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Q8BPI1

- KTU_MOUSE

UniProt

Q8BPI1 - KTU_MOUSE

Protein

Protein kintoun

Gene

Dnaaf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. axonemal dynein complex assembly Source: UniProtKB
    2. bacterial-type flagellum-dependent cell motility Source: Ensembl
    3. cilium-dependent cell motility Source: UniProtKB
    4. response to organic substance Source: MGI
    5. response to retinoic acid Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein kintoun
    Alternative name(s):
    Dynein assembly factor 2, axonemal
    Gene namesi
    Name:Dnaaf2
    Synonyms:Ktu
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1923566. Dnaaf2.

    Subcellular locationi

    Cytoplasm By similarity
    Note: Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia.By similarity

    GO - Cellular componenti

    1. ciliary basal body Source: MGI
    2. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 814814Protein kintounPRO_0000089912Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei444 – 4441PhosphoserineBy similarity
    Modified residuei618 – 6181PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8BPI1.
    PRIDEiQ8BPI1.

    PTM databases

    PhosphoSiteiQ8BPI1.

    Expressioni

    Tissue specificityi

    Expressed in nearly all organs of adult, with higher expression in tissues known to have motile cilia and flagella, such as brain and testis.1 Publication

    Gene expression databases

    BgeeiQ8BPI1.
    CleanExiMM_1110034A24RIK.
    GenevestigatoriQ8BPI1.

    Interactioni

    Subunit structurei

    Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1 By similarity.By similarity

    Protein-protein interaction databases

    DIPiDIP-59777N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BPI1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PIH1 family. Kintoun subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG40282.
    GeneTreeiENSGT00510000048466.
    HOGENOMiHOG000094570.
    HOVERGENiHBG108080.
    InParanoidiQ3U4G5.
    OMAiCLDSRKP.
    OrthoDBiEOG7CRTP9.
    TreeFamiTF336215.

    Family and domain databases

    InterProiIPR012981. PIH1.
    [Graphical view]
    PANTHERiPTHR22997. PTHR22997. 1 hit.
    PfamiPF08190. PIH1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BPI1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKAAASSAL EDLDLSREEV QRFTSAFQDP EFRRMFSEYA AEITDPENRR    50
    RYEEEITALE RERGVDVRFV HPEPGHVLRT SLDGEHRCYV NVCSNSLVGV 100
    PSSRPGPGRG GTAAGSHWSL PYSLAPGRQY AGRNGARYTV YDVVFHPEAL 150
    ALARSHERFR EMLDATALEA VEQQFGVRLD RRNAKTLKIK YKGMPEAAVL 200
    RTPLPGGVPA QPEGEPPGLF PDPPYPYRYP AAAAANTARS PASPAPEAVQ 250
    RPEPTEPRCS VVQRHHVDLQ DYRCSRDAAP STVPHELVVT IELPLLRSVE 300
    RAELEVKGKL LCLDSRNPDY RLRLSLPYPV DDGRGKAQYN KARRQLVVTL 350
    PVALADARQE PPAATPEEPA EETGTDDVAR TSAGDFAAAR EESADGTGAD 400
    HGEKSGVGAP DPGAAHAEGE LVPEPEQDFG GDSVAPLDLG KGTSPGDRSL 450
    PYSAFPGGDT ESLCGDPGVQ TNEEQERTRH DTAGSAMGDP GTESIAPVCP 500
    PLQCNQDEDS LTLLIQVPGI LPQTLHGHLS PVGYELCFST QDSGYSCTLQ 550
    FAPENKLSTR EPETSVSLNN AVIVLAKSPE SHGLWREWYC GLNKESLEER 600
    LFINEENVNG FLEEVLCSPL KQARSLAPPL IEVLQATDEQ VQIHAELQEC 650
    SDPAGLQGKG KGVREGCPLS EAEAADQSAT SPAASDSAAA VEALKINTHG 700
    SAVDLQHGCP EVPHVLSGKP LQPEAKMDPE FIRESSTTYS TEEKENIREP 750
    VISKGEKING DHPSSLLNKT VVQNIPDFDT IKETNMQDGS VQIIRDHTTH 800
    CAFSFQNPLL YDLD 814
    Length:814
    Mass (Da):88,327
    Last modified:March 3, 2009 - v2
    Checksum:i62F63A64B3BE73E3
    GO
    Isoform 2 (identifier: Q8BPI1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         400-437: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:776
    Mass (Da):84,605
    Checksum:iCA6EA380AF386A6F
    GO

    Sequence cautioni

    The sequence AAH58344.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB28455.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC35879.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAE32466.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAE43032.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti463 – 4631L → Q in BAB28455. (PubMed:16141072)Curated
    Sequence conflicti753 – 7531S → T in BAE32466. (PubMed:16141072)Curated
    Sequence conflicti791 – 7911V → E in BAB28455. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei400 – 43738Missing in isoform 2. 1 PublicationVSP_036538Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB455811 mRNA. Translation: BAG75151.1.
    BC055807 mRNA. Translation: AAH55807.1.
    BC058344 mRNA. Translation: AAH58344.1. Different initiation.
    BC062898 mRNA. Translation: AAH62898.1.
    AK012767 mRNA. Translation: BAB28455.1. Different initiation.
    AK075648 mRNA. Translation: BAC35879.1. Different initiation.
    AK154254 mRNA. Translation: BAE32466.1. Different initiation.
    AK172494 mRNA. Translation: BAE43032.1. Different initiation.
    CCDSiCCDS25948.1. [Q8BPI1-1]
    RefSeqiNP_081545.3. NM_027269.3. [Q8BPI1-1]
    UniGeneiMm.107180.

    Genome annotation databases

    EnsembliENSMUST00000021356; ENSMUSP00000021356; ENSMUSG00000020973. [Q8BPI1-1]
    GeneIDi109065.
    KEGGimmu:109065.
    UCSCiuc007nrt.1. mouse. [Q8BPI1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB455811 mRNA. Translation: BAG75151.1 .
    BC055807 mRNA. Translation: AAH55807.1 .
    BC058344 mRNA. Translation: AAH58344.1 . Different initiation.
    BC062898 mRNA. Translation: AAH62898.1 .
    AK012767 mRNA. Translation: BAB28455.1 . Different initiation.
    AK075648 mRNA. Translation: BAC35879.1 . Different initiation.
    AK154254 mRNA. Translation: BAE32466.1 . Different initiation.
    AK172494 mRNA. Translation: BAE43032.1 . Different initiation.
    CCDSi CCDS25948.1. [Q8BPI1-1 ]
    RefSeqi NP_081545.3. NM_027269.3. [Q8BPI1-1 ]
    UniGenei Mm.107180.

    3D structure databases

    ProteinModelPortali Q8BPI1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59777N.

    PTM databases

    PhosphoSitei Q8BPI1.

    Proteomic databases

    PaxDbi Q8BPI1.
    PRIDEi Q8BPI1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021356 ; ENSMUSP00000021356 ; ENSMUSG00000020973 . [Q8BPI1-1 ]
    GeneIDi 109065.
    KEGGi mmu:109065.
    UCSCi uc007nrt.1. mouse. [Q8BPI1-1 ]

    Organism-specific databases

    CTDi 55172.
    MGIi MGI:1923566. Dnaaf2.

    Phylogenomic databases

    eggNOGi NOG40282.
    GeneTreei ENSGT00510000048466.
    HOGENOMi HOG000094570.
    HOVERGENi HBG108080.
    InParanoidi Q3U4G5.
    OMAi CLDSRKP.
    OrthoDBi EOG7CRTP9.
    TreeFami TF336215.

    Miscellaneous databases

    NextBioi 361616.
    PROi Q8BPI1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BPI1.
    CleanExi MM_1110034A24RIK.
    Genevestigatori Q8BPI1.

    Family and domain databases

    InterProi IPR012981. PIH1.
    [Graphical view ]
    PANTHERi PTHR22997. PTHR22997. 1 hit.
    Pfami PF08190. PIH1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH DNAI2 AND HSPA1A.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 387-814 (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 385-814 (ISOFORM 1).
      Strain: C57BL/6J and NOD.
      Tissue: Embryo and Spleen.

    Entry informationi

    Entry nameiKTU_MOUSE
    AccessioniPrimary (citable) accession number: Q8BPI1
    Secondary accession number(s): Q3T9I8
    , Q3U4G5, Q6P5G9, Q9CZC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3