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Protein

RNA binding protein fox-1 homolog 2

Gene

Rbfox2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha (By similarity).By similarity6 Publications

GO - Molecular functioni

GO - Biological processi

  • dendrite morphogenesis Source: MGI
  • intracellular estrogen receptor signaling pathway Source: UniProtKB
  • mRNA processing Source: UniProtKB-KW
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • neuromuscular process controlling balance Source: MGI
  • radial glia guided migration of Purkinje cell Source: MGI
  • regulation of alternative mRNA splicing, via spliceosome Source: BHF-UCL
  • regulation of definitive erythrocyte differentiation Source: BHF-UCL
  • RNA splicing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6803529. FGFR2 alternative splicing.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA binding protein fox-1 homolog 2
Alternative name(s):
Fox-1 homolog B
Fox-1 homolog Fxh
Hexaribonucleotide-binding protein 2
RNA-binding motif protein 9
RNA-binding protein 9
Gene namesi
Name:Rbfox2
Synonyms:Fox2, Fxh, Hrnbp2, Rbm9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1933973. Rbfox2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449RNA binding protein fox-1 homolog 2PRO_0000317115Add
BLAST

Proteomic databases

MaxQBiQ8BP71.
PaxDbiQ8BP71.
PRIDEiQ8BP71.

PTM databases

iPTMnetiQ8BP71.
PhosphoSiteiQ8BP71.

Expressioni

Tissue specificityi

Detected in brain neurons (at protein level). Detected in heart, brain, embryo, lung, liver, kidney and ovary.2 Publications

Inductioni

Up-regulated by androgens in cultured motor neuron cells.1 Publication

Gene expression databases

BgeeiQ8BP71.
CleanExiMM_RBM9.
GenevisibleiQ8BP71. MM.

Interactioni

Subunit structurei

Interacts with ER-alpha N-terminal activation domain.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei181 – 1811Interaction with RNABy similarity
Sitei189 – 1891Interaction with RNABy similarity
Sitei190 – 1901Interaction with RNABy similarity
Sitei214 – 2141Interaction with RNABy similarity
Sitei219 – 2191Interaction with RNABy similarity
Sitei223 – 2231Interaction with RNABy similarity
Sitei247 – 2471Interaction with RNABy similarity
Sitei257 – 2571Interaction with RNABy similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi220236. 4 interactions.
IntActiQ8BP71. 1 interaction.
STRINGi10090.ENSMUSP00000130739.

Structurei

3D structure databases

ProteinModelPortaliQ8BP71.
SMRiQ8BP71. Positions 178-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini180 – 25677RRMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi332 – 436105Ala-richAdd
BLAST

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0125. Eukaryota.
ENOG4111WJT. LUCA.
GeneTreeiENSGT00390000013767.
HOVERGENiHBG000044.
InParanoidiQ8BP71.
KOiK14946.
OMAiSTQPHGE.
OrthoDBiEOG7060R3.
PhylomeDBiQ8BP71.
TreeFamiTF315942.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR025670. Fox-1_C_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR017325. RNA-bd_Fox-1.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF12414. Fox-1_C. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037932. Ataxin_2_bd_A2BP. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BP71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEGGQAQQQ PPQLGPGAAA RGMKRESEVE LPVPGAGADG PEPGLSKRPR
60 70 80 90 100
TEEAADGGMQ NEPLTPGYHG FPARDGQGNQ EPTTTPDAMV QPFTTIPFPP
110 120 130 140 150
PPQNGIPTEY GVPHTQDYAG QTSEHNLTLY GSTQPHGEQS SNSPSNQNGS
160 170 180 190 200
LTQTEGGAQT DGQQSQTQSS ENSESKSTPK RLHVSNIPFR FRDPDLRQMF
210 220 230 240 250
GQFGKILDVE IIFNERGSKG FGFVTFENSA DADRAREKLH GTVVEGRKIE
260 270 280 290 300
VNNATARVMT NKKMVTPYAN GWKLSPVVGA VYGPELYAAS SFQADVSLGN
310 320 330 340 350
EAAVPLSGRG GINTYIPLIS LPLVPGFPYP TAATTAAAFR GAHLRGRGRT
360 370 380 390 400
VYGAVRAVPP TAIPAYPGVV YQDGFYGADL YGGYAAYRYA QPATATAATA
410 420 430 440
AAAAAAAYSD GYGRVYTADP YHALAPAASY GVGAVASLYR GGYSRFAPY
Length:449
Mass (Da):47,330
Last modified:February 5, 2008 - v2
Checksum:iC4B01F814B3C8F5A
GO
Isoform 2 (identifier: Q8BP71-2) [UniParc]FASTAAdd to basket

Also known as: Fox-2A

The sequence of this isoform differs from the canonical sequence as follows:
     19-36: Missing.
     320-324: SLPLV → I

Show »
Length:427
Mass (Da):45,055
Checksum:i31C4B28B1EE6E808
GO
Isoform 3 (identifier: Q8BP71-3) [UniParc]FASTAAdd to basket

Also known as: 1, Fox-2F

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MAEGGQAQQQ...GYHGFPARDG → MEKKKMVT

Show »
Length:381
Mass (Da):40,562
Checksum:iC75B29D5F650FE29
GO
Isoform 4 (identifier: Q8BP71-4) [UniParc]FASTAAdd to basket

Also known as: 2, Fox-2F-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MAEGGQAQQQ...GYHGFPARDG → MEKKKMVT
     153-153: Missing.
     220-250: Missing.
     320-324: SLPLV → I
     369-381: VVYQDGFYGADLY → IVLQEPIISAKIPQ

Show »
Length:346
Mass (Da):36,658
Checksum:i8E96304EC3706B0C
GO
Isoform 5 (identifier: Q8BP71-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     320-324: SLPLV → I
     370-449: VYQDGFYGAD...RGGYSRFAPY → DMQPTDMHSL...TADLPPTEVT

Show »
Length:435
Mass (Da):46,253
Checksum:i62A355605FF8A5B4
GO
Isoform 6 (identifier: Q8BP71-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MAEGGQAQQQ...GYHGFPARDG → MEKKKMVT
     320-324: SLPLV → I
     373-449: DGFYGADLYG...RGGYSRFAPY → DMQPTDMHSL...PLPPAMELAL

Show »
Length:352
Mass (Da):37,905
Checksum:i74F46B287F6C5A38
GO
Isoform 7 (identifier: Q8BP71-7) [UniParc]FASTAAdd to basket

Also known as: 1, F011

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MAEGGQAQQQ...GYHGFPARDG → MEKKKMVT
     320-324: SLPLV → I

Show »
Length:377
Mass (Da):40,166
Checksum:i249FA9BA6A0D155A
GO
Isoform 8 (identifier: Q8BP71-8) [UniParc]FASTAAdd to basket

Also known as: 2, F411

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MAEGGQAQQQ...GYHGFPARDG → MEKKKMVT
     320-324: SLPLV → I
     369-381: VVYQDGFYGADLY → IVLQEPIISAKIPQ

Show »
Length:378
Mass (Da):40,205
Checksum:iF1CB87822F3EC257
GO
Isoform 9 (identifier: Q8BP71-9) [UniParc]FASTAAdd to basket

Also known as: 3, F402

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MAEGGQAQQQ...GYHGFPARDG → MEKKKMVT
     153-250: Missing.

Show »
Length:283
Mass (Da):29,576
Checksum:i6CA06BED5F616238
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881A → G in BAC32147 (PubMed:16141072).Curated
Sequence conflicti306 – 3061L → M in AAL71902 (PubMed:16537540).Curated
Sequence conflicti342 – 3421A → D in BAC36885 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7676MAEGG…PARDG → MEKKKMVT in isoform 3, isoform 4, isoform 6, isoform 7, isoform 8 and isoform 9. 6 PublicationsVSP_030892Add
BLAST
Alternative sequencei19 – 3618Missing in isoform 2. 1 PublicationVSP_030893Add
BLAST
Alternative sequencei153 – 25098Missing in isoform 9. 2 PublicationsVSP_030894Add
BLAST
Alternative sequencei153 – 1531Missing in isoform 4. 1 PublicationVSP_030895
Alternative sequencei220 – 25031Missing in isoform 4. 1 PublicationVSP_030896Add
BLAST
Alternative sequencei320 – 3245SLPLV → I in isoform 2, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 8. 6 PublicationsVSP_030897
Alternative sequencei369 – 38113VVYQD…GADLY → IVLQEPIISAKIPQ in isoform 4 and isoform 8. 2 PublicationsVSP_030898Add
BLAST
Alternative sequencei370 – 44980VYQDG…RFAPY → DMQPTDMHSLLLQPQPQLLQ PLQPLTATVTAGCTQLTPTM PSPLPPAMELALWRVCTEVA TADLPPTEVT in isoform 5. 1 PublicationVSP_030899Add
BLAST
Alternative sequencei373 – 44977DGFYG…RFAPY → DMQPTDMHSLLLQPQPQLLQ PLQPLTATVTAGCTQLTPTM PSPLPPAMELAL in isoform 6. 1 PublicationVSP_030900Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387322 mRNA. Translation: AAK64287.1.
AY659951 mRNA. Translation: AAV74334.1.
AY659952 mRNA. Translation: AAV74335.1.
AY659953 mRNA. Translation: AAV74336.1.
AF229055 mRNA. Translation: AAL71902.1.
AY904025 mRNA. Translation: AAX84842.1.
DQ017388 mRNA. Translation: AAY78494.1.
DQ017389 mRNA. Translation: AAY78495.1.
AK044929 mRNA. Translation: BAC32147.1.
AK077594 mRNA. Translation: BAC36885.1.
BC002124 mRNA. Translation: AAH02124.1.
BC027263 mRNA. Translation: AAH27263.1.
CCDSiCCDS27598.1. [Q8BP71-5]
CCDS49657.1. [Q8BP71-8]
CCDS49658.1. [Q8BP71-3]
CCDS49659.1. [Q8BP71-1]
RefSeqiNP_001104297.1. NM_001110827.2.
NP_001104298.1. NM_001110828.2. [Q8BP71-3]
NP_001104299.1. NM_001110829.2. [Q8BP71-8]
NP_001104300.1. NM_001110830.2. [Q8BP71-7]
NP_001273346.1. NM_001286417.1.
NP_001273347.1. NM_001286418.1. [Q8BP71-9]
NP_001273348.1. NM_001286419.1. [Q8BP71-4]
NP_444334.3. NM_053104.6. [Q8BP71-1]
NP_780596.1. NM_175387.3. [Q8BP71-5]
UniGeneiMm.202774.

Genome annotation databases

EnsembliENSMUST00000048145; ENSMUSP00000048056; ENSMUSG00000033565. [Q8BP71-5]
ENSMUST00000111581; ENSMUSP00000129372; ENSMUSG00000033565. [Q8BP71-8]
ENSMUST00000166610; ENSMUSP00000130673; ENSMUSG00000033565. [Q8BP71-3]
ENSMUST00000171751; ENSMUSP00000130739; ENSMUSG00000033565. [Q8BP71-1]
GeneIDi93686.
KEGGimmu:93686.
UCSCiuc007wnc.3. mouse. [Q8BP71-5]
uc007wnd.2. mouse. [Q8BP71-7]
uc007wne.2. mouse. [Q8BP71-8]
uc007wnf.2. mouse. [Q8BP71-4]
uc007wng.2. mouse. [Q8BP71-1]
uc007wni.2. mouse. [Q8BP71-2]
uc011zvf.1. mouse. [Q8BP71-3]
uc011zvg.2. mouse. [Q8BP71-9]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387322 mRNA. Translation: AAK64287.1.
AY659951 mRNA. Translation: AAV74334.1.
AY659952 mRNA. Translation: AAV74335.1.
AY659953 mRNA. Translation: AAV74336.1.
AF229055 mRNA. Translation: AAL71902.1.
AY904025 mRNA. Translation: AAX84842.1.
DQ017388 mRNA. Translation: AAY78494.1.
DQ017389 mRNA. Translation: AAY78495.1.
AK044929 mRNA. Translation: BAC32147.1.
AK077594 mRNA. Translation: BAC36885.1.
BC002124 mRNA. Translation: AAH02124.1.
BC027263 mRNA. Translation: AAH27263.1.
CCDSiCCDS27598.1. [Q8BP71-5]
CCDS49657.1. [Q8BP71-8]
CCDS49658.1. [Q8BP71-3]
CCDS49659.1. [Q8BP71-1]
RefSeqiNP_001104297.1. NM_001110827.2.
NP_001104298.1. NM_001110828.2. [Q8BP71-3]
NP_001104299.1. NM_001110829.2. [Q8BP71-8]
NP_001104300.1. NM_001110830.2. [Q8BP71-7]
NP_001273346.1. NM_001286417.1.
NP_001273347.1. NM_001286418.1. [Q8BP71-9]
NP_001273348.1. NM_001286419.1. [Q8BP71-4]
NP_444334.3. NM_053104.6. [Q8BP71-1]
NP_780596.1. NM_175387.3. [Q8BP71-5]
UniGeneiMm.202774.

3D structure databases

ProteinModelPortaliQ8BP71.
SMRiQ8BP71. Positions 178-261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220236. 4 interactions.
IntActiQ8BP71. 1 interaction.
STRINGi10090.ENSMUSP00000130739.

PTM databases

iPTMnetiQ8BP71.
PhosphoSiteiQ8BP71.

Proteomic databases

MaxQBiQ8BP71.
PaxDbiQ8BP71.
PRIDEiQ8BP71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048145; ENSMUSP00000048056; ENSMUSG00000033565. [Q8BP71-5]
ENSMUST00000111581; ENSMUSP00000129372; ENSMUSG00000033565. [Q8BP71-8]
ENSMUST00000166610; ENSMUSP00000130673; ENSMUSG00000033565. [Q8BP71-3]
ENSMUST00000171751; ENSMUSP00000130739; ENSMUSG00000033565. [Q8BP71-1]
GeneIDi93686.
KEGGimmu:93686.
UCSCiuc007wnc.3. mouse. [Q8BP71-5]
uc007wnd.2. mouse. [Q8BP71-7]
uc007wne.2. mouse. [Q8BP71-8]
uc007wnf.2. mouse. [Q8BP71-4]
uc007wng.2. mouse. [Q8BP71-1]
uc007wni.2. mouse. [Q8BP71-2]
uc011zvf.1. mouse. [Q8BP71-3]
uc011zvg.2. mouse. [Q8BP71-9]

Organism-specific databases

CTDi23543.
MGIiMGI:1933973. Rbfox2.

Phylogenomic databases

eggNOGiKOG0125. Eukaryota.
ENOG4111WJT. LUCA.
GeneTreeiENSGT00390000013767.
HOVERGENiHBG000044.
InParanoidiQ8BP71.
KOiK14946.
OMAiSTQPHGE.
OrthoDBiEOG7060R3.
PhylomeDBiQ8BP71.
TreeFamiTF315942.

Enzyme and pathway databases

ReactomeiR-MMU-6803529. FGFR2 alternative splicing.

Miscellaneous databases

ChiTaRSiRbfox2. mouse.
PROiQ8BP71.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BP71.
CleanExiMM_RBM9.
GenevisibleiQ8BP71. MM.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR025670. Fox-1_C_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR017325. RNA-bd_Fox-1.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF12414. Fox-1_C. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037932. Ataxin_2_bd_A2BP. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Androgens regulate the mammalian homologues of invertebrate sex determination genes tra-2 and fox-1."
    Lieberman A.P., Friedlich D.L., Harmison G., Howell B.W., Jordan C.L., Breedlove S.M., Fischbeck K.H.
    Biochem. Biophys. Res. Commun. 282:499-506(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7), SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
  2. "Tissue-dependent isoforms of mammalian Fox-1 homologs are associated with tissue-specific splicing activities."
    Nakahata S., Kawamoto S.
    Nucleic Acids Res. 33:2078-2089(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 7; 8 AND 9), FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Brain and Muscle.
  3. "Fox-2 splicing factor binds to a conserved intron motif to promote inclusion of protein 4.1R alternative exon 16."
    Ponthier J.L., Schluepen C., Chen W., Lersch R.A., Gee S.L., Hou V.C., Lo A.J., Short S.A., Chasis J.A., Winkelmann J.C., Conboy J.G.
    J. Biol. Chem. 281:12468-12474(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7), FUNCTION.
  4. "Regulated Fox-2 isoform expression mediates protein 4.1R splicing during erythroid differentiation."
    Yang G., Huang S.-C., Wu J.Y., Benz E.J. Jr.
    Blood 111:392-401(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), FUNCTION, SUBCELLULAR LOCATION.
    Strain: C57BL/6J and DBA/2.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6).
    Strain: C57BL/6J.
    Tissue: Embryo.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 7 AND 5).
    Strain: Czech II.
    Tissue: Mammary tumor.
  7. "Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals."
    Underwood J.G., Boutz P.L., Dougherty J.D., Stoilov P., Black D.L.
    Mol. Cell. Biol. 25:10005-10016(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  8. "Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice."
    Baraniak A.P., Chen J.R., Garcia-Blanco M.A.
    Mol. Cell. Biol. 26:1209-1222(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processing."
    Zhou H.-L., Baraniak A.P., Lou H.
    Mol. Cell. Biol. 27:830-841(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiRFOX2_MOUSE
AccessioniPrimary (citable) accession number: Q8BP71
Secondary accession number(s): Q0R5Z7
, Q0R5Z8, Q0VH84, Q537D4, Q537D5, Q8BRG0, Q8R2T5, Q8VI62, Q923W8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 8, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.