Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Putative uncharacterized protein

Gene

Apc

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • gamma-catenin binding Source: MGI
  • microtubule binding Source: MGI
  • microtubule plus-end binding Source: MGI
  • protein kinase binding Source: MGI
  • protein kinase regulator activity Source: MGI

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • axis specification Source: MGI
  • axonogenesis Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • canonical Wnt signaling pathway involved in negative regulation of apoptotic process Source: MGI
  • canonical Wnt signaling pathway involved in positive regulation of apoptotic process Source: MGI
  • cell cycle arrest Source: MGI
  • cell migration Source: MGI
  • cellular response to DNA damage stimulus Source: MGI
  • chromosome organization Source: MGI
  • cytoplasmic microtubule organization Source: MGI
  • dorsal/ventral pattern formation Source: MGI
  • hair follicle development Source: MGI
  • kidney development Source: MGI
  • metaphase/anaphase transition of mitotic cell cycle Source: MGI
  • mitotic cytokinesis Source: MGI
  • mitotic spindle assembly checkpoint Source: MGI
  • muscle cell cellular homeostasis Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of canonical Wnt signaling pathway Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of epithelial cell proliferation involved in prostate gland development Source: MGI
  • negative regulation of MAPK cascade Source: MGI
  • negative regulation of microtubule depolymerization Source: MGI
  • negative regulation of odontogenesis Source: MGI
  • negative regulation of Wnt signaling pathway Source: MGI
  • pattern specification process Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of cell adhesion Source: MGI
  • positive regulation of cell differentiation Source: MGI
  • positive regulation of cell division Source: MGI
  • positive regulation of cell migration Source: MGI
  • positive regulation of epithelial cell differentiation Source: MGI
  • positive regulation of microtubule polymerization Source: MGI
  • positive regulation of protein catabolic process Source: MGI
  • positive regulation of pseudopodium assembly Source: MGI
  • protein complex assembly Source: MGI
  • proximal/distal pattern formation Source: MGI
  • regulation of attachment of spindle microtubules to kinetochore Source: MGI
  • regulation of cell cycle Source: MGI
  • regulation of cell differentiation Source: MGI
  • regulation of cell migration Source: MGI
  • regulation of epithelial cell differentiation Source: MGI
  • regulation of microtubule-based process Source: MGI
  • regulation of nitrogen compound metabolic process Source: MGI
  • regulation of osteoblast differentiation Source: MGI
  • regulation of osteoclast differentiation Source: MGI
  • retina development in camera-type eye Source: MGI
  • skin development Source: MGI
  • somatic stem cell maintenance Source: MGI
  • stem cell maintenance Source: MGI
  • T cell differentiation in thymus Source: MGI
  • thymus development Source: MGI
  • Wnt signaling pathway Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_274287. Degradation of beta-catenin by the destruction complex.
REACT_277640. Apoptotic cleavage of cellular proteins.
REACT_303008. Beta-catenin phosphorylation cascade.
REACT_317277. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_351655. deactivation of the beta-catenin transactivating complex.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:ApcImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88039. Apc.

Subcellular locationi

GO - Cellular componenti

  • axon Source: MGI
  • axonal growth cone Source: MGI
  • beta-catenin destruction complex Source: MGI
  • catenin complex Source: MGI
  • cell-cell adherens junction Source: Ensembl
  • cell projection Source: MGI
  • cell projection membrane Source: MGI
  • centrosome Source: MGI
  • cytoplasm Source: MGI
  • growth cone Source: MGI
  • kinetochore Source: MGI
  • lamellipodium Source: MGI
  • lateral plasma membrane Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
  • ruffle membrane Source: MGI
  • tight junction Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8BNP7.

Expressioni

Gene expression databases

BgeeiQ8BNP7.
ExpressionAtlasiQ8BNP7. baseline and differential.
GenevestigatoriQ8BNP7.

Structurei

3D structure databases

ProteinModelPortaliQ8BNP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK02085.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026836. APC.
IPR009240. APC_15aa_rpt.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PANTHERiPTHR12607. PTHR12607. 1 hit.
PTHR12607:SF11. PTHR12607:SF11. 1 hit.
PfamiPF05972. APC_15aa. 1 hit.
PF00514. Arm. 3 hits.
PF11414. Suppressor_APC. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8BNP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ
60 70 80 90 100
LQGSIEDETM TSGQIDLLER LKEFNLDSNF PGVKLRSKMS LRSYGSREGS
110 120 130 140 150
VSSRSGECSP VPMGSFPRRT FVNGSRESTG YLEELEKERS LLLADLDKEE
160 170 180 190 200
KEKDWYYAQL QNLTKRIDSL PLTENFSLQT DMTRRQLEYE ARQIRAAMEE
210 220 230 240 250
QLGTCQDMEK RAQRRIARIQ QIEKDILRVR QLLQSQAAEA ERSSQSRHDA
260 270 280 290 300
ASHEAGRQHE GHGVAESNTA ASSSGQSPAT RVDHETASVL SSSGTHSAPR
310 320 330 340 350
RLTSHLGTKV EMVYSLLSML GTHDKDDMSR TLLAMSSSQD SCISMRQSGC
360 370 380 390 400
LPLLIQLLHG NDKDSVLLGN SRGSKEARAR ASAALHNIIH SQPDDKRGRR
410 420 430 440 450
EIRVLHLLEQ IRAYCETCWE WQEAHEQGMD QDKNPMPAPV EHQICPAVCV
460 470 480 490 500
LMKLSFDEEH RHAMNELGGL QAIAELLQVD CEMYGLTNDH YSVTLRRYAG
510 520 530 540 550
MALTNLTFGD VANKATLCSM KGCMRALVAQ LKSESEDLQQ VIASVLRNLS
560 570 580 590 600
WRADVNSKKT LREVGSVKAL MECALEVKKE STLKSVLSAL WNLSAHCTEN
610 620 630 640 650
KADICAVDGA LAFLVGTLTY RSQTNTLAII ESGGGILRNV SSLIATNEDH
660 670 680 690 700
RQILRENNCL QTLLQHLKSH SLTIVSNACG TLWNLSARNP KDQEALWDMG
710 720 730 740 750
AVSMLKNLIH SKHKMIAMGS AAALRNLMAN RPAKYKDANI MSPGSSLPSL
760 770 780 790 800
HVRKQKALEA ELDAQHLSET FDNIDNLSPK ASHRSKQRHK QNLYGDYAFD
810 820 830 840 850
ANRHDDSRSD NFNTGNMTVL SPYLNTTVLP SSSSSRGSLD SSRSEKDRSL
860 870 880 890 900
ERERGIGLSA YHPTTENAGT SSKRGLQITT TAAQIAKVME EVSAIHTSQD
910 920 930 940 950
DRSSASTTEF HCVADDRSAA RRSSASHTHS NTYNFTKSEN SNRTCSMPYA
960 970 980 990 1000
KVEYKRSSND SLNSVTSSDG YGKRGQMKPS VESYSEDDES KFCSYGQYPA
1010 1020 1030 1040 1050
DLAHKIHSAN HMDDNDGELD TPINYSLKYS DEQLNSGRQS PSQNERWARP

KHVIED
Length:1,056
Mass (Da):117,633
Last modified:March 1, 2003 - v1
Checksum:i86C79FDC12C23FAB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1056 – 10561Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK080907 mRNA. Translation: BAC38073.1.
RefSeqiNP_031488.2. NM_007462.3.
UniGeneiMm.384171.

Genome annotation databases

GeneIDi11789.
KEGGimmu:11789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK080907 mRNA. Translation: BAC38073.1.
RefSeqiNP_031488.2. NM_007462.3.
UniGeneiMm.384171.

3D structure databases

ProteinModelPortaliQ8BNP7.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8BNP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11789.
KEGGimmu:11789.

Organism-specific databases

CTDi324.
MGIiMGI:88039. Apc.

Phylogenomic databases

KOiK02085.

Enzyme and pathway databases

ReactomeiREACT_274287. Degradation of beta-catenin by the destruction complex.
REACT_277640. Apoptotic cleavage of cellular proteins.
REACT_303008. Beta-catenin phosphorylation cascade.
REACT_317277. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_351655. deactivation of the beta-catenin transactivating complex.

Miscellaneous databases

ChiTaRSiApc. mouse.
NextBioi279609.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BNP7.
ExpressionAtlasiQ8BNP7. baseline and differential.
GenevestigatoriQ8BNP7.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026836. APC.
IPR009240. APC_15aa_rpt.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PANTHERiPTHR12607. PTHR12607. 1 hit.
PTHR12607:SF11. PTHR12607:SF11. 1 hit.
PfamiPF05972. APC_15aa. 1 hit.
PF00514. Arm. 3 hits.
PF11414. Suppressor_APC. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AdiposeImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AdiposeImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AdiposeImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AdiposeImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AdiposeImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AdiposeImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AdiposeImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AdiposeImported.

Entry informationi

Entry nameiQ8BNP7_MOUSE
AccessioniPrimary (citable) accession number: Q8BNP7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 27, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.