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Protein

MOB kinase activator 1B

Gene

Mob1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79ZincBy similarity1
Metal bindingi84ZincBy similarity1
Metal bindingi161ZincBy similarity1
Metal bindingi166ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-2028269. Signaling by Hippo.

Names & Taxonomyi

Protein namesi
Recommended name:
MOB kinase activator 1B
Alternative name(s):
Mob1 homolog 1A
Mps one binder kinase activator-like 1A
Gene namesi
Name:Mob1b
Synonyms:Mobkl1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1915723. Mob1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001935652 – 216MOB kinase activator 1BAdd BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei12Phosphothreonine; by STK4/MST1By similarity1
Modified residuei35Phosphothreonine; by STK4/MST1By similarity1

Post-translational modificationi

Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BPB0.
PaxDbiQ8BPB0.
PRIDEiQ8BPB0.

PTM databases

iPTMnetiQ8BPB0.
PhosphoSitePlusiQ8BPB0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000006262.
ExpressionAtlasiQ8BPB0. baseline and differential.

Interactioni

Subunit structurei

Binds STK38L. Interacts with LATS1 and LATS2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006424.

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 9Combined sources5
Helixi24 – 34Combined sources11
Helixi35 – 38Combined sources4
Helixi41 – 44Combined sources4
Helixi53 – 74Combined sources22
Turni75 – 78Combined sources4
Turni81 – 83Combined sources3
Beta strandi85 – 92Combined sources8
Beta strandi94 – 98Combined sources5
Helixi111 – 126Combined sources16
Turni129 – 131Combined sources3
Helixi144 – 173Combined sources30
Helixi176 – 193Combined sources18
Helixi198 – 201Combined sources4
Helixi202 – 204Combined sources3
Helixi205 – 209Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5B5VX-ray2.19A/B/C/D/E/F1-216[»]
5B5WX-ray2.96A33-216[»]
5B6BX-ray3.54A/B/D/F/H/K/M/O1-216[»]
ProteinModelPortaliQ8BPB0.
SMRiQ8BPB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

eggNOGiKOG0440. Eukaryota.
ENOG410XSUJ. LUCA.
GeneTreeiENSGT00550000074456.
HOGENOMiHOG000164685.
HOVERGENiHBG052489.
InParanoidiQ8BPB0.
KOiK06685.
PhylomeDBiQ8BPB0.
TreeFamiTF300789.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiIPR005301. MOB_kinase_act_fam.
[Graphical view]
PANTHERiPTHR22599. PTHR22599. 1 hit.
PfamiPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SMARTiSM01388. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMiSSF101152. SSF101152. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BPB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLFGSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRMAVMLPEG
60 70 80 90 100
EDLNEWVAVN TVDFFNQINM LYGTITDFCT EESCPVMSAG PKYEYHWADG
110 120 130 140 150
TNIKKPIKCS APKYIDYLMT WVQDQLDDET LFPSKIGVPF PKNFMSVAKT
160 170 180 190 200
ILKRLFRVYA HIYHQHFDPV IQLQEEAHLN TSFKHFIFFV QEFNLIDRRE
210
LAPLQELIEK LTSKDR
Length:216
Mass (Da):25,091
Last modified:January 23, 2007 - v3
Checksum:i29EBA287B0CDAF90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077320 mRNA. Translation: BAC36748.1.
CCDSiCCDS39139.1.
RefSeqiNP_081011.1. NM_026735.2.
UniGeneiMm.35764.
Mm.392493.
Mm.486660.

Genome annotation databases

EnsembliENSMUST00000006424; ENSMUSP00000006424; ENSMUSG00000006262.
GeneIDi68473.
KEGGimmu:68473.
UCSCiuc008yae.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077320 mRNA. Translation: BAC36748.1.
CCDSiCCDS39139.1.
RefSeqiNP_081011.1. NM_026735.2.
UniGeneiMm.35764.
Mm.392493.
Mm.486660.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5B5VX-ray2.19A/B/C/D/E/F1-216[»]
5B5WX-ray2.96A33-216[»]
5B6BX-ray3.54A/B/D/F/H/K/M/O1-216[»]
ProteinModelPortaliQ8BPB0.
SMRiQ8BPB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006424.

PTM databases

iPTMnetiQ8BPB0.
PhosphoSitePlusiQ8BPB0.

Proteomic databases

MaxQBiQ8BPB0.
PaxDbiQ8BPB0.
PRIDEiQ8BPB0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006424; ENSMUSP00000006424; ENSMUSG00000006262.
GeneIDi68473.
KEGGimmu:68473.
UCSCiuc008yae.1. mouse.

Organism-specific databases

CTDi92597.
MGIiMGI:1915723. Mob1b.

Phylogenomic databases

eggNOGiKOG0440. Eukaryota.
ENOG410XSUJ. LUCA.
GeneTreeiENSGT00550000074456.
HOGENOMiHOG000164685.
HOVERGENiHBG052489.
InParanoidiQ8BPB0.
KOiK06685.
PhylomeDBiQ8BPB0.
TreeFamiTF300789.

Enzyme and pathway databases

ReactomeiR-MMU-2028269. Signaling by Hippo.

Miscellaneous databases

ChiTaRSiMob1b. mouse.
PROiQ8BPB0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006262.
ExpressionAtlasiQ8BPB0. baseline and differential.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiIPR005301. MOB_kinase_act_fam.
[Graphical view]
PANTHERiPTHR22599. PTHR22599. 1 hit.
PfamiPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SMARTiSM01388. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMiSSF101152. SSF101152. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMOB1B_MOUSE
AccessioniPrimary (citable) accession number: Q8BPB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.