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Q8BNP7

- Q8BNP7_MOUSE

UniProt

Q8BNP7 - Q8BNP7_MOUSE

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Protein
Submitted name:

Putative uncharacterized protein

Gene
Apc
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. beta-catenin binding Source: MGI
  2. microtubule plus-end binding Source: MGI
  3. protein binding Source: MGI
  4. protein kinase regulator activity Source: Ensembl

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. axis specification Source: MGI
  3. axonogenesis Source: MGI
  4. canonical Wnt signaling pathway Source: MGI
  5. canonical Wnt signaling pathway involved in negative regulation of apoptotic process Source: MGI
  6. canonical Wnt signaling pathway involved in positive regulation of apoptotic process Source: MGI
  7. cell cycle arrest Source: InterPro
  8. cell migration Source: MGI
  9. cellular response to DNA damage stimulus Source: InterPro
  10. chromosome organization Source: MGI
  11. cytoplasmic microtubule organization Source: MGI
  12. dorsal/ventral pattern formation Source: MGI
  13. hair follicle development Source: MGI
  14. kidney development Source: MGI
  15. metaphase/anaphase transition of mitotic cell cycle Source: MGI
  16. mitotic cytokinesis Source: MGI
  17. mitotic spindle assembly checkpoint Source: Ensembl
  18. muscle cell cellular homeostasis Source: MGI
  19. negative regulation of apoptotic process Source: MGI
  20. negative regulation of canonical Wnt signaling pathway Source: MGI
  21. negative regulation of cell proliferation Source: MGI
  22. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  23. negative regulation of epithelial cell proliferation Source: MGI
  24. negative regulation of epithelial cell proliferation involved in prostate gland development Source: MGI
  25. negative regulation of MAPK cascade Source: MGI
  26. negative regulation of microtubule depolymerization Source: MGI
  27. negative regulation of odontogenesis Source: MGI
  28. negative regulation of Wnt signaling pathway Source: MGI
  29. pattern specification process Source: MGI
  30. positive regulation of apoptotic process Source: MGI
  31. positive regulation of cell adhesion Source: MGI
  32. positive regulation of cell differentiation Source: MGI
  33. positive regulation of cell division Source: MGI
  34. positive regulation of cell migration Source: MGI
  35. positive regulation of epithelial cell differentiation Source: MGI
  36. positive regulation of microtubule polymerization Source: MGI
  37. positive regulation of protein catabolic process Source: MGI
  38. positive regulation of pseudopodium assembly Source: Ensembl
  39. protein complex assembly Source: Ensembl
  40. proximal/distal pattern formation Source: MGI
  41. regulation of attachment of spindle microtubules to kinetochore Source: MGI
  42. regulation of cell cycle Source: MGI
  43. regulation of cell differentiation Source: MGI
  44. regulation of cell migration Source: MGI
  45. regulation of epithelial cell differentiation Source: MGI
  46. regulation of nitrogen compound metabolic process Source: MGI
  47. regulation of osteoblast differentiation Source: MGI
  48. regulation of osteoclast differentiation Source: MGI
  49. retina development in camera-type eye Source: MGI
  50. skin development Source: MGI
  51. somatic stem cell maintenance Source: MGI
  52. stem cell maintenance Source: MGI
  53. T cell differentiation in thymus Source: MGI
  54. thymus development Source: MGI
  55. Wnt signaling pathway Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_203336. Degradation of beta-catenin by the destruction complex.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_218396. Beta-catenin phosphorylation cascade.
REACT_219771. deactivation of the beta-catenin transactivating complex.
REACT_224460. Apoptotic cleavage of cellular proteins.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:ApcImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88039. Apc.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: MGI
  2. axonal growth cone Source: MGI
  3. beta-catenin destruction complex Source: Ensembl
  4. cell-cell adherens junction Source: Ensembl
  5. cell projection Source: MGI
  6. cell projection membrane Source: MGI
  7. centrosome Source: Ensembl
  8. cytoplasm Source: MGI
  9. growth cone Source: MGI
  10. kinetochore Source: Ensembl
  11. lamellipodium Source: Ensembl
  12. lateral plasma membrane Source: Ensembl
  13. nucleus Source: MGI
  14. ruffle membrane Source: Ensembl
  15. tight junction Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8BNP7.

Expressioni

Gene expression databases

ArrayExpressiQ8BNP7.
BgeeiQ8BNP7.
GenevestigatoriQ8BNP7.

Structurei

3D structure databases

ProteinModelPortaliQ8BNP7.

Family & Domainsi

Phylogenomic databases

InParanoidiQ8BNP7.
KOiK02085.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026836. APC.
IPR009240. APC_15aa_rpt.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PANTHERiPTHR12607. PTHR12607. 1 hit.
PTHR12607:SF11. PTHR12607:SF11. 1 hit.
PfamiPF05972. APC_15aa. 1 hit.
PF00514. Arm. 3 hits.
PF11414. Suppressor_APC. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8BNP7-1 [UniParc]FASTAAdd to Basket

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MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ     50
LQGSIEDETM TSGQIDLLER LKEFNLDSNF PGVKLRSKMS LRSYGSREGS 100
VSSRSGECSP VPMGSFPRRT FVNGSRESTG YLEELEKERS LLLADLDKEE 150
KEKDWYYAQL QNLTKRIDSL PLTENFSLQT DMTRRQLEYE ARQIRAAMEE 200
QLGTCQDMEK RAQRRIARIQ QIEKDILRVR QLLQSQAAEA ERSSQSRHDA 250
ASHEAGRQHE GHGVAESNTA ASSSGQSPAT RVDHETASVL SSSGTHSAPR 300
RLTSHLGTKV EMVYSLLSML GTHDKDDMSR TLLAMSSSQD SCISMRQSGC 350
LPLLIQLLHG NDKDSVLLGN SRGSKEARAR ASAALHNIIH SQPDDKRGRR 400
EIRVLHLLEQ IRAYCETCWE WQEAHEQGMD QDKNPMPAPV EHQICPAVCV 450
LMKLSFDEEH RHAMNELGGL QAIAELLQVD CEMYGLTNDH YSVTLRRYAG 500
MALTNLTFGD VANKATLCSM KGCMRALVAQ LKSESEDLQQ VIASVLRNLS 550
WRADVNSKKT LREVGSVKAL MECALEVKKE STLKSVLSAL WNLSAHCTEN 600
KADICAVDGA LAFLVGTLTY RSQTNTLAII ESGGGILRNV SSLIATNEDH 650
RQILRENNCL QTLLQHLKSH SLTIVSNACG TLWNLSARNP KDQEALWDMG 700
AVSMLKNLIH SKHKMIAMGS AAALRNLMAN RPAKYKDANI MSPGSSLPSL 750
HVRKQKALEA ELDAQHLSET FDNIDNLSPK ASHRSKQRHK QNLYGDYAFD 800
ANRHDDSRSD NFNTGNMTVL SPYLNTTVLP SSSSSRGSLD SSRSEKDRSL 850
ERERGIGLSA YHPTTENAGT SSKRGLQITT TAAQIAKVME EVSAIHTSQD 900
DRSSASTTEF HCVADDRSAA RRSSASHTHS NTYNFTKSEN SNRTCSMPYA 950
KVEYKRSSND SLNSVTSSDG YGKRGQMKPS VESYSEDDES KFCSYGQYPA 1000
DLAHKIHSAN HMDDNDGELD TPINYSLKYS DEQLNSGRQS PSQNERWARP 1050
KHVIED 1056
Length:1,056
Mass (Da):117,633
Last modified:March 1, 2003 - v1
Checksum:i86C79FDC12C23FAB
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1056 – 10561Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK080907 mRNA. Translation: BAC38073.1.
RefSeqiNP_031488.2. NM_007462.3.
UniGeneiMm.384171.

Genome annotation databases

GeneIDi11789.
KEGGimmu:11789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK080907 mRNA. Translation: BAC38073.1 .
RefSeqi NP_031488.2. NM_007462.3.
UniGenei Mm.384171.

3D structure databases

ProteinModelPortali Q8BNP7.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8BNP7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 11789.
KEGGi mmu:11789.

Organism-specific databases

CTDi 324.
MGIi MGI:88039. Apc.

Phylogenomic databases

InParanoidi Q8BNP7.
KOi K02085.

Enzyme and pathway databases

Reactomei REACT_203336. Degradation of beta-catenin by the destruction complex.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_218396. Beta-catenin phosphorylation cascade.
REACT_219771. deactivation of the beta-catenin transactivating complex.
REACT_224460. Apoptotic cleavage of cellular proteins.

Miscellaneous databases

ChiTaRSi APC. mouse.
NextBioi 279609.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BNP7.
Bgeei Q8BNP7.
Genevestigatori Q8BNP7.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR026836. APC.
IPR009240. APC_15aa_rpt.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view ]
PANTHERi PTHR12607. PTHR12607. 1 hit.
PTHR12607:SF11. PTHR12607:SF11. 1 hit.
Pfami PF05972. APC_15aa. 1 hit.
PF00514. Arm. 3 hits.
PF11414. Suppressor_APC. 1 hit.
[Graphical view ]
SMARTi SM00185. ARM. 6 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AdiposeImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AdiposeImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AdiposeImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AdiposeImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AdiposeImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AdiposeImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AdiposeImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AdiposeImported.

Entry informationi

Entry nameiQ8BNP7_MOUSE
AccessioniPrimary (citable) accession number: Q8BNP7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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