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Protein

C-type lectin domain family 4 member G

Gene

Clec4g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca2+-dependent manner.By similarity

GO - Molecular functioni

  • polysaccharide binding Source: MGI

GO - Biological processi

  • negative regulation of T cell mediated immunity Source: MGI
  • negative regulation of T cell proliferation Source: MGI
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member G
Gene namesi
Name:Clec4g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1923113. Clec4g.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type II membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030CytoplasmicSequence analysisAdd
BLAST
Transmembranei31 – 5121Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini52 – 294243ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294C-type lectin domain family 4 member GPRO_0000223692Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence analysis
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence analysis
Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence analysis
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence analysis
Disulfide bondi264 ↔ 278PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BNX1.
PRIDEiQ8BNX1.

PTM databases

iPTMnetiQ8BNX1.
PhosphoSiteiQ8BNX1.

Expressioni

Gene expression databases

BgeeiQ8BNX1.
CleanExiMM_CLEC4G.
ExpressionAtlasiQ8BNX1. baseline and differential.
GenevisibleiQ8BNX1. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BACE1P568172EBI-11176364,EBI-2433139From a different organism.

Protein-protein interaction databases

IntActiQ8BNX1. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8BNX1.
SMRiQ8BNX1. Positions 133-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini172 – 287116C-type lectinPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili100 – 15152Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000013222.
HOVERGENiHBG081249.
InParanoidiQ8BNX1.
KOiK10061.
OMAiMLRTGMW.
PhylomeDBiQ8BNX1.
TreeFamiTF333341.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BNX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTGEYNKLG SAIEEVSRGQ LGRWECYKQR LFFLVLALLV ATVLWALILS
60 70 80 90 100
TLLSSASSKL RVLLSHQDLL RTNASEQKMT LSSLKDDIGA CRNCCSVTKA
110 120 130 140 150
QLQTTLAEFK DIQAKLMEQE SILKELQERV TQDLAKASRD RENIRSELFQ
160 170 180 190 200
ALEAVKRQNS SCEQCPPSWL PFQGSCYYFS ETQATWDTAQ SYCGGQGAHL
210 220 230 240 250
VIVRGLNEQG FLSQHTRGRG YWLGLRAVRH LNKIQGYRWV DGASLNFSHW
260 270 280 290
NSGEPNDSRG HEDCIMMLHS GLWNDAPCTN ERDGWICEKR SSCY
Length:294
Mass (Da):33,327
Last modified:March 1, 2003 - v1
Checksum:i020F933346C4787B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21N → S in AAH87963 (PubMed:15489334).Curated
Sequence conflicti8 – 81K → E in AAH87963 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079992 mRNA. Translation: BAC37800.1.
BC025069 mRNA. Translation: AAH25069.1.
BC087963 mRNA. Translation: AAH87963.1.
CCDSiCCDS22072.1.
RefSeqiNP_083741.1. NM_029465.3.
UniGeneiMm.109183.

Genome annotation databases

EnsembliENSMUST00000062037; ENSMUSP00000059574; ENSMUSG00000074491.
GeneIDi75863.
KEGGimmu:75863.
UCSCiuc009ksp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079992 mRNA. Translation: BAC37800.1.
BC025069 mRNA. Translation: AAH25069.1.
BC087963 mRNA. Translation: AAH87963.1.
CCDSiCCDS22072.1.
RefSeqiNP_083741.1. NM_029465.3.
UniGeneiMm.109183.

3D structure databases

ProteinModelPortaliQ8BNX1.
SMRiQ8BNX1. Positions 133-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BNX1. 3 interactions.

PTM databases

iPTMnetiQ8BNX1.
PhosphoSiteiQ8BNX1.

Proteomic databases

PaxDbiQ8BNX1.
PRIDEiQ8BNX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062037; ENSMUSP00000059574; ENSMUSG00000074491.
GeneIDi75863.
KEGGimmu:75863.
UCSCiuc009ksp.2. mouse.

Organism-specific databases

CTDi339390.
MGIiMGI:1923113. Clec4g.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000013222.
HOVERGENiHBG081249.
InParanoidiQ8BNX1.
KOiK10061.
OMAiMLRTGMW.
PhylomeDBiQ8BNX1.
TreeFamiTF333341.

Miscellaneous databases

NextBioi344143.
PROiQ8BNX1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BNX1.
CleanExiMM_CLEC4G.
ExpressionAtlasiQ8BNX1. baseline and differential.
GenevisibleiQ8BNX1. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Aorta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiCLC4G_MOUSE
AccessioniPrimary (citable) accession number: Q8BNX1
Secondary accession number(s): Q5I0T7, Q8R188
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: March 1, 2003
Last modified: January 20, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.