Q8BP92 (RCN2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Reticulocalbin-2

Alternative name(s):
Taipoxin-associated calcium-binding protein 49
Short name=TCBP-49

Gene names

Name:

Rcn2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Not known. Binds calcium By similarity.
Subcellular location	Endoplasmic reticulum lumen By similarity.
Sequence similarities	Belongs to the CREC family. Contains 6 EF-hand domains.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Repeat Signal
Ligand	Calcium Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	By similarity
	Chain	26 – 320	295	Reticulocalbin-2		PRO_0000004149
Regions
	Domain	64 – 99	36	EF-hand 1
	Domain	100 – 135	36	EF-hand 2
	Domain	150 – 185	36	EF-hand 3
	Domain	189 – 224	36	EF-hand 4
	Domain	230 – 265	36	EF-hand 5
	Domain	266 – 301	36	EF-hand 6
	Calcium binding	77 – 88	12	1 Potential
	Calcium binding	113 – 124	12	2 Potential
	Calcium binding	165 – 176	12	3; possibly ancestral Potential
	Calcium binding	202 – 213	12	4 Potential
	Calcium binding	243 – 254	12	5 Potential
	Calcium binding	279 – 290	12	6 Potential
	Motif	317 – 320	4	Prevents secretion from ER Potential
Experimental info
	Sequence conflict	119	1	A → DP in AAC05132. Ref.1
	Sequence conflict	302 – 303	2	EA → DQ in AAC05132. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8BP92 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 62195C004F8D7C9D	FASTA	320	37,271
	10 20 30 40 50 60 MRLGPRPAAL GLLLPLLLYA AVAGASKAEE LHYPQGEHRA DYDREALLGV QEDVDEYVKL 70 80 90 100 110 120 GHEEQQRRLQ SIIKKIDSDS DGFLTENELS QWIQMSFKHY AMQEAKQQFV EYDKNSDGAV 130 140 150 160 170 180 TWDEYNIQMY DRVIDFDENT ALDDTEEGSF RQLHLKDKKR FEKANQDSGP GLSLEEFIAF 190 200 210 220 230 240 EHPEEVDYMT EFVIQEALEE HDKNGDGFVS LEEFLGDYRR DPTANEDPEW ILVEKDRFVN 250 260 270 280 290 300 DYDKDNDGRL DPQELLSWVV PNNQGIAQEE ALHLIDEMDL NSDKKLSEEE ILENQDLFLT 310 320 SEATDYGRQL HDDYFYHDEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mouse taipoxin-associated calcium binding protein 49 (TCBP49)." Perin M.S. Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF049125 mRNA. Translation: AAC05132.1. AK077486 mRNA. Translation: BAC36825.1. BC132320 mRNA. Translation: AAI32321.1. BC145668 mRNA. Translation: AAI45669.1.
IPI	IPI00474959.
PIR	JC5402.
RefSeq	NP_036122.2. NM_011992.2.
UniGene	Mm.1782.
3D structure databases
ProteinModelPortal	Q8BP92.
SMR	Q8BP92. Positions 67-297.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-46963N.
IntAct	Q8BP92. 6 interactions.
STRING	10090.ENSMUSP00000109915.
Proteomic databases
PaxDb	Q8BP92.
PRIDE	Q8BP92.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000114276; ENSMUSP00000109915; ENSMUSG00000032320.
GeneID	26611.
KEGG	mmu:26611.
Organism-specific databases
CTD	5955.
MGI	MGI:1349765. Rcn2.
Phylogenomic databases
eggNOG	NOG124414.
GeneTree	ENSGT00550000074546.
HOGENOM	HOG000230934.
HOVERGEN	HBG002834.
InParanoid	A2RT07.
OMA	EHELEPV.
OrthoDB	EOG4DFPP6.
Gene expression databases
ArrayExpress	Q8BP92.
Bgee	Q8BP92.
CleanEx	MM_RCN2.
Genevestigator	Q8BP92.
GermOnline	ENSMUSG00000032320. Mus musculus.
Family and domain databases
Gene3D	1.10.238.10. 3 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. [Graphical view]
Pfam	PF13202. EF_hand_3. 1 hit. PF13499. EF_hand_5. 2 hits. [Graphical view]
SMART	SM00054. EFh. 5 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 5 hits. PS50222. EF_HAND_2. 5 hits. PS00014. ER_TARGET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RCN2. mouse.
NextBio	304663.
SOURCE	Search...

Entry information

Entry name

RCN2_MOUSE

Accession

Primary (citable) accession number: Q8BP92
Secondary accession number(s): A2RT07, O70341

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2005
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program