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Q8BPI1

- KTU_MOUSE

UniProt

Q8BPI1 - KTU_MOUSE

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Protein

Protein kintoun

Gene

Dnaaf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment By similarity.By similarity

GO - Biological processi

  1. axonemal dynein complex assembly Source: UniProtKB
  2. bacterial-type flagellum-dependent cell motility Source: Ensembl
  3. cilium-dependent cell motility Source: UniProtKB
  4. response to organic substance Source: MGI
  5. response to retinoic acid Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kintoun
Alternative name(s):
Dynein assembly factor 2, axonemal
Gene namesi
Name:Dnaaf2
Synonyms:Ktu
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1923566. Dnaaf2.

Subcellular locationi

Cytoplasm By similarity
Note: Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia.By similarity

GO - Cellular componenti

  1. ciliary basal body Source: MGI
  2. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 814814Protein kintounPRO_0000089912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei444 – 4441PhosphoserineBy similarity
Modified residuei618 – 6181PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BPI1.
PaxDbiQ8BPI1.
PRIDEiQ8BPI1.

PTM databases

PhosphoSiteiQ8BPI1.

Expressioni

Tissue specificityi

Expressed in nearly all organs of adult, with higher expression in tissues known to have motile cilia and flagella, such as brain and testis.1 Publication

Gene expression databases

BgeeiQ8BPI1.
CleanExiMM_1110034A24RIK.
GenevestigatoriQ8BPI1.

Interactioni

Subunit structurei

Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1 By similarity.By similarity

Protein-protein interaction databases

DIPiDIP-59777N.

Structurei

3D structure databases

ProteinModelPortaliQ8BPI1.
SMRiQ8BPI1. Positions 67-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIH1 family. Kintoun subfamily.Curated

Phylogenomic databases

eggNOGiNOG40282.
GeneTreeiENSGT00510000048466.
HOGENOMiHOG000094570.
HOVERGENiHBG108080.
InParanoidiQ8BPI1.
OMAiCLDSRKP.
OrthoDBiEOG7CRTP9.
TreeFamiTF336215.

Family and domain databases

InterProiIPR012981. PIH1.
[Graphical view]
PANTHERiPTHR22997. PTHR22997. 1 hit.
PfamiPF08190. PIH1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BPI1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKAAASSAL EDLDLSREEV QRFTSAFQDP EFRRMFSEYA AEITDPENRR
60 70 80 90 100
RYEEEITALE RERGVDVRFV HPEPGHVLRT SLDGEHRCYV NVCSNSLVGV
110 120 130 140 150
PSSRPGPGRG GTAAGSHWSL PYSLAPGRQY AGRNGARYTV YDVVFHPEAL
160 170 180 190 200
ALARSHERFR EMLDATALEA VEQQFGVRLD RRNAKTLKIK YKGMPEAAVL
210 220 230 240 250
RTPLPGGVPA QPEGEPPGLF PDPPYPYRYP AAAAANTARS PASPAPEAVQ
260 270 280 290 300
RPEPTEPRCS VVQRHHVDLQ DYRCSRDAAP STVPHELVVT IELPLLRSVE
310 320 330 340 350
RAELEVKGKL LCLDSRNPDY RLRLSLPYPV DDGRGKAQYN KARRQLVVTL
360 370 380 390 400
PVALADARQE PPAATPEEPA EETGTDDVAR TSAGDFAAAR EESADGTGAD
410 420 430 440 450
HGEKSGVGAP DPGAAHAEGE LVPEPEQDFG GDSVAPLDLG KGTSPGDRSL
460 470 480 490 500
PYSAFPGGDT ESLCGDPGVQ TNEEQERTRH DTAGSAMGDP GTESIAPVCP
510 520 530 540 550
PLQCNQDEDS LTLLIQVPGI LPQTLHGHLS PVGYELCFST QDSGYSCTLQ
560 570 580 590 600
FAPENKLSTR EPETSVSLNN AVIVLAKSPE SHGLWREWYC GLNKESLEER
610 620 630 640 650
LFINEENVNG FLEEVLCSPL KQARSLAPPL IEVLQATDEQ VQIHAELQEC
660 670 680 690 700
SDPAGLQGKG KGVREGCPLS EAEAADQSAT SPAASDSAAA VEALKINTHG
710 720 730 740 750
SAVDLQHGCP EVPHVLSGKP LQPEAKMDPE FIRESSTTYS TEEKENIREP
760 770 780 790 800
VISKGEKING DHPSSLLNKT VVQNIPDFDT IKETNMQDGS VQIIRDHTTH
810
CAFSFQNPLL YDLD
Length:814
Mass (Da):88,327
Last modified:March 3, 2009 - v2
Checksum:i62F63A64B3BE73E3
GO
Isoform 2 (identifier: Q8BPI1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-437: Missing.

Note: No experimental confirmation available.

Show »
Length:776
Mass (Da):84,605
Checksum:iCA6EA380AF386A6F
GO

Sequence cautioni

The sequence AAH58344.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB28455.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC35879.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAE32466.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAE43032.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti463 – 4631L → Q in BAB28455. (PubMed:16141072)Curated
Sequence conflicti753 – 7531S → T in BAE32466. (PubMed:16141072)Curated
Sequence conflicti791 – 7911V → E in BAB28455. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei400 – 43738Missing in isoform 2. 1 PublicationVSP_036538Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB455811 mRNA. Translation: BAG75151.1.
BC055807 mRNA. Translation: AAH55807.1.
BC058344 mRNA. Translation: AAH58344.1. Different initiation.
BC062898 mRNA. Translation: AAH62898.1.
AK012767 mRNA. Translation: BAB28455.1. Different initiation.
AK075648 mRNA. Translation: BAC35879.1. Different initiation.
AK154254 mRNA. Translation: BAE32466.1. Different initiation.
AK172494 mRNA. Translation: BAE43032.1. Different initiation.
CCDSiCCDS25948.1. [Q8BPI1-1]
RefSeqiNP_081545.3. NM_027269.3. [Q8BPI1-1]
UniGeneiMm.107180.

Genome annotation databases

EnsembliENSMUST00000021356; ENSMUSP00000021356; ENSMUSG00000020973. [Q8BPI1-1]
GeneIDi109065.
KEGGimmu:109065.
UCSCiuc007nrt.1. mouse. [Q8BPI1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB455811 mRNA. Translation: BAG75151.1 .
BC055807 mRNA. Translation: AAH55807.1 .
BC058344 mRNA. Translation: AAH58344.1 . Different initiation.
BC062898 mRNA. Translation: AAH62898.1 .
AK012767 mRNA. Translation: BAB28455.1 . Different initiation.
AK075648 mRNA. Translation: BAC35879.1 . Different initiation.
AK154254 mRNA. Translation: BAE32466.1 . Different initiation.
AK172494 mRNA. Translation: BAE43032.1 . Different initiation.
CCDSi CCDS25948.1. [Q8BPI1-1 ]
RefSeqi NP_081545.3. NM_027269.3. [Q8BPI1-1 ]
UniGenei Mm.107180.

3D structure databases

ProteinModelPortali Q8BPI1.
SMRi Q8BPI1. Positions 67-205.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59777N.

PTM databases

PhosphoSitei Q8BPI1.

Proteomic databases

MaxQBi Q8BPI1.
PaxDbi Q8BPI1.
PRIDEi Q8BPI1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021356 ; ENSMUSP00000021356 ; ENSMUSG00000020973 . [Q8BPI1-1 ]
GeneIDi 109065.
KEGGi mmu:109065.
UCSCi uc007nrt.1. mouse. [Q8BPI1-1 ]

Organism-specific databases

CTDi 55172.
MGIi MGI:1923566. Dnaaf2.

Phylogenomic databases

eggNOGi NOG40282.
GeneTreei ENSGT00510000048466.
HOGENOMi HOG000094570.
HOVERGENi HBG108080.
InParanoidi Q8BPI1.
OMAi CLDSRKP.
OrthoDBi EOG7CRTP9.
TreeFami TF336215.

Miscellaneous databases

NextBioi 361616.
PROi Q8BPI1.
SOURCEi Search...

Gene expression databases

Bgeei Q8BPI1.
CleanExi MM_1110034A24RIK.
Genevestigatori Q8BPI1.

Family and domain databases

InterProi IPR012981. PIH1.
[Graphical view ]
PANTHERi PTHR22997. PTHR22997. 1 hit.
Pfami PF08190. PIH1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH DNAI2 AND HSPA1A.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 387-814 (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 385-814 (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Embryo and Spleen.

Entry informationi

Entry nameiKTU_MOUSE
AccessioniPrimary (citable) accession number: Q8BPI1
Secondary accession number(s): Q3T9I8
, Q3U4G5, Q6P5G9, Q9CZC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3