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Q8BP67

- RL24_MOUSE

UniProt

Q8BP67 - RL24_MOUSE

Protein

60S ribosomal protein L24

Gene

Rpl24

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: Ensembl

    GO - Biological processi

    1. exit from mitosis Source: MGI
    2. mitotic cell cycle checkpoint Source: MGI
    3. optic nerve development Source: MGI
    4. retina development in camera-type eye Source: MGI
    5. retinal ganglion cell axon guidance Source: MGI
    6. ribosomal large subunit assembly Source: MGI
    7. translation Source: MGI

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L24
    Gene namesi
    Name:Rpl24
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1915443. Rpl24.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15715760S ribosomal protein L24PRO_0000136869Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei27 – 271N6-acetyllysine1 Publication
    Modified residuei77 – 771N6-acetyllysineBy similarity
    Modified residuei83 – 831PhosphothreonineBy similarity
    Modified residuei86 – 861PhosphoserineBy similarity
    Modified residuei93 – 931N6-acetyllysineBy similarity
    Modified residuei131 – 1311N6-succinyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8BP67.
    PaxDbiQ8BP67.
    PRIDEiQ8BP67.

    PTM databases

    PhosphoSiteiQ8BP67.

    Expressioni

    Gene expression databases

    BgeeiQ8BP67.
    CleanExiMM_RPL24.
    GenevestigatoriQ8BP67.

    Interactioni

    Protein-protein interaction databases

    BioGridi212718. 9 interactions.
    IntActiQ8BP67. 5 interactions.
    MINTiMINT-1857981.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BP67.
    SMRiQ8BP67. Positions 1-107.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L24e family.Curated

    Phylogenomic databases

    eggNOGiCOG2075.
    GeneTreeiENSGT00550000074809.
    HOVERGENiHBG001066.
    InParanoidiQ8BP67.
    KOiK02896.
    TreeFamiTF312933.

    Family and domain databases

    Gene3Di2.30.170.20. 1 hit.
    InterProiIPR023442. Ribosomal_L24e_CS.
    IPR023441. Ribosomal_L24e_dom.
    IPR000988. Ribosomal_L24e_rel.
    IPR011017. TRASH_dom.
    [Graphical view]
    PANTHERiPTHR10792. PTHR10792. 1 hit.
    PfamiPF01246. Ribosomal_L24e. 1 hit.
    [Graphical view]
    SMARTiSM00746. TRASH. 1 hit.
    [Graphical view]
    PROSITEiPS01073. RIBOSOMAL_L24E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BP67-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVELCSFSG YKIYPGHGRR YARTDGKVFQ FLNAKCESAF LSKRNPRQIN    50
    WTVLYRRKHK KGQSEEIQKK RTRRAVKFQR AITGASLADI MAKRNQKPEV 100
    RKAQREQAIR AAKEAKKAKQ ASKKTAMAAA KAPTKAAPKQ KIVKPVKVSA 150
    PRVGGKR 157
    Length:157
    Mass (Da):17,779
    Last modified:January 16, 2004 - v2
    Checksum:i1D48EEB7C0652574
    GO

    Sequence cautioni

    The sequence AAH02110.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141Y → N in BAC36903. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK018731 mRNA. Translation: BAB31374.1.
    AK077617 mRNA. Translation: BAC36903.1.
    BC002110 mRNA. Translation: AAH02110.2. Different initiation.
    BC053377 mRNA. Translation: AAH53377.1.
    BC058114 mRNA. Translation: AAH58114.1.
    BC092008 mRNA. Translation: AAH92008.1.
    CCDSiCCDS28218.1.
    RefSeqiNP_077180.1. NM_024218.4.
    UniGeneiMm.29221.
    Mm.482104.

    Genome annotation databases

    EnsembliENSMUST00000023269; ENSMUSP00000023269; ENSMUSG00000098274.
    GeneIDi68193.
    KEGGimmu:68193.
    UCSCiuc007zlv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK018731 mRNA. Translation: BAB31374.1 .
    AK077617 mRNA. Translation: BAC36903.1 .
    BC002110 mRNA. Translation: AAH02110.2 . Different initiation.
    BC053377 mRNA. Translation: AAH53377.1 .
    BC058114 mRNA. Translation: AAH58114.1 .
    BC092008 mRNA. Translation: AAH92008.1 .
    CCDSi CCDS28218.1.
    RefSeqi NP_077180.1. NM_024218.4.
    UniGenei Mm.29221.
    Mm.482104.

    3D structure databases

    ProteinModelPortali Q8BP67.
    SMRi Q8BP67. Positions 1-107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212718. 9 interactions.
    IntActi Q8BP67. 5 interactions.
    MINTi MINT-1857981.

    PTM databases

    PhosphoSitei Q8BP67.

    Proteomic databases

    MaxQBi Q8BP67.
    PaxDbi Q8BP67.
    PRIDEi Q8BP67.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023269 ; ENSMUSP00000023269 ; ENSMUSG00000098274 .
    GeneIDi 68193.
    KEGGi mmu:68193.
    UCSCi uc007zlv.2. mouse.

    Organism-specific databases

    CTDi 6152.
    MGIi MGI:1915443. Rpl24.

    Phylogenomic databases

    eggNOGi COG2075.
    GeneTreei ENSGT00550000074809.
    HOVERGENi HBG001066.
    InParanoidi Q8BP67.
    KOi K02896.
    TreeFami TF312933.

    Miscellaneous databases

    NextBioi 326666.
    PROi Q8BP67.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BP67.
    CleanExi MM_RPL24.
    Genevestigatori Q8BP67.

    Family and domain databases

    Gene3Di 2.30.170.20. 1 hit.
    InterProi IPR023442. Ribosomal_L24e_CS.
    IPR023441. Ribosomal_L24e_dom.
    IPR000988. Ribosomal_L24e_rel.
    IPR011017. TRASH_dom.
    [Graphical view ]
    PANTHERi PTHR10792. PTHR10792. 1 hit.
    Pfami PF01246. Ribosomal_L24e. 1 hit.
    [Graphical view ]
    SMARTi SM00746. TRASH. 1 hit.
    [Graphical view ]
    PROSITEi PS01073. RIBOSOMAL_L24E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and FVB/N.
      Tissue: Brain, Colon, Eye and Mammary gland.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-27, SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-131, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiRL24_MOUSE
    AccessioniPrimary (citable) accession number: Q8BP67
    Secondary accession number(s): P38663, Q58EA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: January 16, 2004
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3