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Protein

Phostensin

Gene

Ppp1r18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May target protein phosphatase 1 to F-actin cytoskeleton.By similarity

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phostensin
Alternative name(s):
Protein phosphatase 1 F-actin cytoskeleton-targeting subunit
Protein phosphatase 1 regulatory subunit 18
Gene namesi
Name:Ppp1r18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1923698. Ppp1r18.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508091 – 594PhostensinAdd BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126PhosphoserineBy similarity1
Modified residuei134PhosphoserineBy similarity1
Modified residuei174PhosphoserineBy similarity1
Modified residuei194PhosphoserineCombined sources1
Modified residuei198PhosphothreonineBy similarity1
Modified residuei224PhosphoserineBy similarity1
Modified residuei412PhosphoserineCombined sources1
Modified residuei437N6-acetyllysineCombined sources1
Modified residuei510PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BQ30.
PaxDbiQ8BQ30.
PeptideAtlasiQ8BQ30.
PRIDEiQ8BQ30.

PTM databases

iPTMnetiQ8BQ30.
PhosphoSitePlusiQ8BQ30.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034595.
CleanExiMM_2310014H01RIK.
ExpressionAtlasiQ8BQ30. baseline and differential.
GenevisibleiQ8BQ30. MM.

Interactioni

Subunit structurei

Interacts with Protein phosphatase 1 (PP1).By similarity

Protein-protein interaction databases

BioGridi218132. 1 interactor.
IntActiQ8BQ30. 2 interactors.
STRINGi10090.ENSMUSP00000109445.

Structurei

3D structure databases

ProteinModelPortaliQ8BQ30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi96 – 105Poly-Gln10

Phylogenomic databases

eggNOGiENOG410IJQY. Eukaryota.
ENOG410ZUB8. LUCA.
GeneTreeiENSGT00530000064035.
HOGENOMiHOG000088614.
HOVERGENiHBG080180.
InParanoidiQ8BQ30.
KOiK17559.
OMAiWTPRDTE.
OrthoDBiEOG091G0B2C.
PhylomeDBiQ8BQ30.
TreeFamiTF337604.

Family and domain databases

InterProiIPR025903. Phostensin/Taperin_N_dom.
IPR025907. Phostensin/Taperin_PP1-bd_dom.
IPR026671. PPP1R18/Tprn.
[Graphical view]
PANTHERiPTHR21685. PTHR21685. 1 hit.
PfamiPF13914. Phostensin. 1 hit.
PF13916. Phostensin_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BQ30-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAIPDWKLQ LLARRRQEEA AVRGREKAER DRLSQMPAWK RGILERRRAK
60 70 80 90 100
LGLPPGEGSP VPGNAEAGPP DPDESAVLLE AIGPVHQNRF IQQERQRQQQ
110 120 130 140 150
QQQQQRNEVL GDRKAGPLEV LERRSSPGNL RDQSPKGRES REERLSPRES
160 170 180 190 200
RDRRLVIGGA QESSSRSLRD WRQSPAEARD LSSRPAEAQK WRLSPGETPE
210 220 230 240 250
ESLRLAGSGD DSPKRKEVLE SILSPGEPGD QKASPTDVHK WNLDSREPQK
260 270 280 290 300
QSLIQLEATE WRLKSGEERK DYLEGCGREE EKLSSGIVPV TKEVQDITSS
310 320 330 340 350
EVETAEQRPT ESWKWTLNSG KARERTTWDI DTQTQKPDPP ASSEKHPGPS
360 370 380 390 400
GMEAEEEAEK EEAEAQSRPL RAQQNLCSGP SPLPPEHSGT EGSRQQEEEA
410 420 430 440 450
AEPRPPTPAP LSPPPSAPTA PQPSGDPLMS RLFYGVKPGP GVGAPRRSGH
460 470 480 490 500
TFTVNPRRCA PPASPAPPVN PATADAAGSG SGKKRYPTAE EILVLGGYLR
510 520 530 540 550
LSRSCLVKGS PERHHKQLKI SFSETALETT YQYPSESSVL EDLGPEPETP
560 570 580 590
IAPLATQPDE EEEEEEEEEE LLLQPGLQGG LRTKALIVDE SCRR
Length:594
Mass (Da):65,630
Last modified:March 1, 2003 - v1
Checksum:i6B7B10B39C5B44BA
GO
Isoform 2 (identifier: Q8BQ30-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     589-594: DESCRR → GKRLRPGWRRAPPGVCGVVVL

Show »
Length:609
Mass (Da):67,139
Checksum:iFCCF8597C7C96CD6
GO

Sequence cautioni

The sequence AAH25573 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti278R → I in AAH25573 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014260589 – 594DESCRR → GKRLRPGWRRAPPGVCGVVV L in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009340 mRNA. Translation: BAC25252.1.
AK051656 mRNA. Translation: BAC34706.1.
AK149943 mRNA. Translation: BAE29185.1.
CR974451 Genomic DNA. Translation: CAX15752.1.
CR974451 Genomic DNA. Translation: CAX15753.1.
BC025573 mRNA. Translation: AAH25573.1. Different initiation.
CCDSiCCDS50094.1. [Q8BQ30-1]
RefSeqiNP_001140182.1. NM_001146710.1. [Q8BQ30-1]
NP_001140183.1. NM_001146711.1. [Q8BQ30-1]
NP_780451.1. NM_175242.1. [Q8BQ30-1]
XP_006525155.2. XM_006525092.3. [Q8BQ30-2]
UniGeneiMm.359982.
Mm.421125.

Genome annotation databases

EnsembliENSMUST00000113814; ENSMUSP00000109445; ENSMUSG00000034595. [Q8BQ30-1]
ENSMUST00000122899; ENSMUSP00000120343; ENSMUSG00000034595. [Q8BQ30-1]
ENSMUST00000127442; ENSMUSP00000115753; ENSMUSG00000034595. [Q8BQ30-2]
ENSMUST00000144382; ENSMUSP00000116100; ENSMUSG00000034595. [Q8BQ30-1]
ENSMUST00000187690; ENSMUSP00000141094; ENSMUSG00000034595. [Q8BQ30-1]
GeneIDi76448.
KEGGimmu:76448.
UCSCiuc008cit.2. mouse. [Q8BQ30-2]
uc008ciu.2. mouse. [Q8BQ30-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009340 mRNA. Translation: BAC25252.1.
AK051656 mRNA. Translation: BAC34706.1.
AK149943 mRNA. Translation: BAE29185.1.
CR974451 Genomic DNA. Translation: CAX15752.1.
CR974451 Genomic DNA. Translation: CAX15753.1.
BC025573 mRNA. Translation: AAH25573.1. Different initiation.
CCDSiCCDS50094.1. [Q8BQ30-1]
RefSeqiNP_001140182.1. NM_001146710.1. [Q8BQ30-1]
NP_001140183.1. NM_001146711.1. [Q8BQ30-1]
NP_780451.1. NM_175242.1. [Q8BQ30-1]
XP_006525155.2. XM_006525092.3. [Q8BQ30-2]
UniGeneiMm.359982.
Mm.421125.

3D structure databases

ProteinModelPortaliQ8BQ30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218132. 1 interactor.
IntActiQ8BQ30. 2 interactors.
STRINGi10090.ENSMUSP00000109445.

PTM databases

iPTMnetiQ8BQ30.
PhosphoSitePlusiQ8BQ30.

Proteomic databases

EPDiQ8BQ30.
PaxDbiQ8BQ30.
PeptideAtlasiQ8BQ30.
PRIDEiQ8BQ30.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113814; ENSMUSP00000109445; ENSMUSG00000034595. [Q8BQ30-1]
ENSMUST00000122899; ENSMUSP00000120343; ENSMUSG00000034595. [Q8BQ30-1]
ENSMUST00000127442; ENSMUSP00000115753; ENSMUSG00000034595. [Q8BQ30-2]
ENSMUST00000144382; ENSMUSP00000116100; ENSMUSG00000034595. [Q8BQ30-1]
ENSMUST00000187690; ENSMUSP00000141094; ENSMUSG00000034595. [Q8BQ30-1]
GeneIDi76448.
KEGGimmu:76448.
UCSCiuc008cit.2. mouse. [Q8BQ30-2]
uc008ciu.2. mouse. [Q8BQ30-1]

Organism-specific databases

CTDi170954.
MGIiMGI:1923698. Ppp1r18.

Phylogenomic databases

eggNOGiENOG410IJQY. Eukaryota.
ENOG410ZUB8. LUCA.
GeneTreeiENSGT00530000064035.
HOGENOMiHOG000088614.
HOVERGENiHBG080180.
InParanoidiQ8BQ30.
KOiK17559.
OMAiWTPRDTE.
OrthoDBiEOG091G0B2C.
PhylomeDBiQ8BQ30.
TreeFamiTF337604.

Miscellaneous databases

PROiQ8BQ30.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034595.
CleanExiMM_2310014H01RIK.
ExpressionAtlasiQ8BQ30. baseline and differential.
GenevisibleiQ8BQ30. MM.

Family and domain databases

InterProiIPR025903. Phostensin/Taperin_N_dom.
IPR025907. Phostensin/Taperin_PP1-bd_dom.
IPR026671. PPP1R18/Tprn.
[Graphical view]
PANTHERiPTHR21685. PTHR21685. 1 hit.
PfamiPF13914. Phostensin. 1 hit.
PF13916. Phostensin_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPR18_MOUSE
AccessioniPrimary (citable) accession number: Q8BQ30
Secondary accession number(s): B8JJ63
, B8JJ64, Q3UDS6, Q8CEY9, Q8R3D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.