Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei133SubstrateBy similarity1
Binding sitei164SubstrateBy similarity1
Sitei171Critical for catalysisBy similarity1
Sitei218Critical for catalysisBy similarity1
Metal bindingi251Magnesium or manganeseBy similarity1
Binding sitei251SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi53 – 81NADSequence analysisAdd BLAST29
Nucleotide bindingi306 – 313ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandATP-binding, Magnesium, Manganese, Metal-binding, NAD, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitric dehydrogenase subunit gamma 2
NAD(+)-specific ICDH subunit gamma 2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2142174. 4933405O20Rik.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionSequence analysisAdd BLAST25
ChainiPRO_000040193326 – 396Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrialAdd BLAST371

Proteomic databases

PeptideAtlasiQ8BPC6.
PRIDEiQ8BPC6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000084234.
GenevisibleiQ8BPC6. MM.

Interactioni

Subunit structurei

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8BPC6.
SMRiQ8BPC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00590000083091.
HOVERGENiHBG052080.
InParanoidiQ8BPC6.
KOiK00030.
OMAiHRNIANP.
OrthoDBiEOG091G094X.

Family and domain databases

InterProiView protein in InterPro
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
PfamiView protein in Pfam
PF00180. Iso_dh. 1 hit.
SMARTiView protein in SMART
SM01329. Iso_dh. 1 hit.
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BPC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAVTSCSMK TVLQYAVFLG HSREVVCELV TSFRSFCSHC AVPPSPKYGG
60 70 80 90 100
RHTVAMIPGD GIGPELMVHV KKIFRSNCVP VDFEEVWVTS TSNEEEINNA
110 120 130 140 150
LMAIRRNRVA LKGNIATNHN LPARYKSHNT KFRTILDLYA SVVHFKTFPG
160 170 180 190 200
VMTRHKDIDI LVVRENTEGE YTNLEHESVK GVVESLKIVT KTKSVRIADY
210 220 230 240 250
AFKLAQKMGR KKVTVVHKAN IMKLGDGLFL QCCKDVAAHY PQITLESMII
260 270 280 290 300
DNTTMQLVSK PQQFDVMVMP NLYGNIINSI CTGLVGGSGI VPGANYGDSY
310 320 330 340 350
AIFEMGSKEI GKDLAHRNIA NPVAMLLTSC IMLDYLDLQP YATHIRSAVM
360 370 380 390
ASLQNKAVCT PDIGGQGNTA STVEYILHHM KEQTSGCHPN FFLQFT
Length:396
Mass (Da):43,850
Last modified:March 1, 2003 - v1
Checksum:i1B5D708D2D265398
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077105 mRNA. Translation: BAC36614.1.
CH466603 Genomic DNA. Translation: EDL22983.1.
BC060958 mRNA. Translation: AAH60958.1.
CCDSiCCDS71974.1.
RefSeqiNP_766489.1. NM_172901.2.
UniGeneiMm.443270.

Genome annotation databases

EnsembliENSMUST00000119710; ENSMUSP00000138215; ENSMUSG00000084234.
GeneIDi243996.
KEGGimmu:243996.
UCSCiuc009hca.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077105 mRNA. Translation: BAC36614.1.
CH466603 Genomic DNA. Translation: EDL22983.1.
BC060958 mRNA. Translation: AAH60958.1.
CCDSiCCDS71974.1.
RefSeqiNP_766489.1. NM_172901.2.
UniGeneiMm.443270.

3D structure databases

ProteinModelPortaliQ8BPC6.
SMRiQ8BPC6.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ8BPC6.
PRIDEiQ8BPC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000119710; ENSMUSP00000138215; ENSMUSG00000084234.
GeneIDi243996.
KEGGimmu:243996.
UCSCiuc009hca.1. mouse.

Organism-specific databases

MGIiMGI:2142174. 4933405O20Rik.

Phylogenomic databases

GeneTreeiENSGT00590000083091.
HOVERGENiHBG052080.
InParanoidiQ8BPC6.
KOiK00030.
OMAiHRNIANP.
OrthoDBiEOG091G094X.

Miscellaneous databases

PROiPR:Q8BPC6.

Gene expression databases

BgeeiENSMUSG00000084234.
GenevisibleiQ8BPC6. MM.

Family and domain databases

InterProiView protein in InterPro
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
PfamiView protein in Pfam
PF00180. Iso_dh. 1 hit.
SMARTiView protein in SMART
SM01329. Iso_dh. 1 hit.
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIDHG2_MOUSE
AccessioniPrimary (citable) accession number: Q8BPC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: March 1, 2003
Last modified: May 10, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.