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Protein

snRNA-activating protein complex subunit 4

Gene

Snapc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi317 – 34125H-T-H motifPROSITE-ProRule annotationAdd
BLAST
DNA bindingi424 – 44724H-T-H motifPROSITE-ProRule annotationAdd
BLAST
DNA bindingi476 – 49924H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6807505. RNA polymerase II transcribes snRNA genes.
R-MMU-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
snRNA-activating protein complex subunit 4
Short name:
SNAPc subunit 4
Alternative name(s):
snRNA-activating protein complex 190 kDa subunit
Short name:
SNAPc 190 kDa subunit
Gene namesi
Name:Snapc4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2443935. Snapc4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13331333snRNA-activating protein complex subunit 4PRO_0000197121Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei68 – 681PhosphoserineBy similarity
Modified residuei1252 – 12521PhosphoserineBy similarity
Modified residuei1254 – 12541PhosphoserineBy similarity
Modified residuei1301 – 13011PhosphoserineCombined sources
Modified residuei1309 – 13091PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BP86.
PaxDbiQ8BP86.
PRIDEiQ8BP86.

PTM databases

iPTMnetiQ8BP86.
PhosphoSiteiQ8BP86.

Expressioni

Gene expression databases

BgeeiQ8BP86.
ExpressionAtlasiQ8BP86. baseline and differential.
GenevisibleiQ8BP86. MM.

Interactioni

Subunit structurei

Part of the SNAPc composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC4 interacts with SNAPC1, SNAPC2, SNAPC5, BRF2 and TBP (By similarity).By similarity

Protein-protein interaction databases

BioGridi230655. 2 interactions.
STRINGi10090.ENSMUSP00000041767.

Structurei

3D structure databases

ProteinModelPortaliQ8BP86.
SMRiQ8BP86. Positions 260-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini250 – 28839Myb-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini289 – 34355HTH myb-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini344 – 39552Myb-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini396 – 45156HTH myb-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini452 – 50352HTH myb-type 3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni84 – 13350SNAPC5-bindingBy similarityAdd
BLAST
Regioni1131 – 1247117SNAPC2-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi903 – 1114212Pro-richAdd
BLAST

Sequence similaritiesi

Contains 3 HTH myb-type DNA-binding domains.PROSITE-ProRule annotation
Contains 2 Myb-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
GeneTreeiENSGT00390000001038.
HOGENOMiHOG000231537.
HOVERGENiHBG080315.
InParanoidiQ8BP86.
KOiK09453.
PhylomeDBiQ8BP86.

Family and domain databases

Gene3Di1.10.10.60. 4 hits.
InterProiIPR009057. Homeodomain-like.
IPR017877. Myb-like_dom.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
[Graphical view]
SMARTiSM00717. SANT. 5 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 3 hits.
PROSITEiPS51294. HTH_MYB. 3 hits.
PS50090. MYB_LIKE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1Curated (identifier: Q8BP86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDIDAEREKI TQEIQELERI LYPGSTSVHF EVSESSLSSD SEADSLPDED
60 70 80 90 100
LETAGAPILE EEGSSESSND EEDPKDKALP EDPETCLQLN MVYQEVIREK
110 120 130 140 150
LAEVSQLLAQ NQEQQEEILF DLSGTKCPKV KDGRSLPSYM YIGHFLKPYF
160 170 180 190 200
KDKVTGVGPP ANEETREKAT QGIKAFEQLL VTKWKHWEKA LLRKSVVSDR
210 220 230 240 250
LQRLLQPKLL KLEYLHEKQS RVSSELERQA LEKQIKEAEK EIQDINQLPE
260 270 280 290 300
EALLGNRLDS HDWEKISNIN FEGARSAEEI RKFWQSSEHP SISKQEWSTE
310 320 330 340 350
EVERLKAIAA THGHLEWHLV AEELGTSRSA FQCLQKFQQY NKTLKRKEWT
360 370 380 390 400
EEEDHMLTQL VQEMRVGNHI PYRKIVYFME GRDSMQLIYR WTKSLDPSLK
410 420 430 440 450
RGFWAPEEDA KLLQAVAKYG AQDWFKIREE VPGRSDAQCR DRYIRRLHFS
460 470 480 490 500
LKKGRWNAKE EQQLIQLIEK YGVGHWARIA SELPHRSGSQ CLSKWKILAR
510 520 530 540 550
KKQHLQRKRG QRPRHSSQWS SSGSSSSSSE DYGSSSGSDG SSGSENSDVE
560 570 580 590 600
LEASLEKSRA LTPQQYRVPD IDLWVPTRLI TSQSQREGTG CYPQHPAVSC
610 620 630 640 650
CTQDASQNHH KEGSTTVSAA EKNQLQVPYE THSTVPRGDR FLHFSDTHSA
660 670 680 690 700
SLKDPACKSH TLMKERPKQP LLPSSRSGSD PGNNTAGPHL RQLWHGTYQN
710 720 730 740 750
KQRRKRQALH RRLLKHRLLL AVIPWVGDIN LACTQAPRRP ATVQTKADSI
760 770 780 790 800
RMQLECARLA STPVFTLLIQ LLQIDTAGCM EVVRERKSQP PALLQPGTRN
810 820 830 840 850
TQPHLLQASS NAKNNTGCLP SMTGEQTAKR ASHKGRPRLG SCRTEATPFQ
860 870 880 890 900
VPVAAPRGLR PKPKTVSELL REKRLRESHA KKATQALGLN SQLLVSSPVI
910 920 930 940 950
LQPPLLPVPH GSPVVGPATS SVELSVPVAP VMVSSSPSGS WPVGGISATD
960 970 980 990 1000
KQPPNLQTIS LNPPHKGTQV AAPAAFRSLA LAPGQVPTGG HLSTLGQTST
1010 1020 1030 1040 1050
TSQKQSLPKV LPILRAAPSL TQLSVQPPVS GQPLATKSSL PVNWVLTTQK
1060 1070 1080 1090 1100
LLSVQVPAVV GLPQSVMTPE TIGLQAKQLP SPAKTPAFLE QPPASTDTEP
1110 1120 1130 1140 1150
KGPQGQEIPP TPGPEKAALD LSLLSQESEA AIVTWLKGCQ GAFVPPLGSR
1160 1170 1180 1190 1200
MPYHPPSLCS LRALSSLLLQ KQDLEQKASS LAASQAAGAQ PDPKAGALQA
1210 1220 1230 1240 1250
SLELVQRQFR DNPAYLLLKT RFLAIFSLPA FLATLPPNSI PTTLSPDVAV
1260 1270 1280 1290 1300
VSESDSEDLG DLELKDRARQ LDCMACRVQA SPAAPDPVQS HLVSPGQRAP
1310 1320 1330
SPGEVSAPSP LDASDGLDDL NVLRTRRARH SRR
Note: No experimental confirmation available.Curated
Length:1,333
Mass (Da):147,413
Last modified:October 25, 2005 - v2
Checksum:i586798D3A7D59B4E
GO
Isoform 2Curated (identifier: Q8BP86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1290-1297: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,325
Mass (Da):146,607
Checksum:i37C57AF98542E449
GO
Isoform 3Curated (identifier: Q8BP86-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.
     1290-1297: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,235
Mass (Da):136,713
Checksum:i821B5C2514B9AA00
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti498 – 5058LARKKQHL → DAWADAWV in AAH44754 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9090Missing in isoform 3. 1 PublicationVSP_051855Add
BLAST
Alternative sequencei1290 – 12978Missing in isoform 2 and isoform 3. 2 PublicationsVSP_051857

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077522 mRNA. Translation: BAC36843.1.
BC044754 mRNA. Translation: AAH44754.1.
BC057031 mRNA. Translation: AAH57031.1.
CCDSiCCDS15802.1. [Q8BP86-2]
RefSeqiNP_001277348.1. NM_001290419.1. [Q8BP86-3]
NP_758842.1. NM_172339.4. [Q8BP86-2]
UniGeneiMm.207460.

Genome annotation databases

EnsembliENSMUST00000035427; ENSMUSP00000041767; ENSMUSG00000036281. [Q8BP86-2]
GeneIDi227644.
KEGGimmu:227644.
UCSCiuc008iuu.2. mouse. [Q8BP86-1]
uc008iuv.2. mouse. [Q8BP86-2]
uc008iuw.2. mouse. [Q8BP86-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077522 mRNA. Translation: BAC36843.1.
BC044754 mRNA. Translation: AAH44754.1.
BC057031 mRNA. Translation: AAH57031.1.
CCDSiCCDS15802.1. [Q8BP86-2]
RefSeqiNP_001277348.1. NM_001290419.1. [Q8BP86-3]
NP_758842.1. NM_172339.4. [Q8BP86-2]
UniGeneiMm.207460.

3D structure databases

ProteinModelPortaliQ8BP86.
SMRiQ8BP86. Positions 260-501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230655. 2 interactions.
STRINGi10090.ENSMUSP00000041767.

PTM databases

iPTMnetiQ8BP86.
PhosphoSiteiQ8BP86.

Proteomic databases

EPDiQ8BP86.
PaxDbiQ8BP86.
PRIDEiQ8BP86.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035427; ENSMUSP00000041767; ENSMUSG00000036281. [Q8BP86-2]
GeneIDi227644.
KEGGimmu:227644.
UCSCiuc008iuu.2. mouse. [Q8BP86-1]
uc008iuv.2. mouse. [Q8BP86-2]
uc008iuw.2. mouse. [Q8BP86-3]

Organism-specific databases

CTDi6621.
MGIiMGI:2443935. Snapc4.

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
GeneTreeiENSGT00390000001038.
HOGENOMiHOG000231537.
HOVERGENiHBG080315.
InParanoidiQ8BP86.
KOiK09453.
PhylomeDBiQ8BP86.

Enzyme and pathway databases

ReactomeiR-MMU-6807505. RNA polymerase II transcribes snRNA genes.
R-MMU-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

PROiQ8BP86.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BP86.
ExpressionAtlasiQ8BP86. baseline and differential.
GenevisibleiQ8BP86. MM.

Family and domain databases

Gene3Di1.10.10.60. 4 hits.
InterProiIPR009057. Homeodomain-like.
IPR017877. Myb-like_dom.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
[Graphical view]
SMARTiSM00717. SANT. 5 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 3 hits.
PROSITEiPS51294. HTH_MYB. 3 hits.
PS50090. MYB_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6JImported.
    Tissue: EmbryoImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 498-1325 (ISOFORM 1).
    Strain: 129Imported, C57BL/6JImported and FVB/N.
    Tissue: BrainImported and Mammary glandImported.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1301 AND SER-1309, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Spleen.

Entry informationi

Entry nameiSNPC4_MOUSE
AccessioniPrimary (citable) accession number: Q8BP86
Secondary accession number(s): Q6PGG7, Q80UG9, Q810L1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: June 8, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.