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Q8BP65

- Q8BP65_MOUSE

UniProt

Q8BP65 - Q8BP65_MOUSE

Protein
Submitted name:

Oxysterols receptor LXR-beta

Gene

Nr1h2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    3. protein binding Source: MGI
    4. retinoid X receptor binding Source: MGI
    5. sequence-specific DNA binding Source: InterPro
    6. sequence-specific DNA binding transcription factor activity Source: MGI
    7. steroid hormone receptor activity Source: InterPro
    8. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cellular lipid metabolic process Source: MGI
    2. intracellular receptor signaling pathway Source: GOC
    3. positive regulation of cholesterol efflux Source: MGI
    4. regulation of transcription, DNA-templated Source: MGI
    5. regulation of transcription from RNA polymerase II promoter Source: MGI

    Keywords - Molecular functioni

    ReceptorUniRule annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Oxysterols receptor LXR-betaImported
    Gene namesi
    Name:Nr1h2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1352463. Nr1h2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ8BP65.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00720000108423.
    HOGENOMiHOG000220845.
    HOVERGENiHBG108655.
    KOiK08535.
    TreeFamiTF352167.

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR023257. Liver_X_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR02034. LIVERXRECPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BP65-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSPTSSLDT PVPGNGSPQP STSATSPTIK EEGQETDPPP GSEGSSSAYI    50
    VEPEDEPERK RKKGPAPKML GHELCRVCGD KASGFHYNVL SCEGCKGFFR 100
    RSVVHGGAGR YACRGSGTCQ MDAFMRRKCQ LCRLRKCKEA GMREQCVLSE 150
    EQIRKKRIQK QQQQQPPPPS EPAASSSGRP AASPGTSEAS SQGSGEGEGI 200
    QLTAAQELMI QQLVAAQLQC NKRSFSDQPK VTPWPLGADP QSRDARQQRF 250
    AHFTELAIIS VQEIVDFAKQ VPGFLQLGRE DQIALLKAST IEIMLLETAR 300
    RYNHETECIT FLKDFTYSKD DFHRAGLQVE FINPIFEFSR AMRRLGLDDA 350
    EYALLIAINI FSADRPNVQE PSRVEALQQP YVEALLSYTR IKRPQDQLRF 400
    PRMLMKLVSL RTLSSVHSEQ VFALRLQDKK LPPLLSEIWD VHE 443
    Length:443
    Mass (Da):49,394
    Last modified:March 1, 2003 - v1
    Checksum:i362DCB2D21034F29
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC149607 Genomic DNA. No translation available.
    AC157653 Genomic DNA. No translation available.
    AK077620 mRNA. Translation: BAC36906.1.
    AK156777 mRNA. Translation: BAE33850.1.
    RefSeqiNP_001272447.1. NM_001285518.1.
    NP_001272448.1. NM_001285519.1.
    NP_033499.1. NM_009473.3.
    UniGeneiMm.968.

    Genome annotation databases

    EnsembliENSMUST00000107910; ENSMUSP00000103543; ENSMUSG00000060601.
    ENSMUST00000107911; ENSMUSP00000103544; ENSMUSG00000060601.
    GeneIDi22260.
    KEGGimmu:22260.
    UCSCiuc009gqb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC149607 Genomic DNA. No translation available.
    AC157653 Genomic DNA. No translation available.
    AK077620 mRNA. Translation: BAC36906.1 .
    AK156777 mRNA. Translation: BAE33850.1 .
    RefSeqi NP_001272447.1. NM_001285518.1.
    NP_001272448.1. NM_001285519.1.
    NP_033499.1. NM_009473.3.
    UniGenei Mm.968.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000107910 ; ENSMUSP00000103543 ; ENSMUSG00000060601 .
    ENSMUST00000107911 ; ENSMUSP00000103544 ; ENSMUSG00000060601 .
    GeneIDi 22260.
    KEGGi mmu:22260.
    UCSCi uc009gqb.1. mouse.

    Organism-specific databases

    CTDi 7376.
    MGIi MGI:1352463. Nr1h2.

    Phylogenomic databases

    GeneTreei ENSGT00720000108423.
    HOGENOMi HOG000220845.
    HOVERGENi HBG108655.
    KOi K08535.
    TreeFami TF352167.

    Miscellaneous databases

    ChiTaRSi NR1H2. mouse.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8BP65.

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR023257. Liver_X_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR02034. LIVERXRECPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Whole bodyImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Whole bodyImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Whole bodyImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Whole bodyImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Whole bodyImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Whole bodyImported.
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    8. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Whole bodyImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Whole bodyImported.
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    11. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ8BP65_MOUSE
    AccessioniPrimary (citable) accession number: Q8BP65
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3