Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Armadillo repeat-containing protein 6

Gene

Armc6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • hematopoietic progenitor cell differentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 6
Gene namesi
Name:Armc6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1924063. Armc6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Armadillo repeat-containing protein 6PRO_0000242661Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BNU0.
MaxQBiQ8BNU0.
PaxDbiQ8BNU0.
PeptideAtlasiQ8BNU0.
PRIDEiQ8BNU0.

Expressioni

Gene expression databases

BgeeiQ8BNU0.
CleanExiMM_ARMC6.
ExpressionAtlasiQ8BNU0. baseline and differential.
GenevisibleiQ8BNU0. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8BNU0. 1 interaction.
MINTiMINT-4125449.
STRINGi10090.ENSMUSP00000019679.

Structurei

3D structure databases

ProteinModelPortaliQ8BNU0.
SMRiQ8BNU0. Positions 120-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati195 – 23945ARM 1Add
BLAST
Repeati249 – 29345ARM 2Add
BLAST
Repeati294 – 33643ARM 3Add
BLAST
Repeati337 – 37943ARM 4Add
BLAST

Sequence similaritiesi

Belongs to the ARMC6 family.Curated
Contains 4 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4199. Eukaryota.
ENOG410XR4D. LUCA.
GeneTreeiENSGT00390000002913.
HOGENOMiHOG000290683.
HOVERGENiHBG057500.
InParanoidiQ8BNU0.
OMAiDCEDVAK.
OrthoDBiEOG7MPRFJ.
PhylomeDBiQ8BNU0.
TreeFamiTF324526.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 2 hits.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BNU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASKRITQET FDAAVRENIE EFEMGTEEAI REAVEQFESQ GVDLSNIVKT
60 70 80 90 100
IPKVSLDGLQ EPTHSVLQAL NDLQESLTGS RLQEVSAHLV RFCDQCKQQK
110 120 130 140 150
ASRYLAAQKG AYPILLAAWQ LAATSNQGLL LQALNALAVL TDGQPDLLDA
160 170 180 190 200
QGLHLLVATL AQNAANTELT CCGIRCVRHV CLKHEQNRQD LVKAGVLPLL
210 220 230 240 250
TAAITQHGQH ADVVREACWA LRVMTFDDDI RVPFGHAHEH AKMIVQENKG
260 270 280 290 300
LKVLIEAARA FSDNPGVLSE LCSTLSRLAV RNEFCQEVID LGGLGILVTL
310 320 330 340 350
LADCNDHQDL VKQVLSALRA IAGNDDVKDA IVRAGGTESI VAAMTRHLAS
360 370 380 390 400
PQVCEQSCAA LCVLALRKPD NSRVIIEGGG ALAALQAMKA HPQEAGVQKQ
410 420 430 440 450
ACMLIRNLVS RSQVFSKPIL DLGAEELILQ ARAAHPDCED VAKAALRDLG
460
CRVELRELWT GKKGDLAL
Length:468
Mass (Da):50,683
Last modified:March 1, 2003 - v1
Checksum:i5FA79F94B2BDAF88
GO
Isoform 2 (identifier: Q8BNU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-271: AFSDNPGVLSEL → GRSSPGKRMVGG
     272-468: Missing.

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):29,655
Checksum:iF5939223466437A4
GO

Sequence cautioni

The sequence BAC38256.1 differs from that shown. Reason: Frameshift at position 465. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti277 – 2771R → L in BAC33700 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei260 – 27112AFSDN…VLSEL → GRSSPGKRMVGG in isoform 2. 1 PublicationVSP_019462Add
BLAST
Alternative sequencei272 – 468197Missing in isoform 2. 1 PublicationVSP_019463Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010815 mRNA. Translation: BAB27199.1.
AK049351 mRNA. Translation: BAC33700.1.
AK080609 mRNA. Translation: BAC37956.1.
AK081550 mRNA. Translation: BAC38256.1. Frameshift.
BC005754 mRNA. Translation: AAH05754.1.
BC030077 mRNA. Translation: AAH30077.1.
BC043070 mRNA. Translation: AAH43070.1.
BC055779 mRNA. Translation: AAH55779.1.
CCDSiCCDS40371.1. [Q8BNU0-1]
RefSeqiNP_598733.2. NM_133972.2. [Q8BNU0-1]
UniGeneiMm.383251.

Genome annotation databases

EnsembliENSMUST00000019679; ENSMUSP00000019679; ENSMUSG00000002343. [Q8BNU0-1]
GeneIDi76813.
KEGGimmu:76813.
UCSCiuc009lzi.1. mouse. [Q8BNU0-1]
uc009lzj.1. mouse. [Q8BNU0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010815 mRNA. Translation: BAB27199.1.
AK049351 mRNA. Translation: BAC33700.1.
AK080609 mRNA. Translation: BAC37956.1.
AK081550 mRNA. Translation: BAC38256.1. Frameshift.
BC005754 mRNA. Translation: AAH05754.1.
BC030077 mRNA. Translation: AAH30077.1.
BC043070 mRNA. Translation: AAH43070.1.
BC055779 mRNA. Translation: AAH55779.1.
CCDSiCCDS40371.1. [Q8BNU0-1]
RefSeqiNP_598733.2. NM_133972.2. [Q8BNU0-1]
UniGeneiMm.383251.

3D structure databases

ProteinModelPortaliQ8BNU0.
SMRiQ8BNU0. Positions 120-449.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BNU0. 1 interaction.
MINTiMINT-4125449.
STRINGi10090.ENSMUSP00000019679.

Proteomic databases

EPDiQ8BNU0.
MaxQBiQ8BNU0.
PaxDbiQ8BNU0.
PeptideAtlasiQ8BNU0.
PRIDEiQ8BNU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019679; ENSMUSP00000019679; ENSMUSG00000002343. [Q8BNU0-1]
GeneIDi76813.
KEGGimmu:76813.
UCSCiuc009lzi.1. mouse. [Q8BNU0-1]
uc009lzj.1. mouse. [Q8BNU0-2]

Organism-specific databases

CTDi93436.
MGIiMGI:1924063. Armc6.

Phylogenomic databases

eggNOGiKOG4199. Eukaryota.
ENOG410XR4D. LUCA.
GeneTreeiENSGT00390000002913.
HOGENOMiHOG000290683.
HOVERGENiHBG057500.
InParanoidiQ8BNU0.
OMAiDCEDVAK.
OrthoDBiEOG7MPRFJ.
PhylomeDBiQ8BNU0.
TreeFamiTF324526.

Miscellaneous databases

PROiQ8BNU0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BNU0.
CleanExiMM_ARMC6.
ExpressionAtlasiQ8BNU0. baseline and differential.
GenevisibleiQ8BNU0. MM.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 2 hits.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Brain cortex.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain and Mammary gland.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Liver, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiARMC6_MOUSE
AccessioniPrimary (citable) accession number: Q8BNU0
Secondary accession number(s): Q8C4P5
, Q8C7S1, Q8K2S7, Q99JQ2, Q9CWE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.