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Q8BP92

- RCN2_MOUSE

UniProt

Q8BP92 - RCN2_MOUSE

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Protein

Reticulocalbin-2

Gene
Rcn2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Not known. Binds calcium By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi77 – 88121 Reviewed predictionAdd
BLAST
Calcium bindingi113 – 124122 Reviewed predictionAdd
BLAST
Calcium bindingi165 – 176123; possibly ancestral Reviewed predictionAdd
BLAST
Calcium bindingi202 – 213124 Reviewed predictionAdd
BLAST
Calcium bindingi243 – 254125 Reviewed predictionAdd
BLAST
Calcium bindingi279 – 290126 Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein binding Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulocalbin-2
Alternative name(s):
Taipoxin-associated calcium-binding protein 49
Short name:
TCBP-49
Gene namesi
Name:Rcn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1349765. Rcn2.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 By similarityAdd
BLAST
Chaini26 – 320295Reticulocalbin-2PRO_0000004149Add
BLAST

Proteomic databases

MaxQBiQ8BP92.
PaxDbiQ8BP92.
PRIDEiQ8BP92.

Expressioni

Gene expression databases

ArrayExpressiQ8BP92.
BgeeiQ8BP92.
CleanExiMM_RCN2.
GenevestigatoriQ8BP92.

Interactioni

Protein-protein interaction databases

BioGridi205029. 3 interactions.
DIPiDIP-46963N.
IntActiQ8BP92. 7 interactions.
MINTiMINT-1605271.
STRINGi10090.ENSMUSP00000109915.

Structurei

3D structure databases

ProteinModelPortaliQ8BP92.
SMRiQ8BP92. Positions 59-296.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 9936EF-hand 1Add
BLAST
Domaini100 – 13536EF-hand 2Add
BLAST
Domaini150 – 18536EF-hand 3Add
BLAST
Domaini189 – 22436EF-hand 4Add
BLAST
Domaini230 – 26536EF-hand 5Add
BLAST
Domaini266 – 30136EF-hand 6Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi317 – 3204Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Belongs to the CREC family.
Contains 6 EF-hand domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG124414.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiA2RT07.
OMAiEDYFHDE.
TreeFamiTF314849.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BP92-1 [UniParc]FASTAAdd to Basket

« Hide

MRLGPRPAAL GLLLPLLLYA AVAGASKAEE LHYPQGEHRA DYDREALLGV    50
QEDVDEYVKL GHEEQQRRLQ SIIKKIDSDS DGFLTENELS QWIQMSFKHY 100
AMQEAKQQFV EYDKNSDGAV TWDEYNIQMY DRVIDFDENT ALDDTEEGSF 150
RQLHLKDKKR FEKANQDSGP GLSLEEFIAF EHPEEVDYMT EFVIQEALEE 200
HDKNGDGFVS LEEFLGDYRR DPTANEDPEW ILVEKDRFVN DYDKDNDGRL 250
DPQELLSWVV PNNQGIAQEE ALHLIDEMDL NSDKKLSEEE ILENQDLFLT 300
SEATDYGRQL HDDYFYHDEL 320
Length:320
Mass (Da):37,271
Last modified:March 1, 2003 - v1
Checksum:i62195C004F8D7C9D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191A → DP in AAC05132. 1 Publication
Sequence conflicti302 – 3032EA → DQ in AAC05132. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF049125 mRNA. Translation: AAC05132.1.
AK077486 mRNA. Translation: BAC36825.1.
BC132320 mRNA. Translation: AAI32321.1.
BC145668 mRNA. Translation: AAI45669.1.
CCDSiCCDS23206.1.
PIRiJC5402.
RefSeqiNP_036122.2. NM_011992.2.
UniGeneiMm.1782.

Genome annotation databases

EnsembliENSMUST00000114276; ENSMUSP00000109915; ENSMUSG00000032320.
GeneIDi26611.
KEGGimmu:26611.
UCSCiuc009pss.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF049125 mRNA. Translation: AAC05132.1 .
AK077486 mRNA. Translation: BAC36825.1 .
BC132320 mRNA. Translation: AAI32321.1 .
BC145668 mRNA. Translation: AAI45669.1 .
CCDSi CCDS23206.1.
PIRi JC5402.
RefSeqi NP_036122.2. NM_011992.2.
UniGenei Mm.1782.

3D structure databases

ProteinModelPortali Q8BP92.
SMRi Q8BP92. Positions 59-296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 205029. 3 interactions.
DIPi DIP-46963N.
IntActi Q8BP92. 7 interactions.
MINTi MINT-1605271.
STRINGi 10090.ENSMUSP00000109915.

Proteomic databases

MaxQBi Q8BP92.
PaxDbi Q8BP92.
PRIDEi Q8BP92.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000114276 ; ENSMUSP00000109915 ; ENSMUSG00000032320 .
GeneIDi 26611.
KEGGi mmu:26611.
UCSCi uc009pss.1. mouse.

Organism-specific databases

CTDi 5955.
MGIi MGI:1349765. Rcn2.

Phylogenomic databases

eggNOGi NOG124414.
GeneTreei ENSGT00550000074546.
HOGENOMi HOG000230934.
HOVERGENi HBG002834.
InParanoidi A2RT07.
OMAi EDYFHDE.
TreeFami TF314849.

Miscellaneous databases

ChiTaRSi RCN2. mouse.
NextBioi 304663.
PROi Q8BP92.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BP92.
Bgeei Q8BP92.
CleanExi MM_RCN2.
Genevestigatori Q8BP92.

Family and domain databases

Gene3Di 1.10.238.10. 3 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view ]
SMARTi SM00054. EFh. 5 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse taipoxin-associated calcium binding protein 49 (TCBP49)."
    Perin M.S.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRCN2_MOUSE
AccessioniPrimary (citable) accession number: Q8BP92
Secondary accession number(s): A2RT07, O70341
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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