Q8BNU7 (Q8BNU7_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAC37885.2

Gene names

Name:

Nedd4 MGI 97297

Organism

Mus musculus (Mouse) EMBL BAC37885.2

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	129 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain. RuleBase RU003412

Ontologies

Gene Ontology (GO)
Biological_process	T cell activation Inferred from mutant phenotype PubMed 18931680. Source: MGI adaptive immune response Inferred from mutant phenotype PubMed 18931680. Source: MGI blood vessel morphogenesis Inferred from mutant phenotype PubMed 20026598. Source: MGI development involved in symbiotic interaction Inferred from electronic annotation. Source: Compara endocardial cushion development Inferred from mutant phenotype PubMed 20026598. Source: MGI glucocorticoid receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of sodium ion transport Inferred from direct assay PubMed 10212229. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 20026598. Source: MGI negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage Inferred from electronic annotation. Source: Compara neuromuscular junction development Inferred from mutant phenotype PubMed 19345204. Source: MGI neuron projection development Inferred from electronic annotation. Source: Compara outflow tract morphogenesis Inferred from mutant phenotype PubMed 20026598. Source: MGI positive regulation of nucleocytoplasmic transport Inferred from electronic annotation. Source: Compara positive regulation of phosphatidylinositol 3-kinase cascade Inferred from electronic annotation. Source: Compara positive regulation of protein catabolic process Inferred from direct assay PubMed 11748237. Source: MGI progesterone receptor signaling pathway Inferred from electronic annotation. Source: Compara protein monoubiquitination Inferred from direct assay PubMed 21920314. Source: MGI protein targeting to lysosome Inferred from electronic annotation. Source: Compara protein ubiquitination involved in ubiquitin-dependent protein catabolic process Inferred from mutant phenotype PubMed 18931680. Source: MGI receptor catabolic process Inferred from electronic annotation. Source: Compara receptor internalization Inferred from electronic annotation. Source: Compara regulation of membrane potential Inferred from electronic annotation. Source: Compara regulation of potassium ion transmembrane transporter activity Inferred from electronic annotation. Source: Compara regulation of synapse organization Inferred from mutant phenotype PubMed 19345204. Source: MGI transmission of virus Inferred from electronic annotation. Source: Compara ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara cell cortex Inferred from electronic annotation. Source: Compara chromatin Inferred from electronic annotation. Source: Compara cytosol Inferred from direct assay PubMed 19794060PubMed 9182527. Source: MGI membrane Inferred from direct assay PubMed 14973438. Source: MGI nucleus Inferred from Biological aspect of Ancestor. Source: RefGenome perinuclear region of cytoplasm Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara ubiquitin ligase complex Inferred from physical interaction PubMed 11042109. Source: MGI
Molecular_function	sodium channel inhibitor activity Inferred from direct assay PubMed 10212229. Source: MGI ubiquitin-protein ligase activity Inferred from direct assay PubMed 11717310PubMed 9182527. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	129	1	EMBL BAC37885.2

Sequences

	Sequence		Length	Mass (Da)
	Q8BNU7 [UniParc]. Last modified October 11, 2005. Version 2. Checksum: 22C31B6179365691	FASTA	129	14,018
	10 20 30 40 50 60 MSSDMAADES EAPVLSEDEV WEFCLDKTED GGGSPGSDVT DTCEPPCGCW ELNPNSLEEE 70 80 90 100 110 120 HVLFTADPYL ELHNDDTRVV RVKVIAGIGL AKKDILGASD PYVRVTLYDP MSGILTSVQT KTIKKSLNP

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC37885.2. Tissue: Thymus EMBL BAC37885.2.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC37885.2. Tissue: Thymus EMBL BAC37885.2.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC37885.2. Tissue: Thymus EMBL BAC37885.2.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC37885.2. Tissue: Thymus EMBL BAC37885.2.
[5]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC37885.2. Tissue: Thymus EMBL BAC37885.2.
[6]	Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC37885.2. Tissue: Thymus EMBL BAC37885.2.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC37885.2. Tissue: Thymus EMBL BAC37885.2.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC37885.2. Tissue: Thymus EMBL BAC37885.2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK080349 mRNA. Translation: BAC37885.2.
IPI	IPI00462445.
UniGene	Mm.279923.
3D structure databases
ProteinModelPortal	Q8BNU7.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000034740. Q8BNU7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:97297. Nedd4.
Phylogenomic databases
InParanoid	Q8BNU7.
Gene expression databases
ArrayExpress	Q8BNU7.
Bgee	Q8BNU7.
Genevestigator	Q8BNU7.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. [Graphical view]
Pfam	PF00168. C2. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit.
PROSITE	PS50004. C2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NEDD4. mouse.
SOURCE	Search...

Entry information

Entry name

Q8BNU7_MOUSE

Accession

Primary (citable) accession number: Q8BNU7

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	October 11, 2005
Last modified:	April 3, 2013
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)