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Protein

Reticulocalbin-2

Gene

Rcn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Not known. Binds calcium (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi77 – 88121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi113 – 124122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi165 – 176123; possibly ancestralPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi202 – 213124PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi243 – 254125PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi279 – 290126PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulocalbin-2
Alternative name(s):
Taipoxin-associated calcium-binding protein 49
Short name:
TCBP-49
Gene namesi
Name:Rcn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1349765. Rcn2.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525By similarityAdd
BLAST
Chaini26 – 320295Reticulocalbin-2PRO_0000004149Add
BLAST

Proteomic databases

MaxQBiQ8BP92.
PaxDbiQ8BP92.
PRIDEiQ8BP92.

Expressioni

Gene expression databases

BgeeiQ8BP92.
CleanExiMM_RCN2.
ExpressionAtlasiQ8BP92. baseline and differential.
GenevisibleiQ8BP92. MM.

Interactioni

Protein-protein interaction databases

BioGridi205029. 3 interactions.
DIPiDIP-46963N.
IntActiQ8BP92. 7 interactions.
MINTiMINT-1605271.
STRINGi10090.ENSMUSP00000109915.

Structurei

3D structure databases

ProteinModelPortaliQ8BP92.
SMRiQ8BP92. Positions 67-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 9936EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini100 – 13536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini150 – 18536EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini189 – 22436EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini230 – 26536EF-hand 5PROSITE-ProRule annotationAdd
BLAST
Domaini266 – 30136EF-hand 6PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi317 – 3204Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the CREC family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG124414.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ8BP92.
OMAiRFEKANR.
TreeFamiTF314849.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BP92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLGPRPAAL GLLLPLLLYA AVAGASKAEE LHYPQGEHRA DYDREALLGV
60 70 80 90 100
QEDVDEYVKL GHEEQQRRLQ SIIKKIDSDS DGFLTENELS QWIQMSFKHY
110 120 130 140 150
AMQEAKQQFV EYDKNSDGAV TWDEYNIQMY DRVIDFDENT ALDDTEEGSF
160 170 180 190 200
RQLHLKDKKR FEKANQDSGP GLSLEEFIAF EHPEEVDYMT EFVIQEALEE
210 220 230 240 250
HDKNGDGFVS LEEFLGDYRR DPTANEDPEW ILVEKDRFVN DYDKDNDGRL
260 270 280 290 300
DPQELLSWVV PNNQGIAQEE ALHLIDEMDL NSDKKLSEEE ILENQDLFLT
310 320
SEATDYGRQL HDDYFYHDEL
Length:320
Mass (Da):37,271
Last modified:March 1, 2003 - v1
Checksum:i62195C004F8D7C9D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191A → DP in AAC05132 (Ref. 1) Curated
Sequence conflicti302 – 3032EA → DQ in AAC05132 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049125 mRNA. Translation: AAC05132.1.
AK077486 mRNA. Translation: BAC36825.1.
BC132320 mRNA. Translation: AAI32321.1.
BC145668 mRNA. Translation: AAI45669.1.
CCDSiCCDS23206.1.
PIRiJC5402.
RefSeqiNP_036122.2. NM_011992.2.
UniGeneiMm.1782.

Genome annotation databases

EnsembliENSMUST00000114276; ENSMUSP00000109915; ENSMUSG00000032320.
GeneIDi26611.
KEGGimmu:26611.
UCSCiuc009pss.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049125 mRNA. Translation: AAC05132.1.
AK077486 mRNA. Translation: BAC36825.1.
BC132320 mRNA. Translation: AAI32321.1.
BC145668 mRNA. Translation: AAI45669.1.
CCDSiCCDS23206.1.
PIRiJC5402.
RefSeqiNP_036122.2. NM_011992.2.
UniGeneiMm.1782.

3D structure databases

ProteinModelPortaliQ8BP92.
SMRiQ8BP92. Positions 67-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205029. 3 interactions.
DIPiDIP-46963N.
IntActiQ8BP92. 7 interactions.
MINTiMINT-1605271.
STRINGi10090.ENSMUSP00000109915.

Proteomic databases

MaxQBiQ8BP92.
PaxDbiQ8BP92.
PRIDEiQ8BP92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114276; ENSMUSP00000109915; ENSMUSG00000032320.
GeneIDi26611.
KEGGimmu:26611.
UCSCiuc009pss.1. mouse.

Organism-specific databases

CTDi5955.
MGIiMGI:1349765. Rcn2.

Phylogenomic databases

eggNOGiNOG124414.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ8BP92.
OMAiRFEKANR.
TreeFamiTF314849.

Miscellaneous databases

ChiTaRSiRcn2. mouse.
NextBioi304663.
PROiQ8BP92.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BP92.
CleanExiMM_RCN2.
ExpressionAtlasiQ8BP92. baseline and differential.
GenevisibleiQ8BP92. MM.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse taipoxin-associated calcium binding protein 49 (TCBP49)."
    Perin M.S.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRCN2_MOUSE
AccessioniPrimary (citable) accession number: Q8BP92
Secondary accession number(s): A2RT07, O70341
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.