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Q8BQ27 (Q8BQ27_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Foxp2 MGI 2148705
OrganismMus musculus (Mouse) EMBL BAC34711.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length586 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains fork-head DNA-binding domain. SAAS SAAS001766

Ontologies

Keywords
   LigandDNA-binding SAAS SAAS001766
Gene Ontology (GO)
   Biological_processcamera-type eye development

Inferred from mutant phenotype PubMed 17619227. Source: MGI

caudate nucleus development

Inferred from Biological aspect of Ancestor. Source: RefGenome

cerebellum development

Inferred from mutant phenotype PubMed 15983371PubMed 17619227. Source: MGI

cerebral cortex development

Inferred from Biological aspect of Ancestor. Source: RefGenome

growth

Inferred from mutant phenotype PubMed 17619227. Source: MGI

lung alveolus development

Inferred from mutant phenotype PubMed 17428829. Source: MGI

lung development

Inferred from genetic interaction PubMed 17428829. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 14701752PubMed 17428829. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 11358962. Source: MGI

pattern specification process

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of epithelial cell proliferation

Inferred from genetic interaction PubMed 17428829. Source: MGI

positive regulation of epithelial cell proliferation involved in lung morphogenesis

Inferred from genetic interaction PubMed 17428829. Source: MGI

positive regulation of mesenchymal cell proliferation

Inferred from genetic interaction PubMed 17428829. Source: MGI

post-embryonic development

Inferred from mutant phenotype PubMed 17619227. Source: MGI

putamen development

Inferred from Biological aspect of Ancestor. Source: RefGenome

righting reflex

Inferred from mutant phenotype PubMed 17619227. Source: MGI

skeletal muscle tissue development

Inferred from genetic interaction PubMed 17428829. Source: MGI

smooth muscle tissue development

Inferred from genetic interaction PubMed 17428829. Source: MGI

vocal learning

Inferred from mutant phenotype PubMed 15983371. Source: MGI

   Cellular_componentcytoplasm

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionDNA binding

Inferred from direct assay PubMed 14701752. Source: MGI

DNA binding, bending

Inferred from Biological aspect of Ancestor. Source: RefGenome

chromatin binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein heterodimerization activity

Inferred from physical interaction PubMed 14701752. Source: MGI

protein homodimerization activity

Inferred from physical interaction PubMed 14701752. Source: MGI

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 17428829. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8BQ27 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: F75391FFBB2A98E3

FASTA58666,107
        10         20         30         40         50         60 
MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL HLQQQQALQA 

        70         80         90        100        110        120 
ARQLLLQQQT SGLKSPKSSE KQRPLQVPVS VAMMTPQVIT PQQMQQILQQ QVLSPQQLQA 

       130        140        150        160        170        180 
LLQQQQAVML QQSKWFIQQQ LQEFYKKQQE QLHLQLLQQQ QQQQQQQQQQ QQQQQQQQQQ 

       190        200        210        220        230        240 
QQQQQQQQQQ QQQQQQQQHP GKQAKEQQQQ QQQQQLAAQQ LVFQQQLLQM QQLQQQQHLL 

       250        260        270        280        290        300 
SLQRQGLISI PPGQAALPVQ SLPQAGLSPA EIQQLWKEVT GVHSMEDNGI KHGGLDLTTN 

       310        320        330        340        350        360 
NSSSTTSSTT SKASPPITHH SIVNGQSSVL NARRDSSSHE ETGASHTLYG HGVCKWPGCE 

       370        380        390        400        410        420 
SICEDFGQFL KHLNNEHALD DRSTAQCRVQ MQVVQQLEIQ LSKERERLQA MMTHLHMRPS 

       430        440        450        460        470        480 
EPKPSPKPLN LVSSVTMSKN MLETSPQSLP QTPTTPTAPV TPITQGPSVI TPASVPNVGA 

       490        500        510        520        530        540 
IRRRHSDKYN IPMSSEIAPN YEFYKNADVR PPFTYATLIR QAIMESSDRQ LTLNEIYSWF 

       550        560        570        580 
TRTFAYFRRN AATWKVTPKS SCSPSETQHS SFQIAPGAFI YMTQAD 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC34711.1.
Tissue: Spinal ganglion EMBL BAC34711.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC34711.1.
Tissue: Spinal ganglion EMBL BAC34711.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC34711.1.
Tissue: Spinal ganglion EMBL BAC34711.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC34711.1.
Tissue: Spinal ganglion EMBL BAC34711.1.
[5]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC34711.1.
Tissue: Spinal ganglion EMBL BAC34711.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC34711.1.
Tissue: Spinal ganglion EMBL BAC34711.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC34711.1.
Tissue: Spinal ganglion EMBL BAC34711.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC34711.1.
Tissue: Spinal ganglion EMBL BAC34711.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK051668 mRNA. Translation: BAC34711.1.
UniGeneMm.332919.

3D structure databases

ProteinModelPortalQ8BQ27.
SMRQ8BQ27. Positions 509-555.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:2148705. Foxp2.

Phylogenomic databases

HOVERGENHBG051657.

Gene expression databases

GenevestigatorQ8BQ27.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR011991. WHTH_DNA-bd_dom.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEPS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFOXP2. mouse.
SOURCESearch...

Entry information

Entry nameQ8BQ27_MOUSE
AccessionPrimary (citable) accession number: Q8BQ27
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)