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Protein

Mitochondrial inner membrane protease subunit 2

Gene

Immp2l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei43By similarity1
Active sitei91By similarity1

GO - Molecular functioni

  • peptidase activity Source: MGI
  • serine-type endopeptidase activity Source: GO_Central

GO - Biological processi

  • blood circulation Source: MGI
  • brain development Source: MGI
  • cellular response to DNA damage stimulus Source: MGI
  • cerebellum vasculature development Source: MGI
  • mitochondrial respiratory chain complex assembly Source: MGI
  • ovarian follicle development Source: MGI
  • ovulation Source: MGI
  • protein localization Source: MGI
  • protein processing involved in protein targeting to mitochondrion Source: MGI
  • respiratory electron transport chain Source: MGI
  • signal peptide processing Source: GO_Central
  • spermatogenesis Source: MGI
  • superoxide metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiS26.A09.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial inner membrane protease subunit 2 (EC:3.4.21.-)
Alternative name(s):
IMP2-like protein
Gene namesi
Name:Immp2l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2135611. Immp2l.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 37HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrial inner membrane peptidase complex Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595781 – 175Mitochondrial inner membrane protease subunit 2Add BLAST175

Proteomic databases

PaxDbiQ8BPT6.
PeptideAtlasiQ8BPT6.
PRIDEiQ8BPT6.

PTM databases

PhosphoSitePlusiQ8BPT6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000056899.
ExpressionAtlasiQ8BPT6. baseline and differential.
GenevisibleiQ8BPT6. MM.

Interactioni

Subunit structurei

Heterodimer of 2 subunits, IMMPL1 and IMMPL2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116441.

Structurei

3D structure databases

ProteinModelPortaliQ8BPT6.
SMRiQ8BPT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family. IMP2 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1568. Eukaryota.
COG0681. LUCA.
GeneTreeiENSGT00550000075044.
HOGENOMiHOG000003673.
HOVERGENiHBG081792.
InParanoidiQ8BPT6.
KOiK09648.
OMAiYVFLSRW.
OrthoDBiEOG091G0XJX.
PhylomeDBiQ8BPT6.
TreeFamiTF315065.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
PROSITEiPS00761. SPASE_I_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BPT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSQSWARR CFKAFCKGFF VAVPVAVTFL DRVACVARVE GSSMQPSLNP
60 70 80 90 100
GGSQSSDVVL LNHWKVRNFE VQRGDIVSLV SPKNPEQKII KRVIALEGDI
110 120 130 140 150
VRTIGHKNRL VKVPRGHMWV EGDHHGHSFD SNSFGPVSLG LLHAHATHIL
160 170
WPPERWQRLE SVLPPERCPL QTGEK
Length:175
Mass (Da):19,601
Last modified:March 1, 2003 - v1
Checksum:iEC6A47123A7E7172
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97E → D in BAE36343 (PubMed:16141072).Curated1
Sequence conflicti109R → G in AAK52906 (PubMed:11254443).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF359564 mRNA. Translation: AAK52906.1.
AK053361 mRNA. Translation: BAC35362.1.
AK161351 mRNA. Translation: BAE36343.1.
BC100557 mRNA. Translation: AAI00558.1.
RefSeqiNP_444352.2. NM_053122.4.
UniGeneiMm.363813.

Genome annotation databases

EnsembliENSMUST00000132121; ENSMUSP00000118779; ENSMUSG00000056899.
ENSMUST00000134965; ENSMUSP00000116441; ENSMUSG00000056899.
GeneIDi93757.
KEGGimmu:93757.
UCSCiuc029rsc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF359564 mRNA. Translation: AAK52906.1.
AK053361 mRNA. Translation: BAC35362.1.
AK161351 mRNA. Translation: BAE36343.1.
BC100557 mRNA. Translation: AAI00558.1.
RefSeqiNP_444352.2. NM_053122.4.
UniGeneiMm.363813.

3D structure databases

ProteinModelPortaliQ8BPT6.
SMRiQ8BPT6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116441.

Protein family/group databases

MEROPSiS26.A09.

PTM databases

PhosphoSitePlusiQ8BPT6.

Proteomic databases

PaxDbiQ8BPT6.
PeptideAtlasiQ8BPT6.
PRIDEiQ8BPT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000132121; ENSMUSP00000118779; ENSMUSG00000056899.
ENSMUST00000134965; ENSMUSP00000116441; ENSMUSG00000056899.
GeneIDi93757.
KEGGimmu:93757.
UCSCiuc029rsc.2. mouse.

Organism-specific databases

CTDi83943.
MGIiMGI:2135611. Immp2l.

Phylogenomic databases

eggNOGiKOG1568. Eukaryota.
COG0681. LUCA.
GeneTreeiENSGT00550000075044.
HOGENOMiHOG000003673.
HOVERGENiHBG081792.
InParanoidiQ8BPT6.
KOiK09648.
OMAiYVFLSRW.
OrthoDBiEOG091G0XJX.
PhylomeDBiQ8BPT6.
TreeFamiTF315065.

Miscellaneous databases

ChiTaRSiImmp2l. mouse.
PROiQ8BPT6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056899.
ExpressionAtlasiQ8BPT6. baseline and differential.
GenevisibleiQ8BPT6. MM.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
PROSITEiPS00761. SPASE_I_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIMP2L_MOUSE
AccessioniPrimary (citable) accession number: Q8BPT6
Secondary accession number(s): Q3TTI2, Q925F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.