BQM4.
PaxDbiQ8BQM4.
PRIDEiQ8BQM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034079; ENSMUSP00000034079; ENSMUSG00000031657.
GeneIDi234549.
KEGGimmu:234549.
UCSCiuc009mrc.1. mouse.

Organism-specific databases

CTDi55027.
MGIiMGI:2444491. Heatr3.

Phylogenomic databases

eggNOGiENOG410IGCR. Eukaryota.
ENOG410Y5P1. LUCA.
GeneTreeiENSGT00390000012529.
HOGENOMiHOG000008167.
HOVERGENiHBG047958.
InParanoidiQ8BQM4.
OMAiQTMASKN.
OrthoDBiEOG7S7SD8.
PhylomeDBiQ8BQM4.
TreeFamiTF324159.

Miscellaneous databases

ChiTaRSiHeatr3. mouse.
PROiQ8BQM4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BQM4.
CleanExiMM_HEATR3.
ExpressionAtlasiQ8BQM4. baseline and differential.
GenevisibleiQ8BQM4. MM.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpus striatum and Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-144, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiHEAT3_MOUSE
AccessioniPrimary (citable) accession number: Q8BQM4
Secondary accession number(s): Q8C731
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.