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Q8BNP7

- Q8BNP7_MOUSE

UniProt

Q8BNP7 - Q8BNP7_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Apc

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. beta-catenin binding Source: MGI
    2. microtubule plus-end binding Source: MGI
    3. protein binding Source: MGI
    4. protein kinase regulator activity Source: Ensembl

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. axis specification Source: MGI
    3. axonogenesis Source: MGI
    4. canonical Wnt signaling pathway Source: MGI
    5. canonical Wnt signaling pathway involved in negative regulation of apoptotic process Source: MGI
    6. canonical Wnt signaling pathway involved in positive regulation of apoptotic process Source: MGI
    7. cell cycle arrest Source: InterPro
    8. cell migration Source: MGI
    9. cellular response to DNA damage stimulus Source: InterPro
    10. chromosome organization Source: MGI
    11. cytoplasmic microtubule organization Source: MGI
    12. dorsal/ventral pattern formation Source: MGI
    13. hair follicle development Source: MGI
    14. kidney development Source: MGI
    15. metaphase/anaphase transition of mitotic cell cycle Source: MGI
    16. mitotic cytokinesis Source: MGI
    17. mitotic spindle assembly checkpoint Source: Ensembl
    18. muscle cell cellular homeostasis Source: MGI
    19. negative regulation of apoptotic process Source: MGI
    20. negative regulation of canonical Wnt signaling pathway Source: MGI
    21. negative regulation of cell proliferation Source: MGI
    22. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
    23. negative regulation of epithelial cell proliferation Source: MGI
    24. negative regulation of epithelial cell proliferation involved in prostate gland development Source: MGI
    25. negative regulation of MAPK cascade Source: MGI
    26. negative regulation of microtubule depolymerization Source: MGI
    27. negative regulation of odontogenesis Source: MGI
    28. negative regulation of Wnt signaling pathway Source: MGI
    29. pattern specification process Source: MGI
    30. positive regulation of apoptotic process Source: MGI
    31. positive regulation of cell adhesion Source: MGI
    32. positive regulation of cell differentiation Source: MGI
    33. positive regulation of cell division Source: MGI
    34. positive regulation of cell migration Source: MGI
    35. positive regulation of epithelial cell differentiation Source: MGI
    36. positive regulation of microtubule polymerization Source: MGI
    37. positive regulation of protein catabolic process Source: MGI
    38. positive regulation of pseudopodium assembly Source: Ensembl
    39. protein complex assembly Source: Ensembl
    40. proximal/distal pattern formation Source: MGI
    41. regulation of attachment of spindle microtubules to kinetochore Source: MGI
    42. regulation of cell cycle Source: MGI
    43. regulation of cell differentiation Source: MGI
    44. regulation of cell migration Source: MGI
    45. regulation of epithelial cell differentiation Source: MGI
    46. regulation of nitrogen compound metabolic process Source: MGI
    47. regulation of osteoblast differentiation Source: MGI
    48. regulation of osteoclast differentiation Source: MGI
    49. retina development in camera-type eye Source: MGI
    50. skin development Source: MGI
    51. somatic stem cell maintenance Source: MGI
    52. stem cell maintenance Source: MGI
    53. T cell differentiation in thymus Source: MGI
    54. thymus development Source: MGI
    55. Wnt signaling pathway Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_203336. Degradation of beta-catenin by the destruction complex.
    REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_218396. Beta-catenin phosphorylation cascade.
    REACT_219771. deactivation of the beta-catenin transactivating complex.
    REACT_224460. Apoptotic cleavage of cellular proteins.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:ApcImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:88039. Apc.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: MGI
    2. axonal growth cone Source: MGI
    3. beta-catenin destruction complex Source: Ensembl
    4. cell-cell adherens junction Source: Ensembl
    5. cell projection Source: MGI
    6. cell projection membrane Source: MGI
    7. centrosome Source: Ensembl
    8. cytoplasm Source: MGI
    9. growth cone Source: MGI
    10. kinetochore Source: Ensembl
    11. lamellipodium Source: Ensembl
    12. lateral plasma membrane Source: Ensembl
    13. nucleus Source: MGI
    14. ruffle membrane Source: Ensembl
    15. tight junction Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiQ8BNP7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BNP7.
    BgeeiQ8BNP7.
    GenevestigatoriQ8BNP7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BNP7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    InParanoidiQ8BNP7.
    KOiK02085.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    InterProiIPR026836. APC.
    IPR009240. APC_15aa_rpt.
    IPR026831. APC_dom.
    IPR026818. Apc_fam.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    [Graphical view]
    PANTHERiPTHR12607. PTHR12607. 1 hit.
    PTHR12607:SF11. PTHR12607:SF11. 1 hit.
    PfamiPF05972. APC_15aa. 1 hit.
    PF00514. Arm. 3 hits.
    PF11414. Suppressor_APC. 1 hit.
    [Graphical view]
    SMARTiSM00185. ARM. 6 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50176. ARM_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q8BNP7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ     50
    LQGSIEDETM TSGQIDLLER LKEFNLDSNF PGVKLRSKMS LRSYGSREGS 100
    VSSRSGECSP VPMGSFPRRT FVNGSRESTG YLEELEKERS LLLADLDKEE 150
    KEKDWYYAQL QNLTKRIDSL PLTENFSLQT DMTRRQLEYE ARQIRAAMEE 200
    QLGTCQDMEK RAQRRIARIQ QIEKDILRVR QLLQSQAAEA ERSSQSRHDA 250
    ASHEAGRQHE GHGVAESNTA ASSSGQSPAT RVDHETASVL SSSGTHSAPR 300
    RLTSHLGTKV EMVYSLLSML GTHDKDDMSR TLLAMSSSQD SCISMRQSGC 350
    LPLLIQLLHG NDKDSVLLGN SRGSKEARAR ASAALHNIIH SQPDDKRGRR 400
    EIRVLHLLEQ IRAYCETCWE WQEAHEQGMD QDKNPMPAPV EHQICPAVCV 450
    LMKLSFDEEH RHAMNELGGL QAIAELLQVD CEMYGLTNDH YSVTLRRYAG 500
    MALTNLTFGD VANKATLCSM KGCMRALVAQ LKSESEDLQQ VIASVLRNLS 550
    WRADVNSKKT LREVGSVKAL MECALEVKKE STLKSVLSAL WNLSAHCTEN 600
    KADICAVDGA LAFLVGTLTY RSQTNTLAII ESGGGILRNV SSLIATNEDH 650
    RQILRENNCL QTLLQHLKSH SLTIVSNACG TLWNLSARNP KDQEALWDMG 700
    AVSMLKNLIH SKHKMIAMGS AAALRNLMAN RPAKYKDANI MSPGSSLPSL 750
    HVRKQKALEA ELDAQHLSET FDNIDNLSPK ASHRSKQRHK QNLYGDYAFD 800
    ANRHDDSRSD NFNTGNMTVL SPYLNTTVLP SSSSSRGSLD SSRSEKDRSL 850
    ERERGIGLSA YHPTTENAGT SSKRGLQITT TAAQIAKVME EVSAIHTSQD 900
    DRSSASTTEF HCVADDRSAA RRSSASHTHS NTYNFTKSEN SNRTCSMPYA 950
    KVEYKRSSND SLNSVTSSDG YGKRGQMKPS VESYSEDDES KFCSYGQYPA 1000
    DLAHKIHSAN HMDDNDGELD TPINYSLKYS DEQLNSGRQS PSQNERWARP 1050
    KHVIED 1056
    Length:1,056
    Mass (Da):117,633
    Last modified:March 1, 2003 - v1
    Checksum:i86C79FDC12C23FAB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1056 – 10561Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK080907 mRNA. Translation: BAC38073.1.
    RefSeqiNP_031488.2. NM_007462.3.
    UniGeneiMm.384171.

    Genome annotation databases

    GeneIDi11789.
    KEGGimmu:11789.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK080907 mRNA. Translation: BAC38073.1 .
    RefSeqi NP_031488.2. NM_007462.3.
    UniGenei Mm.384171.

    3D structure databases

    ProteinModelPortali Q8BNP7.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8BNP7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11789.
    KEGGi mmu:11789.

    Organism-specific databases

    CTDi 324.
    MGIi MGI:88039. Apc.

    Phylogenomic databases

    InParanoidi Q8BNP7.
    KOi K02085.

    Enzyme and pathway databases

    Reactomei REACT_203336. Degradation of beta-catenin by the destruction complex.
    REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_218396. Beta-catenin phosphorylation cascade.
    REACT_219771. deactivation of the beta-catenin transactivating complex.
    REACT_224460. Apoptotic cleavage of cellular proteins.

    Miscellaneous databases

    ChiTaRSi APC. mouse.
    NextBioi 279609.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BNP7.
    Bgeei Q8BNP7.
    Genevestigatori Q8BNP7.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    InterProi IPR026836. APC.
    IPR009240. APC_15aa_rpt.
    IPR026831. APC_dom.
    IPR026818. Apc_fam.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    [Graphical view ]
    PANTHERi PTHR12607. PTHR12607. 1 hit.
    PTHR12607:SF11. PTHR12607:SF11. 1 hit.
    Pfami PF05972. APC_15aa. 1 hit.
    PF00514. Arm. 3 hits.
    PF11414. Suppressor_APC. 1 hit.
    [Graphical view ]
    SMARTi SM00185. ARM. 6 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50176. ARM_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: AdiposeImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: AdiposeImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: AdiposeImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: AdiposeImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: AdiposeImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: AdiposeImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: AdiposeImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: AdiposeImported.

    Entry informationi

    Entry nameiQ8BNP7_MOUSE
    AccessioniPrimary (citable) accession number: Q8BNP7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)