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Q8BP00

- IQCB1_MOUSE

UniProt

Q8BP00 - IQCB1_MOUSE

Protein

IQ calmodulin-binding motif-containing protein 1

Gene

Iqcb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (10 May 2004)
      Previous versions | rss
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    Functioni

    Involved in ciliogenesis.1 Publication

    GO - Molecular functioni

    1. calmodulin binding Source: HGNC
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cilium assembly Source: UniProtKB
    2. maintenance of organ identity Source: HGNC
    3. photoreceptor cell maintenance Source: HGNC

    Keywords - Ligandi

    Calmodulin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    IQ calmodulin-binding motif-containing protein 1
    Gene namesi
    Name:Iqcb1
    Synonyms:Kiaa0036
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:2443764. Iqcb1.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
    Note: Localization to the centrosome depends on the interaction with CEP290.By similarity

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. cytoplasm Source: UniProtKB-KW
    3. photoreceptor connecting cilium Source: HGNC
    4. photoreceptor outer segment Source: HGNC

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 598598IQ calmodulin-binding motif-containing protein 1PRO_0000084226Add
    BLAST

    Proteomic databases

    PaxDbiQ8BP00.
    PRIDEiQ8BP00.

    PTM databases

    PhosphoSiteiQ8BP00.

    Expressioni

    Tissue specificityi

    Localized to the outer segment and connecting cilia of photoreceptor cells.1 Publication

    Gene expression databases

    BgeeiQ8BP00.
    CleanExiMM_IQCB1.
    GenevestigatoriQ8BP00.

    Interactioni

    Subunit structurei

    Interacts with calmodulin. Interacts with CEP290 By similarity. Interacts with ATXN10 By similarity. Interacts with NPHP1, INVS, NPHP4 and RPGRIP1L By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Atxn10P286582EBI-4282243,EBI-4284019
    Cep290Q6A0786EBI-4282243,EBI-1811999
    InvsO890192EBI-4282243,EBI-4281337
    Rpgrip1lQ8CG732EBI-4282243,EBI-4281130

    Protein-protein interaction databases

    BioGridi235913. 163 interactions.
    IntActiQ8BP00. 134 interactions.
    STRINGi10090.ENSMUSP00000023535.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BP00.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini294 – 31724IQ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini318 – 33821IQ 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini387 – 41630IQ 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini417 – 43721IQ 4PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili336 – 36227Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 4 IQ domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG261795.
    GeneTreeiENSGT00390000002188.
    HOGENOMiHOG000113095.
    HOVERGENiHBG052142.
    InParanoidiQ8BP00.
    KOiK16774.
    OMAiQVDDYVR.
    OrthoDBiEOG74N5GC.
    PhylomeDBiQ8BP00.
    TreeFamiTF351884.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR028765. IQCB1.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR15673. PTHR15673. 1 hit.
    PfamiPF00612. IQ. 2 hits.
    [Graphical view]
    SMARTiSM00015. IQ. 2 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50096. IQ. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BP00-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKPAGTDPRI LSLAAEVAKS PEQNVPVILL KLKEIINNTP LGSSELKKVK    50
    QDIYCYDLIQ YCLLVLSQDS SRIQGGWSTI SQLTQILSHC CVGLEPGEDG 100
    EEFYKELLPS AAENFLILGR RLQTCFINAT KGEEQDKLLH FFQIVTDSLF 150
    WLLGGHVQLI QNVLQSDHFL HLLQTDNVQI GASVMTLLQN ILQINSGNLL 200
    KIEGKALHSI LDEILFKLLS TPSPVIRSTA TKLLLVLAES HQEILILLRL 250
    SACYKGLRSL LNKQETLTEF SRELRQLVDL LTPKIHQEVE EQKLHKAACL 300
    IQAYWKGFQT RKRLKKLPSA VIALQRSFRS KRTKMMLELN RQKEEEDLRL 350
    KLQLQRQRAM RLSRESRLNM LEIIHPGQVE KYNREMEEKS ALTIQKHWRG 400
    YRERKNFRQQ RPSLTEYKAA VTLQRAVLKF LAKCRKKKKL FASWHGLQEL 450
    TDARRVELKQ QVDDYVKRHP CSQMSEAASR ELHAQAQERL QHYFMGRAIE 500
    ERAQQHREAL MAQISTNIEQ LMKAPSLKEA EGKEPEQFLS RSRPVAAKAK 550
    QAHLTTLKHI QAPWWKKLGE EPGDEVDVPK DELSIDLGML FIGGTKPP 598
    Length:598
    Mass (Da):68,734
    Last modified:May 10, 2004 - v2
    Checksum:i87FBCB9B68899997
    GO
    Isoform 2 (identifier: Q8BP00-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         523-598: KAPSLKEAEG...MLFIGGTKPP → SMLYLHPCFI...ITNFKEVIIF

    Note: No experimental confirmation available.

    Show »
    Length:597
    Mass (Da):69,070
    Checksum:iE360B9345680D54E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41A → P in BAC37333. (PubMed:16141072)Curated
    Sequence conflicti9 – 91R → G in BAC37333. (PubMed:16141072)Curated
    Sequence conflicti19 – 191K → R in BAC37333. (PubMed:16141072)Curated
    Sequence conflicti32 – 321L → V in BAC37333. (PubMed:16141072)Curated
    Sequence conflicti352 – 3521L → W in BAC37333. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei523 – 59876KAPSL…GTKPP → SMLYLHPCFINGIPLARDVA SKLFRRKVPQVVFIQVLGKS YIIPVFNSIPSVCACYKFKY FSFIKITNFKEVIIF in isoform 2. 1 PublicationVSP_010246Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK078554 mRNA. Translation: BAC37333.1.
    AK165220 mRNA. Translation: BAE38084.1.
    BC029084 mRNA. Translation: AAH29084.1.
    CCDSiCCDS28157.1. [Q8BP00-1]
    RefSeqiNP_796102.2. NM_177128.4. [Q8BP00-1]
    XP_006522310.1. XM_006522247.1. [Q8BP00-1]
    XP_006522311.1. XM_006522248.1. [Q8BP00-1]
    XP_006522312.1. XM_006522249.1. [Q8BP00-1]
    UniGeneiMm.222934.

    Genome annotation databases

    EnsembliENSMUST00000023535; ENSMUSP00000023535; ENSMUSG00000022837. [Q8BP00-1]
    ENSMUST00000114819; ENSMUSP00000110467; ENSMUSG00000022837. [Q8BP00-2]
    GeneIDi320299.
    KEGGimmu:320299.
    UCSCiuc007zda.1. mouse. [Q8BP00-2]
    uc007zdb.2. mouse. [Q8BP00-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK078554 mRNA. Translation: BAC37333.1 .
    AK165220 mRNA. Translation: BAE38084.1 .
    BC029084 mRNA. Translation: AAH29084.1 .
    CCDSi CCDS28157.1. [Q8BP00-1 ]
    RefSeqi NP_796102.2. NM_177128.4. [Q8BP00-1 ]
    XP_006522310.1. XM_006522247.1. [Q8BP00-1 ]
    XP_006522311.1. XM_006522248.1. [Q8BP00-1 ]
    XP_006522312.1. XM_006522249.1. [Q8BP00-1 ]
    UniGenei Mm.222934.

    3D structure databases

    ProteinModelPortali Q8BP00.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 235913. 163 interactions.
    IntActi Q8BP00. 134 interactions.
    STRINGi 10090.ENSMUSP00000023535.

    PTM databases

    PhosphoSitei Q8BP00.

    Proteomic databases

    PaxDbi Q8BP00.
    PRIDEi Q8BP00.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023535 ; ENSMUSP00000023535 ; ENSMUSG00000022837 . [Q8BP00-1 ]
    ENSMUST00000114819 ; ENSMUSP00000110467 ; ENSMUSG00000022837 . [Q8BP00-2 ]
    GeneIDi 320299.
    KEGGi mmu:320299.
    UCSCi uc007zda.1. mouse. [Q8BP00-2 ]
    uc007zdb.2. mouse. [Q8BP00-1 ]

    Organism-specific databases

    CTDi 9657.
    MGIi MGI:2443764. Iqcb1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG261795.
    GeneTreei ENSGT00390000002188.
    HOGENOMi HOG000113095.
    HOVERGENi HBG052142.
    InParanoidi Q8BP00.
    KOi K16774.
    OMAi QVDDYVR.
    OrthoDBi EOG74N5GC.
    PhylomeDBi Q8BP00.
    TreeFami TF351884.

    Miscellaneous databases

    NextBioi 396452.
    PROi Q8BP00.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BP00.
    CleanExi MM_IQCB1.
    Genevestigatori Q8BP00.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR028765. IQCB1.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR15673. PTHR15673. 1 hit.
    Pfami PF00612. IQ. 2 hits.
    [Graphical view ]
    SMARTi SM00015. IQ. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50096. IQ. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Ovary and Spleen.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Mammary cancer.
    3. Cited for: INTERACTION WITH CALMODULIN, TISSUE SPECIFICITY.
    4. Cited for: FUNCTION.

    Entry informationi

    Entry nameiIQCB1_MOUSE
    AccessioniPrimary (citable) accession number: Q8BP00
    Secondary accession number(s): Q3TNK4, Q8K306
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3