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Q8BNU7 (Q8BNU7_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Nedd4 MGI 97297
OrganismMus musculus (Mouse) EMBL BAC37885.2
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length129 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain. RuleBase RU003412

Ontologies

Gene Ontology (GO)
   Biological_processT cell activation

Inferred from mutant phenotype PubMed 18931680. Source: MGI

adaptive immune response

Inferred from mutant phenotype PubMed 18931680. Source: MGI

blood vessel morphogenesis

Inferred from mutant phenotype PubMed 20026598. Source: MGI

development involved in symbiotic interaction

Inferred from electronic annotation. Source: Ensembl

endocardial cushion development

Inferred from mutant phenotype PubMed 20026598. Source: MGI

glucocorticoid receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of sodium ion transport

Inferred from direct assay PubMed 10212229. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 20026598. Source: MGI

negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage

Inferred from electronic annotation. Source: Ensembl

neuromuscular junction development

Inferred from mutant phenotype PubMed 19345204. Source: MGI

neuron projection development

Inferred from electronic annotation. Source: Ensembl

outflow tract morphogenesis

Inferred from mutant phenotype PubMed 20026598. Source: MGI

positive regulation of nucleocytoplasmic transport

Inferred from electronic annotation. Source: Ensembl

positive regulation of phosphatidylinositol 3-kinase signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein catabolic process

Inferred from direct assay PubMed 11748237. Source: MGI

progesterone receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

protein monoubiquitination

Inferred from direct assay PubMed 21920314. Source: MGI

protein targeting to lysosome

Inferred from electronic annotation. Source: Ensembl

protein ubiquitination

Inferred from direct assay PubMed 9182527. Source: MGI

protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Inferred from mutant phenotype PubMed 18931680. Source: MGI

receptor catabolic process

Inferred from electronic annotation. Source: Ensembl

receptor internalization

Inferred from electronic annotation. Source: Ensembl

regulation of membrane potential

Inferred from electronic annotation. Source: Ensembl

regulation of potassium ion transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

regulation of synapse organization

Inferred from mutant phenotype PubMed 19345204. Source: MGI

transmission of virus

Inferred from electronic annotation. Source: Ensembl

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

cell cortex

Inferred from electronic annotation. Source: Ensembl

chromatin

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 14973438. Source: MGI

cytosol

Inferred from direct assay PubMed 19794060PubMed 9182527. Source: MGI

membrane

Inferred from direct assay PubMed 14973438. Source: MGI

nucleus

Inferred from Biological aspect of Ancestor. Source: RefGenome

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: Ensembl

ubiquitin ligase complex

Inferred from physical interaction PubMed 11042109. Source: MGI

   Molecular_functionproline-rich region binding

Inferred from physical interaction PubMed 11748237PubMed 9305852. Source: MGI

protein binding

Inferred from physical interaction PubMed 11042109PubMed 11717310PubMed 17544362PubMed 21920314. Source: MGI

sodium channel inhibitor activity

Inferred from direct assay PubMed 10212229. Source: MGI

ubiquitin-protein transferase activity

Inferred from direct assay PubMed 11717310PubMed 9182527. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue1291 EMBL BAC37885.2

Sequences

Sequence LengthMass (Da)Tools
Q8BNU7 [UniParc].

Last modified October 11, 2005. Version 2.
Checksum: 22C31B6179365691

FASTA12914,018
        10         20         30         40         50         60 
MSSDMAADES EAPVLSEDEV WEFCLDKTED GGGSPGSDVT DTCEPPCGCW ELNPNSLEEE 

        70         80         90        100        110        120 
HVLFTADPYL ELHNDDTRVV RVKVIAGIGL AKKDILGASD PYVRVTLYDP MSGILTSVQT 


KTIKKSLNP 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC37885.2.
Tissue: Thymus EMBL BAC37885.2.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC37885.2.
Tissue: Thymus EMBL BAC37885.2.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC37885.2.
Tissue: Thymus EMBL BAC37885.2.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC37885.2.
Tissue: Thymus EMBL BAC37885.2.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC37885.2.
Tissue: Thymus EMBL BAC37885.2.
[6]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC37885.2.
Tissue: Thymus EMBL BAC37885.2.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC37885.2.
Tissue: Thymus EMBL BAC37885.2.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC37885.2.
Tissue: Thymus EMBL BAC37885.2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK080349 mRNA. Translation: BAC37885.2.
UniGeneMm.279923.

3D structure databases

ProteinModelPortalQ8BNU7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000034740.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:97297. Nedd4.

Phylogenomic databases

InParanoidQ8BNU7.

Gene expression databases

ArrayExpressQ8BNU7.
BgeeQ8BNU7.
GenevestigatorQ8BNU7.

Family and domain databases

Gene3D2.60.40.150. 1 hit.
InterProIPR000008. C2_dom.
[Graphical view]
PfamPF00168. C2. 1 hit.
[Graphical view]
SUPFAMSSF49562. SSF49562. 1 hit.
PROSITEPS50004. C2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNEDD4. mouse.
SOURCESearch...

Entry information

Entry nameQ8BNU7_MOUSE
AccessionPrimary (citable) accession number: Q8BNU7
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: October 11, 2005
Last modified: June 11, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)