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Protein

Asparagine--tRNA ligase, cytoplasmic

Gene

Nars

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Asparagine--tRNA ligase, cytoplasmic (EC:6.1.1.22)
Alternative name(s):
Asparaginyl-tRNA synthetase
Short name:
AsnRS
Gene namesi
Name:Nars
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1917473 Nars

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001764971 – 559Asparagine--tRNA ligase, cytoplasmicAdd BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphoserineBy similarity1
Modified residuei255N6-acetyllysineBy similarity1
Modified residuei493PhosphoserineCombined sources1
Modified residuei501N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BP47
MaxQBiQ8BP47
PaxDbiQ8BP47
PeptideAtlasiQ8BP47
PRIDEiQ8BP47

PTM databases

iPTMnetiQ8BP47
PhosphoSitePlusiQ8BP47

Expressioni

Gene expression databases

BgeeiENSMUSG00000024587
CleanExiMM_NARS
GenevisibleiQ8BP47 MM

Interactioni

Protein-protein interaction databases

BioGridi213922, 3 interactors
IntActiQ8BP47, 5 interactors
MINTiQ8BP47
STRINGi10090.ENSMUSP00000025483

Structurei

3D structure databases

ProteinModelPortaliQ8BP47
SMRiQ8BP47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0555 Eukaryota
COG0017 LUCA
GeneTreeiENSGT00550000074893
HOGENOMiHOG000226035
HOVERGENiHBG059844
InParanoidiQ8BP47
KOiK01893
OMAiYMQRCPE
OrthoDBiEOG091G065Q
PhylomeDBiQ8BP47
TreeFamiTF105664

Family and domain databases

InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR004522 Asn-tRNA-ligase
IPR002312 Asp/Asn-tRNA-synth_IIb
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PfamiView protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PRINTSiPR01042 TRNASYNTHASP
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00457 asnS, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BP47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEVIRGTA EMVLAELYVS DREGNDATGD GTKEKPFKTG LKALMTVGKE
60 70 80 90 100
PFPTIYVDSQ KENERWDVIS KSQMKNIKKM WHREQMKNDS REKKEAEDNL
110 120 130 140 150
RREKNLEEAK KIIIKNDPSL PEPACVKISA LEGYRGQRVK VFGWVHRLRR
160 170 180 190 200
QGKNLMFLVL RDGTGYLQCV LSDDLCQCYN GVVLSTESSV AVYGTLNLTP
210 220 230 240 250
KGKQAPGGHE LSCDFWELVG LAPAGGADNL INEESDVDVQ LNNRHMMIRG
260 270 280 290 300
ENMSKILKAR SMITRCFRDH FFDRGYCEVT TPTLVQTQVE GGATLFKLDY
310 320 330 340 350
FGEEAFLTQS SQLYLETCLP ALGDVFCIAQ SYRAEQSRTR RHLAEFTHVE
360 370 380 390 400
AECPFLTFED LLNRLEDLVC DVVDRVLKSP VASIVYELNP NFKPPKRPFR
410 420 430 440 450
RMNYSDAIEW LKEHDVKKED GTFYEFGDDI PEAPERLMTD TINEPILLCR
460 470 480 490 500
FPVEIKSFYM QRCPEDPRLT ESVDVLMPNV GEIVGGSMRS WDSEEILEGY
510 520 530 540 550
KREGIDPAPY YWYTDQRKYG TCPHGGYGLG LERFLSWILN RYHIRDVCLY

PRFLQRCRP
Length:559
Mass (Da):64,279
Last modified:July 1, 2008 - v2
Checksum:iD5F4025B57580DBD
GO

Sequence cautioni

The sequence AAH52849 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB29032 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15Missing in BAB29032 (PubMed:16141072).Curated1
Sequence conflicti82H → R in BAB29032 (PubMed:16141072).Curated1
Sequence conflicti309Q → E in BAB29032 (PubMed:16141072).Curated1
Sequence conflicti469L → P in BAE43117 (PubMed:16141072).Curated1
Sequence conflicti526G → E in AAH52849 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013880 mRNA Translation: BAB29032.1 Different initiation.
AK077699 mRNA Translation: BAC36965.1
AK172657 mRNA Translation: BAE43117.1
BC052849 mRNA Translation: AAH52849.1 Different initiation.
CCDSiCCDS50308.1
RefSeqiNP_001136422.1, NM_001142950.1
NP_081626.2, NM_027350.3
UniGeneiMm.29192

Genome annotation databases

EnsembliENSMUST00000025483; ENSMUSP00000025483; ENSMUSG00000024587
GeneIDi70223
KEGGimmu:70223
UCSCiuc008fek.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSYNC_MOUSE
AccessioniPrimary (citable) accession number: Q8BP47
Secondary accession number(s): Q3T9A7, Q7TPX0, Q9CRY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: July 1, 2008
Last modified: March 28, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health