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Q8BN82

- S17A5_MOUSE

UniProt

Q8BN82 - S17A5_MOUSE

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Protein

Sialin

Gene

Slc17a5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO3-/H+ cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva (By similarity).By similarity

GO - Molecular functioni

  1. sialic acid transmembrane transporter activity Source: Ensembl
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. amino acid transport Source: UniProtKB-KW
  2. sialic acid transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_202500. Sialic acid metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialin
Alternative name(s):
H(+)/nitrate cotransporter
H(+)/sialic acid cotransporter
Short name:
AST
Solute carrier family 17 member 5
Vesicular H(+)/Aspartate-glutamate cotransporter
Gene namesi
Name:Slc17a5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1924105. Slc17a5.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasmic membrane-bounded vesicle Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. lysosomal membrane Source: Ensembl
  5. plasma membrane Source: MGI
  6. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Lysosome, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495SialinPRO_0000220948Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8BN82.

PTM databases

PhosphoSiteiQ8BN82.

Expressioni

Gene expression databases

BgeeiQ8BN82.
GenevestigatoriQ8BN82.

Structurei

3D structure databases

ProteinModelPortaliQ8BN82.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini63 – 10947LumenalSequence AnalysisAdd
BLAST
Topological domaini131 – 1366CytoplasmicSequence Analysis
Topological domaini158 – 1581LumenalSequence Analysis
Topological domaini180 – 20021CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini222 – 2276LumenalSequence Analysis
Topological domaini249 – 27830CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini300 – 32829LumenalSequence AnalysisAdd
BLAST
Topological domaini350 – 36516CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini387 – 3915LumenalSequence Analysis
Topological domaini413 – 42311CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini445 – 45713LumenalSequence AnalysisAdd
BLAST
Topological domaini479 – 49517CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221HelicalSequence AnalysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence AnalysisAdd
BLAST
Transmembranei228 – 24821HelicalSequence AnalysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence AnalysisAdd
BLAST
Transmembranei329 – 34921HelicalSequence AnalysisAdd
BLAST
Transmembranei366 – 38621HelicalSequence AnalysisAdd
BLAST
Transmembranei392 – 41221HelicalSequence AnalysisAdd
BLAST
Transmembranei424 – 44421HelicalSequence AnalysisAdd
BLAST
Transmembranei458 – 47821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi22 – 232Dileucine internalization motifBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000119079.
HOGENOMiHOG000230811.
HOVERGENiHBG008834.
InParanoidiQ8BN82.
KOiK12301.
OMAiKHKRISH.
OrthoDBiEOG789C9Z.
PhylomeDBiQ8BN82.
TreeFamiTF313535.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BN82) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPLLRGPAG NDDEESSDST PLLPGARQTE AAPVCCSARY NLAILAFCGF
60 70 80 90 100
FVLYALRVNL SVALVDMVDS NTTLTDNRTS KECAEHSAPI KVHHNHTGKK
110 120 130 140 150
YKWDAETQGW ILGSFFYGYI VTQIPGGYIA SRVGGKLLLG LGILGTSVFT
160 170 180 190 200
LFTPLAADLG VVTLVVLRAL EGLGEGVTFP AMHAMWSSWA PPLERSKLLT
210 220 230 240 250
ISYAGAQLGT VISLPLSGII CYYMNWTYVF YLFGIVGIVW FILWMWIVSD
260 270 280 290 300
TPETHKTISH YEKEYIVSSL KNQLSSQKVV PWGSILKSLP LWAIVVAHFS
310 320 330 340 350
YNWSFYTLLT LLPTYMKEIL RFNVQENGFL SALPYFGCWL CMILCGQAAD
360 370 380 390 400
YLRVKWNFST ISVRRIFSLV GMVGPAVFLV AAGFIGCDYS LAVAFLTIST
410 420 430 440 450
TLGGFASSGF SINHLDIAPS YAGILLGITN TFATIPGMTG PIIAKSLTPD
460 470 480 490
NTIREWQTVF CIAAAINVFG AIFFTLFAKG EVQSWALSDH HGHRN
Length:495
Mass (Da):54,369
Last modified:June 7, 2004 - v2
Checksum:i6009661215D26437
GO
Isoform 2 (identifier: Q8BN82-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-123: Missing.

Note: No experimental confirmation available.

Show »
Length:469
Mass (Da):51,301
Checksum:iB48BCF204A2D6008
GO
Isoform 3 (identifier: Q8BN82-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-238: GVTFPAMHAM...VFYLFGIVGI → KYPPPGCYVS...YELDLRLLSF
     239-495: Missing.

Note: No experimental confirmation available.

Show »
Length:238
Mass (Da):25,879
Checksum:i95222793B0E39762
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei98 – 12326Missing in isoform 2. 1 PublicationVSP_010484Add
BLAST
Alternative sequencei176 – 23863GVTFP…GIVGI → KYPPPGCYVSSYARHVVFLG SPSGKKQASYHFLCGSTAWD SDLTSSFRNNMLLYELDLRL LSF in isoform 3. 1 PublicationVSP_010485Add
BLAST
Alternative sequencei239 – 495257Missing in isoform 3. 1 PublicationVSP_010486Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK029102 mRNA. Translation: BAC26298.1.
AK087395 mRNA. Translation: BAC39859.1.
AK169868 mRNA. Translation: BAE41423.1.
BC058785 mRNA. Translation: AAH58785.1.
CCDSiCCDS23364.1. [Q8BN82-1]
CCDS72283.1. [Q8BN82-2]
RefSeqiNP_001263381.1. NM_001276452.1. [Q8BN82-2]
NP_766361.1. NM_172773.3. [Q8BN82-1]
UniGeneiMm.46932.

Genome annotation databases

EnsembliENSMUST00000052441; ENSMUSP00000056182; ENSMUSG00000049624. [Q8BN82-1]
ENSMUST00000117645; ENSMUSP00000113003; ENSMUSG00000049624. [Q8BN82-2]
ENSMUST00000119213; ENSMUSP00000113340; ENSMUSG00000049624. [Q8BN82-3]
GeneIDi235504.
KEGGimmu:235504.
UCSCiuc009quo.1. mouse. [Q8BN82-1]
uc009qup.1. mouse. [Q8BN82-3]
uc012gxg.1. mouse. [Q8BN82-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK029102 mRNA. Translation: BAC26298.1 .
AK087395 mRNA. Translation: BAC39859.1 .
AK169868 mRNA. Translation: BAE41423.1 .
BC058785 mRNA. Translation: AAH58785.1 .
CCDSi CCDS23364.1. [Q8BN82-1 ]
CCDS72283.1. [Q8BN82-2 ]
RefSeqi NP_001263381.1. NM_001276452.1. [Q8BN82-2 ]
NP_766361.1. NM_172773.3. [Q8BN82-1 ]
UniGenei Mm.46932.

3D structure databases

ProteinModelPortali Q8BN82.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BN82.

Proteomic databases

PRIDEi Q8BN82.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052441 ; ENSMUSP00000056182 ; ENSMUSG00000049624 . [Q8BN82-1 ]
ENSMUST00000117645 ; ENSMUSP00000113003 ; ENSMUSG00000049624 . [Q8BN82-2 ]
ENSMUST00000119213 ; ENSMUSP00000113340 ; ENSMUSG00000049624 . [Q8BN82-3 ]
GeneIDi 235504.
KEGGi mmu:235504.
UCSCi uc009quo.1. mouse. [Q8BN82-1 ]
uc009qup.1. mouse. [Q8BN82-3 ]
uc012gxg.1. mouse. [Q8BN82-2 ]

Organism-specific databases

CTDi 26503.
MGIi MGI:1924105. Slc17a5.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00760000119079.
HOGENOMi HOG000230811.
HOVERGENi HBG008834.
InParanoidi Q8BN82.
KOi K12301.
OMAi KHKRISH.
OrthoDBi EOG789C9Z.
PhylomeDBi Q8BN82.
TreeFami TF313535.

Enzyme and pathway databases

Reactomei REACT_202500. Sialic acid metabolism.

Miscellaneous databases

ChiTaRSi SLC17A5. mouse.
NextBioi 382720.
PROi Q8BN82.
SOURCEi Search...

Gene expression databases

Bgeei Q8BN82.
Genevestigatori Q8BN82.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Strain: C57BL/6J and NOD.
    Tissue: Eye and Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Olfactory epithelium.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "The lysosomal sialic acid transporter sialin is required for normal CNS myelination."
    Prolo L.M., Vogel H., Reimer R.J.
    J. Neurosci. 29:15355-15365(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiS17A5_MOUSE
AccessioniPrimary (citable) accession number: Q8BN82
Secondary accession number(s): Q3TE25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 29, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3