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Q8BN74

- Q8BN74_MOUSE

UniProt

Q8BN74 - Q8BN74_MOUSE

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Protein
Submitted name: Putative uncharacterized protein
Gene
Ncoa2
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. chromatin binding Source: MGI
  3. histone acetyltransferase activity Source: InterPro
  4. ligand-dependent nuclear receptor transcription coactivator activity Source: MGI
  5. protein binding Source: MGI
  6. receptor binding Source: MGI
  7. signal transducer activity Source: InterPro
  8. thyroid hormone receptor coactivator activity Source: MGI
  9. transcription coactivator activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  2. negative regulation of transcription, DNA-templated Source: MGI
  3. positive regulation of receptor activity Source: GOC
  4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  5. regulation of transcription, DNA-templated Source: MGI
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotations

Keywords - Ligandi

DNA-bindingSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Ncoa2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1276533. Ncoa2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Expressioni

Gene expression databases

GenevestigatoriQ8BN74.

Structurei

3D structure databases

ProteinModelPortaliQ8BN74.

Miscellaneous databases

EvolutionaryTraceiQ8BN74.

Family & Domainsi

Sequence similaritiesi

Contains bHLH (basic helix-loop-helix) domain.SAAS annotations

Keywords - Domaini

RepeatSAAS annotations

Phylogenomic databases

HOVERGENiHBG052583.
InParanoidiQ8BN74.
KOiK11255.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
4.10.630.10. 2 hits.
InterProiIPR011598. bHLH_dom.
IPR028822. NCOA2.
IPR017426. Nuclear_rcpt_coactivator.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR014935. SRC-1.
IPR008955. Src1_rcpt_coact.
[Graphical view]
PANTHERiPTHR10684. PTHR10684. 1 hit.
PTHR10684:SF2. PTHR10684:SF2. 1 hit.
PfamiPF00989. PAS. 1 hit.
PF08832. SRC-1. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BN74-1 [UniParc]FASTAAdd to Basket

« Hide

MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRSTEKRNRE QENKYIEELA    50
ELIFANFNDI DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS 100
DVSSTGQGVI DKDALGPMML EALDGFFFVV NLEGSVVFVS ENVTQYLRYN 150
QEELMNKSVY SILHVGDHTE FVKNLLPKSM VNGGSWSGEP PRRSSHTFNC 200
RMLVKPLPDS EEEGHDSQEA HQKYEAMQCF AVSQPKSIKE EGEDLQSCLI 250
CVARRVPMKE RPTLPSSESF TTRQDLQGKI TSLDTSTMRA AMKPGWEDLV 300
RRCIQKFHTQ HEGESLSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ 350
TKSKLIRSQT TNEPQLVISL HMLHREQNVC VMNPDLTGQA MGKPLNPISS 400
SSPAHQALCS GNPGQDMTLG SNINFPMNGP KEQMGMPMGR FGGSGGMNHV 450
SGMQATTPQG SNYALKMNSP SQSSPGMNPG QASSVLSPRQ RMSPGVAGSP 500
RIPPSQFSPA GSLHSPVGVC SSTGNSHSYT NSSLNALQAL SEGHGVSLGS 550
SLASPDLKMG NLQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA 600
EASCHPEEQK GPNDSSMPQA ASGDRAEGHS RLHDSKGQTK LLQLLTTKSD 650
QMEPSPLPSS LSDTNKDSTG SLPGPGSTHG TSLKEKHKIL HRLLQDSSSP 700
VDLAKLTAEA TGKELSQESS STAPGSEVTV KQEPASPKKK ENALLRYLLD 750
KDDTKDIGLP EITPKLERLD SKTDPASNTK LIAMKTVKEE VSFEPSDQPG 800
SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP TGSVDKQAII NDLMQLTADS 850
SPVPPAGAQK AALRMSQSSK YAL 873
Length:873
Mass (Da):94,702
Last modified:March 1, 2003 - v1
Checksum:iAE903710A7CE71E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK087443 mRNA. Translation: BAC39875.1.
RefSeqiNP_001071163.1. NM_001077695.1.
NP_032704.2. NM_008678.2.
UniGeneiMm.2537.

Genome annotation databases

GeneIDi17978.
KEGGimmu:17978.
UCSCiuc007aip.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK087443 mRNA. Translation: BAC39875.1 .
RefSeqi NP_001071163.1. NM_001077695.1.
NP_032704.2. NM_008678.2.
UniGenei Mm.2537.

3D structure databases

ProteinModelPortali Q8BN74.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 17978.
KEGGi mmu:17978.
UCSCi uc007aip.1. mouse.

Organism-specific databases

CTDi 10499.
MGIi MGI:1276533. Ncoa2.

Phylogenomic databases

HOVERGENi HBG052583.
InParanoidi Q8BN74.
KOi K11255.

Miscellaneous databases

ChiTaRSi NCOA2. mouse.
EvolutionaryTracei Q8BN74.
NextBioi 292941.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8BN74.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
4.10.630.10. 2 hits.
InterProi IPR011598. bHLH_dom.
IPR028822. NCOA2.
IPR017426. Nuclear_rcpt_coactivator.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR014935. SRC-1.
IPR008955. Src1_rcpt_coact.
[Graphical view ]
PANTHERi PTHR10684. PTHR10684. 1 hit.
PTHR10684:SF2. PTHR10684:SF2. 1 hit.
Pfami PF00989. PAS. 1 hit.
PF08832. SRC-1. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
PROSITEi PS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.

Entry informationi

Entry nameiQ8BN74_MOUSE
AccessioniPrimary (citable) accession number: Q8BN74
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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