Unreviewed, UniProtKB/TrEMBL Q8BQ28 (Q8BQ28_MOUSE)

Names and origin

Protein names

Submitted name:
    Putative uncharacterized protein EMBL BAC34709.1

Gene names

Name:

Nck2 MGI 1306821

Organism

Mus musculus (Mouse) EMBL BAC34709.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 1 SH2 domain. Contains 3 SH3 domains.

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338V3
Gene Ontology (GO)
Biological process	actin filament organization Inferred from mutant phenotype. Source: MGI cell migration Inferred from mutant phenotype. Source: MGI lamellipodium assembly Inferred from mutant phenotype. Source: MGI positive regulation of T cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of actin filament polymerization Inferred from electronic annotation. Source: Compara
Cellular component	vesicle membrane Inferred from direct assay. Source: MGI
Molecular function	protein binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8BQ28-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 7B3404B976EA14E6	FASTA	380	42,863
	10 20 30 40 50 60 MTEEVIVIAK WDYTAQQDQE LDIRKNERLW LLDDSKTWWR VRNAANRTGY VPSNYVERKN 70 80 90 100 110 120 SLKKGSLVKN LKDTLGLGKT RRKPSARDAS PTPSTDAEYP ANGSGADRIY DLNIPAFVKF 130 140 150 160 170 180 AYVAEREDEL SLVKGSRVTV MEKCSDGWWR GSFNGQIGWF PSNYVLEEAD EAAAEAPSFL 190 200 210 220 230 240 SLRRGTALSN GQGARVLHVV QTLYPFSSVT EEELSFEKGE TMEVIEKPEN DPEWWKCKNA 250 260 270 280 290 300 RGQVGLVPKN YVVVLSDGPA LHPAHTPQIS YTGPSASGRF AGREWYYGNV TRHQAECALN 310 320 330 340 350 360 ERGVEGDFLI RDSESSPSDF SVSLKASGRN KHFKVQLVDS VYSIGQRRFH SMDELVEHYK 370 380 KAPIFTSEHG EKLYLVRALQ

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J EMBL BAC34709.1. Tissue: Spinal ganglion EMBL BAC34709.1.
[2]	"Phosphoproteomic analysis of the developing mouse brain." Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P. Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed: 15345747] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[3]	"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling." Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R. J. Immunol. 179:5864-5876(2007) [PubMed: 17947660] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[4]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed: 18034455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK051665 mRNA. Translation: BAC34709.1.
IPI	IPI00309413.
RefSeq	NP_035009.3.
UniGene	Mm.389903 Mm.476455
3D structure databases
HSSP	HSSP built from PDB template 2HSP based on UniProtKB P19174.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8BQ28.
Proteomic databases
PRIDE	Q8BQ28.
Genome annotation databases
Ensembl	ENSMUST00000086421; ENSMUSP00000083611; ENSMUSG00000066877; Mus musculus. [Genome view] ENSMUST00000114744; ENSMUSP00000110392; ENSMUSG00000066877; Mus musculus. [Genome view]
GeneID	17974.
KEGG	mmu:17974.
Organism-specific databases
CTD	17974.
MGI	MGI:1306821. Nck2.
Phylogenomic databases
HOVERGEN	Q8BQ28.
InParanoid	Q8BQ28.
Gene expression databases
ArrayExpress	Q8BQ28.
Bgee	Q8BQ28.
Genevestigator	Q8BQ28.
Family and domain databases
InterPro	IPR017304. Cytoplasmic_NCK. IPR000980. SH2. IPR001452. SH3_domain. IPR020473. SH3_region. [Graphical view]
Gene3D	G3DSA:3.30.505.10. SH2. 1 hit.
Pfam	PF00017. SH2. 1 hit. PF00018. SH3_1. 3 hits. [Graphical view]
PIRSF	PIRSF037874. Cytoplasmic_NCK. 1 hit.
PRINTS	PR00401. SH2DOMAIN. PR00452. SH3DOMAIN.
SMART	SM00252. SH2. 1 hit. SM00326. SH3. 3 hits. [Graphical view]
PROSITE	PS50001. SH2. 1 hit. PS50002. SH3. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

Q8BQ28_MOUSE

Accession

Primary (citable) accession number: Q8BQ28

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	February 9, 2010
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)