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Protein

Lysophosphatidic acid phosphatase type 6

Gene

Acp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid (By similarity).By similarity

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei52NucleophileBy similarity1
Active sitei327Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

  • hematopoietic progenitor cell differentiation Source: MGI
  • lysobisphosphatidic acid metabolic process Source: UniProtKB
  • phospholipid metabolic process Source: MGI

Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-1483166 Synthesis of PA

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid phosphatase type 6 (EC:3.1.3.2)
Alternative name(s):
Acid phosphatase 6, lysophosphatidic
Acid phosphatase-like protein 1
PACPL1
Gene namesi
Name:Acp6
Synonyms:Acpl1, Lpap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1931010 Acp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionBy similarityAdd BLAST25
ChainiPRO_000002396626 – 418Lysophosphatidic acid phosphatase type 6Add BLAST393

Proteomic databases

EPDiQ8BP40
PaxDbiQ8BP40
PeptideAtlasiQ8BP40
PRIDEiQ8BP40

PTM databases

iPTMnetiQ8BP40
PhosphoSitePlusiQ8BP40

Expressioni

Gene expression databases

BgeeiENSMUSG00000028093
CleanExiMM_ACP6
GenevisibleiQ8BP40 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiQ8BP40, 3 interactors
MINTiQ8BP40
STRINGi10090.ENSMUSP00000088263

Structurei

3D structure databases

ProteinModelPortaliQ8BP40
SMRiQ8BP40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 161Substrate bindingBy similarityAdd BLAST111

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3720 Eukaryota
ENOG410ZVBQ LUCA
GeneTreeiENSGT00530000062956
HOGENOMiHOG000290692
HOVERGENiHBG079458
InParanoidiQ8BP40
KOiK14395
OMAiFDHKWPP
OrthoDBiEOG091G05TQ
PhylomeDBiQ8BP40
TreeFamiTF318821

Family and domain databases

CDDicd07061 HP_HAP_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR029033 His_PPase_superfam
PfamiView protein in Pfam
PF00328 His_Phos_2, 2 hits
SUPFAMiSSF53254 SSF53254, 2 hits
PROSITEiView protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BP40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVWVPVGVL TSLAYCFHQR RVALAEQRAP NGQRPVDRNL LELKMVQVVF
60 70 80 90 100
RHGARSPLKP LPLEEQVEWN PKLLEIPPQT RFDYTVTNLA GGPKPHSHYD
110 120 130 140 150
TEYRKTTLRG GVLAGQLTKV GMQQMFALGE KLRKNYVEDI PFLSPVYNPQ
160 170 180 190 200
EVFIRSTNMF RNLESTRCLL AGLFQHQKGS AVIHTDEASS EVLYPNYQSC
210 220 230 240 250
WVLKEKTRGR KKAAISQPGI SEDLEKVKTG VGINNGDDVD FFVLLDNVAA
260 270 280 290 300
EQVHSLLNCP ALERFAQLIE QRAVDMALYV VEQEDRESIQ MAVGPFLHIL
310 320 330 340 350
EGNLLKTVDP TTAPSKTRKM YLYATHDVTL LPMLLALGIF DQKWPPFAVD
360 370 380 390 400
LTMELYQHQE SKEWFVQLFY NGKEQVPRGC PDKLCPLDKF LNTMSVYSVS
410
PEKYRTLCSK TRIVELGE
Length:418
Mass (Da):47,625
Last modified:March 1, 2003 - v1
Checksum:iC4124CE0D5CC0966
GO
Isoform 2 (identifier: Q8BP40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-159: EWNPKLLEIP...QEVFIRSTNM → RGGPQRGSWG...QATVLIKCRF
     160-418: Missing.

Note: No experimental confirmation available.
Show »
Length:159
Mass (Da):17,644
Checksum:iD279BF088BE24113
GO

Sequence cautioni

The sequence AAF20010 differs from that shown. Reason: Frameshift at position 418.Curated
The sequence BAA94308 differs from that shown. Reason: Frameshift at position 25.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130 – 131EK → KR in AAF20010 (PubMed:12837850).Curated2
Sequence conflicti137V → L in AAF20010 (PubMed:12837850).Curated1
Sequence conflicti142F → L in AAF20010 (PubMed:12837850).Curated1
Sequence conflicti289I → L in AAF20010 (PubMed:12837850).Curated1
Sequence conflicti302G → E in AAF20010 (PubMed:12837850).Curated1
Sequence conflicti315S → N in AAF20010 (PubMed:12837850).Curated1
Sequence conflicti370Y → F in AAF20010 (PubMed:12837850).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01412368 – 159EWNPK…RSTNM → RGGPQRGSWGHTLASPVGAR AGSRPEGNNSRLALRLWPGV IIPCSSQTTGVVCKPSWLGQ PLPPKLSVAWCSETFERCIR MSQATVLIKCRF in isoform 2. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_014124160 – 418Missing in isoform 2. 1 PublicationAdd BLAST259

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030038 mRNA Translation: BAA94308.1 Frameshift.
AK077729 mRNA Translation: BAC36983.1
AK089736 mRNA Translation: BAC40949.1
AK160271 mRNA Translation: BAE35722.1
AK165356 mRNA Translation: BAE38147.1
AK171757 mRNA Translation: BAE42654.1
BC047276 mRNA Translation: AAH47276.1
AF216223 mRNA Translation: AAF20010.1 Frameshift.
CCDSiCCDS17653.1 [Q8BP40-1]
RefSeqiNP_062774.2, NM_019800.4 [Q8BP40-1]
UniGeneiMm.101368

Genome annotation databases

EnsembliENSMUST00000090759; ENSMUSP00000088263; ENSMUSG00000028093 [Q8BP40-1]
GeneIDi66659
KEGGimmu:66659
UCSCiuc008qoq.2 mouse [Q8BP40-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPPA6_MOUSE
AccessioniPrimary (citable) accession number: Q8BP40
Secondary accession number(s): Q3TNE2
, Q8BN33, Q9JMG5, Q9QXG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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