Q8BNF8 (Q8BNF8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAC39028.1

Gene names

Name:

Vcp MGI 99919

Organism

Mus musculus (Mouse) EMBL BAC39028.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	723 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the AAA ATPase family. RuleBase RU003651

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU003651 Nucleotide-binding
Gene Ontology (GO)
Biological_process	ER to Golgi vesicle-mediated transport Inferred from electronic annotation. Source: Compara activation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from direct assay PubMed 14561754. Source: MGI aggresome assembly Inferred from genetic interaction PubMed 16810319. Source: MGI double-strand break repair Inferred from electronic annotation. Source: Compara positive regulation of proteasomal ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: Compara positive regulation of protein complex assembly Inferred from electronic annotation. Source: Compara protein N-linked glycosylation via asparagine Inferred from electronic annotation. Source: Compara protein homooligomerization Inferred from electronic annotation. Source: Compara retrograde protein transport, ER to cytosol Inferred from electronic annotation. Source: Compara ubiquitin-dependent protein catabolic process Inferred from genetic interaction PubMed 16810319. Source: MGI
Cellular_component	cytosol Inferred from electronic annotation. Source: Compara endoplasmic reticulum Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara proteasome complex Inferred from electronic annotation. Source: Compara protein complex Inferred from physical interaction PubMed 17785525. Source: MGI site of double-strand break Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8BNF8 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: BE6571A7772AA778	FASTA	723	80,149
	10 20 30 40 50 60 MNRVVRNNLR VRLGDVISIQ PCPDVKYGKR IHVLPIDDTV EGITGNLFEV YLKPYFLEAY 70 80 90 100 110 120 RPIRKGDIFL VRGGMRAVEF KVVETDPSPY CIVAPDTVIH CEGEPIKRED EEESLNEVGY 130 140 150 160 170 180 DDIGGCRKQL AQIKEMVELP LRHPALFKAI GVKPPRGILL YGPPGTGKTL IARAVANETG 190 200 210 220 230 240 AFFFLINGPE IMSKLAGESE SNLRKAFEEA EKNAPAIIFI DELDAIAPKR EKTHGEVERR 250 260 270 280 290 300 IVSQLLTLMD GLKQRAHVIV MAATNRPNSI DPALRRFGRF DREVDIGIPD ATGRLEILQI 310 320 330 340 350 360 HTKNMKLADD VDLEQVANET HGHVGADLAA LCSEAALQAI RKKMDLIDLE DETIDAEVMN 370 380 390 400 410 420 SLAVTMDDFR WALSQSNPSA LRETVVEVPQ VTWEDIGGLE DVKRELQELV QYPVEHPDKF 430 440 450 460 470 480 LKFGMTPSKG VLFYGPPGCG KTLLAKAIAN ECQANFISIK GPELLTMWFG ESEANVREIF 490 500 510 520 530 540 DKARQAAPCV LFFDELDSIA KARGGNIGDG GGAADRVINQ ILTEMDGMST KKNVFIIGAT 550 560 570 580 590 600 NRPDIIDPAI LRPGRLDQLI YIPLPDEKSR VAILKANLRK SPVAKDVDLE FLAKMTNGFS 610 620 630 640 650 660 GADLTEICQR ACKLAIRESI ESEIRRERER QTNPSAMEVE EDDPVPEIRR DHFEEAMRFA 670 680 690 700 710 720 RRSVSDNDIR KYEMFAQTLQ QSRGFGSFRF PSGNQGGAGP SQGSGGGTGG SVYTEDNDDD LYG

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC39028.1. Tissue: Spinal ganglion EMBL BAC39028.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC39028.1. Tissue: Spinal ganglion EMBL BAC39028.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC39028.1. Tissue: Spinal ganglion EMBL BAC39028.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC39028.1. Tissue: Spinal ganglion EMBL BAC39028.1.
[5]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC39028.1. Tissue: Spinal ganglion EMBL BAC39028.1.
[6]	Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC39028.1. Tissue: Spinal ganglion EMBL BAC39028.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC39028.1. Tissue: Spinal ganglion EMBL BAC39028.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC39028.1. Tissue: Spinal ganglion EMBL BAC39028.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK083821 mRNA. Translation: BAC39028.1.
IPI	IPI00622235.
UniGene	Mm.245976.
3D structure databases
HSSP	HSSP built from PDB template 1OZ4 based on UniProtKB Q01853.
ProteinModelPortal	Q8BNF8.
SMR	Q8BNF8. Positions 1-680.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8BNF8.
Proteomic databases
PRIDE	Q8BNF8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:99919. Vcp.
Phylogenomic databases
HOVERGEN	HBG001226.
InParanoid	Q8BNF8.
Gene expression databases
ArrayExpress	Q8BNF8.
Bgee	Q8BNF8.
Genevestigator	Q8BNF8.
Family and domain databases
Gene3D	2.40.40.20. 1 hit.
InterPro	IPR003593. AAA+_ATPase. IPR009010. Asp_de-COase-like_dom. IPR005938. ATPase_AAA_CDC48. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. IPR004201. Cdc48_dom2. IPR015415. Vps4_C. [Graphical view]
PANTHER	PTHR23077:SF18. PTHR23077:SF18. 1 hit.
Pfam	PF00004. AAA. 2 hits. PF02933. CDC48_2. 1 hit. PF09336. Vps4_C. 1 hit. [Graphical view]
SMART	SM00382. AAA. 2 hits. SM01072. CDC48_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01243. CDC48. 1 hit.
PROSITE	PS00674. AAA. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	VCP. mouse.
SOURCE	Search...

Entry information

Entry name

Q8BNF8_MOUSE

Accession

Primary (citable) accession number: Q8BNF8

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)