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Q8BP65

- Q8BP65_MOUSE

UniProt

Q8BP65 - Q8BP65_MOUSE

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Protein
Submitted name:

Oxysterols receptor LXR-beta

Gene
Nr1h2
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  3. protein binding Source: MGI
  4. retinoid X receptor binding Source: MGI
  5. sequence-specific DNA binding Source: InterPro
  6. sequence-specific DNA binding transcription factor activity Source: MGI
  7. steroid hormone receptor activity Source: InterPro
  8. zinc ion binding Source: InterPro

GO - Biological processi

  1. cellular lipid metabolic process Source: MGI
  2. intracellular receptor signaling pathway Source: GOC
  3. positive regulation of cholesterol efflux Source: MGI
  4. regulation of transcription, DNA-templated Source: MGI
  5. regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotations

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotations, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Oxysterols receptor LXR-betaImported
Gene namesi
Name:Nr1h2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1352463. Nr1h2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotations

Expressioni

Gene expression databases

GenevestigatoriQ8BP65.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotations

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00720000108423.
HOGENOMiHOG000220845.
HOVERGENiHBG108655.
KOiK08535.
TreeFamiTF352167.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR023257. Liver_X_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BP65-1 [UniParc]FASTAAdd to Basket

« Hide

MSSPTSSLDT PVPGNGSPQP STSATSPTIK EEGQETDPPP GSEGSSSAYI    50
VEPEDEPERK RKKGPAPKML GHELCRVCGD KASGFHYNVL SCEGCKGFFR 100
RSVVHGGAGR YACRGSGTCQ MDAFMRRKCQ LCRLRKCKEA GMREQCVLSE 150
EQIRKKRIQK QQQQQPPPPS EPAASSSGRP AASPGTSEAS SQGSGEGEGI 200
QLTAAQELMI QQLVAAQLQC NKRSFSDQPK VTPWPLGADP QSRDARQQRF 250
AHFTELAIIS VQEIVDFAKQ VPGFLQLGRE DQIALLKAST IEIMLLETAR 300
RYNHETECIT FLKDFTYSKD DFHRAGLQVE FINPIFEFSR AMRRLGLDDA 350
EYALLIAINI FSADRPNVQE PSRVEALQQP YVEALLSYTR IKRPQDQLRF 400
PRMLMKLVSL RTLSSVHSEQ VFALRLQDKK LPPLLSEIWD VHE 443
Length:443
Mass (Da):49,394
Last modified:March 1, 2003 - v1
Checksum:i362DCB2D21034F29
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC149607 Genomic DNA. No translation available.
AC157653 Genomic DNA. No translation available.
AK077620 mRNA. Translation: BAC36906.1.
AK156777 mRNA. Translation: BAE33850.1.
RefSeqiNP_001272447.1. NM_001285518.1.
NP_001272448.1. NM_001285519.1.
NP_033499.1. NM_009473.3.
UniGeneiMm.968.

Genome annotation databases

EnsembliENSMUST00000107910; ENSMUSP00000103543; ENSMUSG00000060601.
ENSMUST00000107911; ENSMUSP00000103544; ENSMUSG00000060601.
GeneIDi22260.
KEGGimmu:22260.
UCSCiuc009gqb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC149607 Genomic DNA. No translation available.
AC157653 Genomic DNA. No translation available.
AK077620 mRNA. Translation: BAC36906.1 .
AK156777 mRNA. Translation: BAE33850.1 .
RefSeqi NP_001272447.1. NM_001285518.1.
NP_001272448.1. NM_001285519.1.
NP_033499.1. NM_009473.3.
UniGenei Mm.968.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000107910 ; ENSMUSP00000103543 ; ENSMUSG00000060601 .
ENSMUST00000107911 ; ENSMUSP00000103544 ; ENSMUSG00000060601 .
GeneIDi 22260.
KEGGi mmu:22260.
UCSCi uc009gqb.1. mouse.

Organism-specific databases

CTDi 7376.
MGIi MGI:1352463. Nr1h2.

Phylogenomic databases

GeneTreei ENSGT00720000108423.
HOGENOMi HOG000220845.
HOVERGENi HBG108655.
KOi K08535.
TreeFami TF352167.

Miscellaneous databases

ChiTaRSi NR1H2. mouse.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8BP65.

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR023257. Liver_X_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Whole bodyImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Whole bodyImported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  11. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8BP65_MOUSE
AccessioniPrimary (citable) accession number: Q8BP65
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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