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Q8BP40 (PPA6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophosphatidic acid phosphatase type 6

EC=3.1.3.2
Alternative name(s):
Acid phosphatase 6, lysophosphatidic
Acid phosphatase-like protein 1
PACPL1
Gene names
Name:Acp6
Synonyms:Acpl1, Lpap
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid By similarity.

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Subunit structure

Monomer By similarity.

Subcellular location

Mitochondrion By similarity Ref.1.

Sequence similarities

Belongs to the histidine acid phosphatase family.

Sequence caution

The sequence AAF20010.1 differs from that shown. Reason: Frameshift at position 418.

The sequence BAA94308.1 differs from that shown. Reason: Frameshift at position 25.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BP40-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BP40-2)

The sequence of this isoform differs from the canonical sequence as follows:
     68-159: EWNPKLLEIP...QEVFIRSTNM → RGGPQRGSWG...QATVLIKCRF
     160-418: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2525Mitochondrion By similarity
Chain26 – 418393Lysophosphatidic acid phosphatase type 6
PRO_0000023966

Regions

Region51 – 161111Substrate binding By similarity

Sites

Active site521Nucleophile By similarity
Active site3271Proton donor By similarity

Natural variations

Alternative sequence68 – 15992EWNPK…RSTNM → RGGPQRGSWGHTLASPVGAR AGSRPEGNNSRLALRLWPGV IIPCSSQTTGVVCKPSWLGQ PLPPKLSVAWCSETFERCIR MSQATVLIKCRF in isoform 2.
VSP_014123
Alternative sequence160 – 418259Missing in isoform 2.
VSP_014124

Experimental info

Sequence conflict130 – 1312EK → KR in AAF20010. Ref.4
Sequence conflict1371V → L in AAF20010. Ref.4
Sequence conflict1421F → L in AAF20010. Ref.4
Sequence conflict2891I → L in AAF20010. Ref.4
Sequence conflict3021G → E in AAF20010. Ref.4
Sequence conflict3151S → N in AAF20010. Ref.4
Sequence conflict3701Y → F in AAF20010. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: C4124CE0D5CC0966

FASTA41847,625
        10         20         30         40         50         60 
MRVWVPVGVL TSLAYCFHQR RVALAEQRAP NGQRPVDRNL LELKMVQVVF RHGARSPLKP 

        70         80         90        100        110        120 
LPLEEQVEWN PKLLEIPPQT RFDYTVTNLA GGPKPHSHYD TEYRKTTLRG GVLAGQLTKV 

       130        140        150        160        170        180 
GMQQMFALGE KLRKNYVEDI PFLSPVYNPQ EVFIRSTNMF RNLESTRCLL AGLFQHQKGS 

       190        200        210        220        230        240 
AVIHTDEASS EVLYPNYQSC WVLKEKTRGR KKAAISQPGI SEDLEKVKTG VGINNGDDVD 

       250        260        270        280        290        300 
FFVLLDNVAA EQVHSLLNCP ALERFAQLIE QRAVDMALYV VEQEDRESIQ MAVGPFLHIL 

       310        320        330        340        350        360 
EGNLLKTVDP TTAPSKTRKM YLYATHDVTL LPMLLALGIF DQKWPPFAVD LTMELYQHQE 

       370        380        390        400        410 
SKEWFVQLFY NGKEQVPRGC PDKLCPLDKF LNTMSVYSVS PEKYRTLCSK TRIVELGE 

« Hide

Isoform 2 [UniParc].

Checksum: D279BF088BE24113
Show »

FASTA15917,644

References

« Hide 'large scale' references
[1]"Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum."
Takayama I., Daigo Y., Ward S.M., Sanders K.M., Walker R.L., Horowitz B., Yamanaka T., Fujino M.A.
Gut 50:790-796(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J and NOD.
Tissue: Embryo, Pituitary and Spleen.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N-3.
Tissue: Mammary tumor.
[4]"Role of phospholipase D in agonist-stimulated lysophosphatidic acid synthesis by ovarian cancer cells."
Luquain C., Singh A., Wang L., Natarajan V., Morris A.J.
J. Lipid Res. 44:1963-1975(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-418 (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB030038 mRNA. Translation: BAA94308.1. Frameshift.
AK077729 mRNA. Translation: BAC36983.1.
AK089736 mRNA. Translation: BAC40949.1.
AK160271 mRNA. Translation: BAE35722.1.
AK165356 mRNA. Translation: BAE38147.1.
AK171757 mRNA. Translation: BAE42654.1.
BC047276 mRNA. Translation: AAH47276.1.
AF216223 mRNA. Translation: AAF20010.1. Frameshift.
RefSeqNP_062774.2. NM_019800.4.
UniGeneMm.101368.

3D structure databases

ProteinModelPortalQ8BP40.
SMRQ8BP40. Positions 35-411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8BP40. 3 interactions.
MINTMINT-1845948.
STRING10090.ENSMUSP00000088263.

PTM databases

PhosphoSiteQ8BP40.

Proteomic databases

PaxDbQ8BP40.
PRIDEQ8BP40.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000090759; ENSMUSP00000088263; ENSMUSG00000028093. [Q8BP40-1]
GeneID66659.
KEGGmmu:66659.
UCSCuc008qoq.2. mouse. [Q8BP40-1]

Organism-specific databases

CTD51205.
MGIMGI:1931010. Acp6.

Phylogenomic databases

eggNOGNOG235758.
GeneTreeENSGT00530000062956.
HOGENOMHOG000290692.
HOVERGENHBG079458.
InParanoidQ8BP40.
KOK14395.
OMAHDVTLMP.
OrthoDBEOG747PJ2.
PhylomeDBQ8BP40.
TreeFamTF318821.

Gene expression databases

BgeeQ8BP40.
CleanExMM_ACP6.
GenevestigatorQ8BP40.

Family and domain databases

InterProIPR000560. His_Pase_superF_clade-2.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
[Graphical view]
PROSITEPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSACP6. mouse.
NextBio322299.
PROQ8BP40.
SOURCESearch...

Entry information

Entry namePPA6_MOUSE
AccessionPrimary (citable) accession number: Q8BP40
Secondary accession number(s): Q3TNE2 expand/collapse secondary AC list , Q8BN33, Q9JMG5, Q9QXG5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot