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Q8BP00 (IQCB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
IQ calmodulin-binding motif-containing protein 1
Gene names
Name:Iqcb1
Synonyms:Kiaa0036
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length598 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in ciliogenesis. Ref.4

Subunit structure

Interacts with calmodulin. Interacts with CEP290 By similarity. Interacts with ATXN10 By similarity. Interacts with NPHP1, INVS, NPHP4 and RPGRIP1L By similarity. Ref.3

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Note: Localization to the centrosome depends on the interaction with CEP290 By similarity.

Tissue specificity

Localized to the outer segment and connecting cilia of photoreceptor cells. Ref.3

Sequence similarities

Contains 4 IQ domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BP00-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BP00-2)

The sequence of this isoform differs from the canonical sequence as follows:
     523-598: KAPSLKEAEG...MLFIGGTKPP → SMLYLHPCFI...ITNFKEVIIF
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 598598IQ calmodulin-binding motif-containing protein 1
PRO_0000084226

Regions

Domain294 – 31724IQ 1
Domain318 – 33821IQ 2
Domain387 – 41630IQ 3
Domain417 – 43721IQ 4
Coiled coil336 – 36227 Potential

Natural variations

Alternative sequence523 – 59876KAPSL…GTKPP → SMLYLHPCFINGIPLARDVA SKLFRRKVPQVVFIQVLGKS YIIPVFNSIPSVCACYKFKY FSFIKITNFKEVIIF in isoform 2.
VSP_010246

Experimental info

Sequence conflict41A → P in BAC37333. Ref.1
Sequence conflict91R → G in BAC37333. Ref.1
Sequence conflict191K → R in BAC37333. Ref.1
Sequence conflict321L → V in BAC37333. Ref.1
Sequence conflict3521L → W in BAC37333. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 10, 2004. Version 2.
Checksum: 87FBCB9B68899997

FASTA59868,734
        10         20         30         40         50         60 
MKPAGTDPRI LSLAAEVAKS PEQNVPVILL KLKEIINNTP LGSSELKKVK QDIYCYDLIQ 

        70         80         90        100        110        120 
YCLLVLSQDS SRIQGGWSTI SQLTQILSHC CVGLEPGEDG EEFYKELLPS AAENFLILGR 

       130        140        150        160        170        180 
RLQTCFINAT KGEEQDKLLH FFQIVTDSLF WLLGGHVQLI QNVLQSDHFL HLLQTDNVQI 

       190        200        210        220        230        240 
GASVMTLLQN ILQINSGNLL KIEGKALHSI LDEILFKLLS TPSPVIRSTA TKLLLVLAES 

       250        260        270        280        290        300 
HQEILILLRL SACYKGLRSL LNKQETLTEF SRELRQLVDL LTPKIHQEVE EQKLHKAACL 

       310        320        330        340        350        360 
IQAYWKGFQT RKRLKKLPSA VIALQRSFRS KRTKMMLELN RQKEEEDLRL KLQLQRQRAM 

       370        380        390        400        410        420 
RLSRESRLNM LEIIHPGQVE KYNREMEEKS ALTIQKHWRG YRERKNFRQQ RPSLTEYKAA 

       430        440        450        460        470        480 
VTLQRAVLKF LAKCRKKKKL FASWHGLQEL TDARRVELKQ QVDDYVKRHP CSQMSEAASR 

       490        500        510        520        530        540 
ELHAQAQERL QHYFMGRAIE ERAQQHREAL MAQISTNIEQ LMKAPSLKEA EGKEPEQFLS 

       550        560        570        580        590 
RSRPVAAKAK QAHLTTLKHI QAPWWKKLGE EPGDEVDVPK DELSIDLGML FIGGTKPP 

« Hide

Isoform 2 [UniParc].

Checksum: E360B9345680D54E
Show »

FASTA59769,070

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Ovary and Spleen.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Mammary cancer.
[3]"Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin."
Otto E.A., Loeys B., Khanna H., Hellemans J., Sudbrak R., Fan S., Muerb U., O'Toole J.F., Helou J., Attanasio M., Utsch B., Sayer J.A., Lillo C., Jimeno D., Coucke P., De Paepe A., Reinhardt R., Klages S. expand/collapse author list , Tsuda M., Kawakami I., Kusakabe T., Omran H., Imm A., Tippens M., Raymond P.A., Hill J., Beales P., He S., Kispert A., Margolis B., Williams D.S., Swaroop A., Hildebrandt F.
Nat. Genet. 37:282-288(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CALMODULIN, TISSUE SPECIFICITY.
[4]"Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways."
Sang L., Miller J.J., Corbit K.C., Giles R.H., Brauer M.J., Otto E.A., Baye L.M., Wen X., Scales S.J., Kwong M., Huntzicker E.G., Sfakianos M.K., Sandoval W., Bazan J.F., Kulkarni P., Garcia-Gonzalo F.R., Seol A.D., O'Toole J.F. expand/collapse author list , Held S., Reutter H.M., Lane W.S., Rafiq M.A., Noor A., Ansar M., Devi A.R., Sheffield V.C., Slusarski D.C., Vincent J.B., Doherty D.A., Hildebrandt F., Reiter J.F., Jackson P.K.
Cell 145:513-528(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK078554 mRNA. Translation: BAC37333.1.
AK165220 mRNA. Translation: BAE38084.1.
BC029084 mRNA. Translation: AAH29084.1.
CCDSCCDS28157.1. [Q8BP00-1]
RefSeqNP_796102.2. NM_177128.4. [Q8BP00-1]
XP_006522310.1. XM_006522247.1. [Q8BP00-1]
XP_006522311.1. XM_006522248.1. [Q8BP00-1]
XP_006522312.1. XM_006522249.1. [Q8BP00-1]
UniGeneMm.222934.

3D structure databases

ProteinModelPortalQ8BP00.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid235913. 163 interactions.
IntActQ8BP00. 134 interactions.
STRING10090.ENSMUSP00000023535.

PTM databases

PhosphoSiteQ8BP00.

Proteomic databases

PaxDbQ8BP00.
PRIDEQ8BP00.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023535; ENSMUSP00000023535; ENSMUSG00000022837. [Q8BP00-1]
ENSMUST00000114819; ENSMUSP00000110467; ENSMUSG00000022837. [Q8BP00-2]
GeneID320299.
KEGGmmu:320299.
UCSCuc007zda.1. mouse. [Q8BP00-2]
uc007zdb.2. mouse. [Q8BP00-1]

Organism-specific databases

CTD9657.
MGIMGI:2443764. Iqcb1.
RougeSearch...

Phylogenomic databases

eggNOGNOG261795.
GeneTreeENSGT00390000002188.
HOGENOMHOG000113095.
HOVERGENHBG052142.
InParanoidQ8BP00.
KOK16774.
OMAQVDDYVR.
OrthoDBEOG74N5GC.
PhylomeDBQ8BP00.
TreeFamTF351884.

Gene expression databases

BgeeQ8BP00.
CleanExMM_IQCB1.
GenevestigatorQ8BP00.

Family and domain databases

InterProIPR016024. ARM-type_fold.
IPR000048. IQ_motif_EF-hand-BS.
IPR028765. IQCB1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR15673. PTHR15673. 1 hit.
PfamPF00612. IQ. 2 hits.
[Graphical view]
SMARTSM00015. IQ. 2 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEPS50096. IQ. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio396452.
PROQ8BP00.
SOURCESearch...

Entry information

Entry nameIQCB1_MOUSE
AccessionPrimary (citable) accession number: Q8BP00
Secondary accession number(s): Q3TNK4, Q8K306
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot