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Q8BND5 (QSOX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sulfhydryl oxidase 1

Short name=mSOx
EC=1.8.3.2
Alternative name(s):
Quiescin Q6
Skin sulfhydryl oxidase
Gene names
Name:Qsox1
Synonyms:Qscn6, Sox
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length748 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.

Catalytic activity

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactor

Binds 1 FAD per subunit By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Isoform 1: Golgi apparatus membrane; Single-pass membrane protein By similarity Ref.1.

Isoform 2: Secreted. Note: Found in the extracellular medium of quiescent cells but not in proliferating cells. Ref.1

Isoform 3: Secreted. Note: Found in the extracellular medium of quiescent cells but not in proliferating cells. Ref.1

Isoform 4: Secreted. Note: Found in the extracellular medium of quiescent cells but not in proliferating cells. Ref.1

Tissue specificity

Expressed in the seminal vesicles and skin. Ref.1

Sequence similarities

Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.

Contains 1 ERV/ALR sulfhydryl oxidase domain.

Contains 1 thioredoxin domain.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BND5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BND5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     660-661: VN → LL
     662-748: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8BND5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     567-568: VM → LL
     569-748: Missing.
Isoform 4 (identifier: Q8BND5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     126-154: FFQAFTKNGSGATLPGAGANVQTLRMRLI → VCEGGATVEWFWPSTQSSVPHFPGTFLGC
     155-748: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 748716Sulfhydryl oxidase 1
PRO_0000249534

Regions

Transmembrane711 – 73121Helical; Potential
Domain33 – 159127Thioredoxin
Domain399 – 506108ERV/ALR sulfhydryl oxidase
Nucleotide binding481 – 4888FAD By similarity

Sites

Active site731Nucleophile By similarity
Active site761Nucleophile By similarity
Binding site4041FAD By similarity
Binding site4111FAD By similarity
Binding site4151FAD By similarity
Binding site4541FAD By similarity
Binding site4581FAD By similarity
Binding site5031FAD By similarity
Binding site5061FAD By similarity

Amino acid modifications

Glycosylation1331N-linked (GlcNAc...) Potential
Glycosylation2461N-linked (GlcNAc...) Potential
Disulfide bond73 ↔ 76Redox-active By similarity
Disulfide bond396 ↔ 408 By similarity
Disulfide bond452 ↔ 455 By similarity
Disulfide bond512 ↔ 515 By similarity

Natural variations

Alternative sequence126 – 15429FFQAF…RMRLI → VCEGGATVEWFWPSTQSSVP HFPGTFLGC in isoform 4.
VSP_020491
Alternative sequence155 – 748594Missing in isoform 4.
VSP_020492
Alternative sequence567 – 5682VM → LL in isoform 3.
VSP_020493
Alternative sequence569 – 748180Missing in isoform 3.
VSP_020494
Alternative sequence660 – 6612VN → LL in isoform 2.
VSP_020495
Alternative sequence662 – 74887Missing in isoform 2.
VSP_020496

Experimental info

Sequence conflict6371M → I in BAE41429. Ref.2
Sequence conflict6561F → L in BAE41429. Ref.2
Isoform 4:
Sequence conflict1271C → Y in BAE37202. Ref.2

Secondary structure

.............................................................................. 748
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 0499F6B8DAB5A8D1

FASTA74882,785
        10         20         30         40         50         60 
MRRCGRLSGP PSLLLLLLLL SPLLFSGPGA YAARLSVLYS SSDPLTLLDA DSVRPTVLGS 

        70         80         90        100        110        120 
SSAWAVEFFA SWCGHCIAFA PTWKELANDV KDWRPALNLA VLDCAEETNS AVCREFNIAG 

       130        140        150        160        170        180 
FPTVRFFQAF TKNGSGATLP GAGANVQTLR MRLIDALESH RDTWPPACPP LEPAKLNDID 

       190        200        210        220        230        240 
GFFTRNKADY LALVFEREDS YLGREVTLDL SQYHAVAVRR VLNTESDLVN KFGVTDFPSC 

       250        260        270        280        290        300 
YLLLRNGSVS RVPVLVESRS FYTSYLRGLP GLTRDAPPTT ATPVTADKIA PTVWKFADRS 

       310        320        330        340        350        360 
KIYMADLESA LHYILRVEVG KFSVLEGQRL VALKKFVAVL AKYFPGQPLV QNFLHSINDW 

       370        380        390        400        410        420 
LQKQQKKRIP YSFFKAALDS RKEDAVLTEK VNWVGCQGSE PHFRGFPCSL WVLFHFLTVQ 

       430        440        450        460        470        480 
ANRYSEAHPQ EPADGQEVLQ AMRSYVQFFF GCRDCADHFE QMAAASMHQV RSPSNAILWL 

       490        500        510        520        530        540 
WTSHNRVNAR LSGALSEDPH FPKVQWPPRE LCSACHNELN GQVPLWDLGA TLNFLKAHFS 

       550        560        570        580        590        600 
PANIVIDSSA SRHTGRRGSP EATPELVMDT LKLESRNSVL GHEQAASAES PGATALDVPA 

       610        620        630        640        650        660 
EKPEASGPQE LYTGLRMGGA SPGQGPPERM EDHQRDMQEN APGQQHLSKR DTEALFLPEV 

       670        680        690        700        710        720 
NHLQGPLELR RGGRSPKQLA PILEEEPEAL AIQGQGQWLQ VLGGGISHLD ISLCVGLYSV 

       730        740 
SFMGLLAMYT YFRARLRTPK GHASYPTA 

« Hide

Isoform 2 [UniParc].

Checksum: AFC4B43576BEE56B
Show »

FASTA66173,297
Isoform 3 [UniParc].

Checksum: 761F44799536DBBB
Show »

FASTA56863,336
Isoform 4 [UniParc].

Checksum: F13FDA0BC3335587
Show »

FASTA15416,624

References

« Hide 'large scale' references
[1]"Sulfhydryl oxidase (SOx) from mouse epidermis: molecular cloning, nucleotide sequence, and expression of recombinant protein in the cultured cells."
Matsuba S., Suga Y., Ishidoh K., Hashimoto Y., Takamori K., Kominami E., Wilhelm B., Seitz J., Ogawa H.
J. Dermatol. Sci. 30:50-62(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
Strain: C57BL/6J and NOD.
Tissue: Cerebellum, Liver and Spinal ganglion.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-538 (ISOFORM 3).
Strain: C57BL/6 and FVB/N.
Tissue: Eye and Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB044284 mRNA. Translation: BAB21936.1.
AK004880 mRNA. Translation: BAB23638.1.
AK083938 mRNA. Translation: BAC39073.1.
AK149465 mRNA. Translation: BAE28897.1.
AK163119 mRNA. Translation: BAE37202.1.
AK166839 mRNA. Translation: BAE39061.1.
AK169877 mRNA. Translation: BAE41429.1.
AK169920 mRNA. Translation: BAE41459.1.
AK170449 mRNA. Translation: BAE41807.1.
BC034131 mRNA. Translation: AAH34131.1.
BC076590 mRNA. Translation: AAH76590.1.
CCDSCCDS15386.1. [Q8BND5-1]
RefSeqNP_001020116.1. NM_001024945.1. [Q8BND5-1]
NP_075757.1. NM_023268.2. [Q8BND5-3]
UniGeneMm.27035.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3T58X-ray2.40A/B/C/D36-550[»]
3T59X-ray2.80A/B/C/D36-550[»]
ProteinModelPortalQ8BND5.
SMRQ8BND5. Positions 38-549.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BND5.

Proteomic databases

MaxQBQ8BND5.
PaxDbQ8BND5.
PRIDEQ8BND5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000035325; ENSMUSP00000035658; ENSMUSG00000033684. [Q8BND5-1]
ENSMUST00000111764; ENSMUSP00000107394; ENSMUSG00000033684. [Q8BND5-2]
GeneID104009.
KEGGmmu:104009.
UCSCuc007dbo.1. mouse. [Q8BND5-3]
uc007dbp.1. mouse. [Q8BND5-1]
uc007dbq.1. mouse. [Q8BND5-4]
uc011wtx.1. mouse. [Q8BND5-2]

Organism-specific databases

CTD5768.
MGIMGI:1330818. Qsox1.

Phylogenomic databases

eggNOGCOG0526.
GeneTreeENSGT00390000008045.
HOVERGENHBG080360.
InParanoidQ8BND5.
KOK10758.
OMASHNRVNA.
OrthoDBEOG73RB9X.
PhylomeDBQ8BND5.
TreeFamTF316749.

Gene expression databases

BgeeQ8BND5.
CleanExMM_QSOX1.
GenevestigatorQ8BND5.

Family and domain databases

Gene3D1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEPS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio356343.
PROQ8BND5.
SOURCESearch...

Entry information

Entry nameQSOX1_MOUSE
AccessionPrimary (citable) accession number: Q8BND5
Secondary accession number(s): Q3TDY9 expand/collapse secondary AC list , Q3TE19, Q3TR29, Q3UEL4, Q8K041, Q9DBL6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot