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Q8BPM6

- RIC3_MOUSE

UniProt

Q8BPM6 - RIC3_MOUSE

Protein

Protein RIC-3

Gene

Ric3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.1 Publication

    GO - Molecular functioni

    1. protein binding involved in protein folding Source: MGI

    GO - Biological processi

    1. cellular protein complex assembly Source: MGI
    2. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    3. protein folding Source: GOC
    4. synaptic transmission, cholinergic Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein RIC-3
    Alternative name(s):
    Resistant to inhibitor of cholinesterase 3
    Gene namesi
    Name:Ric3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2443887. Ric3.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: MGI
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: MGI

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 31311 PublicationAdd
    BLAST
    Chaini32 – 367336Protein RIC-3PRO_0000302732Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei201 – 2011N6-acetyllysine; alternateBy similarity
    Cross-linki201 – 201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity

    Keywords - PTMi

    Acetylation, Isopeptide bond, Ubl conjugation

    Proteomic databases

    PRIDEiQ8BPM6.

    PTM databases

    PhosphoSiteiQ8BPM6.

    Expressioni

    Tissue specificityi

    Expressed in brain, with highest levels in hippocampus, cerebellum and superior colliculus.1 Publication

    Gene expression databases

    BgeeiQ8BPM6.
    GenevestigatoriQ8BPM6.

    Interactioni

    Subunit structurei

    Monomer and homodimer. Interacts with CHRNA7, CHRNA3, CHRNA4, CHRNB2, CHRNB4 and HTR3A By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000056990.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BPM6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini32 – 9564LumenalSequence AnalysisAdd
    BLAST
    Topological domaini117 – 367251CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei96 – 11621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili138 – 169321 PublicationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi81 – 9414Poly-GlyAdd
    BLAST

    Domaini

    The coiled-coil domain mediates transient homodimerization with other acetylcholine receptor-bound RIC3 molecules, promoting stepwise ACHR homomeric assembly at the membrane.

    Sequence similaritiesi

    Belongs to the ric-3 family.Curated

    Keywords - Domaini

    Coiled coil, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46432.
    GeneTreeiENSGT00440000034107.
    HOGENOMiHOG000034648.
    HOVERGENiHBG106009.
    InParanoidiQ8BPM6.
    OMAiHRKITNF.
    OrthoDBiEOG7MKW7H.
    PhylomeDBiQ8BPM6.
    TreeFamiTF333291.

    Family and domain databases

    InterProiIPR026160. Ric3.
    [Graphical view]
    PANTHERiPTHR21723. PTHR21723. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BPM6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAYSTVQRVA LASGLVLAVS LLLPKAFLSR GKRPEPPPGP EGKLDRFPPM    50
    MHHHSAPSDG QTPGARFQRS HLAEAFAKAK GAGGGAGGGG SGRGLMGQII 100
    PIYGFGIFLY ILYILFKLSK GKTAEDRNCS TAPPGNAHRK ITNFELVQLQ 150
    EKLKETEEAM EKLINRVGPN GESRAQAVTS DQEKRLLHQL REITRVMKEG 200
    KFIDTSPEKE AEEAPYMEDW EGYPEETYPI YDLSDGIKRR QETILVDYPD 250
    LKEPSAEEIA EQMGEIEEEG SERLSWDHLP TDPGAQKDNS VAPCDPKPES 300
    CSCCVHEEED PAVLAENAGF SADGYSEQEE ATKENLPQDF TNEGLGVSTD 350
    NAHVGGMLRK RNPQGFE 367
    Length:367
    Mass (Da):40,283
    Last modified:September 11, 2007 - v2
    Checksum:i688D772716BDE892
    GO
    Isoform 2 (identifier: Q8BPM6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-159: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:208
    Mass (Da):23,347
    Checksum:iD59EB1FB2925FC26
    GO
    Isoform 3 (identifier: Q8BPM6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         223-228: YPEETY → KMPLPC
         229-367: Missing.

    Show »
    Length:228
    Mass (Da):24,909
    Checksum:i5A7F826B78472F08
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 461R → Q in BAC38452. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 159159Missing in isoform 2. 1 PublicationVSP_027944Add
    BLAST
    Alternative sequencei223 – 2286YPEETY → KMPLPC in isoform 3. 1 PublicationVSP_027945
    Alternative sequencei229 – 367139Missing in isoform 3. 1 PublicationVSP_027946Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK053760 mRNA. Translation: BAC35510.1.
    AK082275 mRNA. Translation: BAC38452.1.
    AK149334 mRNA. Translation: BAE28817.1.
    BC059258 mRNA. Translation: AAH59258.1.
    CCDSiCCDS21733.1. [Q8BPM6-1]
    RefSeqiNP_001033713.1. NM_001038624.1. [Q8BPM6-1]
    NP_848895.2. NM_178780.3. [Q8BPM6-3]
    XP_006508005.1. XM_006507942.1. [Q8BPM6-2]
    XP_006508006.1. XM_006507943.1. [Q8BPM6-2]
    UniGeneiMm.71007.

    Genome annotation databases

    EnsembliENSMUST00000055993; ENSMUSP00000056990; ENSMUSG00000048330. [Q8BPM6-1]
    GeneIDi320360.
    KEGGimmu:320360.
    UCSCiuc009jdg.1. mouse. [Q8BPM6-1]
    uc009jdi.1. mouse. [Q8BPM6-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK053760 mRNA. Translation: BAC35510.1 .
    AK082275 mRNA. Translation: BAC38452.1 .
    AK149334 mRNA. Translation: BAE28817.1 .
    BC059258 mRNA. Translation: AAH59258.1 .
    CCDSi CCDS21733.1. [Q8BPM6-1 ]
    RefSeqi NP_001033713.1. NM_001038624.1. [Q8BPM6-1 ]
    NP_848895.2. NM_178780.3. [Q8BPM6-3 ]
    XP_006508005.1. XM_006507942.1. [Q8BPM6-2 ]
    XP_006508006.1. XM_006507943.1. [Q8BPM6-2 ]
    UniGenei Mm.71007.

    3D structure databases

    ProteinModelPortali Q8BPM6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000056990.

    PTM databases

    PhosphoSitei Q8BPM6.

    Proteomic databases

    PRIDEi Q8BPM6.

    Protocols and materials databases

    DNASUi 320360.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055993 ; ENSMUSP00000056990 ; ENSMUSG00000048330 . [Q8BPM6-1 ]
    GeneIDi 320360.
    KEGGi mmu:320360.
    UCSCi uc009jdg.1. mouse. [Q8BPM6-1 ]
    uc009jdi.1. mouse. [Q8BPM6-3 ]

    Organism-specific databases

    CTDi 79608.
    MGIi MGI:2443887. Ric3.

    Phylogenomic databases

    eggNOGi NOG46432.
    GeneTreei ENSGT00440000034107.
    HOGENOMi HOG000034648.
    HOVERGENi HBG106009.
    InParanoidi Q8BPM6.
    OMAi HRKITNF.
    OrthoDBi EOG7MKW7H.
    PhylomeDBi Q8BPM6.
    TreeFami TF333291.

    Miscellaneous databases

    NextBioi 396576.
    PROi Q8BPM6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BPM6.
    Genevestigatori Q8BPM6.

    Family and domain databases

    InterProi IPR026160. Ric3.
    [Graphical view ]
    PANTHERi PTHR21723. PTHR21723. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6J.
      Tissue: Cerebellum, Eye and Retina.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Brain.
    3. "Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression."
      Halevi S., Yassin L., Eshel M., Sala F., Sala S., Criado M., Treinin M.
      J. Biol. Chem. 278:34411-34417(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    4. "Mouse RIC-3, an endoplasmic reticulum chaperone, promotes assembly of the alpha7 acetylcholine receptor through a cytoplasmic coiled-coil domain."
      Wang Y., Yao Y., Tang X.Q., Wang Z.Z.
      J. Neurosci. 29:12625-12635(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TOPOLOGY, FUNCTION, COILED-COIL REGION, SIGNAL SEQUENCE CLEAVAGE SITE.

    Entry informationi

    Entry nameiRIC3_MOUSE
    AccessioniPrimary (citable) accession number: Q8BPM6
    Secondary accession number(s): Q6PCM7, Q8C4G2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3