ID   Q8BPV5_MOUSE            Unreviewed;       218 AA.
AC   Q8BPV5;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 116.
DE   RecName: Full=Amyloid-beta A4 protein {ECO:0000256|RuleBase:RU367156};
DE   Flags: Fragment;
GN   Name=App {ECO:0000313|MGI:MGI:88059};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC34997.1};
RN   [1] {ECO:0000313|EMBL:BAC34997.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC34997.1};
RC   TISSUE=Lung {ECO:0000313|EMBL:BAC34997.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2] {ECO:0000313|EMBL:BAC34997.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC34997.1};
RC   TISSUE=Lung {ECO:0000313|EMBL:BAC34997.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT   full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [3] {ECO:0000313|EMBL:BAC34997.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC34997.1};
RC   TISSUE=Lung {ECO:0000313|EMBL:BAC34997.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA   Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA   Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA   Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA   Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA   Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT   pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [4] {ECO:0000313|EMBL:BAC34997.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC34997.1};
RC   TISSUE=Lung {ECO:0000313|EMBL:BAC34997.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [5] {ECO:0000313|EMBL:BAC34997.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC34997.1};
RC   TISSUE=Lung {ECO:0000313|EMBL:BAC34997.1};
RA   Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,
RA   Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K.,
RA   Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K.,
RA   Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y.,
RA   Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T.,
RA   Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R.,
RA   Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K.,
RA   Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T.,
RA   Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S.,
RA   Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M.,
RA   Hayashizaki Y.;
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:BAC34997.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC34997.1};
RC   TISSUE=Lung {ECO:0000313|EMBL:BAC34997.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [7] {ECO:0000313|EMBL:BAC34997.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC34997.1};
RC   TISSUE=Lung {ECO:0000313|EMBL:BAC34997.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [8] {ECO:0000313|EMBL:BAC34997.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC34997.1};
RC   TISSUE=Lung {ECO:0000313|EMBL:BAC34997.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
CC   -!- FUNCTION: Functions as a cell surface receptor and performs
CC       physiological functions on the surface of neurons relevant to neurite
CC       growth, neuronal adhesion and axonogenesis.
CC       {ECO:0000256|RuleBase:RU367156}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367156};
CC       Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367156}.
CC       Cell projection, growth cone {ECO:0000256|ARBA:ARBA00004624}. Cell
CC       surface {ECO:0000256|ARBA:ARBA00004241}. Cytoplasmic vesicle
CC       {ECO:0000256|ARBA:ARBA00004541}. Early endosome
CC       {ECO:0000256|ARBA:ARBA00004412}. Endosome
CC       {ECO:0000256|ARBA:ARBA00004177}. Membrane, clathrin-coated pit
CC       {ECO:0000256|ARBA:ARBA00004600}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}. Perikaryon
CC       {ECO:0000256|ARBA:ARBA00004484}. Vesicle
CC       {ECO:0000256|ARBA:ARBA00004373}.
CC   -!- SIMILARITY: Belongs to the APP family. {ECO:0000256|RuleBase:RU367156}.
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DR   EMBL; AK052448; BAC34997.1; -; mRNA.
DR   AlphaFoldDB; Q8BPV5; -.
DR   PeptideAtlas; Q8BPV5; -.
DR   AGR; MGI:88059; -.
DR   MGI; MGI:88059; App.
DR   ChiTaRS; App; mouse.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR   GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005798; C:Golgi-associated vesicle; IEA:UniProtKB-UniRule.
DR   GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR   GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR   Gene3D; 6.10.250.1670; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR008155; Amyloid_glyco.
DR   InterPro; IPR013803; Amyloid_glyco_Abeta.
DR   InterPro; IPR019745; Amyloid_glyco_intracell_CS.
DR   InterPro; IPR019543; APP_amyloid_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR23103; ALZHEIMER'S DISEASE BETA-AMYLOID RELATED; 1.
DR   PANTHER; PTHR23103:SF7; AMYLOID-BETA PRECURSOR PROTEIN; 1.
DR   Pfam; PF10515; APP_amyloid; 1.
DR   Pfam; PF03494; Beta-APP; 1.
DR   PRINTS; PR00203; AMYLOIDA4.
DR   PRINTS; PR00204; BETAAMYLOID.
DR   PROSITE; PS00320; APP_INTRA; 1.
PE   2: Evidence at transcript level;
KW   Amyloid {ECO:0000256|ARBA:ARBA00023087, ECO:0000256|RuleBase:RU367156};
KW   Cell membrane {ECO:0000256|RuleBase:RU367156};
KW   Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367156};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU367156};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU367156}.
FT   TRANSMEM        149..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367156"
FT   DOMAIN          127..161
FT                   /note="Amyloidogenic glycoprotein amyloid-beta peptide"
FT                   /evidence="ECO:0000259|Pfam:PF03494"
FT   DOMAIN          164..214
FT                   /note="Beta-amyloid precursor protein C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF10515"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAC34997.1"
SQ   SEQUENCE   218 AA;  24118 MW;  95B55AFDAE1D0EF5 CRC64;
     AVAEEIQDEV DELLQKEQNY SDDVLANMIS EPRISYGNDA LMPSLTETKT TVELLPVNGE
     FSLDDLQPWH PFGVDSVPAN TENEVEPVDA RPAADRGLTT RPGSGLTNIK TEEISEVKMD
     AEFGHDSGFE VRHQKLVFFA EDVGSNKGAI IGLMVGGVVI ATVIVITLVM LKKKQYTSIH
     HGVVEVDAAV TPEERHLSKM QQNGYENPTY KFFEQMQN
//