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Protein

BTB/POZ domain-containing protein KCTD6

Gene

Kctd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu7 probably implicating CUL3-dependent proteasomal degradation.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664. Neddylation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD6
Gene namesi
Name:Kctd6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1918643. Kctd6.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002512491 – 237BTB/POZ domain-containing protein KCTD6Add BLAST237

Proteomic databases

MaxQBiQ8BNL5.
PaxDbiQ8BNL5.
PRIDEiQ8BNL5.

PTM databases

PhosphoSitePlusiQ8BNL5.

Expressioni

Tissue specificityi

Highly expressed in cerebellum and brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000021752.
ExpressionAtlasiQ8BNL5. baseline and differential.
GenevisibleiQ8BNL5. MM.

Interactioni

Subunit structurei

Homopentamer. Interacts with KCTD11; KCTD6 and KCTD11 may associate in heteropentameric assemblies. Interacts (via BTB domain) with CUL3; initially a 4:4 stoichiometry has been reported, however, electron microscopy revealed pentameric states with a five-pointed pinwheel shape. The interaction with CUL3 is indicative for a participation in a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. Interacts with HDAC1; probably indirect as the interaction is requiring the presence of KCTD11. Interacts with USP21 (preferentially catalytic inactive form). Interacts with ANK1 isoform Mu7; detected in striated muscle.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8BNL5.
SMRiQ8BNL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 81BTBAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 104Interaction with ANK1 isoform Mu7By similarityAdd BLAST104
Regioni10 – 110Interaction with CUL3By similarityAdd BLAST101
Regioni113 – 187Interaction with USP21By similarityAdd BLAST75

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000236287.
HOVERGENiHBG080695.
InParanoidiQ8BNL5.
KOiK21916.
OMAiNFTKWNK.
OrthoDBiEOG091G0FYS.
PhylomeDBiQ8BNL5.
TreeFamiTF315332.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ_sf.
IPR003131. T1-type_BTB.
PfamiView protein in Pfam
PF02214. BTB_2. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BNL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNGDWGYMM SDPVTLNVGG HLYTTSLTTL TRYPDSMLGA MFGGDFPTAR
60 70 80 90 100
DPQGNYFIDR DGPLFRYVLN FLRTSELTLP LDFKEFDLLR KEADFYQIEP
110 120 130 140 150
LIQCLNDPRP LYPMDTFEEV VELSSTRKLS KYSNPVAVII TQLTITTKVH
160 170 180 190 200
SLLEGISNYF TKWNKHMMDT RDCQVSFTFG PCDYHQEVSL RVHLMEYITK
210 220 230
QGFTIRNTRV HHMSERANEN TVEHNWTFCR LARKTDD
Length:237
Mass (Da):27,624
Last modified:March 1, 2003 - v1
Checksum:i83B641919B0F4D9E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti233R → S in BAE34793 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082924 mRNA. Translation: BAC38692.1.
AK159067 mRNA. Translation: BAE34793.1.
BC096370 mRNA. Translation: AAH96370.1.
CCDSiCCDS26812.1.
RefSeqiNP_001292865.1. NM_001305936.1.
NP_001292866.1. NM_001305937.1.
NP_082058.1. NM_027782.3.
XP_006518168.1. XM_006518105.3.
UniGeneiMm.292712.

Genome annotation databases

EnsembliENSMUST00000022272; ENSMUSP00000022272; ENSMUSG00000021752.
ENSMUST00000170111; ENSMUSP00000129059; ENSMUSG00000021752.
GeneIDi71393.
KEGGimmu:71393.
UCSCiuc007sex.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiKCTD6_MOUSE
AccessioniPrimary (citable) accession number: Q8BNL5
Secondary accession number(s): Q3TXX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways