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Q8BNU7

- Q8BNU7_MOUSE

UniProt

Q8BNU7 - Q8BNU7_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Nedd4

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. proline-rich region binding Source: MGI
    2. protein binding Source: MGI
    3. sodium channel inhibitor activity Source: MGI
    4. ubiquitin-protein transferase activity Source: MGI

    GO - Biological processi

    1. adaptive immune response Source: MGI
    2. blood vessel morphogenesis Source: MGI
    3. development involved in symbiotic interaction Source: Ensembl
    4. endocardial cushion development Source: MGI
    5. glucocorticoid receptor signaling pathway Source: Ensembl
    6. negative regulation of sodium ion transport Source: MGI
    7. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    8. negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage Source: Ensembl
    9. neuromuscular junction development Source: MGI
    10. neuron projection development Source: Ensembl
    11. outflow tract morphogenesis Source: MGI
    12. positive regulation of nucleocytoplasmic transport Source: Ensembl
    13. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    14. positive regulation of protein catabolic process Source: MGI
    15. progesterone receptor signaling pathway Source: Ensembl
    16. protein monoubiquitination Source: MGI
    17. protein targeting to lysosome Source: Ensembl
    18. protein ubiquitination Source: MGI
    19. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: MGI
    20. receptor catabolic process Source: Ensembl
    21. receptor internalization Source: Ensembl
    22. regulation of membrane potential Source: Ensembl
    23. regulation of potassium ion transmembrane transporter activity Source: Ensembl
    24. regulation of synapse organization Source: MGI
    25. T cell activation Source: MGI
    26. transmission of virus Source: Ensembl
    27. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:Nedd4Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:97297. Nedd4.

    Subcellular locationi

    GO - Cellular componenti

    1. cell cortex Source: Ensembl
    2. chromatin Source: Ensembl
    3. cytoplasm Source: MGI
    4. cytosol Source: MGI
    5. Golgi apparatus Source: Ensembl
    6. membrane Source: MGI
    7. nucleus Source: RefGenome
    8. perinuclear region of cytoplasm Source: Ensembl
    9. plasma membrane Source: Ensembl
    10. ubiquitin ligase complex Source: MGI

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BNU7.
    BgeeiQ8BNU7.
    GenevestigatoriQ8BNU7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000034740.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BNU7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 C2 domain.UniRule annotation

    Phylogenomic databases

    InParanoidiQ8BNU7.

    Family and domain databases

    Gene3Di2.60.40.150. 1 hit.
    InterProiIPR000008. C2_dom.
    [Graphical view]
    PfamiPF00168. C2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    PROSITEiPS50004. C2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q8BNU7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSDMAADES EAPVLSEDEV WEFCLDKTED GGGSPGSDVT DTCEPPCGCW    50
    ELNPNSLEEE HVLFTADPYL ELHNDDTRVV RVKVIAGIGL AKKDILGASD 100
    PYVRVTLYDP MSGILTSVQT KTIKKSLNP 129
    Length:129
    Mass (Da):14,018
    Last modified:October 11, 2005 - v2
    Checksum:i22C31B6179365691
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei129 – 1291Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK080349 mRNA. Translation: BAC37885.2.
    UniGeneiMm.279923.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK080349 mRNA. Translation: BAC37885.2 .
    UniGenei Mm.279923.

    3D structure databases

    ProteinModelPortali Q8BNU7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000034740.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:97297. Nedd4.

    Phylogenomic databases

    InParanoidi Q8BNU7.

    Miscellaneous databases

    ChiTaRSi NEDD4. mouse.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BNU7.
    Bgeei Q8BNU7.
    Genevestigatori Q8BNU7.

    Family and domain databases

    Gene3Di 2.60.40.150. 1 hit.
    InterProi IPR000008. C2_dom.
    [Graphical view ]
    Pfami PF00168. C2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    PROSITEi PS50004. C2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.

    Entry informationi

    Entry nameiQ8BNU7_MOUSE
    AccessioniPrimary (citable) accession number: Q8BNU7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)