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Protein

IQ calmodulin-binding motif-containing protein 1

Gene

Iqcb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in ciliogenesis.1 Publication

GO - Molecular functioni

  • calmodulin binding Source: HGNC
  • enzyme binding Source: MGI

GO - Biological processi

  • cilium assembly Source: UniProtKB
  • maintenance of organ identity Source: HGNC
  • photoreceptor cell maintenance Source: HGNC
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Enzyme and pathway databases

ReactomeiREACT_328862. Anchoring of the basal body to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
IQ calmodulin-binding motif-containing protein 1
Gene namesi
Name:Iqcb1
Synonyms:Kiaa0036
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2443764. Iqcb1.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: MGI
  • cytoplasm Source: UniProtKB-KW
  • extracellular exosome Source: MGI
  • intercellular bridge Source: MGI
  • microtubule cytoskeleton Source: MGI
  • nucleoplasm Source: MGI
  • photoreceptor connecting cilium Source: HGNC
  • photoreceptor outer segment Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598IQ calmodulin-binding motif-containing protein 1PRO_0000084226Add
BLAST

Proteomic databases

MaxQBiQ8BP00.
PaxDbiQ8BP00.
PRIDEiQ8BP00.

PTM databases

PhosphoSiteiQ8BP00.

Expressioni

Tissue specificityi

Localized to the outer segment and connecting cilia of photoreceptor cells.1 Publication

Gene expression databases

BgeeiQ8BP00.
CleanExiMM_IQCB1.
GenevisibleiQ8BP00. MM.

Interactioni

Subunit structurei

Interacts with calmodulin. Interacts with CEP290 (By similarity). Interacts with ATXN10 (By similarity). Interacts with NPHP1, INVS, NPHP4 and RPGRIP1L (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Atxn10P286582EBI-4282243,EBI-4284019
Cep290Q6A0786EBI-4282243,EBI-1811999
InvsO890192EBI-4282243,EBI-4281337
Rpgrip1lQ8CG732EBI-4282243,EBI-4281130

Protein-protein interaction databases

BioGridi235913. 163 interactions.
IntActiQ8BP00. 134 interactions.
STRINGi10090.ENSMUSP00000023535.

Structurei

3D structure databases

ProteinModelPortaliQ8BP00.
SMRiQ8BP00. Positions 287-332, 387-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini294 – 31724IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini318 – 33821IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini387 – 41630IQ 3PROSITE-ProRule annotationAdd
BLAST
Domaini417 – 43721IQ 4PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili336 – 36227Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 4 IQ domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG261795.
GeneTreeiENSGT00390000002188.
HOGENOMiHOG000113095.
HOVERGENiHBG052142.
InParanoidiQ8BP00.
KOiK16774.
OMAiQVDDYVR.
OrthoDBiEOG74N5GC.
PhylomeDBiQ8BP00.
TreeFamiTF351884.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR000048. IQ_motif_EF-hand-BS.
IPR028765. IQCB1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15673. PTHR15673. 1 hit.
PfamiPF00612. IQ. 2 hits.
[Graphical view]
SMARTiSM00015. IQ. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BP00-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPAGTDPRI LSLAAEVAKS PEQNVPVILL KLKEIINNTP LGSSELKKVK
60 70 80 90 100
QDIYCYDLIQ YCLLVLSQDS SRIQGGWSTI SQLTQILSHC CVGLEPGEDG
110 120 130 140 150
EEFYKELLPS AAENFLILGR RLQTCFINAT KGEEQDKLLH FFQIVTDSLF
160 170 180 190 200
WLLGGHVQLI QNVLQSDHFL HLLQTDNVQI GASVMTLLQN ILQINSGNLL
210 220 230 240 250
KIEGKALHSI LDEILFKLLS TPSPVIRSTA TKLLLVLAES HQEILILLRL
260 270 280 290 300
SACYKGLRSL LNKQETLTEF SRELRQLVDL LTPKIHQEVE EQKLHKAACL
310 320 330 340 350
IQAYWKGFQT RKRLKKLPSA VIALQRSFRS KRTKMMLELN RQKEEEDLRL
360 370 380 390 400
KLQLQRQRAM RLSRESRLNM LEIIHPGQVE KYNREMEEKS ALTIQKHWRG
410 420 430 440 450
YRERKNFRQQ RPSLTEYKAA VTLQRAVLKF LAKCRKKKKL FASWHGLQEL
460 470 480 490 500
TDARRVELKQ QVDDYVKRHP CSQMSEAASR ELHAQAQERL QHYFMGRAIE
510 520 530 540 550
ERAQQHREAL MAQISTNIEQ LMKAPSLKEA EGKEPEQFLS RSRPVAAKAK
560 570 580 590
QAHLTTLKHI QAPWWKKLGE EPGDEVDVPK DELSIDLGML FIGGTKPP
Length:598
Mass (Da):68,734
Last modified:May 10, 2004 - v2
Checksum:i87FBCB9B68899997
GO
Isoform 2 (identifier: Q8BP00-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     523-598: KAPSLKEAEG...MLFIGGTKPP → SMLYLHPCFI...ITNFKEVIIF

Note: No experimental confirmation available.
Show »
Length:597
Mass (Da):69,070
Checksum:iE360B9345680D54E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41A → P in BAC37333 (PubMed:16141072).Curated
Sequence conflicti9 – 91R → G in BAC37333 (PubMed:16141072).Curated
Sequence conflicti19 – 191K → R in BAC37333 (PubMed:16141072).Curated
Sequence conflicti32 – 321L → V in BAC37333 (PubMed:16141072).Curated
Sequence conflicti352 – 3521L → W in BAC37333 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei523 – 59876KAPSL…GTKPP → SMLYLHPCFINGIPLARDVA SKLFRRKVPQVVFIQVLGKS YIIPVFNSIPSVCACYKFKY FSFIKITNFKEVIIF in isoform 2. 1 PublicationVSP_010246Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078554 mRNA. Translation: BAC37333.1.
AK165220 mRNA. Translation: BAE38084.1.
BC029084 mRNA. Translation: AAH29084.1.
CCDSiCCDS28157.1. [Q8BP00-1]
RefSeqiNP_796102.2. NM_177128.4. [Q8BP00-1]
XP_006522310.1. XM_006522247.2. [Q8BP00-1]
XP_006522311.1. XM_006522248.2. [Q8BP00-1]
XP_006522312.1. XM_006522249.2. [Q8BP00-1]
UniGeneiMm.222934.

Genome annotation databases

EnsembliENSMUST00000023535; ENSMUSP00000023535; ENSMUSG00000022837. [Q8BP00-1]
ENSMUST00000114819; ENSMUSP00000110467; ENSMUSG00000022837. [Q8BP00-2]
GeneIDi320299.
KEGGimmu:320299.
UCSCiuc007zda.1. mouse. [Q8BP00-2]
uc007zdb.2. mouse. [Q8BP00-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078554 mRNA. Translation: BAC37333.1.
AK165220 mRNA. Translation: BAE38084.1.
BC029084 mRNA. Translation: AAH29084.1.
CCDSiCCDS28157.1. [Q8BP00-1]
RefSeqiNP_796102.2. NM_177128.4. [Q8BP00-1]
XP_006522310.1. XM_006522247.2. [Q8BP00-1]
XP_006522311.1. XM_006522248.2. [Q8BP00-1]
XP_006522312.1. XM_006522249.2. [Q8BP00-1]
UniGeneiMm.222934.

3D structure databases

ProteinModelPortaliQ8BP00.
SMRiQ8BP00. Positions 287-332, 387-443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi235913. 163 interactions.
IntActiQ8BP00. 134 interactions.
STRINGi10090.ENSMUSP00000023535.

PTM databases

PhosphoSiteiQ8BP00.

Proteomic databases

MaxQBiQ8BP00.
PaxDbiQ8BP00.
PRIDEiQ8BP00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023535; ENSMUSP00000023535; ENSMUSG00000022837. [Q8BP00-1]
ENSMUST00000114819; ENSMUSP00000110467; ENSMUSG00000022837. [Q8BP00-2]
GeneIDi320299.
KEGGimmu:320299.
UCSCiuc007zda.1. mouse. [Q8BP00-2]
uc007zdb.2. mouse. [Q8BP00-1]

Organism-specific databases

CTDi9657.
MGIiMGI:2443764. Iqcb1.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG261795.
GeneTreeiENSGT00390000002188.
HOGENOMiHOG000113095.
HOVERGENiHBG052142.
InParanoidiQ8BP00.
KOiK16774.
OMAiQVDDYVR.
OrthoDBiEOG74N5GC.
PhylomeDBiQ8BP00.
TreeFamiTF351884.

Enzyme and pathway databases

ReactomeiREACT_328862. Anchoring of the basal body to the plasma membrane.

Miscellaneous databases

NextBioi396452.
PROiQ8BP00.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BP00.
CleanExiMM_IQCB1.
GenevisibleiQ8BP00. MM.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR000048. IQ_motif_EF-hand-BS.
IPR028765. IQCB1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15673. PTHR15673. 1 hit.
PfamiPF00612. IQ. 2 hits.
[Graphical view]
SMARTiSM00015. IQ. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Ovary and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Mammary cancer.
  3. Cited for: INTERACTION WITH CALMODULIN, TISSUE SPECIFICITY.
  4. Cited for: FUNCTION.

Entry informationi

Entry nameiIQCB1_MOUSE
AccessioniPrimary (citable) accession number: Q8BP00
Secondary accession number(s): Q3TNK4, Q8K306
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: June 24, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.