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Protein

Lysophosphatidic acid phosphatase type 6

Gene

Acp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid (By similarity).By similarity

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521NucleophileBy similarity
Active sitei327 – 3271Proton donorBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. lysophosphatidic acid phosphatase activity Source: UniProtKB

GO - Biological processi

  1. dephosphorylation Source: MGI
  2. hematopoietic progenitor cell differentiation Source: MGI
  3. lysobisphosphatidic acid metabolic process Source: UniProtKB
  4. phospholipid metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid metabolism, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid phosphatase type 6 (EC:3.1.3.2)
Alternative name(s):
Acid phosphatase 6, lysophosphatidic
Acid phosphatase-like protein 1
PACPL1
Gene namesi
Name:Acp6
Synonyms:Acpl1, Lpap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1931010. Acp6.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525MitochondrionBy similarityAdd
BLAST
Chaini26 – 418393Lysophosphatidic acid phosphatase type 6PRO_0000023966Add
BLAST

Proteomic databases

MaxQBiQ8BP40.
PaxDbiQ8BP40.
PRIDEiQ8BP40.

PTM databases

PhosphoSiteiQ8BP40.

Expressioni

Gene expression databases

BgeeiQ8BP40.
CleanExiMM_ACP6.
GenevestigatoriQ8BP40.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiQ8BP40. 3 interactions.
MINTiMINT-1845948.
STRINGi10090.ENSMUSP00000088263.

Structurei

3D structure databases

ProteinModelPortaliQ8BP40.
SMRiQ8BP40. Positions 35-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 161111Substrate bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG235758.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000290692.
HOVERGENiHBG079458.
InParanoidiQ8BP40.
KOiK14395.
OMAiHDVTLMP.
OrthoDBiEOG747PJ2.
PhylomeDBiQ8BP40.
TreeFamiTF318821.

Family and domain databases

Gene3Di3.40.50.1240. 2 hits.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 2 hits.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BP40-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVWVPVGVL TSLAYCFHQR RVALAEQRAP NGQRPVDRNL LELKMVQVVF
60 70 80 90 100
RHGARSPLKP LPLEEQVEWN PKLLEIPPQT RFDYTVTNLA GGPKPHSHYD
110 120 130 140 150
TEYRKTTLRG GVLAGQLTKV GMQQMFALGE KLRKNYVEDI PFLSPVYNPQ
160 170 180 190 200
EVFIRSTNMF RNLESTRCLL AGLFQHQKGS AVIHTDEASS EVLYPNYQSC
210 220 230 240 250
WVLKEKTRGR KKAAISQPGI SEDLEKVKTG VGINNGDDVD FFVLLDNVAA
260 270 280 290 300
EQVHSLLNCP ALERFAQLIE QRAVDMALYV VEQEDRESIQ MAVGPFLHIL
310 320 330 340 350
EGNLLKTVDP TTAPSKTRKM YLYATHDVTL LPMLLALGIF DQKWPPFAVD
360 370 380 390 400
LTMELYQHQE SKEWFVQLFY NGKEQVPRGC PDKLCPLDKF LNTMSVYSVS
410
PEKYRTLCSK TRIVELGE
Length:418
Mass (Da):47,625
Last modified:March 1, 2003 - v1
Checksum:iC4124CE0D5CC0966
GO
Isoform 2 (identifier: Q8BP40-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-159: EWNPKLLEIP...QEVFIRSTNM → RGGPQRGSWG...QATVLIKCRF
     160-418: Missing.

Note: No experimental confirmation available.

Show »
Length:159
Mass (Da):17,644
Checksum:iD279BF088BE24113
GO

Sequence cautioni

The sequence AAF20010.1 differs from that shown. Reason: Frameshift at position 418. Curated
The sequence BAA94308.1 differs from that shown. Reason: Frameshift at position 25. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1312EK → KR in AAF20010. (PubMed:12837850)Curated
Sequence conflicti137 – 1371V → L in AAF20010. (PubMed:12837850)Curated
Sequence conflicti142 – 1421F → L in AAF20010. (PubMed:12837850)Curated
Sequence conflicti289 – 2891I → L in AAF20010. (PubMed:12837850)Curated
Sequence conflicti302 – 3021G → E in AAF20010. (PubMed:12837850)Curated
Sequence conflicti315 – 3151S → N in AAF20010. (PubMed:12837850)Curated
Sequence conflicti370 – 3701Y → F in AAF20010. (PubMed:12837850)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei68 – 15992EWNPK…RSTNM → RGGPQRGSWGHTLASPVGAR AGSRPEGNNSRLALRLWPGV IIPCSSQTTGVVCKPSWLGQ PLPPKLSVAWCSETFERCIR MSQATVLIKCRF in isoform 2. 1 PublicationVSP_014123Add
BLAST
Alternative sequencei160 – 418259Missing in isoform 2. 1 PublicationVSP_014124Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030038 mRNA. Translation: BAA94308.1. Frameshift.
AK077729 mRNA. Translation: BAC36983.1.
AK089736 mRNA. Translation: BAC40949.1.
AK160271 mRNA. Translation: BAE35722.1.
AK165356 mRNA. Translation: BAE38147.1.
AK171757 mRNA. Translation: BAE42654.1.
BC047276 mRNA. Translation: AAH47276.1.
AF216223 mRNA. Translation: AAF20010.1. Frameshift.
CCDSiCCDS17653.1. [Q8BP40-1]
RefSeqiNP_062774.2. NM_019800.4. [Q8BP40-1]
UniGeneiMm.101368.

Genome annotation databases

EnsembliENSMUST00000090759; ENSMUSP00000088263; ENSMUSG00000028093. [Q8BP40-1]
GeneIDi66659.
KEGGimmu:66659.
UCSCiuc008qoq.2. mouse. [Q8BP40-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030038 mRNA. Translation: BAA94308.1. Frameshift.
AK077729 mRNA. Translation: BAC36983.1.
AK089736 mRNA. Translation: BAC40949.1.
AK160271 mRNA. Translation: BAE35722.1.
AK165356 mRNA. Translation: BAE38147.1.
AK171757 mRNA. Translation: BAE42654.1.
BC047276 mRNA. Translation: AAH47276.1.
AF216223 mRNA. Translation: AAF20010.1. Frameshift.
CCDSiCCDS17653.1. [Q8BP40-1]
RefSeqiNP_062774.2. NM_019800.4. [Q8BP40-1]
UniGeneiMm.101368.

3D structure databases

ProteinModelPortaliQ8BP40.
SMRiQ8BP40. Positions 35-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BP40. 3 interactions.
MINTiMINT-1845948.
STRINGi10090.ENSMUSP00000088263.

PTM databases

PhosphoSiteiQ8BP40.

Proteomic databases

MaxQBiQ8BP40.
PaxDbiQ8BP40.
PRIDEiQ8BP40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090759; ENSMUSP00000088263; ENSMUSG00000028093. [Q8BP40-1]
GeneIDi66659.
KEGGimmu:66659.
UCSCiuc008qoq.2. mouse. [Q8BP40-1]

Organism-specific databases

CTDi51205.
MGIiMGI:1931010. Acp6.

Phylogenomic databases

eggNOGiNOG235758.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000290692.
HOVERGENiHBG079458.
InParanoidiQ8BP40.
KOiK14395.
OMAiHDVTLMP.
OrthoDBiEOG747PJ2.
PhylomeDBiQ8BP40.
TreeFamiTF318821.

Miscellaneous databases

ChiTaRSiAcp6. mouse.
NextBioi322299.
PROiQ8BP40.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BP40.
CleanExiMM_ACP6.
GenevestigatoriQ8BP40.

Family and domain databases

Gene3Di3.40.50.1240. 2 hits.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 2 hits.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum."
    Takayama I., Daigo Y., Ward S.M., Sanders K.M., Walker R.L., Horowitz B., Yamanaka T., Fujino M.A.
    Gut 50:790-796(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Embryo, Pituitary and Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  4. "Role of phospholipase D in agonist-stimulated lysophosphatidic acid synthesis by ovarian cancer cells."
    Luquain C., Singh A., Wang L., Natarajan V., Morris A.J.
    J. Lipid Res. 44:1963-1975(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-418 (ISOFORM 1).

Entry informationi

Entry nameiPPA6_MOUSE
AccessioniPrimary (citable) accession number: Q8BP40
Secondary accession number(s): Q3TNE2
, Q8BN33, Q9JMG5, Q9QXG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.