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Q8BP92

- RCN2_MOUSE

UniProt

Q8BP92 - RCN2_MOUSE

Protein

Reticulocalbin-2

Gene

Rcn2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Not known. Binds calcium By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi77 – 88121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi113 – 124122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi165 – 176123; possibly ancestralPROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi202 – 213124PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi243 – 254125PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi279 – 290126PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: MGI

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Reticulocalbin-2
    Alternative name(s):
    Taipoxin-associated calcium-binding protein 49
    Short name:
    TCBP-49
    Gene namesi
    Name:Rcn2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1349765. Rcn2.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525By similarityAdd
    BLAST
    Chaini26 – 320295Reticulocalbin-2PRO_0000004149Add
    BLAST

    Proteomic databases

    MaxQBiQ8BP92.
    PaxDbiQ8BP92.
    PRIDEiQ8BP92.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BP92.
    BgeeiQ8BP92.
    CleanExiMM_RCN2.
    GenevestigatoriQ8BP92.

    Interactioni

    Protein-protein interaction databases

    BioGridi205029. 3 interactions.
    DIPiDIP-46963N.
    IntActiQ8BP92. 7 interactions.
    MINTiMINT-1605271.
    STRINGi10090.ENSMUSP00000109915.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BP92.
    SMRiQ8BP92. Positions 59-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 9936EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini100 – 13536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini150 – 18536EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini189 – 22436EF-hand 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini230 – 26536EF-hand 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini266 – 30136EF-hand 6PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi317 – 3204Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the CREC family.Curated
    Contains 6 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG124414.
    GeneTreeiENSGT00550000074546.
    HOGENOMiHOG000230934.
    HOVERGENiHBG002834.
    InParanoidiA2RT07.
    OMAiEDYFHDE.
    TreeFamiTF314849.

    Family and domain databases

    Gene3Di1.10.238.10. 3 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13202. EF-hand_5. 1 hit.
    PF13499. EF-hand_7. 2 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 5 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 5 hits.
    PS50222. EF_HAND_2. 5 hits.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BP92-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLGPRPAAL GLLLPLLLYA AVAGASKAEE LHYPQGEHRA DYDREALLGV    50
    QEDVDEYVKL GHEEQQRRLQ SIIKKIDSDS DGFLTENELS QWIQMSFKHY 100
    AMQEAKQQFV EYDKNSDGAV TWDEYNIQMY DRVIDFDENT ALDDTEEGSF 150
    RQLHLKDKKR FEKANQDSGP GLSLEEFIAF EHPEEVDYMT EFVIQEALEE 200
    HDKNGDGFVS LEEFLGDYRR DPTANEDPEW ILVEKDRFVN DYDKDNDGRL 250
    DPQELLSWVV PNNQGIAQEE ALHLIDEMDL NSDKKLSEEE ILENQDLFLT 300
    SEATDYGRQL HDDYFYHDEL 320
    Length:320
    Mass (Da):37,271
    Last modified:March 1, 2003 - v1
    Checksum:i62195C004F8D7C9D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti119 – 1191A → DP in AAC05132. 1 PublicationCurated
    Sequence conflicti302 – 3032EA → DQ in AAC05132. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF049125 mRNA. Translation: AAC05132.1.
    AK077486 mRNA. Translation: BAC36825.1.
    BC132320 mRNA. Translation: AAI32321.1.
    BC145668 mRNA. Translation: AAI45669.1.
    CCDSiCCDS23206.1.
    PIRiJC5402.
    RefSeqiNP_036122.2. NM_011992.2.
    UniGeneiMm.1782.

    Genome annotation databases

    EnsembliENSMUST00000114276; ENSMUSP00000109915; ENSMUSG00000032320.
    GeneIDi26611.
    KEGGimmu:26611.
    UCSCiuc009pss.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF049125 mRNA. Translation: AAC05132.1 .
    AK077486 mRNA. Translation: BAC36825.1 .
    BC132320 mRNA. Translation: AAI32321.1 .
    BC145668 mRNA. Translation: AAI45669.1 .
    CCDSi CCDS23206.1.
    PIRi JC5402.
    RefSeqi NP_036122.2. NM_011992.2.
    UniGenei Mm.1782.

    3D structure databases

    ProteinModelPortali Q8BP92.
    SMRi Q8BP92. Positions 59-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 205029. 3 interactions.
    DIPi DIP-46963N.
    IntActi Q8BP92. 7 interactions.
    MINTi MINT-1605271.
    STRINGi 10090.ENSMUSP00000109915.

    Proteomic databases

    MaxQBi Q8BP92.
    PaxDbi Q8BP92.
    PRIDEi Q8BP92.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000114276 ; ENSMUSP00000109915 ; ENSMUSG00000032320 .
    GeneIDi 26611.
    KEGGi mmu:26611.
    UCSCi uc009pss.1. mouse.

    Organism-specific databases

    CTDi 5955.
    MGIi MGI:1349765. Rcn2.

    Phylogenomic databases

    eggNOGi NOG124414.
    GeneTreei ENSGT00550000074546.
    HOGENOMi HOG000230934.
    HOVERGENi HBG002834.
    InParanoidi A2RT07.
    OMAi EDYFHDE.
    TreeFami TF314849.

    Miscellaneous databases

    ChiTaRSi RCN2. mouse.
    NextBioi 304663.
    PROi Q8BP92.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BP92.
    Bgeei Q8BP92.
    CleanExi MM_RCN2.
    Genevestigatori Q8BP92.

    Family and domain databases

    Gene3Di 1.10.238.10. 3 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13202. EF-hand_5. 1 hit.
    PF13499. EF-hand_7. 2 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 5 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 5 hits.
    PS50222. EF_HAND_2. 5 hits.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse taipoxin-associated calcium binding protein 49 (TCBP49)."
      Perin M.S.
      Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiRCN2_MOUSE
    AccessioniPrimary (citable) accession number: Q8BP92
    Secondary accession number(s): A2RT07, O70341
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3