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Protein
Submitted name:

Oxysterols receptor LXR-beta

Gene

Nr1h2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Oxysterols receptor LXR-betaImported
Gene namesi
Name:Nr1h2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1352463. Nr1h2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073188.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00780000121834.
HOGENOMiHOG000220845.
HOVERGENiHBG108655.
TreeFamiTF352167.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR023257. Liver_X_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BP65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPTSSLDT PVPGNGSPQP STSATSPTIK EEGQETDPPP GSEGSSSAYI
60 70 80 90 100
VEPEDEPERK RKKGPAPKML GHELCRVCGD KASGFHYNVL SCEGCKGFFR
110 120 130 140 150
RSVVHGGAGR YACRGSGTCQ MDAFMRRKCQ LCRLRKCKEA GMREQCVLSE
160 170 180 190 200
EQIRKKRIQK QQQQQPPPPS EPAASSSGRP AASPGTSEAS SQGSGEGEGI
210 220 230 240 250
QLTAAQELMI QQLVAAQLQC NKRSFSDQPK VTPWPLGADP QSRDARQQRF
260 270 280 290 300
AHFTELAIIS VQEIVDFAKQ VPGFLQLGRE DQIALLKAST IEIMLLETAR
310 320 330 340 350
RYNHETECIT FLKDFTYSKD DFHRAGLQVE FINPIFEFSR AMRRLGLDDA
360 370 380 390 400
EYALLIAINI FSADRPNVQE PSRVEALQQP YVEALLSYTR IKRPQDQLRF
410 420 430 440
PRMLMKLVSL RTLSSVHSEQ VFALRLQDKK LPPLLSEIWD VHE
Length:443
Mass (Da):49,394
Last modified:March 1, 2003 - v1
Checksum:i362DCB2D21034F29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC149607 Genomic DNA. No translation available.
AC157653 Genomic DNA. No translation available.
AK077620 mRNA. Translation: BAC36906.1.
AK156777 mRNA. Translation: BAE33850.1.
RefSeqiNP_001272447.1. NM_001285518.1.
NP_001272448.1. NM_001285519.1.
NP_033499.1. NM_009473.3.
UniGeneiMm.968.

Genome annotation databases

EnsembliENSMUST00000107910; ENSMUSP00000103543; ENSMUSG00000060601.
ENSMUST00000107911; ENSMUSP00000103544; ENSMUSG00000060601.
GeneIDi22260.
UCSCiuc009gqb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC149607 Genomic DNA. No translation available.
AC157653 Genomic DNA. No translation available.
AK077620 mRNA. Translation: BAC36906.1.
AK156777 mRNA. Translation: BAE33850.1.
RefSeqiNP_001272447.1. NM_001285518.1.
NP_001272448.1. NM_001285519.1.
NP_033499.1. NM_009473.3.
UniGeneiMm.968.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073188.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107910; ENSMUSP00000103543; ENSMUSG00000060601.
ENSMUST00000107911; ENSMUSP00000103544; ENSMUSG00000060601.
GeneIDi22260.
UCSCiuc009gqb.2. mouse.

Organism-specific databases

CTDi7376.
MGIiMGI:1352463. Nr1h2.

Phylogenomic databases

GeneTreeiENSGT00780000121834.
HOGENOMiHOG000220845.
HOVERGENiHBG108655.
TreeFamiTF352167.

Miscellaneous databases

ChiTaRSiNr1h2. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR023257. Liver_X_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Whole bodyImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  11. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8BP65_MOUSE
AccessioniPrimary (citable) accession number: Q8BP65
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.