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Protein

60S ribosomal protein L24

Gene

Rpl24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • assembly of large subunit precursor of preribosome Source: GO_Central
  • exit from mitosis Source: MGI
  • mitotic cell cycle checkpoint Source: MGI
  • optic nerve development Source: MGI
  • retina development in camera-type eye Source: MGI
  • retinal ganglion cell axon guidance Source: MGI
  • ribosomal large subunit assembly Source: MGI
  • translation Source: MGI

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L24
Gene namesi
Name:Rpl24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1915443. Rpl24.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001368691 – 15760S ribosomal protein L24Add BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki2Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei27N6-acetyllysine; alternateCombined sources1
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei77N6-acetyllysineBy similarity1
Modified residuei83PhosphothreonineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei93N6-acetyllysineBy similarity1
Modified residuei131N6-succinyllysineCombined sources1
Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei149PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BP67.
MaxQBiQ8BP67.
PeptideAtlasiQ8BP67.
PRIDEiQ8BP67.
TopDownProteomicsiQ8BP67.

PTM databases

iPTMnetiQ8BP67.
PhosphoSitePlusiQ8BP67.
SwissPalmiQ8BP67.

Expressioni

Gene expression databases

BgeeiENSMUSG00000098274.
CleanExiMM_RPL24.
GenevisibleiQ8BP67. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212718. 2 interactors.
IntActiQ8BP67. 5 interactors.
MINTiMINT-1857981.

Structurei

3D structure databases

ProteinModelPortaliQ8BP67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000074809.
HOVERGENiHBG001066.
InParanoidiQ8BP67.
KOiK02896.
OMAiRRHHKKG.
OrthoDBiEOG091G0ZDB.
TreeFamiTF312933.

Family and domain databases

CDDicd00472. Ribosomal_L24e_L24. 1 hit.
InterProiView protein in InterPro
IPR000988. Ribosomal_L24e-rel.
IPR023442. Ribosomal_L24e_CS.
IPR011017. TRASH_dom.
PANTHERiPTHR10792. PTHR10792. 1 hit.
PfamiView protein in Pfam
PF01246. Ribosomal_L24e. 1 hit.
SMARTiView protein in SMART
SM00746. TRASH. 1 hit.
PROSITEiView protein in PROSITE
PS01073. RIBOSOMAL_L24E. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BP67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVELCSFSG YKIYPGHGRR YARTDGKVFQ FLNAKCESAF LSKRNPRQIN
60 70 80 90 100
WTVLYRRKHK KGQSEEIQKK RTRRAVKFQR AITGASLADI MAKRNQKPEV
110 120 130 140 150
RKAQREQAIR AAKEAKKAKQ ASKKTAMAAA KAPTKAAPKQ KIVKPVKVSA

PRVGGKR
Length:157
Mass (Da):17,779
Last modified:January 16, 2004 - v2
Checksum:i1D48EEB7C0652574
GO

Sequence cautioni

The sequence AAH02110 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14Y → N in BAC36903 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018731 mRNA. Translation: BAB31374.1.
AK077617 mRNA. Translation: BAC36903.1.
BC002110 mRNA. Translation: AAH02110.2. Different initiation.
BC053377 mRNA. Translation: AAH53377.1.
BC058114 mRNA. Translation: AAH58114.1.
BC092008 mRNA. Translation: AAH92008.1.
CCDSiCCDS28218.1.
RefSeqiNP_077180.1. NM_024218.4.
UniGeneiMm.29221.
Mm.482104.

Genome annotation databases

EnsembliENSMUST00000023269; ENSMUSP00000023269; ENSMUSG00000098274.
GeneIDi68193.
KEGGimmu:68193.
UCSCiuc007zlv.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiRL24_MOUSE
AccessioniPrimary (citable) accession number: Q8BP67
Secondary accession number(s): P38663, Q58EA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: August 30, 2017
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families