Daam1

Functionⁱ

Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments (By similarity). Involved in building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (PubMed:26526197).By similarity1 Publication

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW
identical protein binding Source: MGI
Rho GTPase binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding
Biological process	Wnt signaling pathway

Enzyme and pathway databases

Reactomeⁱ	R-MMU-4086400. PCP/CE pathway. R-MMU-5663220. RHO GTPases Activate Formins.

Reactomeⁱ

R-MMU-4086400. PCP/CE pathway.
R-MMU-5663220. RHO GTPases Activate Formins.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Disheveled-associated activator of morphogenesis 1
Gene namesⁱ	Name:Daam1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:1914596. Daam1.

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Conditional knockout mice lacking Daam1 in myocardial cells show cardiomyopathy. Conditional knockout mice lacking Daam1 and Daam2 in myocardial cells show stronger cardiomyopathy.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000194908	1 – 1077	Disheveled-associated activator of morphogenesis 1Add BLAST		1077

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	34	PhosphoserineBy similarity	1
Modified residueⁱ	1026	PhosphoserineBy similarity	1
Modified residueⁱ	1029	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8BPM0.
PeptideAtlas More...PeptideAtlasⁱ	Q8BPM0.
PRIDEⁱ	Q8BPM0.

PTM databases

iPTMnetⁱ	Q8BPM0.
PhosphoSitePlusⁱ	Q8BPM0.
SwissPalmⁱ	Q8BPM0.

Expressionⁱ

Tissue specificityⁱ

In early embryogenesis, expressed in embryonic and extraembryonic ectoderm. In later stages of gastrulation, expressed also in somites and ribs and posterior vertebrae of developing skeletal system. During organogenesis, expressed in CNS, PNS, stomach, liver and limb bud.2 Publications

Developmental stageⁱ

Detected throughout the myocardial layer of the heart tube. Not expressed in the myocardium at E9.5 but is present in epicardial cells and the pro-epicardial organ. At E10.5, expressed in the atrial and ventricular myocardia as well as the inter-ventricular septum. Continues to localize to the atrial and ventricular myocardia at E12.5 as well as the ventricular trabeculae.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000034574.
Genevisibleⁱ	Q8BPM0. MM.

Interactionⁱ

Subunit structureⁱ

Interacts with CIP4, FNBP1 and FNBP1L. Interacts with the SH3 domains of Abl, BTK, endophilin, spectrin and SRC. Binds specifically to GTP-bound CDC42 and RHOA. Interacts with INTU; INTU mediates the indirect interaction between DAAM1 and NPHP4 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ARHGEF11	O15085-2	3	EBI-772938,EBI-6169263	From a different organism.

With

Entry

#Exp.

IntAct

Notes

ARHGEF11

O15085-2

3

EBI-772938,EBI-6169263

From a different organism.

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW
identical protein binding Source: MGI
Rho GTPase binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	229018. 1 interactor.
IntActⁱ	Q8BPM0. 2 interactors.
STRINGⁱ	10090.ENSMUSP00000082406.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BPM0.
SMRⁱ	Q8BPM0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	45 – 420	GBD/FH3PROSITE-ProRule annotationAdd BLAST	376
Domainⁱ	528 – 599	FH1Add BLAST	72
Domainⁱ	600 – 1008	FH2PROSITE-ProRule annotationAdd BLAST	409
Domainⁱ	1026 – 1057	DADPROSITE-ProRule annotationAdd BLAST	32

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	693 – 702	Actin-bindingBy similarity		10

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	437 – 526	Sequence analysisAdd BLAST		90

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	528 – 593	Pro-richAdd BLAST		66

Domainⁱ

The C-terminal DAD domain may participate in intramolecular interactions with the N-terminus.

The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).By similarity

Sequence similaritiesⁱ

Belongs to the formin homology family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG1922. Eukaryota. ENOG410XT5Z. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118986.
HOGENOMⁱ	HOG000237318.
HOVERGENⁱ	HBG101333.
InParanoidⁱ	Q8BPM0.
KEGG Orthology (KO) More...KOⁱ	K04512.
OMAⁱ	PLGGIMP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02QJ.
TreeFamⁱ	TF314602.

Family and domain databases

Gene3Dⁱ	1.25.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR027650. DAAM1. IPR014767. DAD_dom. IPR015425. FH2_Formin. IPR010472. FH3_dom. IPR014768. GBD/FH3_dom. IPR010473. GTPase-bd.
PANTHERⁱ	PTHR23213:SF181. PTHR23213:SF181. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06367. Drf_FH3. 1 hit. PF06371. Drf_GBD. 1 hit. PF02181. FH2. 1 hit.
SMARTⁱ	View protein in SMART SM01139. Drf_FH3. 1 hit. SM01140. Drf_GBD. 1 hit. SM00498. FH2. 1 hit.
SUPFAMⁱ	SSF48371. SSF48371. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51231. DAD. 1 hit. PS51444. FH2. 1 hit. PS51232. GBD_FH3. 1 hit.

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8BPM0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPRKRGGRG ISFIFCCFRN NDHPEITYRL RNDSNFALQT MEPALPMPPV 
        60         70         80         90        100
EELDVMFSEL VDELDLTDKH REAMFALPAE KKWQIYCSKK KDQEENKGAT 
       110        120        130        140        150
SWPEFYIDQL NSMAARKSLL ALEKEEEEER SKTIESLKTA LRTKPMRFVT 
       160        170        180        190        200
RFIDLDGLSC ILNFLKTMDY ETSESRIHTS LIGCIKALMN NSQGRAHVLA 
       210        220        230        240        250
HSESINVIAQ SLSTENIKTK VAVLEILGAV CLVPGGHKKV LQAMLHYQKY 
       260        270        280        290        300
ASERTRFQTL INDLDKSTGR YRDEVSLKTA IMSFINAVLS QGAGVESLDF 
       310        320        330        340        350
RLHLRYEFLM LGIQPVIDKL REHENSTLDR HLDFFEMLRN EDELEFAKRF 
       360        370        380        390        400
ELVHIDTKSA TQMFELTRRR LTHSEAYPHF MSILHHCLQM PYKRSGNTVQ 
       410        420        430        440        450
YWLLLDRIIQ QIVIQNDKGQ DPDSTPLENF NIKNVVRMLV NENEVKQWKE 
       460        470        480        490        500
QAEKMRKEHN ELQQKLEKKE RECDAKTQEK EEMMQTLNKM KEKLEKETTE 
       510        520        530        540        550
HKQVKQQVAD LTAQLHELNR RAVCAAVPGG PSPGAPGGPF PSSGLGSLLP 
       560        570        580        590        600
PPPPPLLSGG ALPPPPPPLP PGGPPPPPGP PPLGGVLPPP GAPVSLTLKK 
       610        620        630        640        650
KNIPQPTNAL KSFNWSKLPE NKLDGTVWTE IDDTKVFKIL DLEDLERTFS 
       660        670        680        690        700
AYQRQQEFFV NNSKQKEADA IDDTLSSKLK VKELSVIDGR RAQNCNILLS 
       710        720        730        740        750
RLKLSNDEIK RAILTMDEQE DLPKDMLEQL LKFVPEKSDI DLLEEHKHEL 
       760        770        780        790        800
DRMAKADRFL FEMSRINHYQ QRLQSLYFKK KFAERVAEVK PKVEAIRSGS 
       810        820        830        840        850
EEVFRSRALK QLLEVVLAFG NYMNKGQRGN AYGFKISSLN KIADTKSSID 
       860        870        880        890        900
KNITLLHYLI TIVENKYPKV LNLSEELRDI PQAAKVNMTE LDKEISTLRS 
       910        920        930        940        950
GLKAVETELE YQKSQPPQPG DKFVSVVSQF ITLASFSFSD VEDLLAEAKE 
       960        970        980        990       1000
LFTKAVKHFG EEAGKIQPDE FFGIFDQFLQ AVAEAKQENE NMRKRKEEEE 
      1010       1020       1030       1040       1050
RRARLEAQLK EQRERERKVR KAKESSEESG EFDDLVSALR SGEVFDKDLS 
      1060       1070 
KLKRNRKRIS NQVTDSSRER PITKLNF

Length:1,077

Mass (Da):123,370

Last modified:July 27, 2011 - v4

Checksum:ⁱE16AC9DEF6E05B15

GO

Isoform 2 (identifier: Q8BPM0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
657-665: Missing.

« Hide

        10         20         30         40         50
MAPRKRGGRG ISFIFCCFRN NDHPEITYRL RNDSNFALQT MEPALPMPPV 
        60         70         80         90        100
EELDVMFSEL VDELDLTDKH REAMFALPAE KKWQIYCSKK KDQEENKGAT 
       110        120        130        140        150
SWPEFYIDQL NSMAARKSLL ALEKEEEEER SKTIESLKTA LRTKPMRFVT 
       160        170        180        190        200
RFIDLDGLSC ILNFLKTMDY ETSESRIHTS LIGCIKALMN NSQGRAHVLA 
       210        220        230        240        250
HSESINVIAQ SLSTENIKTK VAVLEILGAV CLVPGGHKKV LQAMLHYQKY 
       260        270        280        290        300
ASERTRFQTL INDLDKSTGR YRDEVSLKTA IMSFINAVLS QGAGVESLDF 
       310        320        330        340        350
RLHLRYEFLM LGIQPVIDKL REHENSTLDR HLDFFEMLRN EDELEFAKRF 
       360        370        380        390        400
ELVHIDTKSA TQMFELTRRR LTHSEAYPHF MSILHHCLQM PYKRSGNTVQ 
       410        420        430        440        450
YWLLLDRIIQ QIVIQNDKGQ DPDSTPLENF NIKNVVRMLV NENEVKQWKE 
       460        470        480        490        500
QAEKMRKEHN ELQQKLEKKE RECDAKTQEK EEMMQTLNKM KEKLEKETTE 
       510        520        530        540        550
HKQVKQQVAD LTAQLHELNR RAVCAAVPGG PSPGAPGGPF PSSGLGSLLP 
       560        570        580        590        600
PPPPPLLSGG ALPPPPPPLP PGGPPPPPGP PPLGGVLPPP GAPVSLTLKK 
       610        620        630        640        650
KNIPQPTNAL KSFNWSKLPE NKLDGTVWTE IDDTKVFKIL DLEDLERTFS 
       660        670        680        690        700
AYQRQQKEAD AIDDTLSSKL KVKELSVIDG RRAQNCNILL SRLKLSNDEI 
       710        720        730        740        750
KRAILTMDEQ EDLPKDMLEQ LLKFVPEKSD IDLLEEHKHE LDRMAKADRF 
       760        770        780        790        800
LFEMSRINHY QQRLQSLYFK KKFAERVAEV KPKVEAIRSG SEEVFRSRAL 
       810        820        830        840        850
KQLLEVVLAF GNYMNKGQRG NAYGFKISSL NKIADTKSSI DKNITLLHYL 
       860        870        880        890        900
ITIVENKYPK VLNLSEELRD IPQAAKVNMT ELDKEISTLR SGLKAVETEL 
       910        920        930        940        950
EYQKSQPPQP GDKFVSVVSQ FITLASFSFS DVEDLLAEAK ELFTKAVKHF 
       960        970        980        990       1000
GEEAGKIQPD EFFGIFDQFL QAVAEAKQEN ENMRKRKEEE ERRARLEAQL 
      1010       1020       1030       1040       1050
KEQRERERKV RKAKESSEES GEFDDLVSAL RSGEVFDKDL SKLKRNRKRI 
      1060 
SNQVTDSSRE RPITKLNF

Show »

Length:1,068

Mass (Da):122,276

Checksum:ⁱF5AD716B8D158DD3

GO

Isoform 3 (identifier: Q8BPM0-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
657-659: EFF → VTT
660-1077: Missing.

« Hide

        10         20         30         40         50
MAPRKRGGRG ISFIFCCFRN NDHPEITYRL RNDSNFALQT MEPALPMPPV 
        60         70         80         90        100
EELDVMFSEL VDELDLTDKH REAMFALPAE KKWQIYCSKK KDQEENKGAT 
       110        120        130        140        150
SWPEFYIDQL NSMAARKSLL ALEKEEEEER SKTIESLKTA LRTKPMRFVT 
       160        170        180        190        200
RFIDLDGLSC ILNFLKTMDY ETSESRIHTS LIGCIKALMN NSQGRAHVLA 
       210        220        230        240        250
HSESINVIAQ SLSTENIKTK VAVLEILGAV CLVPGGHKKV LQAMLHYQKY 
       260        270        280        290        300
ASERTRFQTL INDLDKSTGR YRDEVSLKTA IMSFINAVLS QGAGVESLDF 
       310        320        330        340        350
RLHLRYEFLM LGIQPVIDKL REHENSTLDR HLDFFEMLRN EDELEFAKRF 
       360        370        380        390        400
ELVHIDTKSA TQMFELTRRR LTHSEAYPHF MSILHHCLQM PYKRSGNTVQ 
       410        420        430        440        450
YWLLLDRIIQ QIVIQNDKGQ DPDSTPLENF NIKNVVRMLV NENEVKQWKE 
       460        470        480        490        500
QAEKMRKEHN ELQQKLEKKE RECDAKTQEK EEMMQTLNKM KEKLEKETTE 
       510        520        530        540        550
HKQVKQQVAD LTAQLHELNR RAVCAAVPGG PSPGAPGGPF PSSGLGSLLP 
       560        570        580        590        600
PPPPPLLSGG ALPPPPPPLP PGGPPPPPGP PPLGGVLPPP GAPVSLTLKK 
       610        620        630        640        650
KNIPQPTNAL KSFNWSKLPE NKLDGTVWTE IDDTKVFKIL DLEDLERTFS 

AYQRQQVTT

Note: No experimental confirmation available.

Show »

Length:659

Mass (Da):74,953

Checksum:ⁱ59B031884A39FEA5

GO

Sequence cautionⁱ

The sequence AAH48856 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	36	F → L in AAR05118 (PubMed:15533824).Curated	1
Sequence conflictⁱ	571	P → A in BAC35522 (PubMed:16141072).Curated	1
Sequence conflictⁱ	894	E → G in BAE27943 (PubMed:16141072).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_027771	657 – 665	Missing in isoform 2. 2 Publications	9
Alternative sequenceⁱVSP_027772	657 – 659	EFF → VTT in isoform 3. 1 Publication	3
Alternative sequenceⁱVSP_027773	660 – 1077	Missing in isoform 3. 1 PublicationAdd BLAST	418

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY426535 mRNA. Translation: AAR05118.1. AK006902 mRNA. Translation: BAB24785.1. AK018919 mRNA. Translation: BAB31482.1. AK018950 mRNA. Translation: BAB31491.1. AK053785 mRNA. Translation: BAC35522.1. AK147480 mRNA. Translation: BAE27943.1. BC032287 mRNA. No translation available. BC048856 mRNA. Translation: AAH48856.1. Different initiation. BC076585 mRNA. Translation: AAH76585.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25964.1. [Q8BPM0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001273381.1. NM_001286452.1. [Q8BPM0-2] NP_080378.2. NM_026102.3. [Q8BPM0-1] NP_766052.2. NM_172464.3. [Q8BPM0-1] XP_006515705.1. XM_006515642.2. [Q8BPM0-1] XP_006515706.1. XM_006515643.3. [Q8BPM0-2] XP_006515707.1. XM_006515644.3. [Q8BPM0-2]
UniGeneⁱ	Mm.474935. Mm.87417.

Genome annotation databases

Ensemblⁱ	ENSMUST00000085299; ENSMUSP00000082406; ENSMUSG00000034574. [Q8BPM0-1] ENSMUST00000221317; ENSMUSP00000152532; ENSMUSG00000034574. [Q8BPM0-2] ENSMUST00000223272; ENSMUSP00000152564; ENSMUSG00000034574. [Q8BPM0-1]
GeneIDⁱ	208846.
KEGGⁱ	mmu:208846.
UCSC genome browser More...UCSCⁱ	uc007nuw.2. mouse. [Q8BPM0-3] uc007nux.2. mouse. [Q8BPM0-1] uc007nuz.2. mouse. [Q8BPM0-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8BPM0	Q6ZQ74 Q8BTF1	Mus musculus (Mouse)	1,077	UniRef100_Q8BPM0	Cluster: Disheveled-associated activator of morphogenesis 1	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8BPM0	Q6ZQ74 Q8BTF1 UPI0008464A67 UPI0003AF7B0F W5QIZ2 UPI0008474B01 UPI0003AFBF23 UPI0003EC6563 UPI0003EBCE2F UPI0002C59AB3 +66	Mus musculus (Mouse) Capra hircus (Goat) Ovis aries (Sheep) Myotis davidii (David's myotis) Odobenus rosmarus divergens (Pacific walrus) Myotis brandtii (Brandt's bat) Myotis lucifugus (Little brown bat) Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat) Thamnophis sirtalis Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis) And more	1,077	UniRef90_Q8BPM0	Cluster: Disheveled-associated activator of morphogenesis 1	77
Q8BPM0-2	Q9Y4D1 A0A2I3SJQ7 UPI00015265AF UPI000181D0D3 A0A2I0UFC9 UPI00093A7A96 UPI00052E8264 U3JLL7 F6Z0N7 UPI0001560311 +222	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Limosa lapponica baueri Meleagris gallopavo (Wild turkey) Tinamus guttatus (White-throated tinamou) Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis) Equus caballus (Horse) Sus scrofa (Pig) Taeniopygia guttata (Zebra finch) (Poephila guttata) Pygoscelis adeliae (Adelie penguin) And more	1,078	UniRef90_Q9Y4D1	Cluster: Disheveled-associated activator of morphogenesis 1	233

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8BPM0	Q9Y4D1 A0A2I3SJQ7 UPI00015265AF UPI000181D0D3 A0A2I0UFC9 UPI00093A7A96 UPI00052E8264 U3JLL7 F6Z0N7 UPI0001560311 +879	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Limosa lapponica baueri Meleagris gallopavo (Wild turkey) Tinamus guttatus (White-throated tinamou) Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis) Equus caballus (Horse) Sus scrofa (Pig) Taeniopygia guttata (Zebra finch) (Poephila guttata) Pygoscelis adeliae (Adelie penguin) And more	1,078	UniRef50_Q9Y4D1	Cluster: Disheveled-associated activator of morphogenesis 1	890

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY426535 mRNA. Translation: AAR05118.1. AK006902 mRNA. Translation: BAB24785.1. AK018919 mRNA. Translation: BAB31482.1. AK018950 mRNA. Translation: BAB31491.1. AK053785 mRNA. Translation: BAC35522.1. AK147480 mRNA. Translation: BAE27943.1. BC032287 mRNA. No translation available. BC048856 mRNA. Translation: AAH48856.1. Different initiation. BC076585 mRNA. Translation: AAH76585.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25964.1. [Q8BPM0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001273381.1. NM_001286452.1. [Q8BPM0-2] NP_080378.2. NM_026102.3. [Q8BPM0-1] NP_766052.2. NM_172464.3. [Q8BPM0-1] XP_006515705.1. XM_006515642.2. [Q8BPM0-1] XP_006515706.1. XM_006515643.3. [Q8BPM0-2] XP_006515707.1. XM_006515644.3. [Q8BPM0-2]
UniGeneⁱ	Mm.474935. Mm.87417.

3D structure databases

ProteinModelPortalⁱ	Q8BPM0.
SMRⁱ	Q8BPM0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	229018. 1 interactor.
IntActⁱ	Q8BPM0. 2 interactors.
STRINGⁱ	10090.ENSMUSP00000082406.

PTM databases

iPTMnetⁱ	Q8BPM0.
PhosphoSitePlusⁱ	Q8BPM0.
SwissPalmⁱ	Q8BPM0.

Proteomic databases

PaxDbⁱ	Q8BPM0.
PeptideAtlas More...PeptideAtlasⁱ	Q8BPM0.
PRIDEⁱ	Q8BPM0.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000085299; ENSMUSP00000082406; ENSMUSG00000034574. [Q8BPM0-1] ENSMUST00000221317; ENSMUSP00000152532; ENSMUSG00000034574. [Q8BPM0-2] ENSMUST00000223272; ENSMUSP00000152564; ENSMUSG00000034574. [Q8BPM0-1]
GeneIDⁱ	208846.
KEGGⁱ	mmu:208846.
UCSC genome browser More...UCSCⁱ	uc007nuw.2. mouse. [Q8BPM0-3] uc007nux.2. mouse. [Q8BPM0-1] uc007nuz.2. mouse. [Q8BPM0-2]

Organism-specific databases

CTDⁱ	23002.
MGIⁱ	MGI:1914596. Daam1.

Phylogenomic databases

eggNOGⁱ	KOG1922. Eukaryota. ENOG410XT5Z. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118986.
HOGENOMⁱ	HOG000237318.
HOVERGENⁱ	HBG101333.
InParanoidⁱ	Q8BPM0.
KEGG Orthology (KO) More...KOⁱ	K04512.
OMAⁱ	PLGGIMP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02QJ.
TreeFamⁱ	TF314602.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-4086400. PCP/CE pathway. R-MMU-5663220. RHO GTPases Activate Formins.

Reactomeⁱ

R-MMU-4086400. PCP/CE pathway.
R-MMU-5663220. RHO GTPases Activate Formins.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8BPM0.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000034574.
Genevisibleⁱ	Q8BPM0. MM.

Family and domain databases

Gene3Dⁱ	1.25.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR027650. DAAM1. IPR014767. DAD_dom. IPR015425. FH2_Formin. IPR010472. FH3_dom. IPR014768. GBD/FH3_dom. IPR010473. GTPase-bd.
PANTHERⁱ	PTHR23213:SF181. PTHR23213:SF181. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06367. Drf_FH3. 1 hit. PF06371. Drf_GBD. 1 hit. PF02181. FH2. 1 hit.
SMARTⁱ	View protein in SMART SM01139. Drf_FH3. 1 hit. SM01140. Drf_GBD. 1 hit. SM00498. FH2. 1 hit.
SUPFAMⁱ	SSF48371. SSF48371. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51231. DAD. 1 hit. PS51444. FH2. 1 hit. PS51232. GBD_FH3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DAAM1_MOUSE
Accessionⁱ	Q8BPM0Primary (citable) accession number: Q8BPM0 Secondary accession number(s): Q3UHB4 , Q6DFY0, Q6TAB8, Q80Y68, Q9CQQ2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
	Last sequence update:	July 27, 2011
	Last modified:	February 28, 2018
	This is version 130 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BPM0 (DAAM1_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Disheveled-associated activator of morphogenesis 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ