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Protein

RING finger protein 122

Gene

Rnf122

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May induce necrosis and apoptosis. May play a role in cell viability (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri93 – 134RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 122
Gene namesi
Name:Rnf122
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1916117. Rnf122.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002478531 – 155RING finger protein 122Add BLAST155

Proteomic databases

PaxDbiQ8BP31.
PRIDEiQ8BP31.

PTM databases

iPTMnetiQ8BP31.
PhosphoSitePlusiQ8BP31.

Expressioni

Gene expression databases

CleanExiMM_RNF122.
ExpressionAtlasiQ8BP31. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040478.

Structurei

3D structure databases

ProteinModelPortaliQ8BP31.
SMRiQ8BP31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri93 – 134RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00710000106755.
HOGENOMiHOG000004806.
HOVERGENiHBG058899.
InParanoidiQ8BP31.
KOiK15699.
PhylomeDBiQ8BP31.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF13639. zf-RING_2. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BP31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPFQWCNGC FCGLGLVSTN KSCSMPPISF QDLPLNIYMV IFGTGIFVFM
60 70 80 90 100
LSLIFCCYFI SKLRNQAQSE RYGYKEVVLK GDAKKLQLYG QTCAVCLEDF
110 120 130 140 150
KGKDELGVLP CQHAFHRKCL VKWLEVRCVC PMCNKPIAGP TETSQSIGIL

LDELV
Length:155
Mass (Da):17,448
Last modified:March 1, 2003 - v1
Checksum:iF2AB6769825543A0
GO

Sequence cautioni

The sequence AAH50268 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91Missing in BAC39436 (PubMed:16141072).Curated1
Sequence conflicti91Missing in AAH38399 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077856 mRNA. Translation: BAC37035.1.
AK085376 mRNA. Translation: BAC39436.1.
AK171823 mRNA. Translation: BAE42682.1.
AK136206 mRNA. Translation: BAE22874.1.
BC038399 mRNA. Translation: AAH38399.1.
BC050268 mRNA. Translation: AAH50268.1. Different initiation.
RefSeqiNP_780345.1. NM_175136.2.
XP_006509253.1. XM_006509190.3.
UniGeneiMm.29532.
Mm.400167.

Genome annotation databases

EnsembliENSMUST00000217278; ENSMUSP00000150893; ENSMUSG00000039328.
GeneIDi68867.
KEGGimmu:68867.
UCSCiuc009ljd.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiRN122_MOUSE
AccessioniPrimary (citable) accession number: Q8BP31
Secondary accession number(s): Q80VA7, Q8BGD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot