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Protein
Submitted name:

Putative uncharacterized protein

Gene

App

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • axon cargo transport Source: MGI
  • axon midline choice point recognition Source: MGI
  • axonogenesis Source: MGI
  • cellular copper ion homeostasis Source: MGI
  • cholesterol metabolic process Source: MGI
  • collateral sprouting in absence of injury Source: MGI
  • dendrite development Source: MGI
  • endocytosis Source: MGI
  • extracellular matrix organization Source: MGI
  • forebrain development Source: MGI
  • ionotropic glutamate receptor signaling pathway Source: MGI
  • locomotory behavior Source: MGI
  • mating behavior Source: MGI
  • mRNA polyadenylation Source: MGI
  • negative regulation of endopeptidase activity Source: MGI
  • negative regulation of neuron differentiation Source: MGI
  • neuromuscular process controlling balance Source: MGI
  • neuron apoptotic process Source: MGI
  • neuron projection development Source: MGI
  • neuron remodeling Source: MGI
  • positive regulation of G2/M transition of mitotic cell cycle Source: MGI
  • positive regulation of mitotic cell cycle Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • protein homooligomerization Source: MGI
  • protein phosphorylation Source: MGI
  • regulation of epidermal growth factor-activated receptor activity Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of multicellular organism growth Source: MGI
  • regulation of protein binding Source: MGI
  • regulation of synapse structure or activity Source: MGI
  • regulation of translation Source: MGI
  • response to oxidative stress Source: MGI
  • smooth endoplasmic reticulum calcium ion homeostasis Source: MGI
  • suckling behavior Source: MGI
  • synaptic growth at neuromuscular junction Source: MGI
  • visual learning Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:AppImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88059. App.

Subcellular locationi

GO - Cellular componenti

  • apical part of cell Source: MGI
  • axon Source: MGI
  • cell-cell junction Source: MGI
  • cell surface Source: MGI
  • ciliary rootlet Source: MGI
  • cytoplasm Source: MGI
  • cytoplasmic vesicle Source: MGI
  • endosome Source: MGI
  • ER to Golgi transport vesicle Source: MGI
  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
  • Golgi apparatus Source: MGI
  • integral component of membrane Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • membrane Source: MGI
  • membrane raft Source: MGI
  • neuromuscular junction Source: MGI
  • neuron projection Source: MGI
  • nuclear envelope lumen Source: MGI
  • perinuclear region of cytoplasm Source: MGI
  • plasma membrane Source: MGI
  • receptor complex Source: MGI
  • smooth endoplasmic reticulum Source: GOC
  • spindle midzone Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ8BPV5.
ExpressionAtlasiQ8BPV5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005406.

Structurei

3D structure databases

ProteinModelPortaliQ8BPV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000051.

Family and domain databases

Gene3Di4.10.230.10. 1 hit.
InterProiIPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR019745. Amyloid_glyco_intracell_CS.
IPR028866. APP.
IPR019543. APP_amyloid_C.
[Graphical view]
PANTHERiPTHR23103:SF7. PTHR23103:SF7. 1 hit.
PfamiPF10515. APP_amyloid. 1 hit.
PF03494. Beta-APP. 1 hit.
[Graphical view]
PRINTSiPR00203. AMYLOIDA4.
PR00204. BETAAMYLOID.
PROSITEiPS00320. A4_INTRA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8BPV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AVAEEIQDEV DELLQKEQNY SDDVLANMIS EPRISYGNDA LMPSLTETKT
60 70 80 90 100
TVELLPVNGE FSLDDLQPWH PFGVDSVPAN TENEVEPVDA RPAADRGLTT
110 120 130 140 150
RPGSGLTNIK TEEISEVKMD AEFGHDSGFE VRHQKLVFFA EDVGSNKGAI
160 170 180 190 200
IGLMVGGVVI ATVIVITLVM LKKKQYTSIH HGVVEVDAAV TPEERHLSKM
210
QQNGYENPTY KFFEQMQN
Length:218
Mass (Da):24,118
Last modified:March 1, 2003 - v1
Checksum:i95B55AFDAE1D0EF5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052448 mRNA. Translation: BAC34997.1.
UniGeneiMm.277585.
Mm.489029.
Mm.490986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052448 mRNA. Translation: BAC34997.1.
UniGeneiMm.277585.
Mm.489029.
Mm.490986.

3D structure databases

ProteinModelPortaliQ8BPV5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005406.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:88059. App.

Phylogenomic databases

HOVERGENiHBG000051.

Miscellaneous databases

ChiTaRSiApp. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BPV5.
ExpressionAtlasiQ8BPV5. baseline and differential.

Family and domain databases

Gene3Di4.10.230.10. 1 hit.
InterProiIPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR019745. Amyloid_glyco_intracell_CS.
IPR028866. APP.
IPR019543. APP_amyloid_C.
[Graphical view]
PANTHERiPTHR23103:SF7. PTHR23103:SF7. 1 hit.
PfamiPF10515. APP_amyloid. 1 hit.
PF03494. Beta-APP. 1 hit.
[Graphical view]
PRINTSiPR00203. AMYLOIDA4.
PR00204. BETAAMYLOID.
PROSITEiPS00320. A4_INTRA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.

Entry informationi

Entry nameiQ8BPV5_MOUSE
AccessioniPrimary (citable) accession number: Q8BPV5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.