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Protein

Protein mab-21-like 2

Gene

Mab21l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for several aspects of embryonic development including normal development of the eye, notochord, neural tube and other organ tissues, and for embryonic turning.2 Publications

GO - Biological processi

  • camera-type eye development Source: MGI
  • embryonic body morphogenesis Source: MGI
  • eye development Source: UniProtKB
  • positive regulation of cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein mab-21-like 2
Gene namesi
Name:Mab21l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1346022. Mab21l2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003127881 – 359Protein mab-21-like 2Add BLAST359

Proteomic databases

MaxQBiQ8BPP1.
PaxDbiQ8BPP1.
PRIDEiQ8BPP1.

PTM databases

iPTMnetiQ8BPP1.
PhosphoSitePlusiQ8BPP1.

Expressioni

Tissue specificityi

Expressed in the adult cerebellum and eye, with lower levels in the adult forebrain (PubMed:10556287). In embryos at 10.5 days post-coitum strongly expressed in the rostral and distal regions of the developing neural retina, with no expression immediately adjacent to the closing optic fissure. Expression is also observed in the dorsal and ventral aspects of the developing forelimb bud and in the developing pharyngeal arches, as well as in the midbrain (PubMed:24906020).2 Publications

Developmental stagei

Expressed in the developing dorsal midbrain, the posterior portion of the mesencephalon and the retinal primordium of the optic cup. At E10, expressed in the temporal and nasal aspect of the retina and throughout the length of the dorsal midbrain. At E10.5 this retinal pattern of expression persists, and extraneural sites of expression include the branchial region, limb buds and intestine. Also highly expressed in the alar mesencephalon and the rhombencephalic basal plate from E10.5 to E14.5, and in the posterior third of the tectum and the presumptive gut wall. Also strongly expressed in the hindbrain, optic vesicle, maxillary and mandible process, paraxial mesoderm, developing digits and the umbilical cord.5 Publications

Gene expression databases

BgeeiENSMUSG00000057777.
CleanExiMM_MAB21L2.
GenevisibleiQ8BPP1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076729.

Structurei

3D structure databases

ProteinModelPortaliQ8BPP1.
SMRiQ8BPP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mab-21 family.Curated

Phylogenomic databases

eggNOGiKOG3963. Eukaryota.
ENOG410XNRJ. LUCA.
GeneTreeiENSGT00510000046791.
HOGENOMiHOG000007337.
HOVERGENiHBG053080.
InParanoidiQ8BPP1.
OMAiWDESCIA.
OrthoDBiEOG091G0939.
PhylomeDBiQ8BPP1.
TreeFamiTF315012.

Family and domain databases

InterProiIPR020950. Mab-21-like_1/2.
IPR024810. Mab-21_dom.
IPR000772. Ricin_B_lectin.
[Graphical view]
PANTHERiPTHR10656:SF37. PTHR10656:SF37. 1 hit.
PfamiPF03281. Mab-21. 1 hit.
[Graphical view]
SMARTiSM01265. Mab-21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BPP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAAQAKLVY QLNKYYTERC QARKAAIAKT IREVCKVVSD VLKEVEVQEP
60 70 80 90 100
RFISSLSEID ARYEGLEVIS PTEFEVVLYL NQMGVFNFVD DGSLPGCAVL
110 120 130 140 150
KLSDGRKRSM SLWVEFITAS GYLSARKIRS RFQTLVAQAV DKCSYRDVVK
160 170 180 190 200
MIADTSEVKL RIRERYVVQI TPAFKCTGIW PRSAAQWPMP HIPWPGPNRV
210 220 230 240 250
AEVKAEGFNL LSKECYSLTG KQSSAESDAW VLQFGEAENR LLMGGCRNKC
260 270 280 290 300
LSVLKTLRDR HLELPGQPLN NYHMKTLLLY ECEKHPRETD WDEACLGDRL
310 320 330 340 350
NGILLQLISC LQCRRCPHYF LPNLDLFQGK PHSALESAAK QTWRLAREIL

TNPKSLDKL
Length:359
Mass (Da):40,907
Last modified:March 1, 2003 - v1
Checksum:i24B7A0CF0E78A1AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98 – 99AV → PC in AAD39141 (PubMed:10495284).Curated2
Sequence conflicti98 – 99AV → PC in AAK49026 (PubMed:11857508).Curated2
Sequence conflicti254L → Q in AAD40478 (PubMed:10556287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149877 mRNA. Translation: AAD40478.1.
AF126427 mRNA. Translation: AAD39141.1.
AF223425 Genomic DNA. Translation: AAK49026.1.
AK053645 mRNA. Translation: BAC35460.1.
BC046628 mRNA. Translation: AAH46628.1.
CCDSiCCDS17447.1.
RefSeqiNP_035969.2. NM_011839.3.
UniGeneiMm.389466.

Genome annotation databases

EnsembliENSMUST00000077524; ENSMUSP00000076729; ENSMUSG00000057777.
GeneIDi23937.
KEGGimmu:23937.
UCSCiuc008prj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149877 mRNA. Translation: AAD40478.1.
AF126427 mRNA. Translation: AAD39141.1.
AF223425 Genomic DNA. Translation: AAK49026.1.
AK053645 mRNA. Translation: BAC35460.1.
BC046628 mRNA. Translation: AAH46628.1.
CCDSiCCDS17447.1.
RefSeqiNP_035969.2. NM_011839.3.
UniGeneiMm.389466.

3D structure databases

ProteinModelPortaliQ8BPP1.
SMRiQ8BPP1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076729.

PTM databases

iPTMnetiQ8BPP1.
PhosphoSitePlusiQ8BPP1.

Proteomic databases

MaxQBiQ8BPP1.
PaxDbiQ8BPP1.
PRIDEiQ8BPP1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077524; ENSMUSP00000076729; ENSMUSG00000057777.
GeneIDi23937.
KEGGimmu:23937.
UCSCiuc008prj.1. mouse.

Organism-specific databases

CTDi10586.
MGIiMGI:1346022. Mab21l2.

Phylogenomic databases

eggNOGiKOG3963. Eukaryota.
ENOG410XNRJ. LUCA.
GeneTreeiENSGT00510000046791.
HOGENOMiHOG000007337.
HOVERGENiHBG053080.
InParanoidiQ8BPP1.
OMAiWDESCIA.
OrthoDBiEOG091G0939.
PhylomeDBiQ8BPP1.
TreeFamiTF315012.

Miscellaneous databases

PROiQ8BPP1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057777.
CleanExiMM_MAB21L2.
GenevisibleiQ8BPP1. MM.

Family and domain databases

InterProiIPR020950. Mab-21-like_1/2.
IPR024810. Mab-21_dom.
IPR000772. Ricin_B_lectin.
[Graphical view]
PANTHERiPTHR10656:SF37. PTHR10656:SF37. 1 hit.
PfamiPF03281. Mab-21. 1 hit.
[Graphical view]
SMARTiSM01265. Mab-21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMB212_MOUSE
AccessioniPrimary (citable) accession number: Q8BPP1
Secondary accession number(s): Q9R1B2, Q9WVF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.