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Q8BNF8 (Q8BNF8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Vcp MGI 99919
OrganismMus musculus (Mouse) EMBL BAC39028.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length723 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the AAA ATPase family. RuleBase RU003651

Ontologies

Keywords
   LigandATP-binding RuleBase RU003651
Nucleotide-binding
Gene Ontology (GO)
   Biological_processER to Golgi vesicle-mediated transport

Inferred from electronic annotation. Source: Ensembl

activation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from direct assay PubMed 14561754. Source: MGI

aggresome assembly

Inferred from genetic interaction PubMed 16810319. Source: MGI

double-strand break repair

Inferred from electronic annotation. Source: Ensembl

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein complex assembly

Inferred from electronic annotation. Source: Ensembl

protein N-linked glycosylation via asparagine

Inferred from electronic annotation. Source: Ensembl

protein homooligomerization

Inferred from electronic annotation. Source: Ensembl

retrograde protein transport, ER to cytosol

Inferred from electronic annotation. Source: Ensembl

translesion synthesis

Inferred from electronic annotation. Source: Ensembl

ubiquitin-dependent protein catabolic process

Inferred from genetic interaction PubMed 16810319. Source: MGI

   Cellular_componentcytosol

Inferred from sequence orthology PubMed 23444373. Source: MGI

endoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

lipid particle

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: Ensembl

proteasome complex

Inferred from electronic annotation. Source: Ensembl

protein complex

Inferred from physical interaction PubMed 17785525. Source: MGI

site of double-strand break

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionADP binding

Inferred from electronic annotation. Source: Ensembl

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 11689694PubMed 12504083PubMed 14561754PubMed 14988733PubMed 15723043PubMed 16525503PubMed 18178578PubMed 19805280PubMed 21600962PubMed 23055941. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8BNF8 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: BE6571A7772AA778

FASTA72380,149
        10         20         30         40         50         60 
MNRVVRNNLR VRLGDVISIQ PCPDVKYGKR IHVLPIDDTV EGITGNLFEV YLKPYFLEAY 

        70         80         90        100        110        120 
RPIRKGDIFL VRGGMRAVEF KVVETDPSPY CIVAPDTVIH CEGEPIKRED EEESLNEVGY 

       130        140        150        160        170        180 
DDIGGCRKQL AQIKEMVELP LRHPALFKAI GVKPPRGILL YGPPGTGKTL IARAVANETG 

       190        200        210        220        230        240 
AFFFLINGPE IMSKLAGESE SNLRKAFEEA EKNAPAIIFI DELDAIAPKR EKTHGEVERR 

       250        260        270        280        290        300 
IVSQLLTLMD GLKQRAHVIV MAATNRPNSI DPALRRFGRF DREVDIGIPD ATGRLEILQI 

       310        320        330        340        350        360 
HTKNMKLADD VDLEQVANET HGHVGADLAA LCSEAALQAI RKKMDLIDLE DETIDAEVMN 

       370        380        390        400        410        420 
SLAVTMDDFR WALSQSNPSA LRETVVEVPQ VTWEDIGGLE DVKRELQELV QYPVEHPDKF 

       430        440        450        460        470        480 
LKFGMTPSKG VLFYGPPGCG KTLLAKAIAN ECQANFISIK GPELLTMWFG ESEANVREIF 

       490        500        510        520        530        540 
DKARQAAPCV LFFDELDSIA KARGGNIGDG GGAADRVINQ ILTEMDGMST KKNVFIIGAT 

       550        560        570        580        590        600 
NRPDIIDPAI LRPGRLDQLI YIPLPDEKSR VAILKANLRK SPVAKDVDLE FLAKMTNGFS 

       610        620        630        640        650        660 
GADLTEICQR ACKLAIRESI ESEIRRERER QTNPSAMEVE EDDPVPEIRR DHFEEAMRFA 

       670        680        690        700        710        720 
RRSVSDNDIR KYEMFAQTLQ QSRGFGSFRF PSGNQGGAGP SQGSGGGTGG SVYTEDNDDD 


LYG 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39028.1.
Tissue: Spinal ganglion EMBL BAC39028.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39028.1.
Tissue: Spinal ganglion EMBL BAC39028.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39028.1.
Tissue: Spinal ganglion EMBL BAC39028.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39028.1.
Tissue: Spinal ganglion EMBL BAC39028.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39028.1.
Tissue: Spinal ganglion EMBL BAC39028.1.
[6]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39028.1.
Tissue: Spinal ganglion EMBL BAC39028.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39028.1.
Tissue: Spinal ganglion EMBL BAC39028.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39028.1.
Tissue: Spinal ganglion EMBL BAC39028.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK083821 mRNA. Translation: BAC39028.1.
UniGeneMm.245976.

3D structure databases

ProteinModelPortalQ8BNF8.
SMRQ8BNF8. Positions 1-680.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1736094.

Proteomic databases

PRIDEQ8BNF8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:99919. Vcp.

Phylogenomic databases

HOVERGENHBG001226.
InParanoidQ8BNF8.

Gene expression databases

BgeeQ8BNF8.
GenevestigatorQ8BNF8.

Family and domain databases

Gene3D3.10.330.10. 1 hit.
3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR005938. AAA_ATPase_CDC48.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR004201. Cdc48_dom2.
IPR029067. CDC48_domain_2-like.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamPF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
SM01072. CDC48_2. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF54585. SSF54585. 1 hit.
TIGRFAMsTIGR01243. CDC48. 1 hit.
PROSITEPS00674. AAA. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSVCP. mouse.
SOURCESearch...

Entry information

Entry nameQ8BNF8_MOUSE
AccessionPrimary (citable) accession number: Q8BNF8
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)