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Q8BNF8

- Q8BNF8_MOUSE

UniProt

Q8BNF8 - Q8BNF8_MOUSE

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Protein
Submitted name:

Putative uncharacterized protein

Gene

Vcp

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ADP binding Source: Ensembl
  2. ATPase activity Source: Ensembl
  3. ATP binding Source: UniProtKB-KW
  4. deubiquitinase activator activity Source: Ensembl
  5. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  2. aggresome assembly Source: MGI
  3. double-strand break repair Source: Ensembl
  4. ER to Golgi vesicle-mediated transport Source: Ensembl
  5. positive regulation of Lys63-specific deubiquitinase activity Source: Ensembl
  6. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
  7. positive regulation of protein complex assembly Source: Ensembl
  8. positive regulation of protein K63-linked deubiquitination Source: Ensembl
  9. protein homooligomerization Source: Ensembl
  10. protein N-linked glycosylation via asparagine Source: Ensembl
  11. retrograde protein transport, ER to cytosol Source: Ensembl
  12. translesion synthesis Source: Ensembl
  13. ubiquitin-dependent protein catabolic process Source: MGI
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:VcpImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:99919. Vcp.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. extracellular vesicular exosome Source: Ensembl
  3. Hrd1p ubiquitin ligase complex Source: Ensembl
  4. lipid particle Source: Ensembl
  5. nucleus Source: Ensembl
  6. perinuclear region of cytoplasm Source: Ensembl
  7. proteasome complex Source: Ensembl
  8. protein complex Source: MGI
  9. site of double-strand break Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8BNF8.

Expressioni

Gene expression databases

BgeeiQ8BNF8.
ExpressionAtlasiQ8BNF8. baseline and differential.
GenevestigatoriQ8BNF8.

Interactioni

Protein-protein interaction databases

MINTiMINT-1736094.

Structurei

3D structure databases

ProteinModelPortaliQ8BNF8.
SMRiQ8BNF8. Positions 1-680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG001226.

Family and domain databases

Gene3Di3.10.330.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR005938. AAA_ATPase_CDC48.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR004201. Cdc48_dom2.
IPR029067. CDC48_domain_2-like.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM01072. CDC48_2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54585. SSF54585. 1 hit.
TIGRFAMsiTIGR01243. CDC48. 1 hit.
PROSITEiPS00674. AAA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BNF8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNRVVRNNLR VRLGDVISIQ PCPDVKYGKR IHVLPIDDTV EGITGNLFEV
60 70 80 90 100
YLKPYFLEAY RPIRKGDIFL VRGGMRAVEF KVVETDPSPY CIVAPDTVIH
110 120 130 140 150
CEGEPIKRED EEESLNEVGY DDIGGCRKQL AQIKEMVELP LRHPALFKAI
160 170 180 190 200
GVKPPRGILL YGPPGTGKTL IARAVANETG AFFFLINGPE IMSKLAGESE
210 220 230 240 250
SNLRKAFEEA EKNAPAIIFI DELDAIAPKR EKTHGEVERR IVSQLLTLMD
260 270 280 290 300
GLKQRAHVIV MAATNRPNSI DPALRRFGRF DREVDIGIPD ATGRLEILQI
310 320 330 340 350
HTKNMKLADD VDLEQVANET HGHVGADLAA LCSEAALQAI RKKMDLIDLE
360 370 380 390 400
DETIDAEVMN SLAVTMDDFR WALSQSNPSA LRETVVEVPQ VTWEDIGGLE
410 420 430 440 450
DVKRELQELV QYPVEHPDKF LKFGMTPSKG VLFYGPPGCG KTLLAKAIAN
460 470 480 490 500
ECQANFISIK GPELLTMWFG ESEANVREIF DKARQAAPCV LFFDELDSIA
510 520 530 540 550
KARGGNIGDG GGAADRVINQ ILTEMDGMST KKNVFIIGAT NRPDIIDPAI
560 570 580 590 600
LRPGRLDQLI YIPLPDEKSR VAILKANLRK SPVAKDVDLE FLAKMTNGFS
610 620 630 640 650
GADLTEICQR ACKLAIRESI ESEIRRERER QTNPSAMEVE EDDPVPEIRR
660 670 680 690 700
DHFEEAMRFA RRSVSDNDIR KYEMFAQTLQ QSRGFGSFRF PSGNQGGAGP
710 720
SQGSGGGTGG SVYTEDNDDD LYG
Length:723
Mass (Da):80,149
Last modified:March 1, 2003 - v1
Checksum:iBE6571A7772AA778
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK083821 mRNA. Translation: BAC39028.1.
UniGeneiMm.245976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK083821 mRNA. Translation: BAC39028.1 .
UniGenei Mm.245976.

3D structure databases

ProteinModelPortali Q8BNF8.
SMRi Q8BNF8. Positions 1-680.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1736094.

Proteomic databases

PRIDEi Q8BNF8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:99919. Vcp.

Phylogenomic databases

HOVERGENi HBG001226.

Miscellaneous databases

ChiTaRSi VCP. mouse.
SOURCEi Search...

Gene expression databases

Bgeei Q8BNF8.
ExpressionAtlasi Q8BNF8. baseline and differential.
Genevestigatori Q8BNF8.

Family and domain databases

Gene3Di 3.10.330.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR005938. AAA_ATPase_CDC48.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR004201. Cdc48_dom2.
IPR029067. CDC48_domain_2-like.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view ]
Pfami PF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
SM01072. CDC48_2. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF54585. SSF54585. 1 hit.
TIGRFAMsi TIGR01243. CDC48. 1 hit.
PROSITEi PS00674. AAA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal ganglionImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal ganglionImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal ganglionImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal ganglionImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal ganglionImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal ganglionImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal ganglionImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal ganglionImported.

Entry informationi

Entry nameiQ8BNF8_MOUSE
AccessioniPrimary (citable) accession number: Q8BNF8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)