Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fidgetin-like protein 1

Gene

Fignl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei413 – 4131ATP; via amide nitrogen and carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi453 – 4586ATPBy similarity

GO - Molecular functioni

GO - Biological processi

  • ATP metabolic process Source: UniProtKB
  • cellular response to ionizing radiation Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of intrinsic apoptotic signaling pathway Source: MGI
  • osteoblast differentiation Source: UniProtKB
  • osteoblast proliferation Source: UniProtKB
  • regulation of cell cycle Source: UniProtKB
  • regulation of double-strand break repair via homologous recombination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fidgetin-like protein 1 (EC:3.6.4.-)
Gene namesi
Name:Fignl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1890648. Fignl1.

Subcellular locationi

  • Nucleus By similarity

  • Note: Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) treatment.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: MGI
  • nuclear chromosome Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 683683Fidgetin-like protein 1PRO_0000302724Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei348 – 3481N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BPY9.
MaxQBiQ8BPY9.
PaxDbiQ8BPY9.
PRIDEiQ8BPY9.

PTM databases

iPTMnetiQ8BPY9.
PhosphoSiteiQ8BPY9.

Expressioni

Gene expression databases

BgeeiQ8BPY9.
CleanExiMM_FIGNL1.
ExpressionAtlasiQ8BPY9. baseline and differential.
GenevisibleiQ8BPY9. MM.

Interactioni

Subunit structurei

Hexamer. Interacts (via N-terminal one-half region) with RAD51; the interaction is direct. Interacts (via N-terminal one-half region) with SPIDR (via the C-terminal region); the interaction is direct (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036932.

Structurei

3D structure databases

ProteinModelPortaliQ8BPY9.
SMRiQ8BPY9. Positions 347-683.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminus is necessary for its recruitment to DNA damage sites.By similarity

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0740. Eukaryota.
COG0464. LUCA.
GeneTreeiENSGT00570000078874.
HOGENOMiHOG000225145.
HOVERGENiHBG061204.
InParanoidiQ8BPY9.
OMAiQILRIQY.
OrthoDBiEOG7GXPCR.
PhylomeDBiQ8BPY9.
TreeFamiTF105013.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BPY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSSSMSVE TTRSVQVDEW QKNYCVVTSS ICTPKQKADA YRALLLHIQY
60 70 80 90 100
AYANSEISQV FATNLFKRYT EKYSAIIDSD NVVTGLNNYA ESIFALAGSR
110 120 130 140 150
QADSNKWQSG LSIDNVFKMS CVQEMMQAGK KFEESLLEPA DASVVLCKEP
160 170 180 190 200
TAFEVPQLSV CGGSEDADIL SSSGHDTDKT QAIPGSSLRC SPFQSARLPK
210 220 230 240 250
ETNTTKTCLT SSTSLGESAT AAFHMTPLFG NTEKDTQSFP KTSTGLNMFL
260 270 280 290 300
SNLSCVPSGC ENPQERKAFN DSDIIDILSN PTLNKAPSKT EDRGRREDNS
310 320 330 340 350
LPTFKTAKEQ LWVDQKKKGH QSQHTSKSSN GVMKKSLGAG RSRGIFGKFV
360 370 380 390 400
PPVSNKQDGS EQHAKKHKSS RAGSAEPAHL TDDCLKNVEP RMVELIMNEI
410 420 430 440 450
MDHGPPVHWD DIAGVEFAKA TIKEIVVWPM MRPDIFTGLR GPPKGILLFG
460 470 480 490 500
PPGTGKTLIG KCIASQSGAT FFSISASSLT SKWVGEGEKM VRALFAVARC
510 520 530 540 550
QQPAVIFIDE IDSLLSQRGD GEHESSRRIK TEFLVQLDGA TTSSEDRILV
560 570 580 590 600
VGATNRPQEI DEAARRRLVK RLYIPLPEAS ARKQIVGNLM SKEQCCLSDE
610 620 630 640 650
ETDLVVQQSD GFSGADMTQL CREASLGPIR SLHAADIATI SPDQVRPIAY
660 670 680
IDFENAFKTV RPTVSPKDLE LYENWNETFG CGK
Length:683
Mass (Da):74,850
Last modified:March 1, 2003 - v1
Checksum:i17DE9C0738344F4C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti386 – 3861K → R in BAC40431 (PubMed:16141072).Curated
Sequence conflicti396 – 3961I → V in AAG17290 (PubMed:11017077).Curated
Sequence conflicti678 – 6781T → A in BAC40431 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263914 mRNA. Translation: AAG17290.1.
AK088574 mRNA. Translation: BAC40431.1.
AK051874 mRNA. Translation: BAC34796.1.
AK143850 mRNA. Translation: BAE25569.1.
AK148994 mRNA. Translation: BAE28713.1.
AL596450 Genomic DNA. Translation: CAI25376.1.
BC051942 mRNA. Translation: AAH51942.1.
BC052415 mRNA. Translation: AAH52415.1.
CCDSiCCDS24438.1.
RefSeqiNP_001156831.1. NM_001163359.1.
NP_001156832.1. NM_001163360.1.
NP_068691.2. NM_021891.3.
XP_011242040.1. XM_011243738.1.
UniGeneiMm.236114.

Genome annotation databases

EnsembliENSMUST00000047689; ENSMUSP00000036932; ENSMUSG00000035455.
ENSMUST00000109664; ENSMUSP00000105290; ENSMUSG00000035455.
ENSMUST00000171080; ENSMUSP00000127489; ENSMUSG00000035455.
ENSMUST00000171938; ENSMUSP00000126340; ENSMUSG00000035455.
GeneIDi60530.
KEGGimmu:60530.
UCSCiuc007ias.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263914 mRNA. Translation: AAG17290.1.
AK088574 mRNA. Translation: BAC40431.1.
AK051874 mRNA. Translation: BAC34796.1.
AK143850 mRNA. Translation: BAE25569.1.
AK148994 mRNA. Translation: BAE28713.1.
AL596450 Genomic DNA. Translation: CAI25376.1.
BC051942 mRNA. Translation: AAH51942.1.
BC052415 mRNA. Translation: AAH52415.1.
CCDSiCCDS24438.1.
RefSeqiNP_001156831.1. NM_001163359.1.
NP_001156832.1. NM_001163360.1.
NP_068691.2. NM_021891.3.
XP_011242040.1. XM_011243738.1.
UniGeneiMm.236114.

3D structure databases

ProteinModelPortaliQ8BPY9.
SMRiQ8BPY9. Positions 347-683.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036932.

PTM databases

iPTMnetiQ8BPY9.
PhosphoSiteiQ8BPY9.

Proteomic databases

EPDiQ8BPY9.
MaxQBiQ8BPY9.
PaxDbiQ8BPY9.
PRIDEiQ8BPY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047689; ENSMUSP00000036932; ENSMUSG00000035455.
ENSMUST00000109664; ENSMUSP00000105290; ENSMUSG00000035455.
ENSMUST00000171080; ENSMUSP00000127489; ENSMUSG00000035455.
ENSMUST00000171938; ENSMUSP00000126340; ENSMUSG00000035455.
GeneIDi60530.
KEGGimmu:60530.
UCSCiuc007ias.2. mouse.

Organism-specific databases

CTDi63979.
MGIiMGI:1890648. Fignl1.

Phylogenomic databases

eggNOGiKOG0740. Eukaryota.
COG0464. LUCA.
GeneTreeiENSGT00570000078874.
HOGENOMiHOG000225145.
HOVERGENiHBG061204.
InParanoidiQ8BPY9.
OMAiQILRIQY.
OrthoDBiEOG7GXPCR.
PhylomeDBiQ8BPY9.
TreeFamiTF105013.

Miscellaneous databases

PROiQ8BPY9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BPY9.
CleanExiMM_FIGNL1.
ExpressionAtlasiQ8BPY9. baseline and differential.
GenevisibleiQ8BPY9. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development."
    Cox G.A., Mahaffey C.L., Nystuen A., Letts V.A., Frankel W.N.
    Nat. Genet. 26:198-202(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Eye, Spleen, Sympathetic ganglion and Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  5. "Fidgetin-like 1 gene inhibited by basic fibroblast growth factor regulates the proliferation and differentiation of osteoblasts."
    Park S.J., Kim S.J., Rhee Y., Byun J.H., Kim S.H., Kim M.H., Lee E.J., Lim S.K.
    J. Bone Miner. Res. 22:889-896(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiFIGL1_MOUSE
AccessioniPrimary (citable) accession number: Q8BPY9
Secondary accession number(s): Q3UF48, Q8C2I6, Q9ERZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.