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Q8BP65

- Q8BP65_MOUSE

UniProt

Q8BP65 - Q8BP65_MOUSE

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Protein
Submitted name:

Oxysterols receptor LXR-beta

Gene

Nr1h2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  3. retinoid X receptor binding Source: MGI
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  6. sequence-specific DNA binding transcription factor activity Source: MGI
  7. sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity Source: Ensembl
  8. steroid hormone receptor activity Source: InterPro
  9. zinc ion binding Source: InterPro

GO - Biological processi

  1. cellular lipid metabolic process Source: MGI
  2. negative regulation of cholesterol storage Source: Ensembl
  3. negative regulation of lipid transport Source: Ensembl
  4. negative regulation of pinocytosis Source: Ensembl
  5. negative regulation of transcription, DNA-templated Source: Ensembl
  6. positive regulation of cellular protein metabolic process Source: Ensembl
  7. positive regulation of cholesterol efflux Source: MGI
  8. positive regulation of fatty acid biosynthetic process Source: Ensembl
  9. positive regulation of lipoprotein lipase activity Source: Ensembl
  10. positive regulation of triglyceride biosynthetic process Source: Ensembl
  11. regulation of transcription, DNA-templated Source: MGI
  12. regulation of transcription from RNA polymerase II promoter Source: MGI
  13. retinoic acid receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Oxysterols receptor LXR-betaImported
Gene namesi
Name:Nr1h2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1352463. Nr1h2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ8BP65.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118837.
HOGENOMiHOG000220845.
HOVERGENiHBG108655.
KOiK08535.
TreeFamiTF352167.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR023257. Liver_X_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BP65-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSPTSSLDT PVPGNGSPQP STSATSPTIK EEGQETDPPP GSEGSSSAYI
60 70 80 90 100
VEPEDEPERK RKKGPAPKML GHELCRVCGD KASGFHYNVL SCEGCKGFFR
110 120 130 140 150
RSVVHGGAGR YACRGSGTCQ MDAFMRRKCQ LCRLRKCKEA GMREQCVLSE
160 170 180 190 200
EQIRKKRIQK QQQQQPPPPS EPAASSSGRP AASPGTSEAS SQGSGEGEGI
210 220 230 240 250
QLTAAQELMI QQLVAAQLQC NKRSFSDQPK VTPWPLGADP QSRDARQQRF
260 270 280 290 300
AHFTELAIIS VQEIVDFAKQ VPGFLQLGRE DQIALLKAST IEIMLLETAR
310 320 330 340 350
RYNHETECIT FLKDFTYSKD DFHRAGLQVE FINPIFEFSR AMRRLGLDDA
360 370 380 390 400
EYALLIAINI FSADRPNVQE PSRVEALQQP YVEALLSYTR IKRPQDQLRF
410 420 430 440
PRMLMKLVSL RTLSSVHSEQ VFALRLQDKK LPPLLSEIWD VHE
Length:443
Mass (Da):49,394
Last modified:March 1, 2003 - v1
Checksum:i362DCB2D21034F29
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC149607 Genomic DNA. No translation available.
AC157653 Genomic DNA. No translation available.
AK077620 mRNA. Translation: BAC36906.1.
AK156777 mRNA. Translation: BAE33850.1.
RefSeqiNP_001272447.1. NM_001285518.1.
NP_001272448.1. NM_001285519.1.
NP_033499.1. NM_009473.3.
UniGeneiMm.968.

Genome annotation databases

EnsembliENSMUST00000107910; ENSMUSP00000103543; ENSMUSG00000060601.
ENSMUST00000107911; ENSMUSP00000103544; ENSMUSG00000060601.
GeneIDi22260.
KEGGimmu:22260.
UCSCiuc009gqb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC149607 Genomic DNA. No translation available.
AC157653 Genomic DNA. No translation available.
AK077620 mRNA. Translation: BAC36906.1 .
AK156777 mRNA. Translation: BAE33850.1 .
RefSeqi NP_001272447.1. NM_001285518.1.
NP_001272448.1. NM_001285519.1.
NP_033499.1. NM_009473.3.
UniGenei Mm.968.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000107910 ; ENSMUSP00000103543 ; ENSMUSG00000060601 .
ENSMUST00000107911 ; ENSMUSP00000103544 ; ENSMUSG00000060601 .
GeneIDi 22260.
KEGGi mmu:22260.
UCSCi uc009gqb.1. mouse.

Organism-specific databases

CTDi 7376.
MGIi MGI:1352463. Nr1h2.

Phylogenomic databases

GeneTreei ENSGT00760000118837.
HOGENOMi HOG000220845.
HOVERGENi HBG108655.
KOi K08535.
TreeFami TF352167.

Miscellaneous databases

ChiTaRSi NR1H2. mouse.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8BP65.

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR023257. Liver_X_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Whole bodyImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  11. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8BP65_MOUSE
AccessioniPrimary (citable) accession number: Q8BP65
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3