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Protein

Derlin-2

Gene

Derl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.By similarity

GO - Biological processi

Keywordsi

Biological processUnfolded protein response

Enzyme and pathway databases

ReactomeiR-MMU-382556 ABC-family proteins mediated transport
R-MMU-5358346 Hedgehog ligand biogenesis
R-MMU-901032 ER Quality Control Compartment (ERQC)

Names & Taxonomyi

Protein namesi
Recommended name:
Derlin-21 Publication
Alternative name(s):
Degradation in endoplasmic reticulum protein 2
Der1-like protein 21 Publication
F-LANa1 Publication
Gene namesi
Name:Derl2Imported
Synonyms:Der2, Flana1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2151483 Derl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57CytoplasmicSequence analysisAdd BLAST57
Transmembranei58 – 78Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini79 – 96LumenalSequence analysisAdd BLAST18
Transmembranei97 – 117Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini118 – 150CytoplasmicSequence analysisAdd BLAST33
Transmembranei151 – 171Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini172LumenalSequence analysis1
Transmembranei173 – 193Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini194 – 239CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190461 – 239Derlin-2Add BLAST239

Proteomic databases

EPDiQ8BNI4
PaxDbiQ8BNI4
PeptideAtlasiQ8BNI4
PRIDEiQ8BNI4

PTM databases

iPTMnetiQ8BNI4
PhosphoSitePlusiQ8BNI4

Expressioni

Tissue specificityi

Widely expressed, with lowest levels in brain and heart.2 Publications

Inductioni

Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR).2 Publications

Gene expression databases

BgeeiENSMUSG00000018442
CleanExiMM_DERL2
ExpressionAtlasiQ8BNI4 baseline and differential
GenevisibleiQ8BNI4 MM

Interactioni

Subunit structurei

Forms homo- and heterooligomers with DERL3 and, to a lesser extent, with DERL1 (By similarity). Interacts with the SEL1L/SYVN1 and VCP/SELENOS protein complexes (PubMed:22016385). Mediates association between VCP and EDEM1, as well as that between VCP and the misfolded glycoproteins (By similarity). Interacts with OS9 (By similarity). Interacts with SELENOK and SELENOS (PubMed:22016385). Interacts with the signal recognition particle/SRP and the SRP receptor; in the process of endoplasmic reticulum stress-induced pre-emptive quality control (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi228066, 2 interactors
IntActiQ8BNI4, 1 interactor
STRINGi10090.ENSMUSP00000117052

Structurei

3D structure databases

ProteinModelPortaliQ8BNI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the derlin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0858 Eukaryota
COG5291 LUCA
GeneTreeiENSGT00530000063156
HOGENOMiHOG000200948
HOVERGENiHBG051338
InParanoidiQ8BNI4
KOiK13989
OMAiGRSPAHF
OrthoDBiEOG091G0IPJ
PhylomeDBiQ8BNI4
TreeFamiTF314715

Family and domain databases

InterProiView protein in InterPro
IPR007599 DER1
PANTHERiPTHR11009 PTHR11009, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BNI4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAYQSLRLEY LQIPPVSRAY TTACVLTTAA VQLELITPFQ LYFNPELIFK
60 70 80 90 100
HFQIWRLITN FLFFGPVGFN FLFNMIFLYR YCRMLEEGSF RGRTADFVFM
110 120 130 140 150
FLFGGFLMTL FGLFVSLVFL GQAFTIMLVY VWSRRNPYVR MNFFGLLNFQ
160 170 180 190 200
APFLPWVLMG FSLLLGNSII VDLLGIAVGH IYFFLEDIFP NQPGGIRILK
210 220 230
TPSILRTIFD TPDEDPNYNP LPEERPGGFA WGEGQRLGG
Length:239
Mass (Da):27,640
Last modified:July 19, 2004 - v2
Checksum:iD702B14B47516A8C
GO
Isoform 2 (identifier: Q8BNI4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-239: EGQRLGG → WNKTDLD

Note: No experimental confirmation available.
Show »
Length:239
Mass (Da):27,815
Checksum:iD5DDECCEF2BD42EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228G → A in AAL14868 (PubMed:11500051).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011085233 – 239EGQRLGG → WNKTDLD in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208064 mRNA Translation: AAL14868.1
AK048627 mRNA Translation: BAC33399.1
AK077659 mRNA Translation: BAC36934.1
AK082564 mRNA Translation: BAC38533.1
AK083632 mRNA Translation: BAC38974.1
BC005682 mRNA Translation: AAH05682.1
CCDSiCCDS24972.1 [Q8BNI4-1]
RefSeqiNP_001278075.1, NM_001291146.1
NP_001278076.1, NM_001291147.1
NP_001278077.1, NM_001291148.1
NP_291040.1, NM_033562.4 [Q8BNI4-1]
UniGeneiMm.28131
Mm.446351

Genome annotation databases

EnsembliENSMUST00000108523; ENSMUSP00000104163; ENSMUSG00000018442 [Q8BNI4-2]
ENSMUST00000143850; ENSMUSP00000117052; ENSMUSG00000018442 [Q8BNI4-1]
GeneIDi116891
KEGGimmu:116891
UCSCiuc007jxi.2 mouse [Q8BNI4-2]
uc007jxj.2 mouse [Q8BNI4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDERL2_MOUSE
AccessioniPrimary (citable) accession number: Q8BNI4
Secondary accession number(s): Q920I5, Q99J12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: March 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health