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Q8BPC6

- IDHG2_MOUSE

UniProt

Q8BPC6 - IDHG2_MOUSE

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Protein
Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial
Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei133 – 1331Substrate By similarity
Binding sitei164 – 1641Substrate By similarity
Sitei171 – 1711Critical for catalysis By similarity
Sitei218 – 2181Critical for catalysis By similarity
Metal bindingi251 – 2511Magnesium or manganese By similarity
Binding sitei251 – 2511Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi53 – 8129NAD Reviewed prediction
Add
BLAST
Nucleotide bindingi306 – 3138ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD binding Source: InterPro
  3. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  4. magnesium ion binding Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, NAD, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitric dehydrogenase subunit gamma 2
NAD(+)-specific ICDH subunit gamma 2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2142174. 4933405O20Rik.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525Mitochondrion Reviewed prediction
Add
BLAST
Chaini26 – 396371Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial
PRO_0000401933Add
BLAST

Proteomic databases

PRIDEiQ8BPC6.

Expressioni

Gene expression databases

GenevestigatoriQ8BPC6.

Interactioni

Subunit structurei

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8BPC6.
SMRiQ8BPC6. Positions 47-382.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00590000083091.
HOVERGENiHBG052080.
KOiK00030.
OMAiHRNIANP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BPC6-1 [UniParc]FASTAAdd to Basket

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MLAVTSCSMK TVLQYAVFLG HSREVVCELV TSFRSFCSHC AVPPSPKYGG    50
RHTVAMIPGD GIGPELMVHV KKIFRSNCVP VDFEEVWVTS TSNEEEINNA 100
LMAIRRNRVA LKGNIATNHN LPARYKSHNT KFRTILDLYA SVVHFKTFPG 150
VMTRHKDIDI LVVRENTEGE YTNLEHESVK GVVESLKIVT KTKSVRIADY 200
AFKLAQKMGR KKVTVVHKAN IMKLGDGLFL QCCKDVAAHY PQITLESMII 250
DNTTMQLVSK PQQFDVMVMP NLYGNIINSI CTGLVGGSGI VPGANYGDSY 300
AIFEMGSKEI GKDLAHRNIA NPVAMLLTSC IMLDYLDLQP YATHIRSAVM 350
ASLQNKAVCT PDIGGQGNTA STVEYILHHM KEQTSGCHPN FFLQFT 396
Length:396
Mass (Da):43,850
Last modified:March 1, 2003 - v1
Checksum:i1B5D708D2D265398
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK077105 mRNA. Translation: BAC36614.1.
CH466603 Genomic DNA. Translation: EDL22983.1.
BC060958 mRNA. Translation: AAH60958.1.
CCDSiCCDS71974.1.
RefSeqiNP_766489.1. NM_172901.2.
UniGeneiMm.443270.

Genome annotation databases

EnsembliENSMUST00000119710; ENSMUSP00000138215; ENSMUSG00000084234.
GeneIDi243996.
KEGGimmu:243996.
UCSCiuc009hca.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK077105 mRNA. Translation: BAC36614.1 .
CH466603 Genomic DNA. Translation: EDL22983.1 .
BC060958 mRNA. Translation: AAH60958.1 .
CCDSi CCDS71974.1.
RefSeqi NP_766489.1. NM_172901.2.
UniGenei Mm.443270.

3D structure databases

ProteinModelPortali Q8BPC6.
SMRi Q8BPC6. Positions 47-382.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8BPC6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000119710 ; ENSMUSP00000138215 ; ENSMUSG00000084234 .
GeneIDi 243996.
KEGGi mmu:243996.
UCSCi uc009hca.1. mouse.

Organism-specific databases

MGIi MGI:2142174. 4933405O20Rik.

Phylogenomic databases

GeneTreei ENSGT00590000083091.
HOVERGENi HBG052080.
KOi K00030.
OMAi HRNIANP.

Miscellaneous databases

NextBioi 386086.

Gene expression databases

Genevestigatori Q8BPC6.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIDHG2_MOUSE
AccessioniPrimary (citable) accession number: Q8BPC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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