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Protein

Kelch repeat and BTB domain-containing protein 11

Gene

Kbtbd11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 11
Gene namesi
Name:Kbtbd11
Synonyms:Kiaa0711
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1922151. Kbtbd11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 633633Kelch repeat and BTB domain-containing protein 11PRO_0000119091Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701PhosphoserineCombined sources
Modified residuei73 – 731PhosphoserineCombined sources
Modified residuei92 – 921PhosphoserineCombined sources
Modified residuei95 – 951PhosphoserineCombined sources
Modified residuei107 – 1071PhosphoserineCombined sources
Modified residuei113 – 1131PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BNW9.
MaxQBiQ8BNW9.
PaxDbiQ8BNW9.
PRIDEiQ8BNW9.

PTM databases

iPTMnetiQ8BNW9.

Expressioni

Gene expression databases

BgeeiQ8BNW9.
CleanExiMM_KBTBD11.
GenevisibleiQ8BNW9. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8BNW9. 1 interaction.
STRINGi10090.ENSMUSP00000068321.

Structurei

3D structure databases

ProteinModelPortaliQ8BNW9.
SMRiQ8BNW9. Positions 147-227, 331-509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini146 – 20661BTBPROSITE-ProRule annotationAdd
BLAST
Repeati317 – 36549Kelch 1Add
BLAST
Repeati366 – 41853Kelch 2Add
BLAST
Repeati419 – 46345Kelch 3Add
BLAST
Repeati465 – 50642Kelch 4Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000246990.
HOVERGENiHBG081849.
InParanoidiQ8BNW9.
KOiK10476.
OMAiVGGECLF.
OrthoDBiEOG7NSB21.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00612. Kelch. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BNW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENSVAPFVL YSGTEPRTPG EDSLPLPAEE EGAASTAQTP CSLSASLCFS
60 70 80 90 100
SGDDSPPQSR ASAAEGSEAS PPSLRSDLRV VETQWDVSSA ASPESPEECA
110 120 130 140 150
RPEEPASPED PPSRHEHARP VELESLDELG EPVPVPPGVG SVHGEPDLVI
160 170 180 190 200
EVAGRRLRAH KAVLAARSDY FRARASRDVL RVQGVSFTAL RLLLADAYSG
210 220 230 240 250
RMAGVRPDNV AEVVAGARRL QLPGAAQRAT EAMAPQLSLD NCYEVLSAGK
260 270 280 290 300
RQRLTELRDA AYRFMSDHYL EVLREPAVFG RLSGAERDLL LRRRLCTGRA
310 320 330 340 350
CLLAAALGTT GERSGSRPQS PSGDAESRGD AAVYCYQAEA GEWRELTRLP
360 370 380 390 400
EGAPARGCGL CVLFNYLFLA GGVAPAGPDG RARPSDQVYC YNPVTDSWST
410 420 430 440 450
VRPLRQARSQ VQLLALDGHL YAVGGECLLS VERYDPRADR WTAVAPLPRG
460 470 480 490 500
AFAVAHEAAT CNGEIYVSGG SLFYRLLKYD PRRDEWQECP CSSSRERSAD
510 520 530 540 550
MVALDGFLYR FDLCGSRGEA QAAVGSGGGV SVFRYHCLAK QWSQCAVHLR
560 570 580 590 600
PPGAPAGLQP FRCVALDGTI YCVSRAGTWR FVPSQDTEAG SDMGPGGSFE
610 620 630
PEPLGSPLDV RGVLFPFVLN LPEKPDRGEQ GAV
Length:633
Mass (Da):67,946
Last modified:July 27, 2011 - v3
Checksum:i2D37E3C68C98EC73
GO

Sequence cautioni

The sequence BAC98007.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731A → S in BAC37803 (PubMed:16141072).Curated
Sequence conflicti369 – 3691L → V in BAC98007 (PubMed:14621295).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129197 mRNA. Translation: BAC98007.1. Different initiation.
AK080001 mRNA. Translation: BAC37803.1.
BC080858 mRNA. Translation: AAH80858.1.
CCDSiCCDS52493.1.
RefSeqiNP_083392.1. NM_029116.2.
XP_006508978.1. XM_006508915.1.
XP_006508979.1. XM_006508916.1.
XP_006508980.1. XM_006508917.2.
UniGeneiMm.46675.

Genome annotation databases

EnsembliENSMUST00000069399; ENSMUSP00000068321; ENSMUSG00000055675.
ENSMUST00000183471; ENSMUSP00000139292; ENSMUSG00000055675.
GeneIDi74901.
KEGGimmu:74901.
UCSCiuc009kzk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129197 mRNA. Translation: BAC98007.1. Different initiation.
AK080001 mRNA. Translation: BAC37803.1.
BC080858 mRNA. Translation: AAH80858.1.
CCDSiCCDS52493.1.
RefSeqiNP_083392.1. NM_029116.2.
XP_006508978.1. XM_006508915.1.
XP_006508979.1. XM_006508916.1.
XP_006508980.1. XM_006508917.2.
UniGeneiMm.46675.

3D structure databases

ProteinModelPortaliQ8BNW9.
SMRiQ8BNW9. Positions 147-227, 331-509.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BNW9. 1 interaction.
STRINGi10090.ENSMUSP00000068321.

PTM databases

iPTMnetiQ8BNW9.

Proteomic databases

EPDiQ8BNW9.
MaxQBiQ8BNW9.
PaxDbiQ8BNW9.
PRIDEiQ8BNW9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069399; ENSMUSP00000068321; ENSMUSG00000055675.
ENSMUST00000183471; ENSMUSP00000139292; ENSMUSG00000055675.
GeneIDi74901.
KEGGimmu:74901.
UCSCiuc009kzk.2. mouse.

Organism-specific databases

CTDi9920.
MGIiMGI:1922151. Kbtbd11.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000246990.
HOVERGENiHBG081849.
InParanoidiQ8BNW9.
KOiK10476.
OMAiVGGECLF.
OrthoDBiEOG7NSB21.
TreeFamiTF328485.

Miscellaneous databases

ChiTaRSiKbtbd11. mouse.
NextBioi341767.
PROiQ8BNW9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BNW9.
CleanExiMM_KBTBD11.
GenevisibleiQ8BNW9. MM.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00612. Kelch. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Aorta and Vein.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; SER-73; SER-92; SER-95 AND SER-107, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiKBTBB_MOUSE
AccessioniPrimary (citable) accession number: Q8BNW9
Secondary accession number(s): A3KME3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.