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Q8BNP7 (Q8BNP7_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Apc MGI 88039
OrganismMus musculus (Mouse) EMBL BAC38073.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1056 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processT cell differentiation in thymus

Inferred from mutant phenotype PubMed 16025118. Source: MGI

Wnt signaling pathway

Inferred from direct assay PubMed 10346819. Source: MGI

anterior/posterior pattern specification

Inferred from mutant phenotype PubMed 12645927. Source: MGI

axis specification

Inferred from mutant phenotype PubMed 12645927. Source: MGI

axonogenesis

Inferred from mutant phenotype PubMed 15207235PubMed 18716223. Source: MGI

canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 16887818. Source: MGI

canonical Wnt signaling pathway involved in negative regulation of apoptotic process

Inferred from genetic interaction PubMed 17377531. Source: MGI

canonical Wnt signaling pathway involved in positive regulation of apoptotic process

Inferred from genetic interaction PubMed 17377531. Source: MGI

cell migration

Inferred from mutant phenotype PubMed 15198980. Source: MGI

chromosome organization

Inferred from mutant phenotype PubMed 17200209. Source: MGI

cytoplasmic microtubule organization

Inferred from genetic interaction PubMed 18716223. Source: MGI

dorsal/ventral pattern formation

Inferred from mutant phenotype PubMed 12645927. Source: MGI

hair follicle development

Inferred from mutant phenotype PubMed 17002498. Source: MGI

kidney development

Inferred from mutant phenotype PubMed 15550389. Source: MGI

metaphase/anaphase transition of mitotic cell cycle

Inferred from mutant phenotype PubMed 15767571PubMed 16025118. Source: MGI

mitotic cytokinesis

Inferred from mutant phenotype PubMed 17570218PubMed 17893240. Source: MGI

mitotic spindle assembly checkpoint

Inferred from electronic annotation. Source: Ensembl

muscle cell cellular homeostasis

Inferred from genetic interaction PubMed 18056981. Source: MGI

negative regulation of MAPK cascade

Inferred from mutant phenotype PubMed 16478791. Source: MGI

negative regulation of Wnt signaling pathway

Inferred from mutant phenotype PubMed 11756652PubMed 15198980PubMed 15550389PubMed 15563600PubMed 16740478PubMed 16887818PubMed 17363566. Source: MGI

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 11756652PubMed 16950562. Source: MGI

negative regulation of canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 11756652PubMed 15198980PubMed 15563600. Source: MGI

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 10334197PubMed 10506110PubMed 10535960PubMed 11309311PubMed 11478486PubMed 11559569PubMed 12370429PubMed 15198980PubMed 15550389PubMed 15563600PubMed 16638711PubMed 17596282PubMed 18656477PubMed 7954428PubMed 8945508PubMed 9135000PubMed 9865728PubMed 9927046. Source: MGI

negative regulation of cyclin-dependent protein serine/threonine kinase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 9060821. Source: MGI

negative regulation of epithelial cell proliferation involved in prostate gland development

Inferred from mutant phenotype PubMed 17363566. Source: MGI

negative regulation of microtubule depolymerization

Inferred from mutant phenotype PubMed 16525027. Source: MGI

negative regulation of odontogenesis

Inferred from mutant phenotype PubMed 17002498. Source: MGI

pattern specification process

Inferred from mutant phenotype PubMed 16740478. Source: MGI

positive regulation of apoptotic process

Inferred from mutant phenotype PubMed 17227893. Source: MGI

positive regulation of cell adhesion

Inferred from mutant phenotype PubMed 16368433. Source: MGI

positive regulation of cell differentiation

Inferred from mutant phenotype PubMed 15198980PubMed 16709231. Source: MGI

positive regulation of cell division

Inferred from mutant phenotype PubMed 16950562. Source: MGI

positive regulation of cell migration

Inferred from mutant phenotype PubMed 17192415. Source: MGI

positive regulation of epithelial cell differentiation

Inferred from genetic interaction PubMed 15314168. Source: MGI

positive regulation of microtubule polymerization

Inferred from mutant phenotype PubMed 16525027. Source: MGI

positive regulation of protein catabolic process

Inferred from mutant phenotype PubMed 16478791. Source: MGI

positive regulation of pseudopodium assembly

Inferred from electronic annotation. Source: Ensembl

protein complex assembly

Inferred from electronic annotation. Source: Ensembl

proximal/distal pattern formation

Inferred from mutant phenotype PubMed 16887818. Source: MGI

regulation of attachment of spindle microtubules to kinetochore

Inferred from mutant phenotype PubMed 17227893. Source: MGI

regulation of cell cycle

Inferred from mutant phenotype PubMed 8988060. Source: MGI

regulation of cell differentiation

Inferred from genetic interaction PubMed 17377531. Source: MGI

regulation of cell migration

Inferred from mutant phenotype PubMed 9371501. Source: MGI

regulation of epithelial cell differentiation

Inferred from mutant phenotype PubMed 9771477. Source: MGI

regulation of nitrogen compound metabolic process

Inferred from mutant phenotype PubMed 16740478. Source: MGI

regulation of osteoblast differentiation

Inferred from mutant phenotype PubMed 15802266. Source: MGI

regulation of osteoclast differentiation

Inferred from mutant phenotype PubMed 15802266. Source: MGI

retina development in camera-type eye

Inferred from mutant phenotype PubMed 10982921. Source: MGI

skin development

Inferred from mutant phenotype PubMed 9453487. Source: MGI

somatic stem cell maintenance

Inferred from mutant phenotype PubMed 1541640. Source: MGI

stem cell maintenance

Inferred from mutant phenotype PubMed 18725524. Source: MGI

thymus development

Inferred from mutant phenotype PubMed 16025118PubMed 17002498. Source: MGI

   Cellular_componentaxon

Inferred from direct assay PubMed 15207235. Source: MGI

axonal growth cone

Inferred from direct assay PubMed 18716223. Source: MGI

beta-catenin destruction complex

Inferred from electronic annotation. Source: Ensembl

cell projection

Inferred from direct assay PubMed 16525027. Source: MGI

cell projection membrane

Inferred from direct assay PubMed 16621792. Source: MGI

cell-cell adherens junction

Inferred from electronic annotation. Source: Ensembl

centrosome

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 8670282. Source: MGI

growth cone

Inferred from direct assay PubMed 15207235. Source: MGI

kinetochore

Inferred from electronic annotation. Source: Ensembl

lamellipodium

Inferred from electronic annotation. Source: Ensembl

lateral plasma membrane

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay PubMed 10346819. Source: MGI

ruffle membrane

Inferred from electronic annotation. Source: Ensembl

tight junction

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionbeta-catenin binding

Inferred from direct assay PubMed 10346819. Source: MGI

microtubule plus-end binding

Inferred from direct assay PubMed 18716223. Source: MGI

protein binding

Inferred from physical interaction PubMed 15327768PubMed 21689717. Source: MGI

protein kinase regulator activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue10561 EMBL BAC38073.1

Sequences

Sequence LengthMass (Da)Tools
Q8BNP7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 86C79FDC12C23FAB

FASTA1,056117,633
        10         20         30         40         50         60 
MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ LQGSIEDETM 

        70         80         90        100        110        120 
TSGQIDLLER LKEFNLDSNF PGVKLRSKMS LRSYGSREGS VSSRSGECSP VPMGSFPRRT 

       130        140        150        160        170        180 
FVNGSRESTG YLEELEKERS LLLADLDKEE KEKDWYYAQL QNLTKRIDSL PLTENFSLQT 

       190        200        210        220        230        240 
DMTRRQLEYE ARQIRAAMEE QLGTCQDMEK RAQRRIARIQ QIEKDILRVR QLLQSQAAEA 

       250        260        270        280        290        300 
ERSSQSRHDA ASHEAGRQHE GHGVAESNTA ASSSGQSPAT RVDHETASVL SSSGTHSAPR 

       310        320        330        340        350        360 
RLTSHLGTKV EMVYSLLSML GTHDKDDMSR TLLAMSSSQD SCISMRQSGC LPLLIQLLHG 

       370        380        390        400        410        420 
NDKDSVLLGN SRGSKEARAR ASAALHNIIH SQPDDKRGRR EIRVLHLLEQ IRAYCETCWE 

       430        440        450        460        470        480 
WQEAHEQGMD QDKNPMPAPV EHQICPAVCV LMKLSFDEEH RHAMNELGGL QAIAELLQVD 

       490        500        510        520        530        540 
CEMYGLTNDH YSVTLRRYAG MALTNLTFGD VANKATLCSM KGCMRALVAQ LKSESEDLQQ 

       550        560        570        580        590        600 
VIASVLRNLS WRADVNSKKT LREVGSVKAL MECALEVKKE STLKSVLSAL WNLSAHCTEN 

       610        620        630        640        650        660 
KADICAVDGA LAFLVGTLTY RSQTNTLAII ESGGGILRNV SSLIATNEDH RQILRENNCL 

       670        680        690        700        710        720 
QTLLQHLKSH SLTIVSNACG TLWNLSARNP KDQEALWDMG AVSMLKNLIH SKHKMIAMGS 

       730        740        750        760        770        780 
AAALRNLMAN RPAKYKDANI MSPGSSLPSL HVRKQKALEA ELDAQHLSET FDNIDNLSPK 

       790        800        810        820        830        840 
ASHRSKQRHK QNLYGDYAFD ANRHDDSRSD NFNTGNMTVL SPYLNTTVLP SSSSSRGSLD 

       850        860        870        880        890        900 
SSRSEKDRSL ERERGIGLSA YHPTTENAGT SSKRGLQITT TAAQIAKVME EVSAIHTSQD 

       910        920        930        940        950        960 
DRSSASTTEF HCVADDRSAA RRSSASHTHS NTYNFTKSEN SNRTCSMPYA KVEYKRSSND 

       970        980        990       1000       1010       1020 
SLNSVTSSDG YGKRGQMKPS VESYSEDDES KFCSYGQYPA DLAHKIHSAN HMDDNDGELD 

      1030       1040       1050 
TPINYSLKYS DEQLNSGRQS PSQNERWARP KHVIED 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38073.1.
Tissue: Adipose EMBL BAC38073.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38073.1.
Tissue: Adipose EMBL BAC38073.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38073.1.
Tissue: Adipose EMBL BAC38073.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38073.1.
Tissue: Adipose EMBL BAC38073.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38073.1.
Tissue: Adipose EMBL BAC38073.1.
[6]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38073.1.
Tissue: Adipose EMBL BAC38073.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38073.1.
Tissue: Adipose EMBL BAC38073.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38073.1.
Tissue: Adipose EMBL BAC38073.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK080907 mRNA. Translation: BAC38073.1.
RefSeqNP_031488.2. NM_007462.3.
UniGeneMm.384171.

3D structure databases

ProteinModelPortalQ8BNP7.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ8BNP7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID11789.
KEGGmmu:11789.

Organism-specific databases

CTD324.
MGIMGI:88039. Apc.

Phylogenomic databases

InParanoidQ8BNP7.
KOK02085.

Gene expression databases

ArrayExpressQ8BNP7.
BgeeQ8BNP7.
GenevestigatorQ8BNP7.

Family and domain databases

Gene3D1.25.10.10. 2 hits.
InterProIPR026836. APC.
IPR009240. APC_15aa_rpt.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PANTHERPTHR12607. PTHR12607. 1 hit.
PTHR12607:SF11. PTHR12607:SF11. 1 hit.
PfamPF05972. APC_15aa. 1 hit.
PF00514. Arm. 3 hits.
PF11414. Suppressor_APC. 1 hit.
[Graphical view]
SMARTSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
PROSITEPS50176. ARM_REPEAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAPC. mouse.
NextBio279609.
SOURCESearch...

Entry information

Entry nameQ8BNP7_MOUSE
AccessionPrimary (citable) accession number: Q8BNP7
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)