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Q8BPV5

- Q8BPV5_MOUSE

UniProt

Q8BPV5 - Q8BPV5_MOUSE

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Protein
Submitted name:

Putative uncharacterized protein

Gene

App

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. peptidase activator activity Source: Ensembl
  3. serine-type endopeptidase inhibitor activity Source: Ensembl

GO - Biological processi

  1. adult locomotory behavior Source: MGI
  2. axon cargo transport Source: MGI
  3. axon midline choice point recognition Source: MGI
  4. axonogenesis Source: MGI
  5. cellular copper ion homeostasis Source: MGI
  6. cholesterol metabolic process Source: MGI
  7. collateral sprouting in absence of injury Source: MGI
  8. dendrite development Source: MGI
  9. endocytosis Source: MGI
  10. extracellular matrix organization Source: MGI
  11. forebrain development Source: MGI
  12. ionotropic glutamate receptor signaling pathway Source: MGI
  13. locomotory behavior Source: MGI
  14. mating behavior Source: MGI
  15. mRNA polyadenylation Source: MGI
  16. negative regulation of neuron differentiation Source: MGI
  17. neuromuscular process controlling balance Source: MGI
  18. neuron apoptotic process Source: MGI
  19. neuron projection development Source: MGI
  20. neuron remodeling Source: MGI
  21. positive regulation of G2/M transition of mitotic cell cycle Source: MGI
  22. positive regulation of mitotic cell cycle Source: MGI
  23. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  24. protein homooligomerization Source: MGI
  25. protein phosphorylation Source: MGI
  26. regulation of epidermal growth factor-activated receptor activity Source: MGI
  27. regulation of gene expression Source: MGI
  28. regulation of multicellular organism growth Source: MGI
  29. regulation of protein binding Source: MGI
  30. regulation of synapse structure and activity Source: MGI
  31. regulation of translation Source: MGI
  32. response to oxidative stress Source: MGI
  33. smooth endoplasmic reticulum calcium ion homeostasis Source: MGI
  34. suckling behavior Source: MGI
  35. synaptic growth at neuromuscular junction Source: MGI
  36. visual learning Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:AppImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88059. App.

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: MGI
  2. axon Source: MGI
  3. cell-cell junction Source: MGI
  4. cell surface Source: Ensembl
  5. ciliary rootlet Source: MGI
  6. cytoplasm Source: MGI
  7. cytoplasmic vesicle Source: MGI
  8. dendritic shaft Source: Ensembl
  9. dendritic spine Source: Ensembl
  10. ER to Golgi transport vesicle Source: MGI
  11. extracellular space Source: Ensembl
  12. extracellular vesicular exosome Source: Ensembl
  13. Golgi apparatus Source: MGI
  14. integral component of membrane Source: MGI
  15. membrane Source: MGI
  16. membrane raft Source: Ensembl
  17. neuromuscular junction Source: MGI
  18. neuron projection Source: MGI
  19. nuclear envelope lumen Source: Ensembl
  20. perinuclear region of cytoplasm Source: MGI
  21. plasma membrane Source: MGI
  22. receptor complex Source: MGI
  23. spindle midzone Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ8BPV5.
ExpressionAtlasiQ8BPV5. baseline and differential.
GenevestigatoriQ8BPV5.

Structurei

3D structure databases

ProteinModelPortaliQ8BPV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000051.

Family and domain databases

Gene3Di4.10.230.10. 1 hit.
InterProiIPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR019745. Amyloid_glyco_intracell_CS.
IPR028866. APP.
IPR019543. APP_amyloid_C.
[Graphical view]
PANTHERiPTHR23103:SF7. PTHR23103:SF7. 1 hit.
PfamiPF10515. APP_amyloid. 1 hit.
PF03494. Beta-APP. 1 hit.
[Graphical view]
PRINTSiPR00203. AMYLOIDA4.
PR00204. BETAAMYLOID.
PROSITEiPS00320. A4_INTRA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8BPV5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
AVAEEIQDEV DELLQKEQNY SDDVLANMIS EPRISYGNDA LMPSLTETKT
60 70 80 90 100
TVELLPVNGE FSLDDLQPWH PFGVDSVPAN TENEVEPVDA RPAADRGLTT
110 120 130 140 150
RPGSGLTNIK TEEISEVKMD AEFGHDSGFE VRHQKLVFFA EDVGSNKGAI
160 170 180 190 200
IGLMVGGVVI ATVIVITLVM LKKKQYTSIH HGVVEVDAAV TPEERHLSKM
210
QQNGYENPTY KFFEQMQN
Length:218
Mass (Da):24,118
Last modified:March 1, 2003 - v1
Checksum:i95B55AFDAE1D0EF5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK052448 mRNA. Translation: BAC34997.1.
UniGeneiMm.277585.
Mm.489029.
Mm.490986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK052448 mRNA. Translation: BAC34997.1 .
UniGenei Mm.277585.
Mm.489029.
Mm.490986.

3D structure databases

ProteinModelPortali Q8BPV5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:88059. App.

Phylogenomic databases

HOVERGENi HBG000051.

Miscellaneous databases

ChiTaRSi app. mouse.
SOURCEi Search...

Gene expression databases

Bgeei Q8BPV5.
ExpressionAtlasi Q8BPV5. baseline and differential.
Genevestigatori Q8BPV5.

Family and domain databases

Gene3Di 4.10.230.10. 1 hit.
InterProi IPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR019745. Amyloid_glyco_intracell_CS.
IPR028866. APP.
IPR019543. APP_amyloid_C.
[Graphical view ]
PANTHERi PTHR23103:SF7. PTHR23103:SF7. 1 hit.
Pfami PF10515. APP_amyloid. 1 hit.
PF03494. Beta-APP. 1 hit.
[Graphical view ]
PRINTSi PR00203. AMYLOIDA4.
PR00204. BETAAMYLOID.
PROSITEi PS00320. A4_INTRA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.

Entry informationi

Entry nameiQ8BPV5_MOUSE
AccessioniPrimary (citable) accession number: Q8BPV5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)