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Q8BND5

- QSOX1_MOUSE

UniProt

Q8BND5 - QSOX1_MOUSE

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Protein
Sulfhydryl oxidase 1
Gene
Qsox1, Qscn6, Sox
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

Binds 1 FAD per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Nucleophile By similarity
Active sitei76 – 761Nucleophile By similarity
Binding sitei404 – 4041FAD By similarity
Binding sitei411 – 4111FAD By similarity
Binding sitei415 – 4151FAD By similarity
Binding sitei454 – 4541FAD By similarity
Binding sitei458 – 4581FAD By similarity
Binding sitei503 – 5031FAD By similarity
Binding sitei506 – 5061FAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi481 – 4888FAD By similarity

GO - Molecular functioni

  1. flavin-linked sulfhydryl oxidase activity Source: UniProtKB
  2. protein disulfide isomerase activity Source: UniProtKB

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidase 1 (EC:1.8.3.2)
Short name:
mSOx
Alternative name(s):
Quiescin Q6
Skin sulfhydryl oxidase
Gene namesi
Name:Qsox1
Synonyms:Qscn6, Sox
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1330818. Qsox1.

Subcellular locationi

Isoform 1 : Golgi apparatus membrane; Single-pass membrane protein By similarity 1 Publication
Isoform 2 : Secreted
Note: Found in the extracellular medium of quiescent cells but not in proliferating cells.1 Publication
Isoform 3 : Secreted
Note: Found in the extracellular medium of quiescent cells but not in proliferating cells.1 Publication
Isoform 4 : Secreted
Note: Found in the extracellular medium of quiescent cells but not in proliferating cells.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei711 – 73121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: MGI
  2. endoplasmic reticulum Source: MGI
  3. extracellular space Source: UniProtKB
  4. integral component of Golgi membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232 Reviewed prediction
Add
BLAST
Chaini33 – 748716Sulfhydryl oxidase 1
PRO_0000249534Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi73 ↔ 76Redox-active By similarity
Glycosylationi133 – 1331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi246 – 2461N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi396 ↔ 408 By similarity
Disulfide bondi452 ↔ 455 By similarity
Disulfide bondi512 ↔ 515 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BND5.
PaxDbiQ8BND5.
PRIDEiQ8BND5.

PTM databases

PhosphoSiteiQ8BND5.

Expressioni

Tissue specificityi

Expressed in the seminal vesicles and skin.1 Publication

Gene expression databases

BgeeiQ8BND5.
CleanExiMM_QSOX1.
GenevestigatoriQ8BND5.

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi43 – 486
Turni50 – 523
Helixi53 – 575
Beta strandi61 – 699
Helixi74 – 9017
Helixi91 – 933
Turni94 – 963
Beta strandi97 – 1037
Helixi107 – 1093
Helixi110 – 1156
Beta strandi120 – 1278
Beta strandi137 – 1393
Helixi146 – 15712
Helixi176 – 1794
Helixi182 – 1843
Beta strandi189 – 1968
Helixi202 – 2098
Turni210 – 2123
Beta strandi216 – 2227
Helixi226 – 2327
Beta strandi237 – 2448
Beta strandi249 – 2513
Helixi259 – 2668
Helixi293 – 2964
Beta strandi301 – 3033
Helixi304 – 31613
Helixi319 – 3213
Beta strandi323 – 3264
Helixi327 – 34317
Helixi348 – 36316
Beta strandi367 – 3704
Helixi371 – 38010
Helixi383 – 3864
Beta strandi403 – 4053
Helixi406 – 42621
Helixi437 – 44913
Helixi453 – 46614
Helixi467 – 4693
Helixi473 – 49119
Beta strandi505 – 5073
Turni509 – 5113
Helixi513 – 5153
Helixi528 – 53811
Helixi541 – 5433

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3T58X-ray2.40A/B/C/D36-550[»]
3T59X-ray2.80A/B/C/D36-550[»]
ProteinModelPortaliQ8BND5.
SMRiQ8BND5. Positions 38-549.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 159127Thioredoxin
Add
BLAST
Domaini399 – 506108ERV/ALR sulfhydryl oxidase
Add
BLAST

Sequence similaritiesi

Contains 1 thioredoxin domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0526.
GeneTreeiENSGT00390000008045.
HOVERGENiHBG080360.
InParanoidiQ8BND5.
KOiK10758.
OMAiSHNRVNA.
OrthoDBiEOG73RB9X.
PhylomeDBiQ8BND5.
TreeFamiTF316749.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BND5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRRCGRLSGP PSLLLLLLLL SPLLFSGPGA YAARLSVLYS SSDPLTLLDA    50
DSVRPTVLGS SSAWAVEFFA SWCGHCIAFA PTWKELANDV KDWRPALNLA 100
VLDCAEETNS AVCREFNIAG FPTVRFFQAF TKNGSGATLP GAGANVQTLR 150
MRLIDALESH RDTWPPACPP LEPAKLNDID GFFTRNKADY LALVFEREDS 200
YLGREVTLDL SQYHAVAVRR VLNTESDLVN KFGVTDFPSC YLLLRNGSVS 250
RVPVLVESRS FYTSYLRGLP GLTRDAPPTT ATPVTADKIA PTVWKFADRS 300
KIYMADLESA LHYILRVEVG KFSVLEGQRL VALKKFVAVL AKYFPGQPLV 350
QNFLHSINDW LQKQQKKRIP YSFFKAALDS RKEDAVLTEK VNWVGCQGSE 400
PHFRGFPCSL WVLFHFLTVQ ANRYSEAHPQ EPADGQEVLQ AMRSYVQFFF 450
GCRDCADHFE QMAAASMHQV RSPSNAILWL WTSHNRVNAR LSGALSEDPH 500
FPKVQWPPRE LCSACHNELN GQVPLWDLGA TLNFLKAHFS PANIVIDSSA 550
SRHTGRRGSP EATPELVMDT LKLESRNSVL GHEQAASAES PGATALDVPA 600
EKPEASGPQE LYTGLRMGGA SPGQGPPERM EDHQRDMQEN APGQQHLSKR 650
DTEALFLPEV NHLQGPLELR RGGRSPKQLA PILEEEPEAL AIQGQGQWLQ 700
VLGGGISHLD ISLCVGLYSV SFMGLLAMYT YFRARLRTPK GHASYPTA 748
Length:748
Mass (Da):82,785
Last modified:March 1, 2003 - v1
Checksum:i0499F6B8DAB5A8D1
GO
Isoform 2 (identifier: Q8BND5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     660-661: VN → LL
     662-748: Missing.

Note: No experimental confirmation available.

Show »
Length:661
Mass (Da):73,297
Checksum:iAFC4B43576BEE56B
GO
Isoform 3 (identifier: Q8BND5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     567-568: VM → LL
     569-748: Missing.

Show »
Length:568
Mass (Da):63,336
Checksum:i761F44799536DBBB
GO
Isoform 4 (identifier: Q8BND5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-154: FFQAFTKNGSGATLPGAGANVQTLRMRLI → VCEGGATVEWFWPSTQSSVPHFPGTFLGC
     155-748: Missing.

Note: No experimental confirmation available.

Show »
Length:154
Mass (Da):16,624
Checksum:iF13FDA0BC3335587
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei126 – 15429FFQAF…RMRLI → VCEGGATVEWFWPSTQSSVP HFPGTFLGC in isoform 4.
VSP_020491Add
BLAST
Alternative sequencei155 – 748594Missing in isoform 4.
VSP_020492Add
BLAST
Alternative sequencei567 – 5682VM → LL in isoform 3.
VSP_020493
Alternative sequencei569 – 748180Missing in isoform 3.
VSP_020494Add
BLAST
Alternative sequencei660 – 6612VN → LL in isoform 2.
VSP_020495
Alternative sequencei662 – 74887Missing in isoform 2.
VSP_020496Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti637 – 6371M → I in BAE41429. 1 Publication
Sequence conflicti656 – 6561F → L in BAE41429. 1 Publication
Isoform 4 (identifier: Q8BND5-4)
Sequence conflicti127 – 1271C → Y in BAE37202. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB044284 mRNA. Translation: BAB21936.1.
AK004880 mRNA. Translation: BAB23638.1.
AK083938 mRNA. Translation: BAC39073.1.
AK149465 mRNA. Translation: BAE28897.1.
AK163119 mRNA. Translation: BAE37202.1.
AK166839 mRNA. Translation: BAE39061.1.
AK169877 mRNA. Translation: BAE41429.1.
AK169920 mRNA. Translation: BAE41459.1.
AK170449 mRNA. Translation: BAE41807.1.
BC034131 mRNA. Translation: AAH34131.1.
BC076590 mRNA. Translation: AAH76590.1.
CCDSiCCDS15386.1. [Q8BND5-1]
RefSeqiNP_001020116.1. NM_001024945.1. [Q8BND5-1]
NP_075757.1. NM_023268.2. [Q8BND5-3]
UniGeneiMm.27035.

Genome annotation databases

EnsembliENSMUST00000035325; ENSMUSP00000035658; ENSMUSG00000033684. [Q8BND5-1]
ENSMUST00000111764; ENSMUSP00000107394; ENSMUSG00000033684. [Q8BND5-2]
GeneIDi104009.
KEGGimmu:104009.
UCSCiuc007dbo.1. mouse. [Q8BND5-3]
uc007dbp.1. mouse. [Q8BND5-1]
uc007dbq.1. mouse. [Q8BND5-4]
uc011wtx.1. mouse. [Q8BND5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB044284 mRNA. Translation: BAB21936.1 .
AK004880 mRNA. Translation: BAB23638.1 .
AK083938 mRNA. Translation: BAC39073.1 .
AK149465 mRNA. Translation: BAE28897.1 .
AK163119 mRNA. Translation: BAE37202.1 .
AK166839 mRNA. Translation: BAE39061.1 .
AK169877 mRNA. Translation: BAE41429.1 .
AK169920 mRNA. Translation: BAE41459.1 .
AK170449 mRNA. Translation: BAE41807.1 .
BC034131 mRNA. Translation: AAH34131.1 .
BC076590 mRNA. Translation: AAH76590.1 .
CCDSi CCDS15386.1. [Q8BND5-1 ]
RefSeqi NP_001020116.1. NM_001024945.1. [Q8BND5-1 ]
NP_075757.1. NM_023268.2. [Q8BND5-3 ]
UniGenei Mm.27035.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3T58 X-ray 2.40 A/B/C/D 36-550 [» ]
3T59 X-ray 2.80 A/B/C/D 36-550 [» ]
ProteinModelPortali Q8BND5.
SMRi Q8BND5. Positions 38-549.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BND5.

Proteomic databases

MaxQBi Q8BND5.
PaxDbi Q8BND5.
PRIDEi Q8BND5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035325 ; ENSMUSP00000035658 ; ENSMUSG00000033684 . [Q8BND5-1 ]
ENSMUST00000111764 ; ENSMUSP00000107394 ; ENSMUSG00000033684 . [Q8BND5-2 ]
GeneIDi 104009.
KEGGi mmu:104009.
UCSCi uc007dbo.1. mouse. [Q8BND5-3 ]
uc007dbp.1. mouse. [Q8BND5-1 ]
uc007dbq.1. mouse. [Q8BND5-4 ]
uc011wtx.1. mouse. [Q8BND5-2 ]

Organism-specific databases

CTDi 5768.
MGIi MGI:1330818. Qsox1.

Phylogenomic databases

eggNOGi COG0526.
GeneTreei ENSGT00390000008045.
HOVERGENi HBG080360.
InParanoidi Q8BND5.
KOi K10758.
OMAi SHNRVNA.
OrthoDBi EOG73RB9X.
PhylomeDBi Q8BND5.
TreeFami TF316749.

Miscellaneous databases

NextBioi 356343.
PROi Q8BND5.
SOURCEi Search...

Gene expression databases

Bgeei Q8BND5.
CleanExi MM_QSOX1.
Genevestigatori Q8BND5.

Family and domain databases

Gene3Di 1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEi PS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sulfhydryl oxidase (SOx) from mouse epidermis: molecular cloning, nucleotide sequence, and expression of recombinant protein in the cultured cells."
    Matsuba S., Suga Y., Ishidoh K., Hashimoto Y., Takamori K., Kominami E., Wilhelm B., Seitz J., Ogawa H.
    J. Dermatol. Sci. 30:50-62(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
    Strain: C57BL/6J and NOD.
    Tissue: Cerebellum, Liver and Spinal ganglion.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-538 (ISOFORM 3).
    Strain: C57BL/6 and FVB/N.
    Tissue: Eye and Salivary gland.

Entry informationi

Entry nameiQSOX1_MOUSE
AccessioniPrimary (citable) accession number: Q8BND5
Secondary accession number(s): Q3TDY9
, Q3TE19, Q3TR29, Q3UEL4, Q8K041, Q9DBL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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