Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

La-related protein 6

Gene

Larp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Translation regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
La-related protein 6
Alternative name(s):
Acheron
Short name:
Achn
La ribonucleoprotein domain family member 6
Gene namesi
Name:Larp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914807. Larp6.

Subcellular locationi

  • Cytoplasm
  • Nucleus

  • Note: Shuttles between the nucleus and the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002811422 – 492La-related protein 6Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei56PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BN59.
PaxDbiQ8BN59.
PRIDEiQ8BN59.

PTM databases

iPTMnetiQ8BN59.
PhosphoSitePlusiQ8BN59.

Expressioni

Tissue specificityi

Expressed in numerous tissues. Highest expression in heart and brain, intermediate in kidney, skeletal muscle and testis, lowest expression in testis (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000034839.
CleanExiMM_LARP6.
GenevisibleiQ8BN59. MM.

Interactioni

Subunit structurei

Interacts (via the HTH domain) with VIM/vimentin. Interacts (via C-terminus) with non-muscle myosin MYH10. Interacts (via C-terminus) with DHX9 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040309.

Structurei

3D structure databases

ProteinModelPortaliQ8BN59.
SMRiQ8BN59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 177HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST92
Domaini184 – 296RRMAdd BLAST113

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi186 – 193Nuclear export signalBy similarity8
Motifi296 – 302Nuclear localization signalBy similarity7

Domaini

The RRM domain mediates the association with collagen mRNAs stem-loops.By similarity

Sequence similaritiesi

Contains 1 HTH La-type RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1855. Eukaryota.
ENOG4110VUA. LUCA.
GeneTreeiENSGT00830000128323.
HOGENOMiHOG000010108.
HOVERGENiHBG070244.
InParanoidiQ8BN59.
KOiK18733.
OMAiEEGGMRK.
OrthoDBiEOG091G09LP.
PhylomeDBiQ8BN59.
TreeFamiTF326594.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR024642. SUZ-C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF12901. SUZ-C. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50961. HTH_LA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BN59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLGEQTLP GPETTVQIRV AIQEAEDLED LEEEDEGTSA RAAGDPARYL
60 70 80 90 100
SPGWGSASEE EPSRGHSSAT TSGGENDRED LEPEWRPPDE ELIRKLVDQI
110 120 130 140 150
EFYFSDENLE KDAFLLKHVR RNKLGYVSVK LLTSFKKVKH LTRDWRTTAH
160 170 180 190 200
ALKYSVTLEL NEDHRKVRRT TPVPLFPNEN LPSKMLLVYD LHLSPKLWAL
210 220 230 240 250
ATPQKNGRVQ EKVMEHLLKL FGTFGVISSV RILKPGRELP PDIRRISSRY
260 270 280 290 300
SQVGTQECAI VEFEEVDAAI KAHEFMVTES QSKENMKAVL IGMKPPKKKP
310 320 330 340 350
LKDKNHDDEA TAGTHLSRSL NKRVEELQYM GDESSANSSS DPESNPTSPM
360 370 380 390 400
AGRRHAASNK LSPSGHQNIF LSPNASPCSS PWSSPLAQRK GVSRKSPLAE
410 420 430 440 450
EGRLNFSTSP EIFRKCMDYS SDSSITPSGS PWVRRRRQAE MGTQEKSPGA
460 470 480 490
SPLLSRRMQT ADGLPVGVLR LPRGPDNTRG FHGGHERGRA CV
Length:492
Mass (Da):54,873
Last modified:March 1, 2003 - v1
Checksum:iAA78A6BBCADDE231
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58S → T in BAB30713 (PubMed:16141072).Curated1
Sequence conflicti107E → D in BAC30400 (PubMed:16141072).Curated1
Sequence conflicti314T → N in BAC31306 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017372 mRNA. Translation: BAB30713.1.
AK020966 mRNA. Translation: BAB32263.1.
AK039614 mRNA. Translation: BAC30400.1.
AK042616 mRNA. Translation: BAC31306.1.
AK087521 mRNA. Translation: BAC39909.1.
BC090615 mRNA. Translation: AAH90615.1.
CCDSiCCDS23258.1.
RefSeqiNP_080511.2. NM_026235.4.
UniGeneiMm.44546.

Genome annotation databases

EnsembliENSMUST00000038407; ENSMUSP00000040309; ENSMUSG00000034839.
GeneIDi67557.
KEGGimmu:67557.
UCSCiuc009pzh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017372 mRNA. Translation: BAB30713.1.
AK020966 mRNA. Translation: BAB32263.1.
AK039614 mRNA. Translation: BAC30400.1.
AK042616 mRNA. Translation: BAC31306.1.
AK087521 mRNA. Translation: BAC39909.1.
BC090615 mRNA. Translation: AAH90615.1.
CCDSiCCDS23258.1.
RefSeqiNP_080511.2. NM_026235.4.
UniGeneiMm.44546.

3D structure databases

ProteinModelPortaliQ8BN59.
SMRiQ8BN59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040309.

PTM databases

iPTMnetiQ8BN59.
PhosphoSitePlusiQ8BN59.

Proteomic databases

MaxQBiQ8BN59.
PaxDbiQ8BN59.
PRIDEiQ8BN59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038407; ENSMUSP00000040309; ENSMUSG00000034839.
GeneIDi67557.
KEGGimmu:67557.
UCSCiuc009pzh.1. mouse.

Organism-specific databases

CTDi55323.
MGIiMGI:1914807. Larp6.

Phylogenomic databases

eggNOGiKOG1855. Eukaryota.
ENOG4110VUA. LUCA.
GeneTreeiENSGT00830000128323.
HOGENOMiHOG000010108.
HOVERGENiHBG070244.
InParanoidiQ8BN59.
KOiK18733.
OMAiEEGGMRK.
OrthoDBiEOG091G09LP.
PhylomeDBiQ8BN59.
TreeFamiTF326594.

Miscellaneous databases

PROiQ8BN59.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034839.
CleanExiMM_LARP6.
GenevisibleiQ8BN59. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR024642. SUZ-C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF12901. SUZ-C. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50961. HTH_LA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLARP6_MOUSE
AccessioniPrimary (citable) accession number: Q8BN59
Secondary accession number(s): Q8C9A3
, Q8CA51, Q9CTN3, Q9D3J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.