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Q8BN74 (Q8BN74_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Ncoa2 MGI 1276533
OrganismMus musculus (Mouse) EMBL BAC39875.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length873 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 basic helix-loop-helix (bHLH) domain. RuleBase RU000367

Contains bHLH (basic helix-loop-helix) domain. SAAS SAAS000014

Ontologies

Keywords
   Biological processTranscription
Transcription regulation SAAS SAAS000014
   Cellular componentNucleus SAAS SAAS000014
   DomainRepeat SAAS SAAS000014
   LigandDNA-binding SAAS SAAS000014
   Technical term3D-structure PDB 3ERD
Gene Ontology (GO)
   Biological_processnegative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 8643509. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 8643509. Source: MGI

positive regulation of receptor activity

Inferred from direct assay PubMed 15072553. Source: GOC

positive regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 15383530. Source: MGI

regulation of transcription, DNA-templated

Inferred from direct assay PubMed 11675124PubMed 12130539. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 11675124. Source: MGI

nucleus

Inferred from direct assay PubMed 11675124PubMed 12130539. Source: MGI

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

chromatin binding

Inferred from direct assay PubMed 16109736. Source: MGI

histone acetyltransferase activity

Inferred from electronic annotation. Source: InterPro

ligand-dependent nuclear receptor transcription coactivator activity

Inferred from direct assay PubMed 15072553. Source: MGI

receptor binding

Inferred from direct assay PubMed 8643509. Source: MGI

signal transducer activity

Inferred from electronic annotation. Source: InterPro

thyroid hormone receptor coactivator activity

Inferred from direct assay PubMed 15072553. Source: MGI

transcription coactivator activity

Inferred from direct assay PubMed 11675124PubMed 12130539PubMed 8643509. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8BN74 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: AE903710A7CE71E8

FASTA87394,702
        10         20         30         40         50         60 
MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRSTEKRNRE QENKYIEELA ELIFANFNDI 

        70         80         90        100        110        120 
DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS DVSSTGQGVI DKDALGPMML 

       130        140        150        160        170        180 
EALDGFFFVV NLEGSVVFVS ENVTQYLRYN QEELMNKSVY SILHVGDHTE FVKNLLPKSM 

       190        200        210        220        230        240 
VNGGSWSGEP PRRSSHTFNC RMLVKPLPDS EEEGHDSQEA HQKYEAMQCF AVSQPKSIKE 

       250        260        270        280        290        300 
EGEDLQSCLI CVARRVPMKE RPTLPSSESF TTRQDLQGKI TSLDTSTMRA AMKPGWEDLV 

       310        320        330        340        350        360 
RRCIQKFHTQ HEGESLSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ TKSKLIRSQT 

       370        380        390        400        410        420 
TNEPQLVISL HMLHREQNVC VMNPDLTGQA MGKPLNPISS SSPAHQALCS GNPGQDMTLG 

       430        440        450        460        470        480 
SNINFPMNGP KEQMGMPMGR FGGSGGMNHV SGMQATTPQG SNYALKMNSP SQSSPGMNPG 

       490        500        510        520        530        540 
QASSVLSPRQ RMSPGVAGSP RIPPSQFSPA GSLHSPVGVC SSTGNSHSYT NSSLNALQAL 

       550        560        570        580        590        600 
SEGHGVSLGS SLASPDLKMG NLQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA 

       610        620        630        640        650        660 
EASCHPEEQK GPNDSSMPQA ASGDRAEGHS RLHDSKGQTK LLQLLTTKSD QMEPSPLPSS 

       670        680        690        700        710        720 
LSDTNKDSTG SLPGPGSTHG TSLKEKHKIL HRLLQDSSSP VDLAKLTAEA TGKELSQESS 

       730        740        750        760        770        780 
STAPGSEVTV KQEPASPKKK ENALLRYLLD KDDTKDIGLP EITPKLERLD SKTDPASNTK 

       790        800        810        820        830        840 
LIAMKTVKEE VSFEPSDQPG SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP TGSVDKQAII 

       850        860        870 
NDLMQLTADS SPVPPAGAQK AALRMSQSSK YAL 

« Hide

References

[1]"The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen."
Shiau A.K., Barstad D., Loria P.M., Cheng L., Kushner P.J., Agard D.A., Greene G.L.
Cell 95:927-937(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.03 ANGSTROMS) OF 686-698.
[2]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39875.1.
Tissue: Eyeball EMBL BAC39875.1.
[3]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39875.1.
Tissue: Eyeball EMBL BAC39875.1.
[4]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39875.1.
Tissue: Eyeball EMBL BAC39875.1.
[5]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39875.1.
Tissue: Eyeball EMBL BAC39875.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39875.1.
Tissue: Eyeball EMBL BAC39875.1.
[7]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39875.1.
Tissue: Eyeball EMBL BAC39875.1.
[8]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39875.1.
Tissue: Eyeball EMBL BAC39875.1.
[9]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39875.1.
Tissue: Eyeball EMBL BAC39875.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK087443 mRNA. Translation: BAC39875.1.
RefSeqNP_001071163.1. NM_001077695.1.
NP_032704.2. NM_008678.2.
UniGeneMm.2537.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3ERDX-ray2.03C/D686-698[»]
ProteinModelPortalQ8BN74.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID17978.
KEGGmmu:17978.
UCSCuc007aip.1. mouse.

Organism-specific databases

CTD10499.
MGIMGI:1276533. Ncoa2.

Phylogenomic databases

HOVERGENHBG052583.
InParanoidQ8BN74.
KOK11255.

Gene expression databases

GenevestigatorQ8BN74.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
4.10.630.10. 2 hits.
InterProIPR011598. bHLH_dom.
IPR028822. NCOA2.
IPR017426. Nuclear_rcpt_coactivator.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR014935. SRC-1.
IPR008955. Src1_rcpt_coact.
[Graphical view]
PANTHERPTHR10684. PTHR10684. 1 hit.
PTHR10684:SF2. PTHR10684:SF2. 1 hit.
PfamPF00989. PAS. 1 hit.
PF08832. SRC-1. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
PROSITEPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNCOA2. mouse.
EvolutionaryTraceQ8BN74.
NextBio292941.
SOURCESearch...

Entry information

Entry nameQ8BN74_MOUSE
AccessionPrimary (citable) accession number: Q8BN74
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)