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Q8BP00

- IQCB1_MOUSE

UniProt

Q8BP00 - IQCB1_MOUSE

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Protein
IQ calmodulin-binding motif-containing protein 1
Gene
Iqcb1, Kiaa0036
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in ciliogenesis.1 Publication

GO - Molecular functioni

  1. calmodulin binding Source: HGNC
  2. protein binding Source: IntAct

GO - Biological processi

  1. cilium assembly Source: UniProtKB
  2. maintenance of organ identity Source: HGNC
  3. photoreceptor cell maintenance Source: HGNC
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
IQ calmodulin-binding motif-containing protein 1
Gene namesi
Name:Iqcb1
Synonyms:Kiaa0036
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2443764. Iqcb1.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
Note: Localization to the centrosome depends on the interaction with CEP290 By similarity.

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. cytoplasm Source: UniProtKB-KW
  3. photoreceptor connecting cilium Source: HGNC
  4. photoreceptor outer segment Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598IQ calmodulin-binding motif-containing protein 1
PRO_0000084226Add
BLAST

Proteomic databases

PaxDbiQ8BP00.
PRIDEiQ8BP00.

PTM databases

PhosphoSiteiQ8BP00.

Expressioni

Tissue specificityi

Localized to the outer segment and connecting cilia of photoreceptor cells.1 Publication

Gene expression databases

BgeeiQ8BP00.
CleanExiMM_IQCB1.
GenevestigatoriQ8BP00.

Interactioni

Subunit structurei

Interacts with calmodulin. Interacts with CEP290 By similarity. Interacts with ATXN10 By similarity. Interacts with NPHP1, INVS, NPHP4 and RPGRIP1L By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Atxn10P286582EBI-4282243,EBI-4284019
Cep290Q6A0786EBI-4282243,EBI-1811999
InvsO890192EBI-4282243,EBI-4281337
Rpgrip1lQ8CG732EBI-4282243,EBI-4281130

Protein-protein interaction databases

BioGridi235913. 163 interactions.
IntActiQ8BP00. 134 interactions.
STRINGi10090.ENSMUSP00000023535.

Structurei

3D structure databases

ProteinModelPortaliQ8BP00.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini294 – 31724IQ 1
Add
BLAST
Domaini318 – 33821IQ 2
Add
BLAST
Domaini387 – 41630IQ 3
Add
BLAST
Domaini417 – 43721IQ 4
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili336 – 36227 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 4 IQ domains.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG261795.
GeneTreeiENSGT00390000002188.
HOGENOMiHOG000113095.
HOVERGENiHBG052142.
InParanoidiQ8BP00.
KOiK16774.
OMAiQVDDYVR.
OrthoDBiEOG74N5GC.
PhylomeDBiQ8BP00.
TreeFamiTF351884.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR000048. IQ_motif_EF-hand-BS.
IPR028765. IQCB1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15673. PTHR15673. 1 hit.
PfamiPF00612. IQ. 2 hits.
[Graphical view]
SMARTiSM00015. IQ. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BP00-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKPAGTDPRI LSLAAEVAKS PEQNVPVILL KLKEIINNTP LGSSELKKVK    50
QDIYCYDLIQ YCLLVLSQDS SRIQGGWSTI SQLTQILSHC CVGLEPGEDG 100
EEFYKELLPS AAENFLILGR RLQTCFINAT KGEEQDKLLH FFQIVTDSLF 150
WLLGGHVQLI QNVLQSDHFL HLLQTDNVQI GASVMTLLQN ILQINSGNLL 200
KIEGKALHSI LDEILFKLLS TPSPVIRSTA TKLLLVLAES HQEILILLRL 250
SACYKGLRSL LNKQETLTEF SRELRQLVDL LTPKIHQEVE EQKLHKAACL 300
IQAYWKGFQT RKRLKKLPSA VIALQRSFRS KRTKMMLELN RQKEEEDLRL 350
KLQLQRQRAM RLSRESRLNM LEIIHPGQVE KYNREMEEKS ALTIQKHWRG 400
YRERKNFRQQ RPSLTEYKAA VTLQRAVLKF LAKCRKKKKL FASWHGLQEL 450
TDARRVELKQ QVDDYVKRHP CSQMSEAASR ELHAQAQERL QHYFMGRAIE 500
ERAQQHREAL MAQISTNIEQ LMKAPSLKEA EGKEPEQFLS RSRPVAAKAK 550
QAHLTTLKHI QAPWWKKLGE EPGDEVDVPK DELSIDLGML FIGGTKPP 598
Length:598
Mass (Da):68,734
Last modified:May 10, 2004 - v2
Checksum:i87FBCB9B68899997
GO
Isoform 2 (identifier: Q8BP00-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     523-598: KAPSLKEAEG...MLFIGGTKPP → SMLYLHPCFI...ITNFKEVIIF

Note: No experimental confirmation available.

Show »
Length:597
Mass (Da):69,070
Checksum:iE360B9345680D54E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei523 – 59876KAPSL…GTKPP → SMLYLHPCFINGIPLARDVA SKLFRRKVPQVVFIQVLGKS YIIPVFNSIPSVCACYKFKY FSFIKITNFKEVIIF in isoform 2.
VSP_010246Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41A → P in BAC37333. 1 Publication
Sequence conflicti9 – 91R → G in BAC37333. 1 Publication
Sequence conflicti19 – 191K → R in BAC37333. 1 Publication
Sequence conflicti32 – 321L → V in BAC37333. 1 Publication
Sequence conflicti352 – 3521L → W in BAC37333. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK078554 mRNA. Translation: BAC37333.1.
AK165220 mRNA. Translation: BAE38084.1.
BC029084 mRNA. Translation: AAH29084.1.
CCDSiCCDS28157.1. [Q8BP00-1]
RefSeqiNP_796102.2. NM_177128.4. [Q8BP00-1]
XP_006522310.1. XM_006522247.1. [Q8BP00-1]
XP_006522311.1. XM_006522248.1. [Q8BP00-1]
XP_006522312.1. XM_006522249.1. [Q8BP00-1]
UniGeneiMm.222934.

Genome annotation databases

EnsembliENSMUST00000023535; ENSMUSP00000023535; ENSMUSG00000022837. [Q8BP00-1]
ENSMUST00000114819; ENSMUSP00000110467; ENSMUSG00000022837. [Q8BP00-2]
GeneIDi320299.
KEGGimmu:320299.
UCSCiuc007zda.1. mouse. [Q8BP00-2]
uc007zdb.2. mouse. [Q8BP00-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK078554 mRNA. Translation: BAC37333.1 .
AK165220 mRNA. Translation: BAE38084.1 .
BC029084 mRNA. Translation: AAH29084.1 .
CCDSi CCDS28157.1. [Q8BP00-1 ]
RefSeqi NP_796102.2. NM_177128.4. [Q8BP00-1 ]
XP_006522310.1. XM_006522247.1. [Q8BP00-1 ]
XP_006522311.1. XM_006522248.1. [Q8BP00-1 ]
XP_006522312.1. XM_006522249.1. [Q8BP00-1 ]
UniGenei Mm.222934.

3D structure databases

ProteinModelPortali Q8BP00.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 235913. 163 interactions.
IntActi Q8BP00. 134 interactions.
STRINGi 10090.ENSMUSP00000023535.

PTM databases

PhosphoSitei Q8BP00.

Proteomic databases

PaxDbi Q8BP00.
PRIDEi Q8BP00.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023535 ; ENSMUSP00000023535 ; ENSMUSG00000022837 . [Q8BP00-1 ]
ENSMUST00000114819 ; ENSMUSP00000110467 ; ENSMUSG00000022837 . [Q8BP00-2 ]
GeneIDi 320299.
KEGGi mmu:320299.
UCSCi uc007zda.1. mouse. [Q8BP00-2 ]
uc007zdb.2. mouse. [Q8BP00-1 ]

Organism-specific databases

CTDi 9657.
MGIi MGI:2443764. Iqcb1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG261795.
GeneTreei ENSGT00390000002188.
HOGENOMi HOG000113095.
HOVERGENi HBG052142.
InParanoidi Q8BP00.
KOi K16774.
OMAi QVDDYVR.
OrthoDBi EOG74N5GC.
PhylomeDBi Q8BP00.
TreeFami TF351884.

Miscellaneous databases

NextBioi 396452.
PROi Q8BP00.
SOURCEi Search...

Gene expression databases

Bgeei Q8BP00.
CleanExi MM_IQCB1.
Genevestigatori Q8BP00.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR000048. IQ_motif_EF-hand-BS.
IPR028765. IQCB1.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR15673. PTHR15673. 1 hit.
Pfami PF00612. IQ. 2 hits.
[Graphical view ]
SMARTi SM00015. IQ. 2 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50096. IQ. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Ovary and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Mammary cancer.
  3. Cited for: INTERACTION WITH CALMODULIN, TISSUE SPECIFICITY.
  4. Cited for: FUNCTION.

Entry informationi

Entry nameiIQCB1_MOUSE
AccessioniPrimary (citable) accession number: Q8BP00
Secondary accession number(s): Q3TNK4, Q8K306
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi