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Q8BP40

- PPA6_MOUSE

UniProt

Q8BP40 - PPA6_MOUSE

Protein

Lysophosphatidic acid phosphatase type 6

Gene

Acp6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid By similarity.By similarity

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei52 – 521NucleophileBy similarity
    Active sitei327 – 3271Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC
    2. lysophosphatidic acid phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. dephosphorylation Source: GOC
    2. hematopoietic progenitor cell differentiation Source: MGI
    3. lysobisphosphatidic acid metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid metabolism, Phospholipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophosphatidic acid phosphatase type 6 (EC:3.1.3.2)
    Alternative name(s):
    Acid phosphatase 6, lysophosphatidic
    Acid phosphatase-like protein 1
    PACPL1
    Gene namesi
    Name:Acp6
    Synonyms:Acpl1, Lpap
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1931010. Acp6.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2525MitochondrionBy similarityAdd
    BLAST
    Chaini26 – 418393Lysophosphatidic acid phosphatase type 6PRO_0000023966Add
    BLAST

    Proteomic databases

    MaxQBiQ8BP40.
    PaxDbiQ8BP40.
    PRIDEiQ8BP40.

    PTM databases

    PhosphoSiteiQ8BP40.

    Expressioni

    Gene expression databases

    BgeeiQ8BP40.
    CleanExiMM_ACP6.
    GenevestigatoriQ8BP40.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    IntActiQ8BP40. 3 interactions.
    MINTiMINT-1845948.
    STRINGi10090.ENSMUSP00000088263.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BP40.
    SMRiQ8BP40. Positions 35-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni51 – 161111Substrate bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the histidine acid phosphatase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG235758.
    GeneTreeiENSGT00530000062956.
    HOGENOMiHOG000290692.
    HOVERGENiHBG079458.
    InParanoidiQ8BP40.
    KOiK14395.
    OMAiHDVTLMP.
    OrthoDBiEOG747PJ2.
    PhylomeDBiQ8BP40.
    TreeFamiTF318821.

    Family and domain databases

    Gene3Di3.40.50.1240. 2 hits.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 2 hits.
    PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BP40-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRVWVPVGVL TSLAYCFHQR RVALAEQRAP NGQRPVDRNL LELKMVQVVF    50
    RHGARSPLKP LPLEEQVEWN PKLLEIPPQT RFDYTVTNLA GGPKPHSHYD 100
    TEYRKTTLRG GVLAGQLTKV GMQQMFALGE KLRKNYVEDI PFLSPVYNPQ 150
    EVFIRSTNMF RNLESTRCLL AGLFQHQKGS AVIHTDEASS EVLYPNYQSC 200
    WVLKEKTRGR KKAAISQPGI SEDLEKVKTG VGINNGDDVD FFVLLDNVAA 250
    EQVHSLLNCP ALERFAQLIE QRAVDMALYV VEQEDRESIQ MAVGPFLHIL 300
    EGNLLKTVDP TTAPSKTRKM YLYATHDVTL LPMLLALGIF DQKWPPFAVD 350
    LTMELYQHQE SKEWFVQLFY NGKEQVPRGC PDKLCPLDKF LNTMSVYSVS 400
    PEKYRTLCSK TRIVELGE 418
    Length:418
    Mass (Da):47,625
    Last modified:March 1, 2003 - v1
    Checksum:iC4124CE0D5CC0966
    GO
    Isoform 2 (identifier: Q8BP40-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         68-159: EWNPKLLEIP...QEVFIRSTNM → RGGPQRGSWG...QATVLIKCRF
         160-418: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:159
    Mass (Da):17,644
    Checksum:iD279BF088BE24113
    GO

    Sequence cautioni

    The sequence AAF20010.1 differs from that shown. Reason: Frameshift at position 418.
    The sequence BAA94308.1 differs from that shown. Reason: Frameshift at position 25.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti130 – 1312EK → KR in AAF20010. (PubMed:12837850)Curated
    Sequence conflicti137 – 1371V → L in AAF20010. (PubMed:12837850)Curated
    Sequence conflicti142 – 1421F → L in AAF20010. (PubMed:12837850)Curated
    Sequence conflicti289 – 2891I → L in AAF20010. (PubMed:12837850)Curated
    Sequence conflicti302 – 3021G → E in AAF20010. (PubMed:12837850)Curated
    Sequence conflicti315 – 3151S → N in AAF20010. (PubMed:12837850)Curated
    Sequence conflicti370 – 3701Y → F in AAF20010. (PubMed:12837850)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei68 – 15992EWNPK…RSTNM → RGGPQRGSWGHTLASPVGAR AGSRPEGNNSRLALRLWPGV IIPCSSQTTGVVCKPSWLGQ PLPPKLSVAWCSETFERCIR MSQATVLIKCRF in isoform 2. 1 PublicationVSP_014123Add
    BLAST
    Alternative sequencei160 – 418259Missing in isoform 2. 1 PublicationVSP_014124Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB030038 mRNA. Translation: BAA94308.1. Frameshift.
    AK077729 mRNA. Translation: BAC36983.1.
    AK089736 mRNA. Translation: BAC40949.1.
    AK160271 mRNA. Translation: BAE35722.1.
    AK165356 mRNA. Translation: BAE38147.1.
    AK171757 mRNA. Translation: BAE42654.1.
    BC047276 mRNA. Translation: AAH47276.1.
    AF216223 mRNA. Translation: AAF20010.1. Frameshift.
    CCDSiCCDS17653.1. [Q8BP40-1]
    RefSeqiNP_062774.2. NM_019800.4. [Q8BP40-1]
    UniGeneiMm.101368.

    Genome annotation databases

    EnsembliENSMUST00000090759; ENSMUSP00000088263; ENSMUSG00000028093. [Q8BP40-1]
    GeneIDi66659.
    KEGGimmu:66659.
    UCSCiuc008qoq.2. mouse. [Q8BP40-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB030038 mRNA. Translation: BAA94308.1 . Frameshift.
    AK077729 mRNA. Translation: BAC36983.1 .
    AK089736 mRNA. Translation: BAC40949.1 .
    AK160271 mRNA. Translation: BAE35722.1 .
    AK165356 mRNA. Translation: BAE38147.1 .
    AK171757 mRNA. Translation: BAE42654.1 .
    BC047276 mRNA. Translation: AAH47276.1 .
    AF216223 mRNA. Translation: AAF20010.1 . Frameshift.
    CCDSi CCDS17653.1. [Q8BP40-1 ]
    RefSeqi NP_062774.2. NM_019800.4. [Q8BP40-1 ]
    UniGenei Mm.101368.

    3D structure databases

    ProteinModelPortali Q8BP40.
    SMRi Q8BP40. Positions 35-411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8BP40. 3 interactions.
    MINTi MINT-1845948.
    STRINGi 10090.ENSMUSP00000088263.

    PTM databases

    PhosphoSitei Q8BP40.

    Proteomic databases

    MaxQBi Q8BP40.
    PaxDbi Q8BP40.
    PRIDEi Q8BP40.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000090759 ; ENSMUSP00000088263 ; ENSMUSG00000028093 . [Q8BP40-1 ]
    GeneIDi 66659.
    KEGGi mmu:66659.
    UCSCi uc008qoq.2. mouse. [Q8BP40-1 ]

    Organism-specific databases

    CTDi 51205.
    MGIi MGI:1931010. Acp6.

    Phylogenomic databases

    eggNOGi NOG235758.
    GeneTreei ENSGT00530000062956.
    HOGENOMi HOG000290692.
    HOVERGENi HBG079458.
    InParanoidi Q8BP40.
    KOi K14395.
    OMAi HDVTLMP.
    OrthoDBi EOG747PJ2.
    PhylomeDBi Q8BP40.
    TreeFami TF318821.

    Miscellaneous databases

    ChiTaRSi ACP6. mouse.
    NextBioi 322299.
    PROi Q8BP40.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BP40.
    CleanExi MM_ACP6.
    Genevestigatori Q8BP40.

    Family and domain databases

    Gene3Di 3.40.50.1240. 2 hits.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 2 hits.
    PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum."
      Takayama I., Daigo Y., Ward S.M., Sanders K.M., Walker R.L., Horowitz B., Yamanaka T., Fujino M.A.
      Gut 50:790-796(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J and NOD.
      Tissue: Embryo, Pituitary and Spleen.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N-3.
      Tissue: Mammary tumor.
    4. "Role of phospholipase D in agonist-stimulated lysophosphatidic acid synthesis by ovarian cancer cells."
      Luquain C., Singh A., Wang L., Natarajan V., Morris A.J.
      J. Lipid Res. 44:1963-1975(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-418 (ISOFORM 1).

    Entry informationi

    Entry nameiPPA6_MOUSE
    AccessioniPrimary (citable) accession number: Q8BP40
    Secondary accession number(s): Q3TNE2
    , Q8BN33, Q9JMG5, Q9QXG5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3